{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:15:09Z","timestamp":1791400509776,"version":"4.3.3"},"reference-count":125,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T00:00:00Z","timestamp":1583971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.biopha.2020.110103","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T01:07:19Z","timestamp":1584580039000},"page":"110103","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":73,"special_numbering":"C","title":["Angiogenesis in obesity"],"prefix":"10.1016","volume":"126","author":[{"given":"Priya","family":"Nijhawans","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapan","family":"Behl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaveta","family":"Bhardwaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2020.110103_bib0005","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1001\/jama.2014.732","article-title":"Prevalence of childhood and adult obesity in the United States","volume":"311","author":"Ogden","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.biopha.2020.110103_bib0010","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.ecl.2008.07.002","article-title":"The adipocyte as an endocrine cell","volume":"37","author":"Halberg","year":"2008","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"10.1016\/j.biopha.2020.110103_bib0015","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3109\/10739689709146786","article-title":"A review of the microcirculation of adipose tissue: anatomic, metabolic, and angiogenic perspectives","volume":"4","author":"Crandall","year":"1997","journal-title":"Microcirculation"},{"issue":"2001","key":"10.1016\/j.biopha.2020.110103_bib0020","doi-asserted-by":"crossref","first-page":"6390","DOI":"10.1073\/pnas.101564798","article-title":"Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF","volume":"98","author":"Cao","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biopha.2020.110103_bib0025","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1126\/science.281.5383.1683","article-title":"Biological action of leptin as an angiogenic factor","volume":"281","author":"Sierra-Honigmann","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.biopha.2020.110103_bib0030","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1074\/jbc.M310389200","article-title":"Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells","volume":"279","author":"Ouchi","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2020.110103_bib0035","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.2337\/db06-1749","article-title":"Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels","volume":"56","author":"Nishimura","year":"2007","journal-title":"Diabetes"},{"issue":"2 Pt 1","key":"10.1016\/j.biopha.2020.110103_bib0040","first-page":"1","article-title":"Angiogenesis in adipose tissue","volume":"63","author":"Bouloumie","year":"2002","journal-title":"Ann. Endocrinol."},{"key":"10.1016\/j.biopha.2020.110103_bib0045","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/249565","article-title":"Systemic ghrelin administration alters serum biomarkers of angiogenesis in diet-induced obese mice","author":"Khazaei","year":"2013","journal-title":"Int. J. Pept."},{"key":"10.1016\/j.biopha.2020.110103_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.med.57.121304.131306","article-title":"Angiogenesis","volume":"57","author":"Folkman","year":"2006","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.biopha.2020.110103_bib0055","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nm0603-653","article-title":"Angiogenesis in health and disease","volume":"9","author":"Carmeliet","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.biopha.2020.110103_bib0060","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1146\/annurev.cb.11.110195.000445","article-title":"Vasculogenesis","volume":"11","author":"Risau","year":"1995","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.biopha.2020.110103_bib0065","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1182\/blood-2002-01-0185","article-title":"Kalistatin is a new inhibitor of angiogenesis and tumor growth","volume":"100","author":"SMiao","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.biopha.2020.110103_bib0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1582-4934.2002.tb00307.x","article-title":"Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumor growth","volume":"6","author":"Lawler","year":"2002","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.biopha.2020.110103_bib0075","doi-asserted-by":"crossref","first-page":"C1358","DOI":"10.1152\/ajpcell.2001.280.6.C1358","article-title":"Role of vascular endothelial growth factor in regulation of physiological angiogenesis","volume":"280","author":"Ferrara","year":"2001","journal-title":"Am. J. Physiol., Cell Physiol."