{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:20:21Z","timestamp":1793035221329,"version":"4.5.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T00:00:00Z","timestamp":1581638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.biopha.2020.110022","type":"journal-article","created":{"date-parts":[[2020,2,24]],"date-time":"2020-02-24T23:46:09Z","timestamp":1582587969000},"page":"110022","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":157,"special_numbering":"C","title":["STING is an essential regulator of heart inflammation and fibrosis in mice with pathological cardiac hypertrophy via endoplasmic reticulum (ER) stress"],"prefix":"10.1016","volume":"125","author":[{"given":"Yan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2020.110022_bib0005","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.yjmcc.2016.06.001","article-title":"Physiological and pathological cardiac hypertrophy","volume":"97","author":"Shimizu","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"10","key":"10.1016\/j.biopha.2020.110022_bib0010","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1042\/CS20180228","article-title":"Leflunomide counterakts cardiac hypertrophy","volume":"132","author":"Pescatore","year":"2018","journal-title":"Clin. Sci."},{"issue":"11","key":"10.1016\/j.biopha.2020.110022_bib0015","first-page":"5063","article-title":"Systemic inflammation is associated with myocardial fibrosis, diastolic dysfunction, and cardiac hypertrophy in patients with hypertrophic cardiomyopathy","volume":"9","author":"Fang","year":"2017","journal-title":"Am. J. Transl. Res."},{"issue":"10","key":"10.1016\/j.biopha.2020.110022_bib0020","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/nm.4179","article-title":"The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy","volume":"22","author":"Wang","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.biopha.2020.110022_bib0025","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3389\/fcvm.2018.00134","article-title":"Cardiomyocytes and macrophages discourse on the method to govern cardiac repair","volume":"5","author":"Gomez","year":"2018","journal-title":"Front. Cardiovasc. Med."},{"issue":"11","key":"10.1016\/j.biopha.2020.110022_bib0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027294","article-title":"\u03b2-AR blockers suppresses ER stress in cardiac hypertrophy and heart failure","volume":"6","author":"Ni","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2020.110022_bib0035","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.cbi.2015.09.025","article-title":"4-PBA prevents pressure overload-induced myocardial hypertrophy and interstitial fibrosis by attenuating endoplasmic reticulum stress","volume":"242","author":"Luo","year":"2015","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.biopha.2020.110022_bib0040","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.freeradbiomed.2019.05.031","article-title":"Endoplasmic reticulum stress-induced iRhom2 up-regulation promotes macrophage-regulated cardiac inflammation and lipid deposition in high fat diet (HFD)-challenged mice: intervention of fisetin and metformin","volume":"141","author":"Ge","year":"2019","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.biopha.2020.110022_bib0045","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3390\/cells9020317","article-title":"Role of the TRPV channels in the endoplasmic reticulum calcium homeostasis","volume":"9","author":"Haustrate","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.biopha.2020.110022_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101232","article-title":"Targeting ER stress\/ER stress response in myopathies","volume":"26","author":"Zito","year":"2019","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.biopha.2020.110022_bib0055","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/jcp.25098","article-title":"Endoplasmic reticulum stress interacts with inflammation in human diseases","volume":"231","author":"Cao","year":"2016","journal-title":"J. Cell. Physiol."},{"issue":"4","key":"10.1016\/j.biopha.2020.110022_bib0060","doi-asserted-by":"crossref","first-page":"H871","DOI":"10.1152\/ajpheart.00362.2016","article-title":"Endoplasmic reticulum stress increases brain MAPK signaling, inflammation and renin-angiotensin system activity and sympathetic nerve activity in heart failure","volume":"311","author":"Wei","year":"2016","journal-title":"Am. J. Physiol.-Heart Circulatory Physiol."