{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:50:19Z","timestamp":1792785019531,"version":"4.5.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,18]],"date-time":"2020-01-18T00:00:00Z","timestamp":1579305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Taizhou People's Hospital Research","id":[{"id":"https:\/\/ror.org\/02fvevm64","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Effect of glycyrrhizin on peripheral blood Th17\/Treg","award":["ZL201922"],"award-info":[{"award-number":["ZL201922"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.biopha.2020.109930","type":"journal-article","created":{"date-parts":[[2020,1,25]],"date-time":"2020-01-25T05:48:56Z","timestamp":1579931336000},"page":"109930","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["MiR-195 regulates CD40 to maintain Th17\/Treg balance in rats with non-alcoholic fatty liver disease"],"prefix":"10.1016","volume":"124","author":[{"given":"Yang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Tao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Bing","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-He","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.biopha.2020.109930_bib0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0194153","article-title":"Non-alcoholic fatty liver disease, liver biomarkers and stroke risk: the reasons for geographic and racial differences in stroke cohort","volume":"13","author":"Alexander","year":"2018","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.biopha.2020.109930_bib0010","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/hep.29489","article-title":"Performance characteristics of vibration-controlled transient elastography for evaluation of nonalcoholic fatty liver disease","volume":"67","author":"Vuppalanchi","year":"2018","journal-title":"Hepatology (Baltimore, Md.)"},{"issue":"1","key":"10.1016\/j.biopha.2020.109930_bib0015","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-30760-8","article-title":"Multiomics reveal non-alcoholic fatty liver disease in rats following chronic exposure to an ultra-low dose of Roundup herbicide","volume":"8","author":"Mesnage","year":"2018","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.biopha.2020.109930_bib0020","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s12072-018-9843-4","article-title":"Repeated liver stiffness measurement compared with paired liver biopsy in patients with non-alcoholic fatty liver disease","volume":"12","author":"Kamarajah","year":"2018","journal-title":"Hepatol. Int."},{"issue":"2","key":"10.1016\/j.biopha.2020.109930_bib0025","first-page":"1089","article-title":"Diosgenin prevents high-fat diet-induced rat non-alcoholic fatty liver disease through the AMPK and LXR signaling pathways","volume":"41","author":"Cheng","year":"2018","journal-title":"Int. J. Mol. Med."},{"issue":"1","key":"10.1016\/j.biopha.2020.109930_bib0030","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.clim.2008.01.009","article-title":"The Th17\/Treg imbalance in patients with acute coronary syndrome","volume":"127","author":"Cheng","year":"2008","journal-title":"Clin. Immunol. (Orlando, Fla.)."},{"issue":"3","key":"10.1016\/j.biopha.2020.109930_bib0035","doi-asserted-by":"crossref","first-page":"127","DOI":"10.5114\/ceh.2017.68466","article-title":"The interplay between Th17 and T-regulatory responses as well as adipokines in the progression of non-alcoholic fatty liver disease","volume":"3","author":"\u015awiderska","year":"2017","journal-title":"Clin. Exp. Hepatol."},{"issue":"39","key":"10.1016\/j.biopha.2020.109930_bib0040","doi-asserted-by":"crossref","first-page":"e8179","DOI":"10.1097\/MD.0000000000008179","article-title":"Prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus: a meta-analysis","volume":"96","author":"Dai","year":"2017","journal-title":"Medicine"},{"issue":"6","key":"10.1016\/j.biopha.2020.109930_bib0045","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1136\/gutjnl-2017-313884","article-title":"Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases","volume":"66","author":"Adams","year":"2017","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.biopha.2020.109930_bib0050","doi-asserted-by":"crossref","DOI":"10.1038\/mi.2016.102","article-title":"The signaling axis of microRNA-31\/interleukin-25 regulates Th1\/Th17-mediated inflammation response in colitis","volume":"10","author":"Shi","year":"2016","journal-title":"Mucosal Immunol."},{"issue":"2","key":"10.1016\/j.biopha.2020.109930_bib0055","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/1348-0421.12471","article-title":"The contrasting roles of Th17 immunity in human health and disease","volume":"61","author":"Hoe","year":"2017","journal-title":"Microbiol. Immunol."},{"issue":"7682","key":"10.1016\/j.biopha.2020.109930_bib0060","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nature24628","article-title":"Salt-responsive gut commensal modulates TH17 axis and disease","volume":"551","author":"Wilck","year":"2017","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.biopha.2020.109930_bib0065","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/s41467-018-03072-8","article-title":"Ultraconserved element uc.372 drives hepatic lipid accumulation by suppressing miR-195\/miR4668 maturation","volume":"9","author":"Guo","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biopha.2020.109930_bib0070","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1186\/s12864-015-1896-3","article-title":"Weight-reduction through a low-fat diet causes differential expression of circulating microRNAs in obese C57BL\/6 mice","volume":"16","author":"Hsieh","year":"2015","journal-title":"BMC Genomics"},{"key":"10.1016\/j.biopha.2020.109930_bib0075","doi-asserted-by":"crossref","first-page":"15439","DOI":"10.1038\/ncomms15439","article-title":"Erratum: CD40-signalling abrogates induction of RORgammat(+) Treg cells by intestinal CD103(+) DCs and causes fatal colitis","volume":"8","author":"Barthels","year":"2017","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.biopha.2020.109930_bib0080","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1007\/s12026-016-8877-8","article-title":"Effect of CD40\/CD40L signaling on IL-10-producing regulatory B cells in Chinese children with Henoch-Schonlein purpura nephritis","volume":"65","author":"Yang","year":"2017","journal-title":"Immunol. Res."