},{"key":"10.1016\/j.biopha.2020.110103_bib0080","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1053\/sonc.2002.37263","article-title":"Role of angiogenesis in tumor growth and metastasis","volume":"29","author":"Folkman","year":"2002","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.biopha.2020.110103_bib0085","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.79.18.5597","article-title":"Differentiation-dependent stimulation of neovascularization and endothelial cell chemotaxis by 3T3 adipocytes","volume":"79","author":"Castellot","year":"1982","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biopha.2020.110103_bib0090","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0006-291X(88)81229-4","article-title":"Angiogenic activity of adipose tissue","volume":"153","author":"Silverman","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2020.110103_bib0095","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1172\/JCI32239","article-title":"Angiogenesis modulates adipogenesis and obesity","volume":"117","author":"Cao","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biopha.2020.110103_bib0100","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1038\/sj.ijo.0802987","article-title":"Angiogenic factors are elevated in overweight and obese individuals","volume":"29","author":"Silha","year":"2005","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.biopha.2020.110103_bib0105","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.2337\/db15-0004","article-title":"Biologic responses to weight loss and weight regain: report from an American Diabetes Association Research Symposium","volume":"64","author":"Leibel","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.biopha.2020.110103_bib0110","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S2213-8587(15)00009-1","article-title":"Treating obesity seriously: When recommendations for lifestyle change confront biological adaptations","volume":"3","author":"Ochner","year":"2015","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.biopha.2020.110103_bib0115","first-page":"29","article-title":"Study of phendimetrazine bitartrate as an appetite suppressant in relation to dosage, weight loss and side effects","volume":"87","author":"Le Riche","year":"1962","journal-title":"Can. Med. Assoc. J."},{"key":"10.1016\/j.biopha.2020.110103_bib0120","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1001\/jama.2016.7602","article-title":"Association of pharmacological treatments for obesity with weight loss and adverse events: a systematic review and meta-analysis","volume":"315","author":"Khera","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.biopha.2020.110103_bib0125","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0016-6480(02)00072-2","article-title":"Immunocytochemical detection of leptin innonmammalian vertebrate stomach","volume":"128","author":"Muruzaabal","year":"2002","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.biopha.2020.110103_bib0130","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/S0140-6736(11)60205-5","article-title":"Effects of low-dose, controlled-release, Phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial","volume":"377","author":"Gadde","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.biopha.2020.110103_bib0135","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S2213-8587(15)00419-2","article-title":"Sweetening of the global diet, particularly beverages: patterns, trends, and policy responses","volume":"4","author":"Popkin","year":"2006","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.biopha.2020.110103_bib0140","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1210\/jc.2014-3415","article-title":"Pharmacological management of obesity: an endocrine society clinical practice guideline","volume":"100","author":"Apovian","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2020.110103_bib0145","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nature05162","article-title":"Identification of nesfatin-1 as a satiety molecule in the hypothalamus","volume":"443","author":"Oh-I","year":"2006","journal-title":"Nature"},{"issue":"Suppl. 3","key":"10.1016\/j.biopha.2020.110103_bib0150","first-page":"201","article-title":"American Association of Clinical Endocrinologists and American College of Endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity","volume":"22","author":"Garvey","year":"2016","journal-title":"Endocr. Pract."},{"key":"10.1016\/j.biopha.2020.110103_bib0155","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.tem.2015.10.003","article-title":"Emerging technologies and their applications in lipid compartment measurement","volume":"26","author":"Heymsfield","year":"2015","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2020.110103_bib0160","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.atherosclerosis.2013.12.023","article-title":"Visceral adipose tissue as a source of inflammation and promoter of atherosclerosis","volume":"233","author":"Alexopoulos","year":"2014","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.biopha.2020.110103_bib0165","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.cmet.2010.03.005","article-title":"Transcriptional control of brown fat development","volume":"11","author":"Kajimura","year":"2010","journal-title":"Cell Metab."},{"issue":"6","key":"10.1016\/j.biopha.2020.110103_bib0170","doi-asserted-by":"crossref","first-page":"E827","DOI":"10.1152\/ajpendo.2001.280.6.E827","article-title":"The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation","volume":"2280","author":"Fr\u00fchbeck","year":"2001","journal-title":"Am. J. Physiol.