{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T06:31:52Z","timestamp":1794378712960,"version":"4.9.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T00:00:00Z","timestamp":1579478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573488"],"award-info":[{"award-number":["81573488"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81722049"],"award-info":[{"award-number":["81722049"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017A03031387"],"award-info":[{"award-number":["2017A03031387"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["201904010472"],"award-info":[{"award-number":["201904010472"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.biopha.2020.109936","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T06:21:03Z","timestamp":1580278863000},"page":"109936","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Chronopharmacological targeting of Rev-erb\u03b1 by puerarin alleviates hyperhomocysteinemia in mice"],"prefix":"10.1016","volume":"125","author":[{"given":"Min","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiman","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianpeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baojian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2020.109936_bib0005","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/0955-2863(90)90070-2","article-title":"Methionine metabolism in mammals","volume":"1","author":"Finkelstein","year":"1990","journal-title":"J. Nutr. Biochem."},{"issue":"5","key":"10.1016\/j.biopha.2020.109936_bib0010","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1002\/hep.30675","article-title":"Reverse erythroblastosis virus \u03b1Antagonism promotes homocysteine catabolism and Ammonia clearance","volume":"70","author":"Zhang","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.biopha.2020.109936_bib0015","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1172\/JCI118776","article-title":"The oxidant stress of hyperhomocyst(e)inemia","volume":"98","author":"Loscalzo","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biopha.2020.109936_bib0020","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev.med.60.041807.123308","article-title":"The treatment of hyperhomocysteinemia","volume":"60","author":"Maron","year":"2009","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.biopha.2020.109936_bib0025","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1001\/jama.1995.03530130055028","article-title":"A quantitative assessment of plasma homocysteine as a risk factor for vascular disease, Probable benefits of increasing folic acid intakes","volume":"74","author":"Boushey","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/j.biopha.2020.109936_bib0030","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1001\/jama.288.16.2015","article-title":"Homocysteine and risk of ischemic heart disease and stroke;a meta-analysis","volume":"288","author":"Homocysteine Studies Collaboration","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.biopha.2020.109936_bib0035","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1056\/NEJMoa011613","article-title":"Plasma homocysteine as a risk factor for dementia and Alzheimer\u2019s disease","volume":"346","author":"Seshadri","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biopha.2020.109936_bib0040","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1515\/CCLM.2011.084","article-title":"Homocysteine: a biomarker in neurodegenerative diseases","volume":"49","author":"Herrmann","year":"2011","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.biopha.2020.109936_bib0045","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1089\/ars.2007.1771","article-title":"Homocysteine and glutathione peroxidase-1","volume":"9","author":"Lubos","year":"2007","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.biopha.2020.109936_bib0050","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/bs.acc.2015.07.002","article-title":"Homocysteine in chronic kidney disease","volume":"72","author":"Ostrakhovitch","year":"2015","journal-title":"Adv. Clin. Chem."},{"issue":"1","key":"10.1016\/j.biopha.2020.109936_bib0055","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1080\/13880209.2016.1231695","article-title":"Hesperidin, a citrus flavonoid, protects against l-methionine-induced hyperhomocysteinemia by abrogation of oxidative stress, endothelial dysfunction and neurotoxicity in Wistar rats","volume":"55","author":"Hemanth Kumar","year":"2017","journal-title":"Pharm. Biol."},{"issue":"7","key":"10.1016\/j.biopha.2020.109936_bib0060","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1002\/ptr.5083","article-title":"Puerarin: a review of pharmacological effects","volume":"28","author":"Zhou","year":"2014","journal-title":"Phytother. Res."},{"key":"10.1016\/j.biopha.2020.109936_bib0065","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.jnutbio.2011.05.015","article-title":"Puerarin prevents isoprenalineinduced myocardial fibrosis in mice by reduction of myocardial TGF-\u03b21 expression","volume":"23","author":"Chen","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.biopha.2020.109936_bib0070","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/BF02934409","article-title":"The potential effect of puerarin in preventing atherosclerosis","volume":"8","author":"Zhu","year":"2002","journal-title":"CJIM"},{"key":"10.1016\/j.biopha.2020.109936_bib0075","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1124\/jpet.107.125567","article-title":"Activation of large-conductance calcium-activated potassium channels by puerarin: the underlying mechanism of puerarin-mediated vasodilation","volume":"323","author":"Sun","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.biopha.2020.109936_bib0080","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.bbrc.2011.09.077","article-title":"Restoration of autophagy by puerarin in ethanol-treated hepatocytes via the activation of AMP-activated protein kinase","volume":"414","author":"Noh","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.biopha.2020.109936_bib0085","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1142\/S0192415X19500022","article-title":"Puerarin reduces blood pressure in spontaneously hypertensive rats by targeting eNOS","volume":"47","author":"Shi","year":"2019","journal-title":"Am. J. Chin. Med."