{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T01:16:12Z","timestamp":1792977372806,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T00:00:00Z","timestamp":1583280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81774013"],"award-info":[{"award-number":["81774013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004884","name":"Education Department of Sichuan Province","doi-asserted-by":"publisher","award":["2018JC013"],"award-info":[{"award-number":["2018JC013"]}],"id":[{"id":"10.13039\/501100004884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["19PTDJ0026"],"award-info":[{"award-number":["19PTDJ0026"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2018JY0237"],"award-info":[{"award-number":["2018JY0237"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.biopha.2020.110073","type":"journal-article","created":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T06:56:48Z","timestamp":1584082608000},"page":"110073","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Tandospirone enhances the anti-myocardial fibrosis effect of valsartan in spontaneously hypertensive rats"],"prefix":"10.1016","volume":"126","author":[{"given":"Xuefei","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqi","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinrui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-Guo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalian","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shousong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qibin","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6136-7469","authenticated-orcid":false,"given":"Jianming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2020.110073_bib0005","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/s41569-019-0178-1","article-title":"Neuroimmune crosstalk in the pathophysiology of hypertension","volume":"16","author":"Calvillo","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.biopha.2020.110073_bib0010","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1161\/CIRCULATIONAHA.108.845792","article-title":"The progression of hypertensive heart disease","volume":"123","author":"Drazner","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2020.110073_bib0015","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.yjmcc.2010.12.021","article-title":"Molecular and cellular mechanisms involved in cardiac remodeling after acute myocardial infarction","volume":"50","author":"Vilahur","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.biopha.2020.110073_bib0020","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/e82f77a8-3d29-44be-a9ef-7abc6c7e584a","article-title":"Toll-like receptor (TLR) 2 and TLR4 differentially regulate doxorubicin induced cardiomyopathy in mice","volume":"7","author":"Ma","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2020.110073_bib0025","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/nrd.2016.89","article-title":"Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease. Nature reviews","volume":"15","author":"Gourdie","year":"2016","journal-title":"Drug Discov."},{"key":"10.1016\/j.biopha.2020.110073_bib0030","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s10741-007-9060-z","article-title":"Pathways involved in the transition from hypertension to hypertrophy to heart failure. Treatment strategies","volume":"13","author":"Wright","year":"2008","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.biopha.2020.110073_bib0035","doi-asserted-by":"crossref","first-page":"53780","DOI":"10.18632\/oncotarget.17255","article-title":"Transforming growth factor beta: a potential biomarker and therapeutic target of ventricular remodeling","volume":"8","author":"Ma","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.biopha.2020.110073_bib0040","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1093\/cvr\/cvy038","article-title":"Multiple common comorbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress, and myocardial stiffening","volume":"114","author":"Sorop","year":"2018","journal-title":"Cardiovasc. Res."},{"issue":"311","key":"10.1016\/j.biopha.2020.110073_bib0045","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1001\/jama.2013.284427","article-title":"evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8)","volume":"2014","author":"James","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.biopha.2020.110073_bib0050","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1097\/HJH.0b013e328364a2a1","article-title":"Moxonidine-induced central sympathoinhibition improves prognosis in rats with hypertensive heart failure","volume":"31","author":"Honda","year":"2013","journal-title":"J. Hypertens."},{"key":"10.1016\/j.biopha.2020.110073_bib0055","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ahj.2017.02.008","article-title":"The design of the valsartan for attenuating disease evolution in early sarcomeric hypertrophic cardiomyopathy (VANISH) trial","volume":"187","author":"Ho","year":"2017","journal-title":"Am. Heart J."