\u2014Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2020.110103_bib0175","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1172\/JCI45887","article-title":"Adipose tissue remodeling and obesity","volume":"121","author":"Sun","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biopha.2020.110103_bib0180","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1172\/JCI29881","article-title":"Obesity induces a phenotypic switch in adipose tissue macrophage polarization","volume":"117","author":"Lumeng","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biopha.2020.110103_bib0185","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.ceb.2010.08.010","article-title":"Dynamics of endothelial cell behavior in sprouting angiogenesis","volume":"22","author":"Eilken","year":"2010","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.biopha.2020.110103_bib0190","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10144","article-title":"Molecular mechanisms and clinical applications of angiogenesis","volume":"473","author":"Carmeliet","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2020.110103_bib0195","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev-cellbio-092910-154002","article-title":"Developmental and pathological angiogenesis","volume":"27","author":"Chung","year":"2011","journal-title":"Annu. Rev.Cell Dev. Biol."},{"key":"10.1016\/j.biopha.2020.110103_bib0200","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.cell.2011.08.039","article-title":"Basic and therapeutic aspects ofangiogenesis","volume":"146","author":"Potente","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2020.110103_bib0205","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1161\/ATVBAHA.108.170316","article-title":"Adipose macrophage infiltration is associated with insulin resistance Endothelial Dysfunction and vascular endothelial dysfunction in obese subjects","volume":"28","author":"Apovian","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"6801","key":"10.1016\/j.biopha.2020.110103_bib0210","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/35025220","article-title":"Angiogenesis in cancer and other diseases","volume":"407","author":"Carmeliet","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2020.110103_bib0215","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1210\/me.2012-1283","article-title":"Mini review. The year in obesity and cancer","volume":"26","author":"Hursting","year":"2012","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.biopha.2020.110103_bib0220","series-title":"Tumor Angiogenesis Regulators","article-title":"Obesity, diabetes and metabolic syndrome impact on tumor angiogenesis","author":"Incio","year":"2013"},{"key":"10.1016\/j.biopha.2020.110103_bib0225","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.bbadis.2013.06.003","article-title":"Adipose tissue angiogenesis: impact on obesity and type-2diabetes","volume":"1842","author":"Corvera","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biopha.2020.110103_bib0230","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1160\/TH13-01-0073","article-title":"Adipose tissue angiogenesis in obesity","volume":"110","author":"Lemoine","year":"2014","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.biopha.2020.110103_bib0235","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/sj.ijo.0802407","article-title":"Effect of hypoxia on the expression of proangiogenic factors in differentiated 3T3-F442A adipocytes","volume":"27","author":"Lolmede","year":"2003","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"10.1016\/j.biopha.2020.110103_bib0240","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.1128\/MCB.16.9.4604","article-title":"Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factosr 1","volume":"16","author":"Forsythe","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.biopha.2020.110103_bib0245","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0092-8674(94)90187-2","article-title":"The implications of angiogenesis for biology and therapy for cancer metastasis","volume":"79","author":"Fidler","year":"1994","journal-title":"Cell."},{"key":"10.1016\/j.biopha.2020.110103_bib0250","first-page":"2377","article-title":"Tumor associated angiogenesis in prostate cancer","volume":"13","author":"Fregene","year":"1993","journal-title":"Anticancer Res."},{"key":"10.1016\/j.biopha.2020.110103_bib0255","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0304-3835(02)00681-X","article-title":"The significance of circulating vascular endothelial growth factor (VEGF) protein in gastric cancer","volume":"19","author":"Ohta","year":"2003","journal-title":"Caner let."},{"key":"10.1016\/j.biopha.2020.110103_bib0260","first-page":"1361","article-title":"Expression of VEGF-D and its receptor, as a prognostic factor in endometrial carcinoma","volume":"9","author":"Yokoyama","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.biopha.2020.110103_bib0265","first-page":"2749","article-title":"Placental growth factor is a survival factor in tumor progression and macrophages","volume":"62","author":"Adini","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.biopha.2020.110103_bib0270","doi-asserted-by":"crossref","first-page":"11244","DOI":"10.1158\/0008-5472.CAN-07-0969","article-title":"Delta like 4 notch ligands regulate tumor angiogenesis improve tumor vascular function and tumor growth in vivo","volume":"67","author":"Li","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.biopha.2020.110103_bib0275","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/nature05313","article-title":"Inhibition of DLL4 signaling inhibit tumor growth by deregulating angiogenesis","volume":"444","author":"Ridguay","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2020.110103_bib0280","first-page":"3527","article-title":"Endothelial cells in physiology and in the pathophysiology of vascular