},{"issue":"5","key":"10.1016\/j.biopha.2020.110022_bib0065","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/ATVBAHA.111.224519","article-title":"C\/EBP homologous protein deficiency attenuates myocardial reperfusion injury by inhibiting myocardial apoptosis and inflammation","volume":"31","author":"Miyazaki","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"2","key":"10.1016\/j.biopha.2020.110022_bib0070","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bbadis.2014.05.006","article-title":"Endoplasmic reticulum stress and protein quality control in diabetic cardiomyopathy","volume":"1852","author":"Yang","year":"2015","journal-title":"Biochim. et Biophys. Acta (BBA)-Mol. Basis Dis."},{"issue":"12","key":"10.1016\/j.biopha.2020.110022_bib0075","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/nri3921","article-title":"STING: infection, inflammation and cancer","volume":"15","author":"Barber","year":"2015","journal-title":"Nat. Rev. Immunol."},{"issue":"7","key":"10.1016\/j.biopha.2020.110022_bib0080","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1080\/21505594.2017.1321191","article-title":"cGAS-STING-TBK1-IRF3\/7 induced interferon-\u03b2 contributes to the clearing of non tuberculous mycobacterial infection in mice","volume":"8","author":"Ruangkiattikul","year":"2017","journal-title":"Virulence"},{"issue":"13","key":"10.1016\/j.biopha.2020.110022_bib0085","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.15252\/embj.201593458","article-title":"HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression","volume":"35","author":"Christensen","year":"2016","journal-title":"EMBO J."},{"issue":"17","key":"10.1016\/j.biopha.2020.110022_bib0090","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.7150\/thno.26687","article-title":"Aphthous ulcer drug inhibits prostate tumor metastasis by targeting IKK\u03b5\/TBK1\/NF-\u03baB signaling","volume":"8","author":"Cheng","year":"2018","journal-title":"Theranostics"},{"issue":"3","key":"10.1016\/j.biopha.2020.110022_bib0095","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00011-019-01213-3","article-title":"MiR-19a mediates the negative regulation of the NF-\u03baB pathway in lipopolysaccharide-induced endometritis by targeting TBK1","volume":"68","author":"Yin","year":"2019","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.biopha.2020.110022_bib0100","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.biopha.2017.01.142","article-title":"Knockdown of IRF3 inhibits extracellular matrix expression in keloid fibroblasts","volume":"88","author":"Zhang","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.biopha.2020.110022_bib0105","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1161\/HYPERTENSIONAHA.113.02795","article-title":"IRFs in heart: stress response beyond inflammation","volume":"63","author":"Sun","year":"2014","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.biopha.2020.110022_bib0110","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1161\/HYPERTENSIONAHA.113.01506","article-title":"Signal regulatory protein-\u03b1 protects against cardiac hypertrophy via the disruption of toll-like receptor 4 signaling","volume":"63","author":"Jiang","year":"2014","journal-title":"Hypertension"},{"issue":"6","key":"10.1016\/j.biopha.2020.110022_bib0115","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1161\/HYPERTENSIONAHA.111.00614","article-title":"Role of interferon regulatory factor 4 in the regulation of pathological cardiac hypertrophy","volume":"61","author":"Jiang","year":"2013","journal-title":"Hypertension"},{"issue":"31","key":"10.1016\/j.biopha.2020.110022_bib0120","doi-asserted-by":"crossref","first-page":"13818","DOI":"10.1073\/pnas.1008397107","article-title":"Regulator of G protein signaling 5 protects against cardiac hypertrophy and fibrosis during biomechanical stress of pressure overload","volume":"107","author":"Li","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.biopha.2020.110022_bib0125","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.bbadis.2010.07.003","article-title":"Beta2-adrenergic receptor regulates cardiac fibroblast autophagy and collagen degradation","volume":"1812","author":"Ar\u00e1nguiz-Urroz","year":"2011","journal-title":"Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease"},{"issue":"8","key":"10.1016\/j.biopha.2020.110022_bib0130","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-019-1787-7","article-title":"Translationally controlled tumor protein (TCTP) plays a pivotal role in cardiomyocyte survival through a Bnip3-dependent mechanism","volume":"10","author":"Cai","year":"2019","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.biopha.2020.110022_bib0135","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1161\/01.RES.0000173297.53793.fa","article-title":"CD31\u2212 but not CD31+ cardiac side population cells exhibit functional cardiomyogenic differentiation","volume":"97","author":"Pfister","year":"2005","journal-title":"Circ. Res."