},{"key":"10.1016\/j.biopha.2020.110073_bib0060","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.cardiores.2006.07.012","article-title":"TGFbeta, cardiac fibroblasts, and the fibrotic response","volume":"74","author":"Leask","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.biopha.2020.110073_bib0065","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1291\/hypres.31.1835","article-title":"Long-term treatment with valsartan improved cyclic variation of the myocardial integral backscatter signal and diastolic dysfunction in hypertensive patients: the echocardiographic assessment","volume":"31","author":"Mizuta","year":"2008","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.biopha.2020.110073_bib0070","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/ajh.2008.27","article-title":"Cardioprotective mechanism of telmisartan via PPAR-gamma-eNOS pathway in dahl salt-sensitive hypertensive rats","volume":"21","author":"Kobayashi","year":"2008","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.biopha.2020.110073_bib0075","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00228-005-0931-8","article-title":"Effects of valsartan and perindopril combination therapy on left ventricular hypertrophy and aortic arterial stiffness in patients with essential hypertension","volume":"61","author":"Anan","year":"2005","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.biopha.2020.110073_bib0080","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.tins.2015.11.003","article-title":"FGFR1-5-HT1A heteroreceptor complexes: implications for understanding and treating major depression","volume":"39","author":"Borroto-Escuela","year":"2016","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.biopha.2020.110073_bib0085","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/S0002-9149(00)01146-2","article-title":"Effect of concomitant digoxin and carvedilol therapy on mortality and morbidity in patients with chronic heart failure","volume":"86","author":"Eichhorn","year":"2000","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.biopha.2020.110073_bib0090","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cbi.2018.07.008","article-title":"New insights into TGF-beta\/Smad signaling in tissue fibrosis","volume":"292","author":"Hu","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.biopha.2020.110073_bib0095","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1093\/ajh\/hpt188","article-title":"Telmisartan reduces mortality and left ventricular hypertrophy with sympathoinhibition in rats with hypertension and heart failure","volume":"27","author":"Kishi","year":"2014","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.biopha.2020.110073_bib0100","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jpsychires.2018.01.020","article-title":"Effects of tandospirone augmentation in major depressive disorder patients with high anxiety: a multicenter, randomized, parallel-controlled, open-label study","volume":"99","author":"Lin","year":"2018","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.biopha.2020.110073_bib0105","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ijcard.2013.10.022","article-title":"Tandospirone reduces wasting and improves cardiac function in experimental cancer cachexia","volume":"170","author":"Elkina","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.biopha.2020.110073_bib0110","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3892\/br.2015.458","article-title":"Reversion of left ventricle remodeling in spontaneously hypertensive rats by valsartan is associated with the inhibition of caspase-3, -8 and -9 activities","volume":"3","author":"Deng","year":"2015","journal-title":"Biomed. Rep."},{"key":"10.1016\/j.biopha.2020.110073_bib0115","first-page":"6","article-title":"Angiotensin II receptor-neprilysin inhibitor sacubitril\/valsartan improves endothelial dysfunction in spontaneously hypertensive rats","author":"Seki","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.biopha.2020.110073_bib0120","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.vascn.2008.08.002","article-title":"Blood pressure measurement with the tail-cuff method in Wistar and spontaneously hypertensive rats: influence of adrenergic- and nitric oxide-mediated vasomotion","volume":"58","author":"Fritz","year":"2008","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.biopha.2020.110073_bib0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jad.2015.03.054","article-title":"Chronic treatment with tandospirone, a serotonin 1A receptor partial agonist, inhibits psychosocial stress-induced changes in hippocampal neurogenesis and behavior","volume":"180","author":"Murata","year":"2015","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.biopha.2020.110073_bib0130","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1016\/S0140-6736(04)16451-9","article-title":"Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial","volume":"363","author":"Julius","year":"2004","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.biopha.2020.110073_bib0135","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.euroneuro.2005.11.009","article-title":"The pharmacokinetics and pharmacodynamics of tandospirone in rats exposed to conditioned fear stress","volume":"16","author":"Nishitsuji","year":"2006","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.biopha.2020.110073_bib0140","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1172\/JCI31044","article-title":"ECM remodeling in hypertensive heart disease","volume":"117","author":"Berk","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biopha.2020.110073_bib0145","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00018-013-1349-6","article-title":"The pathogenesis of cardiac fibrosis","volume":"71","author":"Kong","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.biopha.2020.110073_bib0150","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1016\/j.jacc.2003.12.051","article-title":"Comparative effects of valsartan versus amlodipine on left ventricular mass and reactive oxygen species formation by monocytes in hypertensive patients with left ventricular