{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:21:05Z","timestamp":1791084065713,"version":"4.1.0"},"reference-count":88,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"the Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","award":["2009\/53989-4"],"award-info":[{"award-number":["2009\/53989-4"]}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","award":["88882.434430\/2019-01"],"award-info":[{"award-number":["88882.434430\/2019-01"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.biopha.2019.109794","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T21:38:53Z","timestamp":1577137133000},"page":"109794","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":90,"special_numbering":"C","title":["Berberine associated photodynamic therapy promotes autophagy and apoptosis via ROS generation in renal carcinoma cells"],"prefix":"10.1016","volume":"123","author":[{"given":"Tairine Zara","family":"Lopes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio Rog\u00e9rio","family":"de Moraes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Claudio","family":"Tedesco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghuvir Krishnaswamy","family":"Arni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Rahal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilia Freitas","family":"Calmon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.biopha.2019.109794_bib0005","first-page":"517","article-title":"Landmarks in the diagnosis and treatment of renal cell carcinoma, Nature reviews","volume":"11","author":"Bhatt","year":"2014","journal-title":"Urology"},{"issue":"9","key":"10.1016\/j.biopha.2019.109794_bib0010","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1007\/s00345-018-2286-7","article-title":"Epidemiology and screening for renal cancer","volume":"36","author":"Rossi","year":"2018","journal-title":"World J. Urol."},{"issue":"5","key":"10.1016\/j.biopha.2019.109794_bib0015","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.biopha.2019.109794_bib0020","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.biopha.2017.12.029","article-title":"Resveratrol inhibits proliferation, migration and invasion via Akt and ERK1\/2 signaling pathways in renal cell carcinoma cells","volume":"98","author":"Zhao","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"13","key":"10.1016\/j.biopha.2019.109794_bib0025","doi-asserted-by":"crossref","first-page":"16172","DOI":"10.18632\/oncotarget.7473","article-title":"Genetic mutations associated with metastatic clear cell renal cell carcinoma","volume":"7","author":"Li","year":"2016","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.biopha.2019.109794_bib0030","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.urolonc.2016.01.005","article-title":"Histological subtype of renal cell carcinoma significantly affects survival in the era of partial nephrectomy","volume":"34","author":"Nguyen","year":"2016","journal-title":"Urol. Oncol."},{"issue":"3","key":"10.1016\/j.biopha.2019.109794_bib0035","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/SPC.0b013e3283644c30","article-title":"Side-effects associated with targeted therapies in renal cell carcinoma","volume":"7","author":"Soulieres","year":"2013","journal-title":"Curr. Opin. Support. Palliat. Care"},{"issue":"Suppl. 1","key":"10.1016\/j.biopha.2019.109794_bib0040","doi-asserted-by":"crossref","first-page":"S181","DOI":"10.4103\/0975-7406.155895","article-title":"Naturally occurring products in cancer therapy","volume":"7","author":"Rajesh","year":"2015","journal-title":"J. Pharm. Bioallied Sci."},{"issue":"9","key":"10.1016\/j.biopha.2019.109794_bib0045","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1097\/CAD.0b013e328330d95b","article-title":"A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs","volume":"20","author":"Sun","year":"2009","journal-title":"Anti-cancer Drugs"},{"issue":"8","key":"10.1016\/j.biopha.2019.109794_bib0050","doi-asserted-by":"crossref","first-page":"12349","DOI":"10.3390\/molecules190812349","article-title":"Berberine, an epiphany against cancer","volume":"19","author":"Ortiz","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2019.109794_bib0055","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.ejphar.2014.06.025","article-title":"Targets and mechanisms of berberine, a natural drug with potential to treat cancer with special focus on breast cancer","volume":"740","author":"Jabbarzadeh Kaboli","year":"2014","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.biopha.2019.109794_bib0060","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.3892\/mmr.2014.2929","article-title":"Berberine targets epidermal growth factor receptor signaling to suppress prostate cancer proliferation in vitro","volume":"11","author":"Huang","year":"2015","journal-title":"Mol. Med. Rep."