{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T07:13:42Z","timestamp":1785827622081,"version":"3.56.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T00:00:00Z","timestamp":1583798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016209","name":"Universidade Federal de Vi\u00e7osa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016209","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007374","name":"Universidade Federal de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014543","name":"Institute for Collaborative Biotechnologies","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.biopha.2020.110097","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T06:05:29Z","timestamp":1584684329000},"page":"110097","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Lipophosphoglycan-3 recombinant protein vaccine controls hepatic parasitism and prevents tissue damage in mice infected by Leishmania infantum chagasi"],"prefix":"10.1016","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7442-8067","authenticated-orcid":false,"given":"Daniel Silva Sena","family":"Bastos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca Meirelles","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4979-1304","authenticated-orcid":false,"given":"Thais Viana","family":"Fialho Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Ot\u00e1vio","family":"Guimar\u00e3es Ervilha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5840-2641","authenticated-orcid":false,"given":"Ana Cl\u00e1udia Ferreira","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4620-5154","authenticated-orcid":false,"given":"Sabrina","family":"de Oliveira Emerick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Carneiro da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00f4mulo Dias","family":"Novaes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Machado","family":"Neves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizi\u00e1ria Cardoso","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4353-7011","authenticated-orcid":false,"given":"Leandro Licursi","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4015-5915","authenticated-orcid":false,"given":"Eduardo de Almeida","family":"Marques-da-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2020.110097_bib0005","series-title":"Leishmaniasis in high-burden countries: an epidemiological update based on data reported in 2014","first-page":"285","author":"WHO\/Department of Control of Neglected Tropical Diseases","year":"2016"},{"key":"10.1016\/j.biopha.2020.110097_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2016.00153","article-title":"The contribution of immune evasive mechanisms to parasite persistence in visceral leishmaniasis","volume":"7","author":"de Freitas","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.biopha.2020.110097_bib0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000584","article-title":"Control of visceral leishmaniasis in latin America - A systematic review","volume":"4","author":"Romero","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.biopha.2020.110097_bib0020","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1590\/S0074-02762010000600014","article-title":"Immune response to Leishmania (Leishmania) chagasi infection is reduced in malnourished BALB\/c mice","volume":"105","author":"Serafim","year":"2010","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.biopha.2020.110097_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13071-017-2028-5","article-title":"The history of leishmaniasis","volume":"10","author":"Steverding","year":"2017","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.biopha.2020.110097_bib0030","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1007\/s00436-012-2985-8","article-title":"Canine visceral leishmaniasis: relationships between oxidative stress, liver and kidney variables, trace elements, and clinical status","volume":"111","author":"Heidarpour","year":"2012","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.biopha.2020.110097_bib0035","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1074\/jbc.M113.496323","article-title":"Leishmania donovani prevents oxidative burst-mediated apoptosis of host macrophages through selective induction of suppressors of cytokine signaling (SOCS) proteins","volume":"289","author":"Srivastav","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2020.110097_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/AAC.02360-16","article-title":"Glucantime\u00ae causes oxidative stress-derived DNA damage in BALB\/c mice infected by Leishmania (Leishmania) infantum","volume":"61","author":"Moreira","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.biopha.2020.110097_bib0045","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/iep.12080","article-title":"O.G. Ferreira Rocha, S.D. Canguss\u00fa, W.L. Tafuri, A potential link among antioxidant enzymes, histopathology and trace elements in canine visceral leishmaniasis","volume":"95","author":"Souza","year":"2014","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.biopha.2020.110097_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0148084","article-title":"The role of nitric oxide and reactive oxygen species in the killing of Leishmania braziliensis by