},{"issue":"4945","key":"10.1016\/j.biopha.2020.109936_bib0090","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1126\/science.2305266","article-title":"Transplanted suprachiasmatic nucleus determines circadian period","volume":"247","author":"Ralph","year":"1990","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.biopha.2020.109936_bib0095","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1517\/17425255.2011.544251","article-title":"The role of circadian timing system on drug metabolism and detoxification","volume":"7","author":"Gachon","year":"2011","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.biopha.2020.109936_bib0100","doi-asserted-by":"crossref","first-page":"16219","DOI":"10.1073\/pnas.1408886111","article-title":"A circadian gene expression atlas in mammals: implications for biology and medicine","volume":"111","author":"Zhang","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.biopha.2020.109936_bib0105","first-page":"1","article-title":"Circadian clock-controlled drug metabolism and transport","volume":"1","author":"Zhao","year":"2019","journal-title":"Xenobiotica"},{"key":"10.1016\/j.biopha.2020.109936_bib0110","doi-asserted-by":"crossref","first-page":"e001","DOI":"10.1621\/nrs.08001","article-title":"Nuclear receptor Rev-erba: a heme receptor that coordinates circadian rhythm and metabolism","volume":"8","author":"Yin","year":"2010","journal-title":"Nucl. Recept. Signal."},{"issue":"6","key":"10.1016\/j.biopha.2020.109936_bib0115","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1210\/me.2005-0057","article-title":"The orphan nuclear receptor Rev-erbalpha recruits the N-CoR\/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene","volume":"19","author":"Yin","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.biopha.2020.109936_bib0120","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1210\/en.2009-0800","article-title":"Regulation of adipogenesis by natural and synthetic REV-ERB ligands","volume":"151","author":"Kumar","year":"2010","journal-title":"Endocrinology"},{"issue":"7396","key":"10.1016\/j.biopha.2020.109936_bib0125","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nature11048","article-title":"Regulation of circadian behaviour and metabolism by REV-ERB-\u03b1 and REV-ERB-\u03b2","volume":"485","author":"Cho","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2020.109936_bib0130","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.tem.2014.06.011","article-title":"Nuclear receptor Rev-erbalpha: up, down, and all around","volume":"25","author":"Everett","year":"2014","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2020.109936_bib0135","doi-asserted-by":"crossref","first-page":"5246","DOI":"10.7150\/thno.28676","article-title":"Small heterodimer partner regulates circadian cytochromes p450 and drug-induced hepatotoxicity","volume":"8","author":"Zhang","year":"2018","journal-title":"Theranostics"},{"issue":"3","key":"10.1016\/j.biopha.2020.109936_bib0140","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1124\/dmd.117.078105","article-title":"REV-ERB\u03b1 regulates CYP7A1 through repression of liver receptor homolog-1","volume":"46","author":"Zhang","year":"2018","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.biopha.2020.109936_bib0145","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.bcp.2019.01.019","article-title":"The nuclear receptor Shp regulates morphine withdrawal syndrome via modulation of Ugt2b expression in mice","volume":"161","author":"Chen","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biopha.2020.109936_bib0150","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/nrrheum.2011.115","article-title":"Rheumatoid arthritis: circadian and circannual rhythms in RA","volume":"7","author":"Cutolo","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.biopha.2020.109936_bib0155","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1056\/NEJM198511213132103","article-title":"Circadian variation in the frequency of onset of acute myocardial infarction","volume":"313","author":"Muller","year":"1985","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biopha.2020.109936_bib0160","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nature10852","article-title":"Circadian rhythms govern cardiac repolarization and arrhythmogenesis","volume":"483","author":"Jeyaraj","year":"2012","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.biopha.2020.109936_bib0165","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.cmet.2018.05.002","article-title":"Chrono-pharmacological targeting of the CCL2-CCR2 Axis Ameliorates atherosclerosis","volume":"28","author":"Winter","year":"2018","journal-title":"Cell Metab."