},{"issue":"4","key":"10.1016\/j.biopha.2019.109794_bib0065","first-page":"334","article-title":"Effects of berberine on proliferation, cell cycle distribution and apoptosis of human breast cancer T47D and MCF7 cell lines","volume":"18","author":"Barzegar","year":"2015","journal-title":"Iran. J. Basic Med. Sci."},{"issue":"3","key":"10.1016\/j.biopha.2019.109794_bib0070","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.bbadis.2014.12.004","article-title":"Berberine suppresses Id-1 expression and inhibits the growth and development of lung metastases in hepatocellular carcinoma","volume":"1852","author":"Tsang","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.biopha.2019.109794_bib0075","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1590\/1414-431x20144293","article-title":"Berberine induces apoptosis via ROS generation in PANC-1 and MIA-PaCa2 pancreatic cell lines","volume":"48","author":"Park","year":"2015","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"3","key":"10.1016\/j.biopha.2019.109794_bib0080","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/labinvest.2012.172","article-title":"Berberine represses DAXX gene transcription and induces cancer cell apoptosis","volume":"93","author":"Li","year":"2013","journal-title":"Lab. Invest. J. Tech. Methods Pathol."},{"issue":"1","key":"10.1016\/j.biopha.2019.109794_bib0085","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF00987648","article-title":"Berberine: a naturally occurring phototoxic alkaloid","volume":"10","author":"Philogene","year":"1984","journal-title":"J. Chem. Ecol."},{"issue":"5","key":"10.1016\/j.biopha.2019.109794_bib0090","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.saa.2009.05.001","article-title":"Characterization of the transient species generated by the photoionization of Berberine: a laser flash photolysis study","volume":"73","author":"Cheng","year":"2009","journal-title":"Spectrochim. Acta A. Mol. Biomol. Spectrosc."},{"issue":"3","key":"10.1016\/j.biopha.2019.109794_bib0095","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jphotobiol.2006.07.001","article-title":"Photochemical and phototoxic activity of berberine on murine fibroblast NIH-3T3 and Ehrlich ascites carcinoma cells","volume":"85","author":"Jantova","year":"2006","journal-title":"J. Photochem. Photobiol. B, Biol."},{"issue":"11","key":"10.1016\/j.biopha.2019.109794_bib0100","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1021\/tx0155247","article-title":"Photochemistry and photocytotoxicity of alkaloids from Goldenseal (Hydrastis canadensis L.) 1. Berberine","volume":"14","author":"Inbaraj","year":"2001","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.biopha.2019.109794_bib0105","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.pdpdt.2017.05.003","article-title":"Photodynamic process induced by chloro-aluminum phthalocyanine nanoemulsion in glioblastoma","volume":"19","author":"Castilho-Fernandes","year":"2017","journal-title":"Photodiagnosis Photodyn. Ther."},{"issue":"1","key":"10.1016\/j.biopha.2019.109794_bib0110","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.3892\/ol.2017.6237","article-title":"Metformin enhances the cytotoxicity of 5-aminolevulinic acid-mediated photodynamic therapy in vitro","volume":"14","author":"Osaki","year":"2017","journal-title":"Oncol. Lett."},{"issue":"4","key":"10.1016\/j.biopha.2019.109794_bib0115","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3322\/caac.20114","article-title":"Photodynamic therapy of cancer: an update","volume":"61","author":"Agostinis","year":"2011","journal-title":"CA Cancer J. Clin."},{"issue":"3","key":"10.1016\/j.biopha.2019.109794_bib0120","doi-asserted-by":"crossref","first-page":"953","DOI":"10.3892\/ijo.2017.3854","article-title":"Novel zinc phthalocyanine as a promising photosensitizer for photodynamic treatment of esophageal cancer","volume":"50","author":"Kuzyniak","year":"2017","journal-title":"Int. J. Oncol."