{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T12:42:27Z","timestamp":1793104947078,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T00:00:00Z","timestamp":1578614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772086"],"award-info":[{"award-number":["81772086"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["20161424"],"award-info":[{"award-number":["20161424"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.biopha.2020.109824","type":"journal-article","created":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T23:04:24Z","timestamp":1579561464000},"page":"109824","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Investigating the potential of LSKL peptide as a novel hypertrophic scar treatment"],"prefix":"10.1016","volume":"124","author":[{"given":"Xiangwen","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi Min","family":"Khoong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuchen","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie-Yi","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Hui","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haizhou","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2020.109824_bib0005","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2119\/molmed.2009.00153","article-title":"Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies","volume":"17","author":"Gauglitz","year":"2011","journal-title":"Mol. Med."},{"key":"10.1016\/j.biopha.2020.109824_bib0010","first-page":"463","article-title":"Prevention and curative management of hypertrophic scar formation","volume":"35","author":"Niessen","year":"2008","journal-title":"Burns"},{"key":"10.1016\/j.biopha.2020.109824_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s41038-018-0129-9","article-title":"Chinese expert consensus on clinical prevention and treatment of scar+","volume":"6","author":"Lv","year":"2018","journal-title":"Burns & Trauma"},{"issue":"Suppl 1","key":"10.1016\/j.biopha.2020.109824_bib0020","first-page":"S6","article-title":"Cellular and molecular pathology of HTS: basis for treatment","volume":"15","author":"Armour","year":"2007","journal-title":"Wound Repair Regener."},{"key":"10.1016\/j.biopha.2020.109824_bib0025","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/00000637-199408000-00005","article-title":"Modulation of collagen synthesis by transforming growth factor-beta in keloid and hypertrophic scar fibroblasts","volume":"33","author":"Younai","year":"1994","journal-title":"Ann. Plast. Surg."},{"key":"10.1016\/j.biopha.2020.109824_bib0030","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1006\/cyto.1995.1025","article-title":"Immunolocalization of TGF-beta 1 in human hypertrophic scar and normal dermal tissues","volume":"7","author":"Ghahary","year":"1995","journal-title":"Cytokine"},{"key":"10.1016\/j.biopha.2020.109824_bib0035","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1097\/BOR.0b013e32835b13cd","article-title":"Biomechanical regulation of mesenchymal cell function","volume":"25","author":"Tschumperlin","year":"2013","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.biopha.2020.109824_bib0040","first-page":"2537","article-title":"LSKL peptide alleviates subarachnoid fibrosis and hydrocephalus by inhibiting TSP1-mediated TGF-\u03b21 signaling activity following subarachnoid hemorrhage in rats","author":"Fan","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.biopha.2020.109824_bib0045","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1083\/jcb.114.4.827","article-title":"Identification and analysis of discrete functional domains in the pro region of pre-pro-transforming growth factor beta","volume":"114","author":"Sha","year":"1991","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.biopha.2020.109824_bib0050","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/S0092-8674(00)81460-9","article-title":"Thrombospondin-1 is a major activator of TGF-beta1 in vivo","volume":"93","author":"Crawford","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2020.109824_bib0055","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0945-053X(03)00005-2","article-title":"Thrombospondins 1 and 2 function as inhibitors of angiogenesis","volume":"22","author":"Armstrong","year":"2003","journal-title":"Matrix Biol."},{"issue":"Aug;68-69","key":"10.1016\/j.biopha.2020.109824_bib0060","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.matbio.2017.12.009","article-title":"Thrombospondin-1 regulation of latent TGF-\u03b2 activation: a therapeutic target for fibrotic disease","author":"Murphy-Ullrich","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.biopha.2020.109824_bib0065","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1359-6101(99)00029-5","article-title":"Activation of latent TGF-\u03b2 by thrombospondin-1: mechanisms and physiology","volume":"11","author":"Murphy-Ullrich","year":"2000","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.biopha.2020.109824_bib0070","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s12272-010-0213-6","article-title":"LSKL, a peptide antagonist of Thrombospondin-1, attenuates renal interstitial fibrosis in rats with unilateral ureteral obstruction","volume":"33","author":"Xie","year":"2010","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.biopha.2020.109824_bib0075","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/jcp.24143","article-title":"HGF regulates the activation of TGF-\u03b21 in rat hepatocytes and hepatic stellate cells","volume":"228","author":"Narmada","year":"2013","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.biopha.2020.109824_bib0080","first-page":"1","article-title":"Hematopoietic id deletion triggers endomyocardial fibrotic and vascular defects in the adult heart","volume":"7","author":"Chang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2020.109824_bib0085","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1097\/PRS.0000000000005274","article-title":"A novel model for cutaneous wound healing and scarring in the rat","volume":"143","author":"He","year":"2019","journal-title":"Plast. Reconstruct. Surg."