{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T12:47:53Z","timestamp":1785588473430,"version":"3.56.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T00:00:00Z","timestamp":1575936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["2017A95NCJ\/2017A95NCJ_002"],"award-info":[{"award-number":["2017A95NCJ\/2017A95NCJ_002"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.biopha.2019.109788","type":"journal-article","created":{"date-parts":[[2019,12,25]],"date-time":"2019-12-25T07:55:02Z","timestamp":1577260502000},"page":"109788","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Temporin L-derived peptide as a regulator of the acute inflammatory response in zymosan-induced peritonitis"],"prefix":"10.1016","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2163-5163","authenticated-orcid":false,"given":"Rosa","family":"Bellavita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Raucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Merlino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marialuisa","family":"Piccolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia","family":"Ferraro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Irace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Santamaria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3224-3651","authenticated-orcid":false,"given":"Asif J.","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ettore","family":"Novellino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Grieco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Mascolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2280-4299","authenticated-orcid":false,"given":"Francesco","family":"Maione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2019.109788_bib0005","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3389\/fcimb.2016.00194","article-title":"Antimicrobial peptides: an emerging category of therapeutic agents","volume":"6","author":"Mahlapuu","year":"2016","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.biopha.2019.109788_bib0010","first-page":"1","article-title":"Antimicrobial peptides: promising alternatives in the post feeding antibiotic era","volume":"39","author":"Wang","year":"2018","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.biopha.2019.109788_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12275-017-6452-1","article-title":"The therapeutic applications of antimicrobial peptides (AMPs): a patent review","volume":"55","author":"Kang","year":"2017","journal-title":"J. Microbiol."},{"key":"10.1016\/j.biopha.2019.109788_bib0020","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1007\/s00018-005-5536-y","article-title":"Temporins, anti-infective peptides with expanding properties","volume":"63","author":"Mangoni","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.biopha.2019.109788_bib0025","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1046\/j.1432-1327.2000.01143.x","article-title":"Structure-function relationships of temporins, small antimicrobial peptides from amphibian skin","volume":"267","author":"Mangoni","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.biopha.2019.109788_bib0030","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.ejmech.2017.08.040","article-title":"Glycine-replaced derivatives of [Pro3,DLeu9]TL, a temporin L analogue: evaluation of antimicrobial, cytotoxic and hemolytic activities","volume":"139","author":"Merlino","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.biopha.2019.109788_bib0035","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1002\/cmdc.201900221","article-title":"The outcomes of decorated prolines in the discovery of antimicrobial peptides from Temporin-L","volume":"14","author":"Buommino","year":"2019","journal-title":"Chem. Med. Chem."},{"key":"10.1016\/j.biopha.2019.109788_bib0040","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00109-006-0143-4","article-title":"Multifunctional antimicrobial peptides: therapeutic targets in several human diseases","volume":"85","author":"Zaiou","year":"2007","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.biopha.2019.109788_bib0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0061614","article-title":"Novel \u03b1-MSH peptide analogues with broad spectrum antimicrobial activity","volume":"8","author":"Grieco","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2019.109788_bib0050","article-title":"A synthetic cationic antimicrobial peptide inhibits inflammatory response and the NLRP3 inflammasome by neutralizing LPS and ATP","volume":"12","author":"Li","year":"2017","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.biopha.2019.109788_bib0055","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.2353\/ajpath.2010.100322","article-title":"Novel lipid mediators and resolution mechanisms in acute inflammation: to resolve or not?","volume":"177","author":"Serhan","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.biopha.2019.109788_bib0060","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1586\/eri.12.2","article-title":"The immune response to severe bacterial infections: consequences for therapy","volume":"10","author":"Giamarellos-Bourboulis","year":"2012","journal-title":"Expert Rev. Anti-Infective Ther."},{"key":"10.1016\/j.biopha.2019.109788_bib0065","doi-asserted-by":"crossref","first-page":"40228","DOI":"10.1038\/srep40228","article-title":"Antimicrobial and anti-inflammatory activities of three chensinin-1 peptides containing mutation of glycine and histidine residues","volume":"7","author":"Dong","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2019.109788_bib0070","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/167572","article-title":"Inhibitory effects of antimicrobial peptides on lipopolysaccharide-induced inflammation","volume":"2015","author":"Sun","year":"2015","journal-title":"Mediators Inflamm."},{"issue":"16","key":"10.1016\/j.biopha.2019.109788_bib0075","doi-asserted-by":"crossref","first-page":"6378","DOI":"10.1021\/acs.orglett.9b02283","article-title":"Boosting fmoc solid-phase peptide synthesis by ultrasonication","volume":"21","author":"Merlino","year":"2019","journal-title":"Org. Lett."