},{"issue":"2","key":"10.1016\/j.biopha.2019.109794_bib0125","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/php.12857","article-title":"Cell death pathways associated with photodynamic therapy: an update","volume":"94","author":"Kessel","year":"2018","journal-title":"Photochem. Photobiol."},{"issue":"3","key":"10.1016\/j.biopha.2019.109794_bib0130","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/jcb.22741","article-title":"Cellular stress induced by resazurin leads to autophagy and cell death via production of reactive oxygen species and mitochondrial impairment","volume":"111","author":"Erikstein","year":"2010","journal-title":"J. Cell. Biochem."},{"issue":"6","key":"10.1016\/j.biopha.2019.109794_bib0135","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.3892\/or.2016.4703","article-title":"Aloe-emodin-mediated photodynamic therapy induces autophagy and apoptosis in human osteosarcoma cell line MG63 through the ROS\/JNK signaling pathway","volume":"35","author":"Tu","year":"2016","journal-title":"Oncol. Rep."},{"issue":"12","key":"10.1016\/j.biopha.2019.109794_bib0140","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/jnci\/90.12.889","article-title":"Photodynamic therapy","volume":"90","author":"Dougherty","year":"1998","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.biopha.2019.109794_bib0145","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.biopha.2016.07.058","article-title":"The potential of photodynamic therapy (PDT)-Experimental investigations and clinical use","volume":"83","author":"Oniszczuk","year":"2016","journal-title":"Biomed. Pharmacother."},{"issue":"7","key":"10.1016\/j.biopha.2019.109794_bib0150","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1039\/b822363g","article-title":"Solvent effect on the UV\/Vis absorption and fluorescence spectroscopic properties of berberine","volume":"8","author":"Diaz","year":"2009","journal-title":"Photochem. Photobiol. Sci."},{"issue":"7","key":"10.1016\/j.biopha.2019.109794_bib0155","first-page":"557","article-title":"Metabolic footprinting and systems biology: the medium is the message, Nature reviews","volume":"3","author":"Kell","year":"2005","journal-title":"Microbiology"},{"issue":"8","key":"10.1016\/j.biopha.2019.109794_bib0160","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/yea.1499","article-title":"Metabolic footprinting as a tool for discriminating between brewing yeasts","volume":"24","author":"Pope","year":"2007","journal-title":"Yeast"},{"issue":"Database issue","key":"10.1016\/j.biopha.2019.109794_bib0165","first-page":"D801","article-title":"HMDB 3.0\u2013the human metabolome database in 2013","volume":"41","author":"Wishart","year":"2013","journal-title":"Nucleic Acids Res."},{"issue":"W1","key":"10.1016\/j.biopha.2019.109794_bib0170","doi-asserted-by":"crossref","first-page":"W486","DOI":"10.1093\/nar\/gky310","article-title":"MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis","volume":"46","author":"Chong","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"12","key":"10.1016\/j.biopha.2019.109794_bib0175","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1002\/ijc.30396","article-title":"Higher expression of XPF is a critical factor in intrinsic chemotherapy resistance of human renal cell carcinoma","volume":"139","author":"Zhang","year":"2016","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.biopha.2019.109794_bib0180","doi-asserted-by":"crossref","DOI":"10.1002\/jcb.27116","article-title":"Betulinic acid induces apoptosis and inhibits metastasis of human renal carcinoma cells in vitro and in vivo","author":"Yang","year":"2018","journal-title":"J. Cell. Biochem."},{"issue":"23","key":"10.1016\/j.biopha.2019.109794_bib0185","doi-asserted-by":"crossref","first-page":"6597","DOI":"10.1039\/C6CS00271D","article-title":"Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy","volume":"45","author":"Zhou","year":"2016","journal-title":"Chem. Soc. Rev."},{"issue":"1","key":"10.1016\/j.biopha.2019.109794_bib0190","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1039\/C5CC08242K","article-title":"Berberine as a novel light-up i-motif fluorescence ligand and its application in designing molecular logic systems","volume":"52","author":"Xu","year":"2016","journal-title":"Chem. Commun."