{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:52:50Z","timestamp":1792641170961,"version":"4.5.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,2]],"date-time":"2019-11-02T00:00:00Z","timestamp":1572652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012829","name":"Guangdong Provincial Hospital of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["20171174"],"award-info":[{"award-number":["20171174"]}],"id":[{"id":"10.13039\/100012829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Science, Technology and Innovation Commission of Shenzhen Municipality","doi-asserted-by":"publisher","award":["JCYJ20170307144103633"],"award-info":[{"award-number":["JCYJ20170307144103633"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.biopha.2019.109643","type":"journal-article","created":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T05:34:33Z","timestamp":1574314473000},"page":"109643","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Transition of the abnormal Savda syndrome to the hepatic carcinoma shifted unfolded protein response to autophagy was partly reversed by Savda Munziq in a rat model"],"prefix":"10.1016","volume":"121","author":[{"given":"Yi","family":"Hao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.biopha.2019.109643_bib0005","doi-asserted-by":"crossref","first-page":"301","DOI":"10.4314\/ajtcam.v11i2.13","article-title":"An assessment of traditional Uighur medicine in current Xinjiang region (China)","volume":"11","author":"Ma","year":"2014","journal-title":"Afr. J. Tradit. Complement Altern. Med."},{"issue":"1","key":"10.1016\/j.biopha.2019.109643_bib0010","first-page":"477","article-title":"Anti-tumor effects of Abnormal Savda Munziq on the transplanted cervical cancer (U27) mouse model","volume":"16","author":"Omarniyaz","year":"2016","journal-title":"BMC"},{"key":"10.1016\/j.biopha.2019.109643_bib0015","series-title":"Uyghur Medical Plastid Body Fluid and Its Modern Research","author":"Wuur","year":"2003"},{"key":"10.1016\/j.biopha.2019.109643_bib0020","series-title":"A New Theory on Abnormal Savda in Uygur Medicine","author":"Wuur","year":"2005"},{"issue":"3","key":"10.1016\/j.biopha.2019.109643_bib0025","first-page":"3","article-title":"Classify study on nomaI and unnomal physique fluid of uygour traditional medicine","volume":"10","author":"Touoti","year":"2004","journal-title":"J. Med. Pharm. Chin. Minor."},{"issue":"2","key":"10.1016\/j.biopha.2019.109643_bib0030","first-page":"119","article-title":"Study on the classification of malignant tumors and the neuroendocrine immune network disorder","volume":"14","author":"Zhang","year":"2008","journal-title":"Chin. J. Basic Med. Tradit. Chin. Med."},{"key":"10.1016\/j.biopha.2019.109643_bib0035","first-page":"9","article-title":"Identification of plasma protein markers common to patients with malignant tumour and Abnormal Savda in Uighur medicine: a prospective clinical study","volume":"15","author":"Upur","year":"2015","journal-title":"BMC"},{"issue":"5","key":"10.1016\/j.biopha.2019.109643_bib0040","first-page":"197","article-title":"Osteonecrosis of the femur head. Pathogenetic considerations","volume":"20","author":"Barbieri","year":"1969","journal-title":"Minerva Ortop."},{"issue":"1","key":"10.1016\/j.biopha.2019.109643_bib0045","first-page":"9","article-title":"Identification of plasma protein markers common to patients with malignant tumour and Abnormal Savda in Uighur medicine: a prospective clinical study","volume":"15","author":"Upur","year":"2015","journal-title":"BMC"},{"issue":"3","key":"10.1016\/j.biopha.2019.109643_bib0050","first-page":"3","article-title":"Classify study on nomaI and unnomal physique fluid of uygour traditional medicine","volume":"10","author":"Kuzesigian","year":"2004","journal-title":"J. Med. Pharm. Chin. Minor."},{"issue":"4","key":"10.1016\/j.biopha.2019.109643_bib0055","doi-asserted-by":"crossref","first-page":"483","DOI":"10.2515\/therapie:2004083","article-title":"Uighur traditional medicine syndrome of Abnormal Savda in men is associated with oxidative stress, which can be improved by Munziq and Mushil of Abnormal Savda","volume":"59","author":"Upur","year":"2004","journal-title":"Therapie"},{"key":"10.1016\/j.biopha.2019.109643_bib0060","article-title":"The reverse effect of Uygur medicine ASMq on the drug resistance cells of liver cancer","volume":"09","author":"Mayinur","year":"2007","journal-title":"Chin. J. Inf. Tradit. Chin.Med."