monocytes from patients with cutaneous leishmaniasis","volume":"11","author":"Carneiro","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2020.110097_bib0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002914","article-title":"Immune regulation during chronic visceral leishmaniasis","volume":"8","author":"Faleiro","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.biopha.2020.110097_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pntd.0006052","article-title":"Drug resistance and treatment failure in leishmaniasis: a 21st century challenge","volume":"11","author":"Ponte-Sucre","year":"2017","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.biopha.2020.110097_bib0065","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.molbiopara.2015.12.005","article-title":"Leishmania chagasi heparin-binding protein: cell localization and participation in L. chagasi infection","volume":"204","author":"Martins","year":"2015","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.biopha.2020.110097_bib0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/4074357","article-title":"Oxidative stress-mediated overexpression of uracil DNA glycosylase inLeishmania donovani confers tolerance against antileishmanial drugs","volume":"2018","author":"Mishra","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.biopha.2020.110097_bib0075","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.molimm.2013.05.231","article-title":"Dogs immunized with LBSap vaccine displayed high levels of IL-12 and IL-10 cytokines and CCL4, CCL5 and CXCL8 chemokines in the dermis","volume":"56","author":"Vitoriano-Souza","year":"2013","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.biopha.2020.110097_bib0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2018.00503","article-title":"STAT6 mediates footpad immunopathology in the absence of IL-12p40 following infection of susceptible BALB\/c mice with Leishmania major","volume":"9","author":"Kauffmann","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.biopha.2020.110097_bib0085","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.biopha.2017.09.061","article-title":"New insights to structure and immunological features of Leishmania lipophosphoglycan3","volume":"95","author":"Hosseini","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2020.110097_bib0090","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/pim.12147","article-title":"Immune response in susceptible BALB\/c mice immunized with DNA encoding lipophosphoglycan 3 of Leishmania infantum","volume":"36","author":"Pirdel","year":"2014","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.biopha.2020.110097_bib0095","doi-asserted-by":"crossref","DOI":"10.1111\/pim.12345","article-title":"Immune response to recombinant Leishmania infantum lipophosphoglycan 3 plus CpG oligodeoxynucleotides in BALB\/c mice","volume":"39","author":"Pirdel","year":"2017","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.biopha.2020.110097_bib0100","doi-asserted-by":"crossref","DOI":"10.1177\/1177932218763363","article-title":"Lipophosphoglycan 3 from Leishmania infantum chagasi binds heparin with micromolar affinity","volume":"12","author":"Martins","year":"2018","journal-title":"Bioinform. Biol. Insights"},{"key":"10.1016\/j.biopha.2020.110097_bib0105","first-page":"424","article-title":"Biochemical alterations of liver enzymes and microelements during Leishmania major infection in BALB\/c mice after treatment with paromomycin","volume":"3","author":"Davachi","year":"2009","journal-title":"Pharmacologyonline"},{"key":"10.1016\/j.biopha.2020.110097_bib0110","article-title":"Dynatech Europe., The enzyme linked immunosorbent assay (ELISA)\u202f: a guide with abstracts of microplate applications","author":"Voller","year":"1979","journal-title":"Ed. S Voice List. Authors Is Important Elem. A Sci. Publ."},{"key":"10.1016\/j.biopha.2020.110097_bib0115","doi-asserted-by":"crossref","unstructured":"S. Dieterich, U. Bieligk, K. Beulich, G. Hasenfuss, J. Prestle, Gene expression of antioxidative enzymes in the human heart: increased expression of catalase in the end-stage failing heart, Circulation. 101 (n.d) 33\u201339. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10618301 (accessed May 2, 2019).","DOI":"10.1161\/01.CIR.101.1.33"},{"key":"10.1016\/j.biopha.2020.110097_bib0120","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.biopha.2020.110097_bib0125","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione S-transferases. The first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2020.110097_bib0130","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(78)52032-6","article-title":"Microsomal lipid peroxidation","volume":"52","author":"Buege","year":"1978","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.biopha.2020.110097_bib0135","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/0076-6879(90)86141-H","article-title":"Determination of carbonyl content in oxidatively modified proteins","volume":"186","author":"Levine","year":"1990","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.biopha.2020.110097_bib0140","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.biopha.2020.110097_bib0145","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jchromb.2006.07.054","article-title":"Analysis of nitrite and nitrate in biological fluids by assays based on the Griess reaction: appraisal of the Griess reaction in the l-arginine\/nitric oxide area of research","volume":"851","author":"Tsikas","year":"2007","journal-title":"J. Chromatogr. B."