},{"issue":"1","key":"10.1016\/j.biopha.2019.109794_bib0195","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1039\/C5OB01723H","article-title":"Highly selective, sensitive and fluorescent sensing of dimeric G-quadruplexes by a dimeric berberine","volume":"14","author":"Zhou","year":"2016","journal-title":"Org. Biomol. Chem."},{"issue":"2","key":"10.1016\/j.biopha.2019.109794_bib0200","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3727\/096504016X14742891049073","article-title":"Induction of apoptosis by berberine in hepatocellular carcinoma HepG2 cells via downregulation of NF-kappaB","volume":"25","author":"Li","year":"2017","journal-title":"Oncol. Res."},{"issue":"1","key":"10.1016\/j.biopha.2019.109794_bib0205","doi-asserted-by":"crossref","first-page":"10599","DOI":"10.1038\/s41598-018-28952-3","article-title":"Cell-specific pattern of berberine pleiotropic effects on different human cell lines","volume":"8","author":"Agnarelli","year":"2018","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.biopha.2019.109794_bib0210","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1042\/BJ20150942","article-title":"New photosensitizers for photodynamic therapy","volume":"473","author":"Abrahamse","year":"2016","journal-title":"Biochem. J."},{"issue":"2","key":"10.1016\/j.biopha.2019.109794_bib0215","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.apsb.2017.09.003","article-title":"An updated overview on the development of new photosensitizers for anticancer photodynamic therapy","volume":"8","author":"Zhang","year":"2018","journal-title":"Acta Pharm. Sin. B"},{"issue":"7\u20138","key":"10.1016\/j.biopha.2019.109794_bib0220","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1080\/10715762.2017.1368506","article-title":"Differential modes of photosensitisation in cancer cells by berberine and coralyne","volume":"51","author":"Bhattacharyya","year":"2017","journal-title":"Free Radic. Res."},{"issue":"2","key":"10.1016\/j.biopha.2019.109794_bib0225","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00405-010-1361-5","article-title":"Photodynamic therapy of early stage oral cavity and oropharynx neoplasms: an outcome analysis of 170 patients","volume":"268","author":"Karakullukcu","year":"2011","journal-title":"Eur. Arch. Otorhinolaryngol."},{"issue":"3","key":"10.1016\/j.biopha.2019.109794_bib0230","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/cam4.1012","article-title":"Induction of cell death by pyropheophorbide-alpha methyl ester-mediated photodynamic therapy in lung cancer A549 cells","volume":"6","author":"Tu","year":"2017","journal-title":"Cancer Med."},{"issue":"11","key":"10.1016\/j.biopha.2019.109794_bib0235","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1007\/s10495-017-1424-9","article-title":"Induction of reactive oxygen species: an emerging approach for cancer therapy","volume":"22","author":"Zou","year":"2017","journal-title":"Apoptosis"},{"key":"10.1016\/j.biopha.2019.109794_bib0240","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.redox.2014.12.003","article-title":"Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy","volume":"4","author":"Poillet-Perez","year":"2015","journal-title":"Redox Biol."},{"issue":"3","key":"10.1016\/j.biopha.2019.109794_bib0245","doi-asserted-by":"crossref","first-page":"464","DOI":"10.3390\/cells1030464","article-title":"Autophagy contributes to the death\/survival balance in cancer photo dynamic therapy","volume":"1","author":"Inguscio","year":"2012","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.biopha.2019.109794_bib0250","first-page":"1601","article-title":"Alpha-hederin induces autophagic cell death in colorectal cancer cells through reactive oxygen species dependent AMPK\/mTOR signaling pathway activation","volume":"54","author":"Sun","year":"2019","journal-title":"Int. J. Oncol."