},{"key":"10.1016\/j.biopha.2019.109643_bib0065","doi-asserted-by":"crossref","first-page":"92682","DOI":"10.18632\/oncotarget.21563","article-title":"Enhanced antitumor efficacy and reduced toxicity of Abnormal Savda Munziq on tumor bearing mice treated with chemotherapy","author":"Yang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.biopha.2019.109643_bib0070","article-title":"Anti-cancer effects of Uighur Medicine Abnormal Savda Munzip and its influence on cell migration","volume":"3","author":"Hi","year":"2011","journal-title":"Sci. Technol. Rev."},{"key":"10.1016\/j.biopha.2019.109643_bib0075","article-title":"Inhibition of cell growth and cellular protein, DNA and RNA synthesis in human hepatoma (HepG2) cells by ethanol extract of Abnormal Savda Munziq of Uighur medicine","volume":"2011","author":"Upur","year":"2011","journal-title":"eCAM"},{"key":"10.1016\/j.biopha.2019.109643_bib0080","article-title":"Ethanol extract of Abnormal Savda Munziq, a herbal preparation of traditional Uighur medicine, inhibits caco-2 cells proliferation via cell cycle arrest and apoptosis","volume":"2012","author":"Yusup","year":"2012","journal-title":"eCAM"},{"issue":"4","key":"10.1016\/j.biopha.2019.109643_bib0085","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1472-8206.2004.00249.x","article-title":"Protective effects of Munziq and Mushil of abnormal Savda to mitochondrial oxidative damage","volume":"18","author":"Yusup","year":"2004","journal-title":"Fund. Clin. Pharmacol."},{"issue":"2","key":"10.1016\/j.biopha.2019.109643_bib0090","first-page":"743","article-title":"Mechanisms of hela cell apoptosis induced by abnormal Savda Munziq total phenolics combined with chemotherapeutic agents","volume":"15","author":"Zhang","year":"2014","journal-title":"APJCP"},{"key":"10.1016\/j.biopha.2019.109643_bib0095","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.exer.2018.01.018","article-title":"Nrf2 protects human lens epithelial cells against H2O2-induced oxidative and ER stress: the ATF4 may be involved","volume":"169","author":"Ma","year":"2018","journal-title":"Exp. Eye Res."},{"issue":"2","key":"10.1016\/j.biopha.2019.109643_bib0100","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/35055065","article-title":"Translational control by the ER transmembrane kinase\/ribonuclease IRE1 under ER stress","volume":"3","author":"Iwawaki","year":"2001","journal-title":"Nat. Cell Biol."},{"issue":"7","key":"10.1016\/j.biopha.2019.109643_bib0105","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/onc.2012.130","article-title":"The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies","volume":"32","author":"Luo","year":"2013","journal-title":"Oncogene"},{"issue":"8","key":"10.1016\/j.biopha.2019.109643_bib0110","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/ncb0805-766","article-title":"ERAD: the long road to destruction","volume":"7","author":"Meusser","year":"2005","journal-title":"Nat. Cell Biol."},{"issue":"14","key":"10.1016\/j.biopha.2019.109643_bib0115","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1007\/s00018-012-1173-4","article-title":"Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress","volume":"70","author":"Deegan","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.biopha.2019.109643_bib0120","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.12659\/MSM.902870","article-title":"cancer-associated fibroblasts autophagy enhances progression of triple-negative breast cancer cells","volume":"23","author":"Wang","year":"2017","journal-title":"Med. Sci. Monitor"},{"issue":"24","key":"10.1016\/j.biopha.2019.109643_bib0125","doi-asserted-by":"crossref","first-page":"9220","DOI":"10.1128\/MCB.01453-06","article-title":"Autophagy is activated for cell survival after endoplasmic reticulum stress","volume":"26","author":"Ogata","year":"2006","journal-title":"Mol. Cell. Biol."