disorders","volume":"91","author":"Cines","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.biopha.2020.110103_bib0285","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/sj.ijo.0803744","article-title":"Obesity in C57BL\/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration","volume":"32","author":"Rausch","year":"2008","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.biopha.2020.110103_bib0290","doi-asserted-by":"crossref","first-page":"E1118","DOI":"10.1152\/ajpendo.00435.2007","article-title":"Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob\/ob and dietary obese mice","volume":"29","author":"Ye","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2020.110103_bib0295","doi-asserted-by":"crossref","first-page":"901","DOI":"10.2337\/db06-0911","article-title":"Adiposetissuehypoxiainobesity and its impact on adipocytokines dysregulation","volume":"56","author":"Hosogai","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.biopha.2020.110103_bib0300","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/sj.ijo.0802407","article-title":"Effects of hypoxia on the expression of proangiogenic factors in differentiated3T3-F442A adipocytes","volume":"27","author":"Lolmede","year":"2003","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"10.1016\/j.biopha.2020.110103_bib0305","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1161\/CIRCULATIONAHA.111.027813","article-title":"Increased adipose tissue oxygen tension in obese compared with lean men is accompanied by insulin resistance, impaired adipose tissue capillarization, and inflammation","volume":"124","author":"Goossens","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2020.110103_bib0310","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.00017.2012","article-title":"Hypoxia and adipose tissue function and dysfunction in obesity","volume":"93","author":"Trayhurn","year":"2013","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.biopha.2020.110103_bib0315","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.1128\/MCB.00192-09","article-title":"Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue","volume":"29","author":"Halberg","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.biopha.2020.110103_bib0320","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.2337\/db11-0174","article-title":"Disruption of hypoxia-inducible factor 1 in adipocytes improves insulin sensitivity and decreases adiposity in high-fat diet-fed mice","volume":"60","author":"Jiang","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.biopha.2020.110103_bib0325","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.cmet.2011.08.006","article-title":"The differential role ofHif1beta and the hypoxic response in adipose function, fibrosis, and in-Flammarion","volume":"14","author":"Lee","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.biopha.2020.110103_bib0330","doi-asserted-by":"crossref","first-page":"32869","DOI":"10.1074\/jbc.M110.135509","article-title":"Adipose tissue-specific inhibition of hypoxia-inducible factor 1{alpha} induces obesity and glucose intolerance by impeding energy expenditure in mice","volume":"285","author":"Zhang","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2020.110103_bib0335","first-page":"23","article-title":"Hazards of obesity\u2014the Framingham experience","volume":"723","author":"Higgins","year":"1998","journal-title":"Acta Med. Scand. Suppl."},{"key":"10.1016\/j.biopha.2020.110103_bib0340","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cccn.2005.04.020","article-title":"Mechanisms of endothelial dysfunction in obesity","volume":"360","author":"Avogaro","year":"2005","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.biopha.2020.110103_bib0345","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1161\/01.RES.86.9.974","article-title":"Hypoxia-induced endothelial apoptosis through nuclear factor-kappaB (NF-kappaB)-mediated bcl-2 suppression: in vivo evidence of the importance of NF-kappaB in endothelial cell regulation","volume":"86","author":"Matsushita","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.biopha.2020.110103_bib0350","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.tips.2009.05.003","article-title":"BAT: a new target for human obesity?","volume":"30","author":"Fr\u00fchbeck","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.biopha.2020.110103_bib0355","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1517\/14656560802618811","article-title":"Adipokines in the treatment of diabetes mellitus and obesity","volume":"10","author":"Catal\u00e1n","year":"2009","journal-title":"Expert Opin. Pharmacother."},{"key":"10.1016\/j.biopha.2020.110103_bib0360","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.drudis.2012.04.007","article-title":"Physiological, pathological and potential therapeutic roles of adipokines","volume":"17","author":"Falcao-Pires","year":"2012","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.biopha.2020.110103_bib0365","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.2174\/138161207781039599","article-title":"Visceral and sub-cutaneous adiposity: are both potential therapeutic targets for tacklingthe metabolic syndrome?","volume":"13","author":"Rodr\u00edguez","year":"2007","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.biopha.2020.110103_bib0370","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1161\/CIRCULATIONAHA.106.675355","article-title":"Abdominal visceral and subcutaneous adipose tissue compartments: associa-tion with metabolic risk factors in the Framingham Heart Study","volume":"116","author":"Fox","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2020.110103_bib0375","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1038\/oby.2010.86","article-title":"Body fat distribution and inflammation among obese older adults with and without metabolic syndrome","volume":"18","author":"Koster","year":"2010","journal-title":"Obesity"},{"key":"10.1016\/j.biopha.2020.110103_sbref0380a","first-page":"121","article-title":"The associations between obesity, adipose tissue distribution and disease","volume":"723","author":"Bjorntorp","year":"1988","journal-title":"Acta Med. Scand. Suppl."