},{"key":"10.1016\/j.biopha.2019.109788_bib0080","doi-asserted-by":"crossref","first-page":"45236","DOI":"10.1038\/srep45236","article-title":"Antiproliferative effects of ruthenium-based nucleolipidic nanoaggregates in human models of breast cancer in vitro: insights into their mode of action","volume":"7","author":"Irace","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2019.109788_bib0085","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1111\/j.1476-5381.2010.00872.x","article-title":"Animal research: reporting in vivo experiments: the ARRIVE guidelines","volume":"160","author":"Kilkenny","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.biopha.2019.109788_bib0090","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1111\/bph.12955","article-title":"Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP","volume":"172","author":"McGrath","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.biopha.2019.109788_bib0095","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1189\/jlb.0405206","article-title":"Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro","volume":"78","author":"Chatterjee","year":"2005","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.biopha.2019.109788_bib0100","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1038\/s41598-017-03696-8","article-title":"Sex differences in prostaglandin biosynthesis in neutrophils during acute inflammation","volume":"7","author":"Pace","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2019.109788_bib0105","doi-asserted-by":"crossref","first-page":"672","DOI":"10.3109\/08916931003678296","article-title":"Analysis of the inflammatory response in HY-TCR transgenic mice highlights the pathogenic potential of CD4- CD8- T cells","volume":"43","author":"Maione","year":"2010","journal-title":"Autoimmunity"},{"key":"10.1016\/j.biopha.2019.109788_bib0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104351","article-title":"IL-17A neutralizing antibody regulates monosodium urate crystal-induced gouty inflammation","volume":"147","author":"Raucci","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.biopha.2019.109788_bib0115","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.3389\/fimmu.2018.02752","article-title":"Repetitive Exposure of IL-17 into the murine air pouch favors the recruitment of inflammatory monocytes and the release of IL-16 and TREM-1 in the inflammatory fluids","volume":"9","author":"Maione","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.biopha.2019.109788_bib0120","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3390\/molecules24010139","article-title":"Anti-inflammatory and anti-oxidant activity of portulaca oleracea extract on LPS-induced rat lung injury","volume":"24","author":"Baradaran Rahimi","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2019.109788_bib0125","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.1111\/bph.12856","article-title":"Experimental design and analysis and their reporting: new guidance for publication in BJP","volume":"172","author":"Curtis","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.biopha.2019.109788_bib0130","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1097\/00024382-199705000-00007","article-title":"Role of nitric oxide in a non-septic shock model induced by zymosan in the rat","volume":"7","author":"Cuzzocrea","year":"1997","journal-title":"Shock"},{"key":"10.1016\/j.biopha.2019.109788_bib0135","first-page":"408","article-title":"Phagocytosis and induction of nitric oxide synthase in murine macrophages","author":"Cunha","year":"1993","journal-title":"Immunology"},{"key":"10.1016\/j.biopha.2019.109788_bib0140","doi-asserted-by":"crossref","first-page":"45566","DOI":"10.1074\/jbc.M207419200","article-title":"Antisense oligonucleotide to cofilin enhances respiratory burst and phagocytosis in opsonized zymosan-stimulated mouse macrophage J774.1 cells","author":"Adachi","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2019.109788_bib0145","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1001\/archsurg.1991.01410250037005","article-title":"Studies of the route, magnitude, and time course of bacterial translocation in a model of systemic inflammation","volume":"126","author":"Mainous","year":"1991","journal-title":"Arch. Surg."},{"key":"10.1016\/j.biopha.2019.109788_bib0150","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1365-3083.1991.tb01537.x","article-title":"Tumor necrosis factor alpha and interleukin 6 in zymosan-induced shock model","volume":"34","author":"Von Asmuth","year":"1991","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.biopha.2019.109788_bib0155","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1097\/00003246-199607000-00022","article-title":"Inflammatory cytokines in an experimental model for the multiple organ dysfunction syndrome","volume":"24","author":"Jansen","year":"1996","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.biopha.2019.109788_bib0160","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.bcp.2009.09.015","article-title":"From IL-15 to IL-33: the never-ending list of new players in inflammation. Is it time to forget the humble aspirin and move ahead?","volume":"79","author":"D\u2019Acquisto","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biopha.2019.109788_bib0165","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/SHK.0000000000000502","article-title":"The protective role of curcumin in zymosan-induced multiple organ dysfunction syndrome in mice","volume":"45","author":"Liu","year":"2016","journal-title":"Shock"},{"key":"10.1016\/j.biopha.2019.109788_bib0170","doi-asserted-by":"crossref","first-page":"27665","DOI":"10.1038\/srep27665","article-title":"Macrophage migration inhibitor factor upregulates MCP-1 expression in an autocrine manner in hepatocytes during acute mouse liver injury","volume":"6","author":"Xie","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2019.109788_bib0175","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.immunol.19.1.683","article-title":"Interleukin-10 and the interleukin-10 receptor","volume":"19","author":"Moore","year":"2001","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.biopha.2019.109788_bib0180","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/nature05877","article-title":"Resolvin E1 and protectin D1 activate inflammation-resolution programmes","volume":"447","author":"Schwab","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2019.109788_bib0185","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0076-6879(09)05417-2","article-title":"Zymosan-induced peritonitis as a simple experimental system for the study of inflammation","volume":"461","author":"Cash","year":"2009","journal-title":"Methods Enzymol."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219354101?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219354101?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T18:38:10Z","timestamp":1777574290000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332219354101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":37,"alternative-id":["S0753332219354101"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109788","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Temporin L-derived peptide as a regulator of the acute inflammatory response in zymosan-induced peritonitis","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109788","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s). Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"109788"}}