},{"issue":"12","key":"10.1016\/j.biopha.2019.109643_bib0130","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.1016\/j.bbamcr.2013.06.028","article-title":"ER stress-induced cell death mechanisms","volume":"1833","author":"Sano","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"5","key":"10.1016\/j.biopha.2019.109643_bib0135","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1083\/jcb.201003138","article-title":"Regulation of basal cellular physiology by the homeostatic unfolded protein response","volume":"189","author":"Rutkowski","year":"2010","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.biopha.2019.109643_bib0140","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ccr.2006.06.001","article-title":"Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis","volume":"10","author":"Degenhardt","year":"2006","journal-title":"Cancer Cell"},{"key":"10.1016\/j.biopha.2019.109643_bib0145","doi-asserted-by":"crossref","first-page":"27831","DOI":"10.1038\/srep27831","article-title":"Differential integrative omic analysis for mechanism insights and biomarker discovery of abnormal Savda syndrome and its unique Munziq prescription","volume":"6","author":"Guo","year":"2016","journal-title":"Sci. Rep."},{"issue":"41","key":"10.1016\/j.biopha.2019.109643_bib0150","doi-asserted-by":"crossref","first-page":"157","DOI":"10.4103\/0973-1296.149732","article-title":"Development and validation of an high-performance liquid chromatography-diode array detector method for the simultaneous determination of six phenolic compounds in abnormal savda munziq decoction","volume":"11","author":"Tian","year":"2015","journal-title":"Pharmacogn. Mag."},{"key":"10.1016\/j.biopha.2019.109643_bib0155","article-title":"Differential integrative omic analysis for mechanism insights and biomarker discovery of abnormal Savda syndrome and its unique Munziq prescription","volume":"6","author":"Guo","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2019.109643_bib0160","first-page":"10","article-title":"Towards modernization of the formulation of the traditional Uighur medicine herbal preparation Abnormal Savda Munziq","volume":"2012","author":"Kizaibek","year":"2012","journal-title":"Evid.-Based Compl. Altern. Med."},{"issue":"4","key":"10.1016\/j.biopha.2019.109643_bib0165","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4161\/auto.19496","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy","volume":"8","author":"Klionsky","year":"2012","journal-title":"Autophagy"},{"issue":"12","key":"10.1016\/j.biopha.2019.109643_bib0170","doi-asserted-by":"crossref","first-page":"e423","DOI":"10.1371\/journal.pbio.0040423","article-title":"Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response","volume":"4","author":"Bernales","year":"2006","journal-title":"PLoS Biol."},{"issue":"2","key":"10.1016\/j.biopha.2019.109643_bib0175","doi-asserted-by":"crossref","first-page":"84","DOI":"10.4161\/auto.1.2.1697","article-title":"Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy","volume":"1","author":"Tanida","year":"2005","journal-title":"Autophagy"},{"issue":"7","key":"10.1016\/j.biopha.2019.109643_bib0180","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1002\/jcp.24923","article-title":"Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis","volume":"230","author":"Zhu","year":"2015","journal-title":"J. Cell. Physiol."},{"issue":"3","key":"10.1016\/j.biopha.2019.109643_bib0185","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/jb\/mvr143","article-title":"CHOP is a multifunctional transcription factor in the ER stress response","volume":"151","author":"Nishitoh","year":"2011","journal-title":"J. Biochem."},{"key":"10.1016\/j.biopha.2019.109643_bib0190","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.freeradbiomed.2015.11.024","article-title":"HERPUD1 protects against oxidative stress-induced apoptosis through downregulation of the inositol 1,4,5-trisphosphate receptor","volume":"90","author":"Paredes","year":"2016","journal-title":"Free Radic. Biol. Med."},{"issue":"23","key":"10.1016\/j.biopha.2019.109643_bib0195","doi-asserted-by":"crossref","first-page":"35454","DOI":"10.18632\/oncotarget.7721","article-title":"Control of CREB expression in tumors: from molecular mechanisms and signal transduction pathways to therapeutic target","volume":"7","author":"Steven","year":"2016","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.biopha.2019.109643_bib0200","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/s41467-017-01052-y","article-title":"Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1","volume":"8","author":"Feng","year":"2017","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.biopha.2019.109643_bib0205","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s12885-018-4041-2","article-title":"HtrA1 