},{"key":"10.1016\/j.biopha.2020.110103_sbref0380b","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.cell.2007.10.004","article-title":"Developmental origin of fat: tracking obesity toits source","volume":"131","author":"Gesta","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2020.110103_bib0385","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/nyas.12009","article-title":"Human adipose dynamics and metabolic health","volume":"1281","author":"Feng","year":"2013","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.biopha.2020.110103_bib0390","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1152\/physrev.00015.2003","article-title":"Brown adipose tissue: function and physiological significance","volume":"84","author":"Cannon","year":"2004","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.biopha.2020.110103_bib0395","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1136\/bmj.315.7117.1219","article-title":"ABC of palliative care. Anorexia, cachexia, and nutrition","volume":"315","author":"Bruera","year":"1997","journal-title":"BMJ"},{"key":"10.1016\/j.biopha.2020.110103_bib0400","doi-asserted-by":"crossref","first-page":"4372","DOI":"10.1158\/0008-5472.CAN-11-3536","article-title":"Activation of thermogenesis in brown adipose tissue and dysregulated lipid metabolism associated with cancer cachexia in mice","volume":"72","author":"Tsoli","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.biopha.2020.110103_bib0405","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1101\/gad.211649.112","article-title":"Adaptive thermogenesis in adipocytes: is beige the new brown?","volume":"27","author":"Wu","year":"2013","journal-title":"Genes Dev."},{"key":"10.1016\/j.biopha.2020.110103_bib0410","first-page":"338","article-title":"Adipose tissue expandability, lipotoxicity and the metabolic syndrome \u2013 an allostatic perspective","volume":"1801","author":"Virtue","year":"2010","journal-title":"Biochem. Biophys."},{"key":"10.1016\/j.biopha.2020.110103_bib0415","doi-asserted-by":"crossref","first-page":"3958","DOI":"10.1200\/JCO.2009.27.0793","article-title":"Fatty acid synthase polymorphisms, tumor expression, body mass index, prostate cancer risk, and survival","volume":"28","author":"Nguyen","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.biopha.2020.110103_bib0420","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.2337\/db09-1756","article-title":"Extracellular fatty acid synthase: a possible surrogate biomarker of insulin resistance","volume":"59","author":"Fernandez-Real","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.biopha.2020.110103_bib0425","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/ijo.2011.100","article-title":"Body mass index classification misses subjects with increased cardiometabolic risk factors related to elevated adiposity","volume":"36","author":"G \u0301omez Ambrosi","year":"2012","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.biopha.2020.110103_bib0430","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1152\/physrev.00033.2011","article-title":"Pathophysiology of human visceral obesity: an update","volume":"93","author":"Tchernof","year":"2013","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.biopha.2020.110103_bib0435","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S2213-8587(13)70062-7","article-title":"Metabolically healthy obesity: epidemiology, mechanisms, and clinical implications","volume":"1","author":"Stefan","year":"2013","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.biopha.2020.110103_bib0440","first-page":"35971","article-title":"Characterizing the profile of obese patients who are metabolically healthy","author":"Primeau","year":"2011","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.biopha.2020.110103_bib0445","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1001\/archinte.168.15.1617","article-title":"The obese without cardiometabolic risk factor clustering and the normal weight with cardio-metabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999-2004)","volume":"168","author":"Wildman","year":"2008","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.biopha.2020.110103_bib0450","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00125-013-3066-y","article-title":"Characterizing metabolically healthy obesity in weight-discordant monozygotic twins","volume":"57","author":"Naukkarinen","year":"2014","journal-title":"Diabetologia"},{"key":"10.1016\/j.biopha.2020.110103_bib0455","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/ejcn.2011.170","article-title":"The association between inflammatory biomarkers and metabolically healthy obesity depends of the definition