},{"issue":"6","key":"10.1016\/j.biopha.2020.109936_bib0170","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1101\/gad.237081.113","article-title":"The circadian clock regulates rhythmic activation of the NRF2\/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis","volume":"28","author":"Pekovic-Vaughan","year":"2014","journal-title":"Genes Dev."},{"key":"10.1016\/j.biopha.2020.109936_bib0175","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev.nutr.19.1.217","article-title":"Homocysteine metabolism","volume":"19","author":"Selhub","year":"1999","journal-title":"Annu. Rev. Nutr."},{"issue":"9","key":"10.1016\/j.biopha.2020.109936_bib0180","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1161\/ATVBAHA.108.166421","article-title":"Murine models of hyperhomocysteinemia and their vascular phenotypes","volume":"28","author":"Dayal","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.biopha.2020.109936_bib0185","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1146\/annurev.pharmtox.47.120505.105208","article-title":"Circadian rhythms: mechanisms and therapeutic implications","volume":"47","author":"L\u00e9vi","year":"2007","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"3","key":"10.1016\/j.biopha.2020.109936_bib0190","doi-asserted-by":"crossref","first-page":"e94","DOI":"10.14440\/jbm.2018.244","article-title":"Development and implementation of a cell-based assay to discover agonists of the nuclear receptor REV-ERB\u03b1","volume":"5","author":"Hering","year":"2018","journal-title":"J. Biol. Methods"},{"issue":"11","key":"10.1016\/j.biopha.2020.109936_bib0195","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1016\/j.bmcl.2012.04.023","article-title":"Synthesis and SAR of tetrahydroisoquinolines as Rev-erb\u03b1 agonists","volume":"22","author":"Noel","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"11","key":"10.1016\/j.biopha.2020.109936_bib0200","doi-asserted-by":"crossref","first-page":"4729","DOI":"10.1021\/jm400458q","article-title":"Optimized chemical probes for REV-ERB\u03b1","volume":"56","author":"Trump","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.biopha.2020.109936_bib0205","first-page":"83","article-title":"Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain","volume":"6","author":"usunose","year":"2010","journal-title":"Mol. Pain"},{"issue":"11","key":"10.1016\/j.biopha.2020.109936_bib0210","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1007\/s00204-012-0874-7","article-title":"UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for puerarin metabolism in human liver microsomes","volume":"86","author":"Luo","year":"2012","journal-title":"Arch. Toxicol."},{"issue":"18","key":"10.1016\/j.biopha.2020.109936_bib0215","doi-asserted-by":"crossref","first-page":"5122","DOI":"10.7150\/thno.35773","article-title":"Circadian clock gene Bmal1 regulates bilirubin detoxification: a potential mechanism of feedback control of Hyperbilirubinemia","volume":"9","author":"Wang","year":"2019","journal-title":"Theranostics"},{"issue":"48","key":"10.1016\/j.biopha.2020.109936_bib0220","doi-asserted-by":"crossref","first-page":"E6683","DOI":"10.1073\/pnas.1519735112","article-title":"Shifting the feeding of mice to the rest phase creates metabolic alterations, which, on their own, shift the peripheral circadian clocks by 12 hours","volume":"112","author":"Mukherji","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biopha.2020.109936_bib0225","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1194\/jlr.M200386-JLR200","article-title":"Identification of Rev-erba as a physiological repressor of apoC-III gene transcription","volume":"43","author":"Rasp\u00e9","year":"2002","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.biopha.2020.109936_bib0230","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.phrs.2019.01.010","article-title":"Rev-erb\u03b1 activation down-regulates hepatic Pck1 enzyme to lower plasma glucose in mice","volume":"141","author":"Yuan","year":"2019","journal-title":"Pharmacol. Res."},{"issue":"1\u20133","key":"10.1016\/j.biopha.2020.109936_bib0235","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.ejphar.2010.09.054","article-title":"Puerarin improves insulin resistance and modulates adipokine expression in rats fed a high-fat diet","volume":"649","author":"Zhang","year":"2010","journal-title":"Eur. J. Pharmacol."},{"issue":"10","key":"10.1016\/j.biopha.2020.109936_bib0240","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1172\/JCI11596","article-title":"Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways","volume":"107","author":"Werstuck","year":"2001","journal-title":"J. Clin. Invest."},{"issue":"12","key":"10.1016\/j.biopha.2020.109936_bib0245","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1038\/nsmb1344","article-title":"Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta","volume":"14","author":"Raghuram","year":"2007","journal-title":"Nat. Struct. Mol. Biol."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220301268?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220301268?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:00:03Z","timestamp":1790607603000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332220301268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":49,"alternative-id":["S0753332220301268"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2020.109936","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronopharmacological targeting of Rev-erb\u03b1 by puerarin alleviates hyperhomocysteinemia in mice","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2020.109936","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"109936"}}