},{"issue":"7","key":"10.1016\/j.biopha.2019.109794_bib0255","doi-asserted-by":"crossref","first-page":"10747","DOI":"10.1002\/jcp.27749","article-title":"Induction of autophagic cell death in human ovarian carcinoma cells by Antrodia salmonea through increased reactive oxygen species generation","volume":"234","author":"Yang","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"4","key":"10.1016\/j.biopha.2019.109794_bib0260","doi-asserted-by":"crossref","first-page":"8415","DOI":"10.3390\/ijms16048415","article-title":"Autophagy induction by silibinin positively contributes to its anti-metastatic capacity via AMPK\/mTOR pathway in renal cell carcinoma","volume":"16","author":"Li","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2019.109794_bib0265","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.pdpdt.2017.02.001","article-title":"In vitro evaluation of ruthenium complexes for photodynamic therapy","volume":"18","author":"Li","year":"2017","journal-title":"Photodiagnosis Photodyn. Ther."},{"issue":"2","key":"10.1016\/j.biopha.2019.109794_bib0270","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.abb.2009.12.014","article-title":"Mild thermotolerance induced at 40 degrees C increases antioxidants and protects HeLa cells against mitochondrial apoptosis induced by hydrogen peroxide: role of p53","volume":"495","author":"Pallepati","year":"2010","journal-title":"Arch. Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.biopha.2019.109794_bib0275","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.bbrc.2015.01.137","article-title":"Calcium and mitochondria in the regulation of cell death","volume":"460","author":"Orrenius","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"12","key":"10.1016\/j.biopha.2019.109794_bib0280","doi-asserted-by":"crossref","first-page":"870","DOI":"10.4111\/kju.2010.51.12.870","article-title":"Dimethoxycurcumin, a structural analogue of curcumin, induces apoptosis in human renal carcinoma caki cells through the production of reactive oxygen species, the release of cytochrome C, and the activation of caspase-3","volume":"51","author":"Lee","year":"2010","journal-title":"Korean J. Urol."},{"issue":"1\u20133","key":"10.1016\/j.biopha.2019.109794_bib0285","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2011.04.021","article-title":"Induction of G1 cell cycle arrest and apoptosis by berberine in bladder cancer cells","volume":"661","author":"Yan","year":"2011","journal-title":"Eur. J. Pharmacol."},{"issue":"41","key":"10.1016\/j.biopha.2019.109794_bib0290","doi-asserted-by":"crossref","first-page":"66944","DOI":"10.18632\/oncotarget.11396","article-title":"Berberine induces autophagy in glioblastoma by targeting the AMPK\/mTOR\/ULK1-pathway","volume":"7","author":"Wang","year":"2016","journal-title":"Oncotarget"},{"issue":"9","key":"10.1016\/j.biopha.2019.109794_bib0295","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.7150\/jca.19106","article-title":"Berberine enhances chemosensitivity and induces apoptosis through dose-orchestrated AMPK signaling in breast cancer","volume":"8","author":"Pan","year":"2017","journal-title":"J. Cancer"},{"issue":"1","key":"10.1016\/j.biopha.2019.109794_bib0300","doi-asserted-by":"crossref","DOI":"10.3390\/biom8010001","article-title":"Emerging roles for VEGF-D in human disease","volume":"8","author":"Stacker","year":"2018","journal-title":"Biomolecules"},{"issue":"4","key":"10.1016\/j.biopha.2019.109794_bib0305","first-page":"721","article-title":"Lymphangiogenesis in kidney cancer: expression of VEGF-C, VEGF-D and VEGFR-3 in clear cell and papillary renal cell carcinoma","volume":"20","author":"Bierer","year":"2008","journal-title":"Oncol. Rep."},{"issue":"1","key":"10.1016\/j.biopha.2019.109794_bib0310","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3892\/ijo.2016.3527","article-title":"VEGF-D-enhanced lymph node metastasis of ovarian cancer is reversed by vesicular stomatitis virus matrix protein","volume":"49","author":"Qi","year":"2016","journal-title":"Int. J. Oncol."