used","volume":"66","author":"Marques-Vidal","year":"2012","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.biopha.2020.110103_bib0460","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.numecd.2013.12.002","article-title":"Current issues in the identification and treatment of metabolically healthy but obese individuals","volume":"24","author":"Plourde","year":"2014","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.biopha.2020.110103_bib0465","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/ejcn.2010.114","article-title":"Metabolically healthy obesity: different prevalence\u2019s using different criteria","volume":"64","author":"Velho","year":"2010","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.biopha.2020.110103_bib0470","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1096\/fj.00-0249com","article-title":"sLeptin-induced lipolysis opposes the tonic inhibition of endogenous adenosine in white adipocytes","volume":"15","author":"Fr \u0308uhbeck","year":"2001","journal-title":"FASEB J."},{"key":"10.1016\/j.biopha.2020.110103_bib0475","doi-asserted-by":"crossref","first-page":"E71","DOI":"10.1002\/oby.20061","article-title":"Uric acid best predicts metabolically unhealthy obesity with increased cardiovascular risk in youth and adults","volume":"21","author":"Mangge","year":"2013","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.biopha.2020.110103_bib0480","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.metabol.2009.06.020","article-title":"Metabolically healthy but obese individuals: relationship with hepatic enzymes","volume":"59","author":"Messier","year":"2010","journal-title":"Metabolism"},{"key":"10.1016\/j.biopha.2020.110103_bib0485","doi-asserted-by":"crossref","first-page":"762","DOI":"10.2337\/diacare.22.5.762","article-title":"Impact of new diagnostic criteria for diabetes on different populations","volume":"22","author":"Shaw","year":"1999","journal-title":"Diabetes Care"},{"key":"10.1016\/j.biopha.2020.110103_bib0490","doi-asserted-by":"crossref","first-page":"4761","DOI":"10.1016\/j.ijcard.2013.07.230","article-title":"Combined effect of obesity and cardio-metabolic ab-normality on the risk of cardiovascular disease: a meta-analysis of prospective cohort studies","volume":"168","author":"Fan","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.biopha.2020.110103_bib0495","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.2337\/dc12-1654","article-title":"Metabolically healthy obesity and risk of mortality: does the definition of metabolic health matter?","volume":"36","author":"Hinnouho","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.biopha.2020.110103_bib0500","doi-asserted-by":"crossref","first-page":"758","DOI":"10.7326\/0003-4819-159-11-201312030-00008","article-title":"Are metabolically healthy overweight and obesity benign conditions? A systematic review and meta-analysis","volume":"159","author":"Kramer","year":"2013","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.biopha.2020.110103_bib0505","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00441-008-0685-6","article-title":"Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity","volume":"335","author":"Bakker","year":"2009","journal-title":"Cell Tissue Res."},{"issue":"2","key":"10.1016\/j.biopha.2020.110103_bib0510","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nrd3055","article-title":"Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic disorders","volume":"9","author":"Cao","year":"2010","journal-title":"Nat Rev Drug Discv."},{"issue":"1\u20132","key":"10.1016\/j.biopha.2020.110103_bib0515","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mce.2009.08.006","article-title":"Angiogenesis and development of tissue","volume":"318","author":"Christiaens","year":"2010","journal-title":"Mol. Cell. Endocrionol."},{"issue":"1","key":"10.1016\/j.biopha.2020.110103_bib0520","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S1262-3636(07)70084-8","article-title":"Adipose tissue and adipokines: for better or worse","volume":"30","author":"Guerro","year":"2014","journal-title":"Diabetes Metab."},{"issue":"12","key":"10.1016\/j.biopha.2020.110103_bib0525","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1161\/01.RES.0000132745.76882.70","article-title":"Angiogenesis inhibitor TNP470 prevent diet induce obesity and genetic obesity in mice","volume":"94","author":"Brakheliem","year":"2004","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.biopha.2020.110103_bib0530","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1677\/jme.1.02165","article-title":"Assessment of the anti-obesity effects of the TNP-470 analog, CKD-732","volume":"38","author":"Kim","year":"2007","journal-title":"J. Mol. Endocrinol."},{"issue":"16","key":"10.1016\/j.biopha.2020.110103_bib0535","doi-asserted-by":"crossref","first-page":"10730","DOI":"10.1073\/pnas.162349799","article-title":"Adipose tissue mass can be regulated through the vasculature","volume":"99","author":"Rupnick","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.biopha.2020.110103_bib0540","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0004974","article-title":"Blockade of VEGFR2 and not VEGFR1 can limit diet induced fat tissue expansion: role of local versus bone marrow derived endothelial cells","volume":"4","author":"Tam","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2020.110103_bib0545","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1056\/NEJMoa0804748","article-title":"Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates","volume":"360","author":"Sacks","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biopha.2020.110103_bib0550","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1056\/NEJMoa066254","article-title":"Effects