hypertrophy","volume":"43","author":"Yasunari","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.biopha.2020.110073_bib0155","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/hr.2014.85","article-title":"Valsartan improves the electrophysiological characteristics of left ventricular hypertrophic myocardium in spontaneously hypertensive rats","volume":"37","author":"Zhi-Bin","year":"2014","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.biopha.2020.110073_bib0160","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1172\/JCI94753","article-title":"Fibroblast-specific TGF-\u03b2\u2013Smad2\/3 signaling underlies cardiac fibrosis","volume":"127","author":"Khalil","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biopha.2020.110073_bib0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/JCI115821","article-title":"Transforming growth factor-beta in disease: the dark side of tissue repair","volume":"90","author":"Border","year":"1992","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biopha.2020.110073_bib0170","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.yjmcc.2010.10.033","article-title":"Transforming growth factor (TGF)-beta signaling in cardiac remodeling","volume":"51","author":"Dobaczewski","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.biopha.2020.110073_bib0175","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ijcard.2017.02.032","article-title":"Transforming growth factor (TGF)-beta1 signal pathway: a promising therapeutic target for attenuating cardiac fibrosis","volume":"239","author":"Xie","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.biopha.2020.110073_bib0180","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1006\/mgme.2000.3032","article-title":"Induction of cardiac fibrosis by transforming growth factor-beta(1)","volume":"71","author":"Lijnen","year":"2000","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.biopha.2020.110073_bib0185","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1161\/HYPERTENSIONAHA.117.10094","article-title":"MicroRNA-221\/222 family counteracts myocardial fibrosis in pressure overload-induced heart failure","volume":"71","author":"Verjans","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.biopha.2020.110073_bib0190","first-page":"1413","article-title":"Transforming growth factor-beta-dependent Wnt secretion controls myofibroblast formation and myocardial fibrosis progression in experimental autoimmune myocarditis","volume":"38","author":"Blyszczuk","year":"2017","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.biopha.2020.110073_bib0195","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.cardiores.2004.04.030","article-title":"TGF-beta1 and angiotensin networking in cardiac remodeling","volume":"63","author":"Rosenkranz","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.biopha.2020.110073_bib0200","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1172\/JCI117251","article-title":"Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells","volume":"93","author":"Kagami","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biopha.2020.110073_bib0205","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nature02006","article-title":"Smad-dependent and Smad-independent pathways in TGF-beta family signalling","volume":"425","author":"Derynck","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2020.110073_bib0210","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1755-1536-5-15","article-title":"Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease","volume":"5","author":"Fan","year":"2012","journal-title":"Fibrogenesis Tissue Repair"},{"key":"10.1016\/j.biopha.2020.110073_bib0215","first-page":"H1861","article-title":"Cardiac hypertrophy-induced changes in mRNA levels for TGF-beta 1, fibronectin, and collagen","volume":"262","author":"Villarreal","year":"1992","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.biopha.2020.110073_bib0220","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0008-6363(00)00030-4","article-title":"Role of mechanical factors in modulating cardiac fibroblast function and extracellular matrix synthesis","volume":"46","author":"MacKenna","year":"2000","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.biopha.2020.110073_bib0225","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1111\/j.1440-1746.2006.04331.x","article-title":"Effects of perindopril and valsartan on expression of transforming growth factor-beta-Smads in experimental hepatic fibrosis in rats","volume":"21","author":"Xu","year":"2006","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.biopha.2020.110073_bib0230","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.cyto.2010.11.004","article-title":"Valsartan decreases TGF-beta1 production and protects against chlorhexidine digluconate-induced liver peritoneal fibrosis in rats","volume":"53","author":"Subeq","year":"2011","journal-title":"Cytokine"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S075333222030264X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S075333222030264X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T02:47:35Z","timestamp":1762310855000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S075333222030264X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":46,"alternative-id":["S075333222030264X"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110073","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tandospirone enhances the anti-myocardial fibrosis effect of valsartan in spontaneously hypertensive rats","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110073","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"110073"}}