},{"key":"10.1016\/j.biopha.2020.109824_bib0090","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1002\/jcp.26877","article-title":"Thrombospondin-4 critically controls transforming growth factor \u03b21 induced hypertrophic scar formation","volume":"234","author":"Qian","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.biopha.2020.109824_bib0095","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.matbio.2016.03.003","article-title":"Thrombospondin-1 promotes mesenchymal stromal cell functions via TGFbeta and in cooperation with PDGF","volume":"55","author":"Belotti","year":"2016","journal-title":"Matrix Biol."},{"key":"10.1016\/j.biopha.2020.109824_bib0100","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.surg.2013.08.003","article-title":"Thrombospondin-1-induced vascular smooth muscle cell migration and proliferation are functionally dependent on microRNA-21","volume":"155","author":"Stein","year":"2014","journal-title":"Surgery"},{"key":"10.1016\/j.biopha.2020.109824_bib0105","first-page":"757","article-title":"Thrombospondin-1 (TSP-1) and TSP-1-derived heparin-binding peptides induce promyelocytic leukemia cell differentiation and apoptosis","volume":"25","author":"Bruel","year":"2005","journal-title":"Anticancer Res."},{"key":"10.1016\/j.biopha.2020.109824_bib0110","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.matbio.2012.01.006","article-title":"Thrombospondin1 in tissue repair and fibrosis: TGF-beta-dependent and independent mechanisms","volume":"31","author":"Sweetwyne","year":"2012","journal-title":"Matrix Biol."},{"key":"10.1016\/j.biopha.2020.109824_bib0115","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1113\/jphysiol.2007.144394","article-title":"When the lung is stretched, could it be thrombospondin via TGFbeta1 peptide activation?","volume":"584","author":"Warburton","year":"2007","journal-title":"J. Physiol."},{"key":"10.1016\/j.biopha.2020.109824_bib0120","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1755-1536-4-9","article-title":"Thrombospondin 1 is a key mediator of transforming growth factor \u03b2-mediated cell contractility in systemic sclerosis via a mitogen-activated protein kinase kinase (MEK)\/extracellular signal-regulated kinase (ERK)-dependent mechanism","volume":"4","author":"Chen","year":"2011","journal-title":"Fibrogenesis Tissue Repair"},{"key":"10.1016\/j.biopha.2020.109824_bib0125","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jdermsci.2010.04.010","article-title":"Ultraviolet irradiation induces thrombospondin-1 which attenuates type I procollagen downregulation in human dermal fibroblasts","volume":"59","author":"Seo","year":"2010","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.biopha.2020.109824_bib0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2017.00206","article-title":"Honokiol alleviates hypertrophic scar by targeting transforming growth factor-\u03b2\/smad2\/3 signaling pathway","volume":"8","author":"Zhao","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.biopha.2020.109824_bib0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12929-015-0172-9","article-title":"Investigating the potential of Shikonin as a novel hypertrophic scar treatment","volume":"22","author":"Fan","year":"2015","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.biopha.2020.109824_bib0140","first-page":"0","article-title":"miR-155 inhibits the formation of hypertrophic scar fibroblasts by targeting HIF-1\u03b1 via PI3K\/AKT pathway","volume":"0","author":"Wu","year":"2018","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.biopha.2020.109824_bib0145","doi-asserted-by":"crossref","first-page":"3250","DOI":"10.1096\/fj.07-8218com","article-title":"Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis","volume":"21","author":"Aarabi","year":"2007","journal-title":"FASEB J."},{"key":"10.1016\/j.biopha.2020.109824_bib0150","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1524-475X.2010.00643.x","article-title":"Akt-mediated mechanotransduction in murine fibroblasts during hypertrophic scar formation","volume":"19","author":"Paterno","year":"2011","journal-title":"Wound Repair Regener."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220300147?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220300147?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:27:48Z","timestamp":1778754468000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332220300147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":30,"alternative-id":["S0753332220300147"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2020.109824","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigating the potential of LSKL peptide as a novel hypertrophic scar treatment","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2020.109824","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"109824"}}