{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:47:06Z","timestamp":1786985226929,"version":"build-2736575974"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T00:00:00Z","timestamp":1575849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.biopha.2019.109753","type":"journal-article","created":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T06:18:07Z","timestamp":1576736287000},"page":"109753","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":93,"special_numbering":"C","title":["Antipyretic, anti-inflammatory and analgesic activities of Periplaneta americana extract and underlying mechanisms"],"prefix":"10.1016","volume":"123","author":[{"given":"Tienthanh","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinwei","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4525-5803","authenticated-orcid":false,"given":"Xueqing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2019.109753_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneuroim.2016.01.016","article-title":"Evidence of substance P autocrine circuitry that involves TNF-alpha, IL-6, and PGE2 in endogenous pyrogen-induced fever","volume":"293","author":"Brito","year":"2016","journal-title":"J. Neuroimmunol."},{"issue":"Suppl 2","key":"10.1016\/j.biopha.2019.109753_bib0010","doi-asserted-by":"crossref","first-page":"S294","DOI":"10.1086\/513856","article-title":"Cytokines as endogenous pyrogens","volume":"179","author":"Dinarello","year":"1999","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.biopha.2019.109753_bib0015","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1080\/23328940.2015.1102802","article-title":"Central mediators involved in the febrile response: effects of antipyretic drugs","volume":"2","author":"Zampronio","year":"2015","journal-title":"Temperature (Austin)"},{"key":"10.1016\/j.biopha.2019.109753_bib0020","doi-asserted-by":"crossref","first-page":"4154","DOI":"10.1111\/j.1582-4934.2009.00893.x","article-title":"Sepsis, complement and the dysregulated inflammatory response","volume":"13","author":"Ward","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.biopha.2019.109753_bib0025","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/00325481.2018.1412799","article-title":"Cardiovascular safety of non-steroidal anti-inflammatory drugs revisited","volume":"130","author":"Walker","year":"2018","journal-title":"Postgrad. Med."},{"key":"10.1016\/j.biopha.2019.109753_bib0030","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11882-017-0694-1","article-title":"New insights into cockroach allergens","volume":"17","author":"Pomes","year":"2017","journal-title":"Curr. Allergy Asthma Rep."},{"key":"10.1016\/j.biopha.2019.109753_bib0035","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.cbi.2017.06.007","article-title":"Mechanistic evaluation of gastroprotective effects of Kangfuxin on ethanol-induced gastric ulcer in mice","volume":"273","author":"Shen","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.biopha.2019.109753_bib0040","first-page":"413","article-title":"Evidence based anti-osteoporosis effects of Periplaneta americana L on osteoblasts, osteoclasts, vascular endothelial cells and bone marrow derived mesenchymal stem cells, BMC Complement","volume":"17","author":"Huang","year":"2017","journal-title":"Altern. Med."},{"key":"10.1016\/j.biopha.2019.109753_bib0045","first-page":"249","article-title":"Clinical analysis of 63 cases of Kangfuxin in treatment of limb injury wound","volume":"10","author":"Fang","year":"2012","journal-title":"Guide China Med."},{"key":"10.1016\/j.biopha.2019.109753_bib0050","first-page":"198","article-title":"Curative effect analysis of Kangfuxin to recurrent oral ulcer","volume":"9","author":"Guo","year":"2011","journal-title":"Guide China Med."},{"key":"10.1016\/j.biopha.2019.109753_bib0055","first-page":"286","article-title":"Investigation of the clinical effect of microwave combined with Kangfuxin in treatment of severe cervical erosion","volume":"21","author":"Cui","year":"2013","journal-title":"Pharm. Clin. Res."},{"key":"10.1016\/j.biopha.2019.109753_bib0060","first-page":"167","article-title":"Clinical observation of 60 cases of Kangfuxin combined with San Qi in treatment of ulcerative colitis","volume":"9","author":"Sun","year":"2015","journal-title":"Chin. J. Mod. Drug Appl."