of bariatric surgery on mortality in Swedish obese subjects","volume":"57","author":"Sjostrom","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biopha.2020.110103_bib0555","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.2337\/db11-1579","article-title":"Rapid and weight-independent improvement of glucose tolerance induced by a peptide designed to elicit apoptosis in adipose tissue endothelium","volume":"61","author":"Kim","year":"2012","journal-title":"Diabetes"},{"issue":"7","key":"10.1016\/j.biopha.2020.110103_bib0560","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1038\/oby.2012.66","article-title":"Randomized placebo-controlled clinical trial of lorcaserin for weight loss in type 2 diabetes mellitus: the BLOOM-DM study","volume":"20","author":"O\u2019Neil","year":"2012","journal-title":"Obesity"},{"issue":"7","key":"10.1016\/j.biopha.2020.110103_bib0565","doi-asserted-by":"crossref","DOI":"10.1007\/s11883-016-0589-y","article-title":"Pharmacologic approaches to weight management: recent gains and shortfalls in combating obesity","volume":"18","author":"Saunders","year":"2017","journal-title":"Curr. Atheroscler. Rep."},{"issue":"2","key":"10.1016\/j.biopha.2020.110103_bib0570","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1517\/14728214.2013.807796","article-title":"Emerging gliptins for type 2 diabetes","volume":"18","author":"Cahn","year":"2013","journal-title":"Expert Opin. Emerg. Drugs"},{"issue":"2","key":"10.1016\/j.biopha.2020.110103_bib0575","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jconrel.2013.07.013","article-title":"A comparative study between nanoparticle-targeted therapeutics and biconjugate as obesity medication","volume":"171","author":"Hossen","year":"2013","journal-title":"J. Control. Release"},{"issue":"2","key":"10.1016\/j.biopha.2020.110103_bib0580","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jconrel.2012.09.002","article-title":"Vascular-targeted nanotherapy for obesity: unexpected passive targeting mechanism to obese fat for the enhancement of active drug delivery","volume":"163","author":"Hossen","year":"2012","journal-title":"J. Control. Release"},{"issue":"20","key":"10.1016\/j.biopha.2020.110103_bib0585","doi-asserted-by":"crossref","first-page":"5552","DOI":"10.1073\/pnas.1603840113","article-title":"Preventing diet-induced obesity in mice by adipose tissue transformation and angiogenesis using targeted nanoparticles","volume":"113","author":"Xue","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.biopha.2020.110103_bib0590","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nm1048","article-title":"Reversal of obesity by targeted ablation of adipose tissue","volume":"10","author":"Kolonin","year":"2004","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.biopha.2020.110103_bib0595","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/MIB.0000000000000592","article-title":"Flavaglines ameliorate experimental colitis and protect against intestinal epithelial cell apoptosis and mitochondrial dysfunction","volume":"22","author":"Han","year":"2016","journal-title":"Inflamm. Bowel Dis."},{"issue":"18","key":"10.1016\/j.biopha.2020.110103_bib0600","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.4155\/fmc.13.177","article-title":"Flavaglines: potent anticancer drugs that target prohibitins and the helicase eIF4A","volume":"5","author":"Basmadjian","year":"2013","journal-title":"Future Med. Chem."},{"issue":"2","key":"10.1016\/j.biopha.2020.110103_bib0605","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11051-015-2904-x","article-title":"Targeted delivery using peptide-functionalized gold nanoparticles to white adipose tissues of obese rats","volume":"17","author":"Thovhogi","year":"2015","journal-title":"J. Nanopart. Res."},{"issue":"10","key":"10.1016\/j.biopha.2020.110103_bib0610","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1007\/s11095-016-1958-5","article-title":"Nanoparticle-based medicines: a review of FDA-approved materials and clinical trials to date","volume":"33","author":"Bobo","year":"2016","journal-title":"Pharm. Res."},{"issue":"1","key":"10.1016\/j.biopha.2020.110103_bib0615","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/btm2.10003","article-title":"Nanoparticles in the clinic","volume":"1","author":"Anselmo","year":"2016","journal-title":"Bioeng. Transl. Med."},{"issue":"2","key":"10.1016\/j.biopha.2020.110103_bib0620","first-page":"13","article-title":"Nanomedicines for cancer therapy: an update of FDA approved and those under various stages of development","volume":"1","author":"Pillai","year":"2014","journal-title":"SOJ Pharm Sci."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S075333222030295X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S075333222030295X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T15:39:11Z","timestamp":1750865951000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S075333222030295X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":125,"alternative-id":["S075333222030295X"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110103","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Angiogenesis in obesity","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110103","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"110103"}}