},{"issue":"5","key":"10.1016\/j.biopha.2019.109794_bib0315","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.ejca.2008.12.006","article-title":"Interleukin 7\/interleukin 7 receptor induce c-Fos\/c-Jun-dependent vascular endothelial growth factor-D up-regulation: a mechanism of lymphangiogenesis in lung cancer","volume":"45","author":"Ming","year":"2009","journal-title":"Eur. J. Cancer"},{"issue":"1","key":"10.1016\/j.biopha.2019.109794_bib0320","doi-asserted-by":"crossref","first-page":"271","DOI":"10.7314\/APJCP.2015.16.1.271","article-title":"VEGF-C and VEGF-D expression and its correlation with lymph node metastasis in esophageal squamous cell cancer tissue","volume":"16","author":"Yang","year":"2015","journal-title":"Asian Pac. J. Cancer Prev.: APJCP"},{"issue":"2","key":"10.1016\/j.biopha.2019.109794_bib0325","doi-asserted-by":"crossref","first-page":"R129","DOI":"10.1530\/JME-16-0195","article-title":"TERT biology and function in cancer: beyond immortalisation","volume":"58","author":"Pestana","year":"2017","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.biopha.2019.109794_bib0330","article-title":"Characterization and impact of TERT promoter region mutations on clinical outcome in renal cell carcinoma","author":"Casuscelli","year":"2017","journal-title":"Eur. Urol. Focus"},{"issue":"44","key":"10.1016\/j.biopha.2019.109794_bib0335","doi-asserted-by":"crossref","first-page":"77540","DOI":"10.18632\/oncotarget.20560","article-title":"TERT promoter status and gene copy number gains: effect on TERT expression and association with prognosis in breast cancer","volume":"8","author":"Gay-Bellile","year":"2017","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.biopha.2019.109794_bib0340","doi-asserted-by":"crossref","DOI":"10.3390\/genes7060022","article-title":"Telomere and telomerase therapeutics in cancer","volume":"7","author":"Xu","year":"2016","journal-title":"Genes"},{"issue":"43","key":"10.1016\/j.biopha.2019.109794_bib0345","doi-asserted-by":"crossref","first-page":"6633","DOI":"10.1038\/sj.onc.1205850","article-title":"Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways","volume":"21","author":"Bahassi el","year":"2002","journal-title":"Oncogene"},{"issue":"8","key":"10.1016\/j.biopha.2019.109794_bib0350","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/cr.2016.78","article-title":"Ligand stimulation of CD95 induces activation of Plk3 followed by phosphorylation of caspase-8","volume":"26","author":"Helmke","year":"2016","journal-title":"Cell Res."},{"issue":"21","key":"10.1016\/j.biopha.2019.109794_bib0355","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1080\/15384101.2017.1373224","article-title":"Polo-like kinase 3, hypoxic responses, and tumorigenesis","volume":"16","author":"Xu","year":"2017","journal-title":"Cell Cycle"},{"key":"10.1016\/j.biopha.2019.109794_bib0360","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jchromb.2015.12.004","article-title":"Serum metabolomics strategy for understanding pharmacological effects of ShenQi pill acting on kidney yang deficiency syndrome","volume":"1026","author":"Nan","year":"2016","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.biopha.2019.109794_bib0365","first-page":"354671","article-title":"Metabolomics for biomarker discovery: moving to the clinic","volume":"2015","author":"Zhang","year":"2015","journal-title":"BioMed Res. Int."},{"issue":"1","key":"10.1016\/j.biopha.2019.109794_bib0370","first-page":"831","article-title":"Serum level of octanoic acid predicts the efficacy of chemotherapy for colorectal cancer","volume":"17","author":"Iemoto","year":"2019","journal-title":"Oncol. Lett."},{"issue":"3","key":"10.1016\/j.biopha.2019.109794_bib0375","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1385\/MO:23:3:411","article-title":"Effect of ascorbic acid, lysine, proline, and green tea extract on human osteosarcoma cell line MNNG-HOS xenografts in nude mice: evaluation of tumor growth and immunohistochemistry","volume":"23","author":"Roomi","year":"2006","journal-title":"Med. Oncol."},{"issue":"5","key":"10.1016\/j.biopha.2019.109794_bib0380","first-page":"943","article-title":"Anticancer effect of lysine, proline, arginine, ascorbic acid and green tea extract on human renal adenocarcinoma line 786-0","volume":"16","author":"Roomi","year":"2006","journal-title":"Oncol. Rep."},{"issue":"1","key":"10.1016\/j.biopha.2019.109794_bib0385","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.gendis.2014.12.002","article-title":"Targeting matrix metalloproteinases in cancer: bringing new life to old ideas","volume":"2","author":"Cathcart","year":"2015","journal-title":"Genes Dis."