},{"issue":"23","key":"10.1016\/j.biopha.2020.110022_bib0140","doi-asserted-by":"crossref","first-page":"5457","DOI":"10.1111\/bph.12881","article-title":"The interferon regulatory factors as novel potential targets in the treatment of cardiovascular diseases","volume":"172","author":"Zhang","year":"2015","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.biopha.2020.110022_bib0145","doi-asserted-by":"crossref","first-page":"383","DOI":"10.7150\/ijbs.7.383","article-title":"Tanshinone IIA protects against cardiac hypertrophy via inhibiting calcineurin\/NFATc3 pathway","volume":"7","author":"Tan","year":"2011","journal-title":"Int. J. Biol. Sci."},{"issue":"41","key":"10.1016\/j.biopha.2020.110022_bib0150","doi-asserted-by":"crossref","first-page":"16544","DOI":"10.1073\/pnas.1308331110","article-title":"STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease","volume":"110","author":"Petrasek","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"5","key":"10.1016\/j.biopha.2020.110022_bib0155","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1161\/CIRCRESAHA.110.226803","article-title":"Interrelationship between cardiac hypertrophy, heart failure, and chronic kidney disease: endoplasmic reticulum stress as a mediator of pathogenesis","volume":"108","author":"Dickhout","year":"2011","journal-title":"Circ. Res."},{"issue":"10","key":"10.1016\/j.biopha.2020.110022_bib0160","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1161\/CIRCRESAHA.107.161273","article-title":"Endoplasmic reticulum stress in the heart","volume":"101","author":"Glembotski","year":"2007","journal-title":"Circ. Res."},{"issue":"9","key":"10.1016\/j.biopha.2020.110022_bib0165","doi-asserted-by":"crossref","first-page":"4630","DOI":"10.4049\/jimmunol.1102737","article-title":"Endoplasmic reticulum stress regulates the innate immunity critical transcription factor IRF3","volume":"189","author":"Liu","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.biopha.2020.110022_bib0170","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.metabol.2017.09.010","article-title":"Activation of the STING-IRF3 pathway promotes hepatocyte inflammation, apoptosis and induces metabolic disorders in nonalcoholic fatty liver disease","volume":"81","author":"Qiao","year":"2018","journal-title":"Metabolism"},{"issue":"4","key":"10.1016\/j.biopha.2020.110022_bib0175","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.cmet.2019.08.003","article-title":"Mitochondrial damage and activation of the STING pathway lead to renal inflammation and fibrosis","volume":"30","author":"Chung","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.biopha.2020.110022_bib0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101215","article-title":"STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3","volume":"24","author":"Li","year":"2019","journal-title":"Redox Biol."},{"issue":"46","key":"10.1016\/j.biopha.2020.110022_bib0185","doi-asserted-by":"crossref","first-page":"12196","DOI":"10.1073\/pnas.1708744114","article-title":"DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway","volume":"114","author":"Bai","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"6","key":"10.1016\/j.biopha.2020.110022_bib0190","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1053\/j.gastro.2018.09.010","article-title":"Expression of STING is increased in liver tissues from patients with NAFLD and promotes macrophage-mediated hepatic inflammation and fibrosis in mice","volume":"155","author":"Luo","year":"2018","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.biopha.2020.110022_bib0195","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1161\/ATVBAHA.117.309017","article-title":"STING-IRF3 triggers endothelial inflammation in response to free fatty acid-induced mitochondrial damage in diet-induced obesity","volume":"37","author":"Mao","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"1","key":"10.1016\/j.biopha.2020.110022_bib0200","doi-asserted-by":"crossref","first-page":"5226","DOI":"10.1038\/s41467-018-07425-1","article-title":"STING-dependent sensing of self-DNA drives silica-induced lung inflammation","volume":"9","author":"Benmerzoug","year":"2018","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.biopha.2020.110022_bib0205","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.yexmp.2012.04.006","article-title":"Vitamin D deficiency induces cardiac hypertrophy and inflammation in epicardial adipose tissue in hypercholesterolemic swine","volume":"93","author":"Gupta","year":"2012","journal-title":"Exp. Mol. Pathol."