{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T12:15:38Z","timestamp":1767183338184,"version":"build-2065373602"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T00:00:00Z","timestamp":1586131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Research Project of Health and Family Planning Commission of Heilong jiang Province","award":["2019-308"],"award-info":[{"award-number":["2019-308"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.biopha.2020.110154","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T18:24:26Z","timestamp":1587407066000},"page":"110154","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["LASP2 is downregulated in human liver cancer and contributes to hepatoblastoma cell malignant phenotypes through MAPK\/ERK pathway"],"prefix":"10.1016","volume":"127","author":[{"given":"Jing","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaojun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiusheng","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2020.110154_bib0005","doi-asserted-by":"crossref","first-page":"0","DOI":"10.1053\/trre.2000.16513","article-title":"Cancer and liver transplantation","volume":"14","author":"Molmenti","year":"2000","journal-title":"Transplant. Rev."},{"key":"10.1016\/j.biopha.2020.110154_bib0010","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"6","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.biopha.2020.110154_bib0015","doi-asserted-by":"crossref","first-page":"e2758","DOI":"10.1097\/MD.0000000000002758","article-title":"The epidemiological investigation on the risk factors of hepatocellular carcinoma: a case-control study in Southeast China","volume":"6","author":"Niu","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.biopha.2020.110154_bib0020","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1006\/jmbi.1998.1999","article-title":"Characterization of nebulette and nebulin and emerging concepts of their roles for vertebrate Z-discs","volume":"1","author":"Millevoi","year":"1998","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.biopha.2020.110154_bib0025","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1253\/circj.CJ-15-0854","article-title":"Roles of Nebulin family members in the heart","volume":"10","author":"Bang","year":"2015","journal-title":"Circ. J."},{"key":"10.1016\/j.biopha.2020.110154_bib0030","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.tcb.2010.09.005","article-title":"The Nebulin family: an actin support group","volume":"1","author":"Pappas","year":"2011","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.biopha.2020.110154_bib0035","first-page":"353","article-title":"Linker region of nebulin family members plays an important role in targeting these molecules to cellular structures","volume":"2","author":"Panaviene","year":"2007","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.biopha.2020.110154_bib0040","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12964-017-0179-9","article-title":"LASP2 suppresses colorectal cancer progression through JNK\/p38 MAPK pathway meditated epithelial-mesenchymal transition","volume":"1","author":"Wang","year":"2017","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.biopha.2020.110154_bib0045","doi-asserted-by":"crossref","first-page":"13651","DOI":"10.1002\/jcb.28638","article-title":"Upregulation of LASP2 inhibits pancreatic cancer cell migration and invasion through suppressing TGF-\u03b2-induced EMT","volume":"8","author":"Zhang","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.biopha.2020.110154_bib0050","doi-asserted-by":"crossref","first-page":"20401","DOI":"10.1074\/jbc.M310304200","article-title":"Zyxin interacts with the SH3 domains of the cytoskeletal proteins LIM-nebulette and Lasp-1","volume":"19","author":"Li","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2020.110154_bib0055","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.bbrc.2003.11.085","article-title":"A novel LIM and SH3 protein (lasp-2) highly expressing in chicken brain","volume":"1","author":"Terasaki","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2020.110154_bib0060","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1002\/mc.22700","article-title":"Lasp2 enhances tumor invasion via facilitating phosphorylation of FAK and predicts poor overall survival of non-small cell lung cancer patients","volume":"12","author":"Zhang","year":"2017","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.biopha.2020.110154_bib0065","first-page":"541","article-title":"LASP1 in tumor and tumor microenvironment","volume":"8","author":"Hu","year":"2017","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.biopha.2020.110154_bib0070","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.3892\/or.2012.2199","article-title":"Overexpression of LASP1 is associated with proliferation, migration and invasion in esophageal squamous cell carcinoma","volume":"3","author":"He","year":"2013","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.biopha.2020.110154_bib0075","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.yexcr.2005.12.016","article-title":"Silencing of LASP-1 influences zyxin localization, inhibits proliferation and reduces migration in breast cancer cells","volume":"312","author":"Grunewald","year":"2006","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.biopha.2020.110154_bib0080","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/sj.bjc.6603545","article-title":"Overexpression of LASP-1 mediates migration and proliferation of human ovarian cancer cells and influences zyxin localization","volume":"96","author":"Grunewald","year":"2007","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.biopha.2020.110154_bib0085","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1136\/gut.2009.202739","article-title":"Promotion of colorectal cancer growth and metastasis by the LIM and SH3 domain protein 1","volume":"59","author":"Zhao","year":"2010","journal-title":"Gut"},{"key":"10.1016\/j.biopha.2020.110154_bib0090","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/cm.970320305","article-title":"Nebulette: a 107\u2009kD nebulin-like protein in cardiac muscle","volume":"3","author":"Moncman","year":"1995","journal-title":"Cell Motil. Cytoskeleton"},{"key":"10.1016\/j.biopha.2020.110154_bib0095","first-page":"3314","article-title":"circRNA\u2011CER mediates malignant progression of breast cancer through targeting the miR\u2011136\/MMP13 axis","volume":"4","author":"Qu","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.biopha.2020.110154_bib0100","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1242\/jeb.00220","article-title":"Mitogen-activated protein kinases: new signaling pathways functioning in cellular responses to environmental stress","volume":"206","author":"Cowan","year":"2003","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.biopha.2020.110154_bib0105","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s12957-015-0451-7","article-title":"pERK1\/2 silencing sensitizes pancreatic cancer bxpc-3 cell to gemcitabine-induced apoptosis via regulating bax and bcl-2 expression","volume":"13","author":"Wang","year":"2015","journal-title":"World J. Surg. Oncol."},{"key":"10.1016\/j.biopha.2020.110154_bib0110","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1002\/mnfr.200800269","article-title":"Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells through inhibition of ERK1\/2 and cyclin D1","volume":"53","author":"Corona","year":"2009","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.biopha.2020.110154_bib0115","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S1357-2725(98)00006-5","article-title":"Molecules in focus bax. The pro-apoptotic bcl-2 family member, bax","volume":"30","author":"Ackermann","year":"1998","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.biopha.2020.110154_bib0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/excr.1996.0243","article-title":"Common principles in cell adhesion","volume":"227","author":"Ruoslahti","year":"1996","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.biopha.2020.110154_bib0125","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1091\/mbc.e12-10-0723","article-title":"Investigating lasp-2 in cell adhesion: new binding partners and roles in motility","volume":"24","author":"Bliss","year":"2013","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.biopha.2020.110154_bib0130","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1083\/jcb.200308011","article-title":"Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility","volume":"165","author":"Subauste","year":"2004","journal-title":"J. Cell Biol."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220303462?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220303462?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:51:25Z","timestamp":1760097085000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332220303462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":26,"alternative-id":["S0753332220303462"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110154","relation":{},"ISSN":["0753-3322"],"issn-type":[{"type":"print","value":"0753-3322"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LASP2 is downregulated in human liver cancer and contributes to hepatoblastoma cell malignant phenotypes through MAPK\/ERK pathway","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110154","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"110154"}}