},{"issue":"1","key":"10.1016\/j.biopha.2019.109794_bib0390","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1186\/s12885-017-3418-y","article-title":"Inhibition of MMP-2 and MMP-9 decreases cellular migration, and angiogenesis in in vitro models of retinoblastoma","volume":"17","author":"Webb","year":"2017","journal-title":"BMC Cancer"},{"issue":"1\u20132","key":"10.1016\/j.biopha.2019.109794_bib0395","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.autneu.2009.01.012","article-title":"Effects of L-arginine and L-lysine mixtures on splenic sympathetic nerve activity and tumor proliferation","volume":"147","author":"Shen","year":"2009","journal-title":"Auton. Neurosci.: Basic Clin."},{"issue":"3","key":"10.1016\/j.biopha.2019.109794_bib0400","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1515\/cclm-2012-0552","article-title":"Formate: an essential metabolite, a biomarker, or more?","volume":"51","author":"Lamarre","year":"2013","journal-title":"Clin. Chem. Lab. Med."},{"issue":"1","key":"10.1016\/j.biopha.2019.109794_bib0405","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1038\/s41467-018-03777-w","article-title":"Increased formate overflow is a hallmark of oxidative cancer","volume":"9","author":"Meiser","year":"2018","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.biopha.2019.109794_bib0410","doi-asserted-by":"crossref","first-page":"220","DOI":"10.21037\/atm.2019.02.32","article-title":"Lactate and cancer: a \"lactatic\" perspective on spinal tumor metabolism (part 1)","volume":"7","author":"Goodwin","year":"2019","journal-title":"Ann. Transl. Med."},{"issue":"22","key":"10.1016\/j.biopha.2019.109794_bib0415","doi-asserted-by":"crossref","first-page":"6921","DOI":"10.1158\/0008-5472.CAN-11-1457","article-title":"Lactate: a metabolic key player in cancer","volume":"71","author":"Hirschhaeuser","year":"2011","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.biopha.2019.109794_bib0420","first-page":"119","article-title":"Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect","volume":"38","author":"San-Millan","year":"2017","journal-title":"Carcinogenesis"},{"issue":"1","key":"10.1016\/j.biopha.2019.109794_bib0425","doi-asserted-by":"crossref","DOI":"10.3390\/diseases4010007","article-title":"Renal cell carcinoma: a study through NMR-based metabolomics combined with transcriptomics","volume":"4","author":"Ragone","year":"2016","journal-title":"Diseases"},{"issue":"4","key":"10.1016\/j.biopha.2019.109794_bib0430","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1215\/15228517-2008-106","article-title":"Lactate promotes glioma migration by TGF-beta2-dependent regulation of matrix metalloproteinase-2","volume":"11","author":"Baumann","year":"2009","journal-title":"Neuro-oncology"},{"issue":"2","key":"10.1016\/j.biopha.2019.109794_bib0435","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/joim.12016","article-title":"Endothelial cell metabolism and tumour angiogenesis: glucose and glutamine as essential fuels and lactate as the driving force","volume":"273","author":"Polet","year":"2013","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.biopha.2019.109794_bib0440","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/978-0-387-74911-2_9","article-title":"Lactate, with oxygen, incites angiogenesis","volume":"614","author":"Hunt","year":"2008","journal-title":"Adv. Exp. Med. Biol."}],"updated-by":[{"DOI":"10.1016\/j.biopha.2020.110038","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000}},{"DOI":"10.1016\/j.biopha.2020.111175","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000}}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219354162?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219354162?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T09:51:06Z","timestamp":1695549066000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332219354162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":88,"alternative-id":["S0753332219354162"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109794","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.biopha.2020.111175","asserted-by":"object"},{"id-type":"doi","id":"10.1016\/j.biopha.2020.110038","asserted-by":"object"}]},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Berberine associated photodynamic therapy promotes autophagy and apoptosis via ROS generation in renal carcinoma cells","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109794","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s). Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"109794"}}