},{"issue":"1","key":"10.1016\/j.biopha.2020.109930_bib0085","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nm.2597","article-title":"Recipient nonhematopoietic antigen-presenting cells are sufficient to induce lethal acute graft-versus-host disease","volume":"18","author":"Koyama","year":"2011","journal-title":"Nat. Med."},{"issue":"6","key":"10.1016\/j.biopha.2020.109930_bib0090","first-page":"4822","article-title":"MicroRNA-216b-3p inhibits lung adenocarcinoma cell growth via regulating PDZ binding kinase\/T-LAK-cell-originated protein kinase","volume":"15","author":"Chai","year":"2018","journal-title":"Exp. Ther. Med."},{"issue":"1","key":"10.1016\/j.biopha.2020.109930_bib0095","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12865-017-0215-y","article-title":"The imbalance of Th17\/Treg cells is involved in the progression of nonalcoholic fatty liver disease in mice","volume":"18","author":"He","year":"2017","journal-title":"BMC Immunol."},{"issue":"8","key":"10.1016\/j.biopha.2020.109930_bib0100","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1111\/liv.14067","article-title":"MicroRNA-30b regulates insulin sensitivity by targeting SERCA2b in non-alcoholic fatty liver disease","volume":"39","author":"Dai","year":"2019","journal-title":"Liver Int."},{"issue":"1","key":"10.1016\/j.biopha.2020.109930_bib0105","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/MCG.0b013e3181dd1348","article-title":"Generalizability of the NASH CRN histological scoring system for nonalcoholic fatty liver disease","volume":"45","author":"Juluri","year":"2011","journal-title":"J. Clin. Gastroenterol."},{"issue":"1","key":"10.1016\/j.biopha.2020.109930_bib0110","first-page":"1","article-title":"Association between obstructive sleep apnea and non-alcoholic fatty liver disease: a systematic review and meta-analysis","author":"Jin","year":"2018","journal-title":"Sleep Breath."},{"issue":"2","key":"10.1016\/j.biopha.2020.109930_bib0115","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3390\/md16020039","article-title":"Protective effect of meretrix meretrix oligopeptides on high-fat-diet-induced non-alcoholic fatty liver disease in mice","volume":"16","author":"Huang","year":"2018","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.biopha.2020.109930_bib0120","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3389\/fimmu.2017.00294","article-title":"Interactions between type 1 interferons and the Th17 response in tuberculosis: lessons learned from autoimmune diseases","volume":"8","author":"Mourik","year":"2017","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.biopha.2020.109930_bib0125","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1700492","article-title":"High frequency of intestinal TH17 cells correlates with microbiota alterations and disease activity in multiple sclerosis","volume":"3","author":"Cosorich","year":"2017","journal-title":"Sci. Adv."},{"issue":"376","key":"10.1016\/j.biopha.2020.109930_bib0130","doi-asserted-by":"crossref","first-page":"eaaf9655","DOI":"10.1126\/scitranslmed.aaf9655","article-title":"IgA-coated E. coli enriched in Crohn\u2019s disease spondyloarthritis promote TH17-dependent inflammation","volume":"9","author":"Viladomiu","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.biopha.2020.109930_bib0135","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3389\/fimmu.2017.00235","article-title":"T Cell polarization toward TH2\/TFH2 and TH17\/TFH17 in patients with IgG4-related disease","volume":"8","author":"Grados","year":"2017","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.biopha.2020.109930_bib0140","doi-asserted-by":"crossref","first-page":"987","DOI":"10.33549\/physiolres.933615","article-title":"Roles of miR-31 and endothelin-1 in psoriasis vulgaris: pathophysiological functions and potential biomarkers","volume":"66","author":"Borska","year":"2017","journal-title":"Physiol. Res."},{"issue":"1","key":"10.1016\/j.biopha.2020.109930_bib0145","first-page":"633","article-title":"MicroRNA-31 promotes arterial smooth muscle cell proliferation and migration by targeting mitofusin-2 in arteriosclerosis obliterans of the lower extremitie","volume":"15","author":"Huang","year":"2018","journal-title":"Exp. Ther. Med."},{"issue":"11","key":"10.1016\/j.biopha.2020.109930_bib0150","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1093\/ibd\/izy213","article-title":"MicroRNA-31 targets thymic stromal lymphopoietin in mucosal infiltrated CD4+ T cells: a role in achieving mucosal healing in ulcerative colitis?","volume":"24","author":"Whiteoak","year":"2018","journal-title":"Inflamm. Bowel Dis."},{"issue":"7","key":"10.1016\/j.biopha.2020.109930_bib0155","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/ni.3755","article-title":"The microRNA miR-31 inhibits CD8(+) T cell function in chronic viral infection","volume":"18","author":"Moffett","year":"2017","journal-title":"Nat. Immunol."},{"issue":"Suppl 2","key":"10.1016\/j.biopha.2020.109930_bib0160","first-page":"1","article-title":"OP0150 3-bromopyruvate ameliorates autoimmune arthritis by exerting a dual effect on both Th17 and Treg cell differentiation and dendritic cell activation","volume":"75","author":"Okano","year":"2016","journal-title":"Ann. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.biopha.2020.109930_bib0165","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/cei.12396","article-title":"Soluble CD40-ligand (sCD40L, sCD154) plays an immunosuppressive role via regulatory T cell expansion in HIV infection","volume":"178","author":"Jenabian","year":"2014","journal-title":"Clin. Exp. Immunol."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220301207?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220301207?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:53:19Z","timestamp":1760097199000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332220301207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":33,"alternative-id":["S0753332220301207"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2020.109930","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MiR-195 regulates CD40 to maintain Th17\/Treg balance in rats with non-alcoholic fatty liver disease","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2020.109930","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"109930"}}