},{"issue":"7","key":"10.1016\/j.biopha.2020.110022_bib0210","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1080\/15548627.2015.1052206","article-title":"B cell autophagy mediates TLR7-dependent autoimmunity and inflammation","volume":"11","author":"Weindel","year":"2015","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.biopha.2020.110022_bib0215","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.toxlet.2012.03.006","article-title":"Inhibition of Rho-kinase ameliorates myocardial remodeling and fibrosis in pressure overload and myocardial infarction: role of TGF-\u03b21-TAK1","volume":"211","author":"Li","year":"2012","journal-title":"Toxicol. Lett."},{"issue":"2","key":"10.1016\/j.biopha.2020.110022_bib0220","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0014-4827(02)00015-0","article-title":"TGF-\u03b21-mediated fibroblast-myofibroblast terminal differentiation-the role of smad proteins","volume":"282","author":"Evans","year":"2003","journal-title":"Exp. Cell Res."},{"issue":"52","key":"10.1016\/j.biopha.2020.110022_bib0225","doi-asserted-by":"crossref","first-page":"26794","DOI":"10.1074\/jbc.M116.736991","article-title":"Endoplasmic reticulum stress-induced hepatocellular death pathways mediate liver injury and fibrosis via stimulator of interferon genes","volume":"291","author":"Iracheta-Vellve","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.biopha.2020.110022_bib0230","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.yjmcc.2010.10.019","article-title":"Immune-inflammatory dysregulation modulates the incidence of progressive fibrosis and diastolic stiffness in the aging heart","volume":"50","author":"Cieslik","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"214","key":"10.1016\/j.biopha.2020.110022_bib0235","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2002521","article-title":"STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway","volume":"5","author":"Tanaka","year":"2012","journal-title":"Sci. Signal."},{"issue":"4","key":"10.1016\/j.biopha.2020.110022_bib0240","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.cell.2017.09.034","article-title":"STING senses microbial viability to orchestrate stress-mediated autophagy of the endoplasmic reticulum","volume":"171","author":"Moretti","year":"2017","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.biopha.2020.110022_bib0245","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1189\/jlb.2MR0416-201R","article-title":"Cell-autonomous stress responses in innate immunity","volume":"101","author":"Moretti","year":"2017","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.biopha.2020.110022_bib0250","first-page":"1","volume":"291","author":"Iracheta-Vellve","year":"2016"},{"issue":"3","key":"10.1016\/j.biopha.2020.110022_bib0255","doi-asserted-by":"crossref","first-page":"205","DOI":"10.2174\/187152907781745260","article-title":"Endoplasmic reticulum stress as a novel therapeutic target in heart diseases","volume":"7","author":"Toth","year":"2007","journal-title":"Cardiovasc. Haematol. Disord.-Drug Targets (Formerly Current Drug Targets-Cardiovascular & Hematological Disorders)"},{"issue":"4","key":"10.1016\/j.biopha.2020.110022_bib0260","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/ijc.30074","article-title":"Mitochondrial DNA sensing by STING signaling participates in inflammation, cancer and beyond","volume":"139","author":"Liu","year":"2016","journal-title":"Int. J. Cancer"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220302134?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220302134?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:54:54Z","timestamp":1790607294000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332220302134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":52,"alternative-id":["S0753332220302134"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110022","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"STING is an essential regulator of heart inflammation and fibrosis in mice with pathological cardiac hypertrophy via endoplasmic reticulum (ER) stress","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"110022"}}