},{"key":"10.1016\/j.biopha.2020.110097_bib0150","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.ecoenv.2017.11.024","article-title":"Exposure to deltamethrin induces oxidative stress and decreases of energy reserve in tissues of the neotropical fruit-eating bat Artibeus lituratus","volume":"148","author":"Oliveira","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.biopha.2020.110097_bib0155","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.carpath.2012.12.001","article-title":"Trypanosoma cruzi infection induces morphological reorganization of the myocardium parenchyma and stroma, and modifies the mechanical properties of atrial and ventricular cardiomyocytes in rats","volume":"22","author":"Novaes","year":"2013","journal-title":"Cardiovasc. Pathol."},{"key":"10.1016\/j.biopha.2020.110097_bib0160","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s12011-017-1147-3","article-title":"Effects of arsenic compounds on microminerals content and antioxidant enzyme activities in rat liver","volume":"183","author":"Souza","year":"2018","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.biopha.2020.110097_bib0165","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1590\/S0001-37652003000400006","article-title":"Stereological tools in biomedical research","volume":"75","author":"Mandarim-De-Lacerda","year":"2003","journal-title":"An. Acad. Bras. Ci\u00eanc."},{"key":"10.1016\/j.biopha.2020.110097_bib0170","doi-asserted-by":"crossref","first-page":"7674","DOI":"10.1016\/j.vaccine.2007.08.009","article-title":"Immunogenicity of a killed Leishmania vaccine with saponin adjuvant in dogs","volume":"25","author":"Giunchetti","year":"2007","journal-title":"Vaccine."},{"key":"10.1016\/j.biopha.2020.110097_bib0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0049780","article-title":"Performance of LBSap vaccine after intradermal challenge withL. infantum and saliva of Lu. longipalpis: immunogenicity and parasitological evaluation","volume":"7","author":"Roatt","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2020.110097_bib0180","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.cyto.2016.02.002","article-title":"Oral treatment with zinc sulfate increases the expression of Th1 cytokines mRNA in BALB\/c mice infected with Leishmania major","volume":"81","author":"Afshari","year":"2016","journal-title":"Cytokine."},{"key":"10.1016\/j.biopha.2020.110097_bib0185","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.4049\/jimmunol.147.9.3149","article-title":"IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis","volume":"147","author":"Scott","year":"1991","journal-title":"J. Immunol."},{"key":"10.1016\/j.biopha.2020.110097_bib0190","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1080\/08820139.2016.1208217","article-title":"T Helper 1 (Th1), Th2, and Th17 responses to Leishmania major lipophosphoglycan 3","volume":"45","author":"Miahipour","year":"2016","journal-title":"Immunol. Invest."},{"key":"10.1016\/j.biopha.2020.110097_bib0195","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/sj.icb7100011","article-title":"Balancing immunity and pathology in visceral leishmaniasis","volume":"85","author":"Stanley","year":"2007","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.biopha.2020.110097_bib0200","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/nrmicro2608","article-title":"Leishmaniasis: complexity at the host-pathogen interface","volume":"9","author":"Kaye","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.biopha.2020.110097_bib0205","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1297-9716-42-39","article-title":"Mechanisms of resistance and susceptibility to experimental visceral leishmaniosis: BALB\/c mouse versus syrian hamster model","volume":"42","author":"Nieto","year":"2011","journal-title":"Vet. Res."},{"key":"10.1016\/j.biopha.2020.110097_bib0210","doi-asserted-by":"crossref","first-page":"606","DOI":"10.4269\/ajtmh.2012.11-0386","article-title":"Development of Leishmania (Leishmania) infantum chagasi in Its natural sandfly vector Lutzomyia longipalpis","volume":"86","author":"Freitas","year":"2012","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.biopha.2020.110097_bib0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2013.00035","article-title":"Functional complexity of the Leishmania granuloma and the potential of in silico modeling","volume":"4","author":"Moore","year":"2013","journal-title":"Front. Immunol."},{"key":"10.1016\/j.biopha.2020.110097_bib0220","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/ki.1996.12","article-title":"Lipid peroxidation contributes to hydrogen peroxide induced cytotoxicity in renal epithelial cells","volume":"49","author":"Sheridan","year":"1996","journal-title":"Kidney Int."},{"key":"10.1016\/j.biopha.2020.110097_bib0225","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4103\/0973-7847.70902","article-title":"Free radicals, antioxidants and functional foods: impact on human health","volume":"4","author":"Lobo","year":"2010","journal-title":"Pharmacogn. Rev."