},{"key":"10.1016\/j.biopha.2019.109753_bib0065","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1074\/mcp.M700497-MCP200","article-title":"Toward an understanding of the molecular mechanism for successful blood feeding by coupling proteomics analysis with pharmacological testing of horsefly salivary glands","volume":"7","author":"Xu","year":"2008","journal-title":"Mol. Cell Proteomics"},{"key":"10.1016\/j.biopha.2019.109753_bib0070","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jep.2015.11.015","article-title":"Anticoagulant activity of crude extract of Holotrichia diomphalia larvae","volume":"177","author":"Xu","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2019.109753_bib0075","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s11655-014-1952-x","article-title":"Antipyretic and anti-asthmatic activities of traditional Chinese herb-pairs, Ephedra and Gypsum","volume":"22","author":"Mei","year":"2016","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.biopha.2019.109753_bib0080","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1007\/s11655-017-2778-0","article-title":"Antipyretic effect of herba ephedrae-ramulus cinnamomi herb pair on yeast-induced pyrexia rats: a metabolomics study","volume":"24","author":"Wang","year":"2018","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.biopha.2019.109753_bib0085","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/1811199a0","article-title":"Antioxidant determinations by the use of a stable free radical","volume":"181","author":"BLOIS","year":"1958","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2019.109753_bib0090","doi-asserted-by":"crossref","first-page":"10709","DOI":"10.1021\/acs.jmedchem.8b01358","article-title":"Functional characterization of a novel lipopolysaccharide-binding antimicrobial and anti-inflammatory peptide in vitro and in vivo","volume":"63","author":"Zeng","year":"2018","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.biopha.2019.109753_bib0095","first-page":"178","article-title":"Chemical constituents from Periplaneta americana","volume":"53","author":"Si","year":"2018","journal-title":"Chinese Pharmaceutical Journal."},{"key":"10.1016\/j.biopha.2019.109753_bib0100","first-page":"375","article-title":"Chemical constituents from Periplaneta americana","volume":"40","author":"Gao","year":"2018","journal-title":"Chin. Trad. Patent Med."},{"key":"10.1016\/j.biopha.2019.109753_bib0105","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jep.2012.10.031","article-title":"Mechanisms of anti-inflammatory property of Anacardium occidentale stem bark: inhibition of NF-kappaB and MAPK signalling in the microglia","volume":"145","author":"Olajide","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2019.109753_bib0110","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1615\/CritRevImmunol.v31.i5.20","article-title":"LPS-induced cytokine production in human monocytes and macrophages","volume":"31","author":"Rossol","year":"2011","journal-title":"Crit. Rev. Immunol."},{"key":"10.1016\/j.biopha.2019.109753_bib0115","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1161\/ATVBAHA.110.207449","article-title":"Prostaglandins and inflammation","volume":"31","author":"Ricciotti","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.biopha.2019.109753_bib0120","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.4049\/jimmunol.165.2.1013","article-title":"Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin","volume":"165","author":"Chandel","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.biopha.2019.109753_bib0125","doi-asserted-by":"crossref","first-page":"944","DOI":"10.3389\/fphar.2018.00944","article-title":"Periplaneta americana ameliorates dextran sulfate sodium-induced ulcerative colitis in rats by Keap1\/Nrf-2 activation, intestinal barrier function, and gut microbiota regulation","volume":"9","author":"Ma","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.biopha.2019.109753_bib0130","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1002\/j.2040-4603.2014.tb00582.x","article-title":"Mechanisms of fever production and lysis: lessons from experimental LPS fever","volume":"4","author":"Roth","year":"2014","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.biopha.2019.109753_bib0135","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1097\/j.pain.0000000000001328","article-title":"Analgesic effects of a novel pH-dependent \u03bc-opioid receptor agonist in models of neuropathic and abdominal pain","volume":"159","author":"Rodriguez-Gaztelumendi","year":"2018","journal-title":"Pain"},{"key":"10.1016\/j.biopha.2019.109753_bib0140","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s10787-018-0504-y","article-title":"Ginsenoside metabolite compound K exerts anti-inflammatory and analgesic effects via downregulating