as a promising tissue marker in cancer: a meta-analysis","volume":"18","author":"Altobelli","year":"2018","journal-title":"BMC Cancer"},{"issue":"4","key":"10.1016\/j.biopha.2019.109643_bib0210","doi-asserted-by":"crossref","first-page":"462","DOI":"10.4161\/auto.6.4.11553","article-title":"Cyclophilin D is required for mitochondrial removal by autophagy in cardiac cells","volume":"6","author":"Carreira","year":"2010","journal-title":"Autophagy"},{"key":"10.1016\/j.biopha.2019.109643_bib0215","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3389\/fgene.2016.00165","article-title":"Cyclophilin D Is involved in the regulation of autophagy and affects the lifespan of P. anserina in response to mitochondrial oxidative stress","volume":"7","author":"Kramer","year":"2016","journal-title":"Front. Genet."},{"key":"10.1016\/j.biopha.2019.109643_bib0220","first-page":"131","article-title":"Type I insulin-like growth factor as a liver reserve assessment tool in hepatocellular carcinoma","volume":"2","author":"Abdel-Wahab","year":"2015","journal-title":"J. Hepatocell. Carcinoma"},{"key":"10.1016\/j.biopha.2019.109643_bib0225","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/0470869976.ch16","article-title":"Nutrition, insulin, IGF-1 metabolism and cancer risk: a summary of epidemiological evidence","volume":"262","author":"Kaaks","year":"2004","journal-title":"Novartis Found Symp"},{"issue":"3","key":"10.1016\/j.biopha.2019.109643_bib0230","doi-asserted-by":"crossref","first-page":"256","DOI":"10.7150\/ijms.10735","article-title":"Upregulation of heat shock proteins (HSPA12A, HSP90B1, HSPA4, HSPA5 and HSPA6) in tumour tissues is associated with poor outcomes from HBV-related early-stage hepatocellular carcinoma","volume":"12","author":"Yang","year":"2015","journal-title":"Int. J. Med. Sci."},{"issue":"11","key":"10.1016\/j.biopha.2019.109643_bib0235","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17111808","article-title":"PPIC, EMP3 and CHI3L1 are novel prognostic markers for high grade glioma","volume":"17","author":"Gao","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.biopha.2019.109643_bib0240","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1158\/1535-7163.MCT-11-0047","article-title":"The role of autophagy in cancer: therapeutic implications","volume":"10","author":"Yang","year":"2011","journal-title":"Mol Cancer Ther"},{"issue":"2","key":"10.1016\/j.biopha.2019.109643_bib0245","doi-asserted-by":"crossref","first-page":"C93","DOI":"10.1152\/ajpcell.00266.2016","article-title":"Endoplasmic reticulum proteostasis: a key checkpoint in cancer","volume":"312","author":"Oakes","year":"2017","journal-title":"Am J. Physiol. Cell. Physiol."},{"key":"10.1016\/j.biopha.2019.109643_bib0250","doi-asserted-by":"crossref","DOI":"10.1002\/cncr.31335","article-title":"Targeting autophagy in cancer","author":"Onorati","year":"2018","journal-title":"Cancer"},{"key":"10.1016\/j.biopha.2019.109643_bib0255","doi-asserted-by":"crossref","DOI":"10.1007\/s10555-018-9727-z","article-title":"Pro-survival autophagy and cancer cell resistance to therapy","author":"Das","year":"2018","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.biopha.2019.109643_bib0260","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.biopha.2017.05.132","article-title":"An oasis in the desert of cancer chemotherapeutic resistance: the enlightenment from reciprocal crosstalk between signaling pathways of UPR and autophagy in cancers","volume":"92","author":"Zhang","year":"2017","journal-title":"Biomed. Pharmacother."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219352655?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219352655?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:01:47Z","timestamp":1778241707000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332219352655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":52,"alternative-id":["S0753332219352655"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109643","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transition of the abnormal Savda syndrome to the hepatic carcinoma shifted unfolded protein response to autophagy was partly reversed by Savda Munziq in a rat model","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109643","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"109643"}}