},{"key":"10.1016\/j.biopha.2020.110097_bib0230","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s11259-008-9121-3","article-title":"Superoxide dismutase and Glutathione peroxidase in the blood of dogs with leishmaniasis","volume":"32","author":"Britti","year":"2008","journal-title":"Vet. Res. Commun."},{"key":"10.1016\/j.biopha.2020.110097_bib0235","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1385\/BTER:94:2:141","article-title":"Serum and hair levels of zinc and other elements in dogs with visceral leishmaniasis","volume":"94","author":"Pasa","year":"2003","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.biopha.2020.110097_bib0240","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1590\/S0036-46652010000500006","article-title":"Hyponatremia in visceral leishmaniasis","volume":"52","author":"Lima Verde","year":"2010","journal-title":"Rev. Inst. Med. Trop. Sao Paulo"},{"key":"10.1016\/j.biopha.2020.110097_bib0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003330","article-title":"IL-1\u03b2 production through the NLRP3 Inflammasome by hepatic macrophages links hepatitis C virus infection with liver inflammation and disease","volume":"9","author":"Negash","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.biopha.2020.110097_bib0250","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1002\/eji.201546015","article-title":"The Nlrp3 inflammasome, IL-1\u03b2, and neutrophil recruitment are required for susceptibility to a nonhealing strain of Leishmania major in C57BL\/6 mice","volume":"46","author":"Charmoy","year":"2016","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.biopha.2020.110097_bib0255","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1471-2334-4-50","article-title":"Zinc\/copper imbalance reflects immune dysfunction in human leishmaniasis: an ex vivo and in vitro study","volume":"4","author":"Van Weyenbergh","year":"2004","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.biopha.2020.110097_bib0260","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.tox.2007.11.021","article-title":"The current state of serum biomarkers of hepatotoxicity","volume":"245","author":"Ozer","year":"2008","journal-title":"Toxicology."},{"key":"10.1016\/j.biopha.2020.110097_bib0265","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1177\/0192623311425059","article-title":"Effect of bark extract of Bathysa cuspidata on hepatic oxidative damage and blood glucose kinetics in rats exposed to paraquat","volume":"40","author":"Novaes","year":"2012","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.biopha.2020.110097_bib0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2018.08.054","article-title":"Arsenic aggravates oxidative stress causing hepatic alterations and inflammation in diabetic rats","volume":"209","author":"Souza","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.biopha.2020.110097_bib0275","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1177\/0192623312447550","article-title":"Metabolic adaptive ALT isoenzyme response in livers of C57BL\/6 mice treated with dexamethasone","volume":"40","author":"Reagan","year":"2012","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.biopha.2020.110097_bib0280","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/eji.200939863","article-title":"Leishmania donovani induced expression of signal regulatory protein \u03b1 on Kupffer cells enhances hepatic invariant NKT-cell activation","volume":"40","author":"Beattie","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.biopha.2020.110097_bib0285","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1046\/j.1365-2613.2001.00199.x","article-title":"Tissue granuloma structure-function in experimental visceral leishmaniasis","volume":"82","author":"Murray","year":"2001","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.biopha.2020.110097_bib0290","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1016\/S0002-9440(10)63262-2","article-title":"Distinct roles for lymphotoxin-\u03b1 and tumor necrosis factor in the control of Leishmania donovani infection","volume":"165","author":"Engwerda","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.biopha.2020.110097_bib0295","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s00436-001-0577-0","article-title":"Histopathologic analysis of hamster hepatocytes submitted to experimental infection with Leishmania donovani","volume":"88","author":"Vianna","year":"2002","journal-title":"Parasitol. Res."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220302894?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220302894?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T02:50:02Z","timestamp":1762311002000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332220302894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":59,"alternative-id":["S0753332220302894"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110097","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lipophosphoglycan-3 recombinant protein vaccine controls hepatic parasitism and prevents tissue damage in mice infected by Leishmania infantum chagasi","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110097","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"110097"}}