COX2","volume":"27","author":"Chen","year":"2019","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.biopha.2019.109753_bib0145","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.pbb.2012.01.018","article-title":"Acetic acid- and phenyl-p-benzoquinone-induced overt pain-like behavior depends on spinal activation of MAP kinases, PI(3)K and microglia in mice","volume":"101","author":"Pavao-de-Souza","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.biopha.2019.109753_bib0150","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jep.2005.08.027","article-title":"Evaluation of the analgesic effect of Echium amoenum Fisch & C.A. Mey. Extract in mice: possible mechanism involved","volume":"103","author":"Heidari","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2019.109753_bib0155","doi-asserted-by":"crossref","first-page":"292","DOI":"10.4103\/0253-7613.157127","article-title":"A study of the mechanisms underlying the anti-inflammatory effect of ellagic acid in carrageenan-induced paw edema in rats","volume":"47","author":"Mansouri","year":"2015","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.biopha.2019.109753_bib0160","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1089\/jmf.2014.3197","article-title":"Analgesic and anti-inflammatory activities of Rosa taiwanensis Nakai in mice","volume":"18","author":"Tsai","year":"2015","journal-title":"J. Med. Food"},{"key":"10.1016\/j.biopha.2019.109753_bib0165","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/cbf.1812","article-title":"Effects of desipramine on the antioxidant status in rat tissues at carrageenan-induced paw inflammation","volume":"30","author":"Vircheva","year":"2012","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.biopha.2019.109753_bib0170","doi-asserted-by":"crossref","first-page":"7990","DOI":"10.4049\/jimmunol.0800377","article-title":"Myeloperoxidase deficiency attenuates lipopolysaccharide-induced acute lung inflammation and subsequent cytokine and chemokine production","volume":"182","author":"Haegens","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.biopha.2019.109753_bib0175","doi-asserted-by":"crossref","DOI":"10.1155\/2008\/135625","article-title":"Myeloperoxidase: a new biomarker of inflammation in ischemic heart disease and acute coronary syndromes","volume":"2008","author":"Loria","year":"2008","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.biopha.2019.109753_bib0180","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3892\/etm.2013.1074","article-title":"Antioxidant and anti-inflammatory effects of Astragalus polysaccharide on EA.hy926 cells","volume":"6","author":"Huang","year":"2013","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.biopha.2019.109753_bib0185","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1002\/jcb.21717","article-title":"p38\/NF-kB-dependent expression of COX-2 during differentiation and inflammatory response of chondrocytes","volume":"104","author":"Ulivi","year":"2008","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.biopha.2019.109753_bib0190","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.3892\/mmr.2016.5556","article-title":"Neuroprotective effect of ginsenoside Rg1 prevents cognitive impairment induced by isoflurane anesthesia in aged rats via antioxidant, anti-inflammatory and anti-apoptotic effects mediated by the PI3K\/AKT\/GSK-3 pathway","volume":"14","author":"Zhang","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.biopha.2019.109753_bib0195","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.archoralbio.2015.02.026","article-title":"The ethanol extract of Osmanthus fragrans attenuates Porphyromonas gingivalis lipopolysaccharide-stimulated inflammatory effect through the nuclear factor erythroid 2-related factor-mediated antioxidant signalling pathway","volume":"60","author":"Huang","year":"2015","journal-title":"Arch. Oral Biol."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219353752?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219353752?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:47:42Z","timestamp":1760096862000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332219353752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":39,"alternative-id":["S0753332219353752"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109753","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antipyretic, anti-inflammatory and analgesic activities of Periplaneta americana extract and underlying mechanisms","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109753","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"109753"}}