{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:13:44Z","timestamp":1790846024824,"version":"4.1.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T00:00:00Z","timestamp":1587340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Fondecyt","award":["1190341"],"award-info":[{"award-number":["1190341"]}]},{"name":"Fondecyt","award":["1190340"],"award-info":[{"award-number":["1190340"]}]},{"name":"Fondecyt","award":["3180452"],"award-info":[{"award-number":["3180452"]}]},{"name":"Fondecyt","award":["3190449"],"award-info":[{"award-number":["3190449"]}]},{"name":"ERANET-LAC"},{"name":"Posdoctoral PUCV"},{"name":"DIE-PUCV"},{"name":"DI- Regular-PUCV"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.biopha.2020.110178","type":"journal-article","created":{"date-parts":[[2020,5,3]],"date-time":"2020-05-03T16:05:16Z","timestamp":1588521916000},"page":"110178","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Microalgae extracts: Potential anti-Trypanosoma cruzi agents?"],"prefix":"10.1016","volume":"127","author":[{"given":"Rhonda","family":"Veas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura","family":"Rojas-Pirela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Olea-Azar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Moncada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Ulloa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Rojas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Kemmerling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2020.110178_bib0005","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.4269\/ajtmh.16-0761","article-title":"Experimental and clinical treatment of chagas disease: a review","volume":"97","author":"Sales Junior","year":"2017","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.biopha.2020.110178_bib0010","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/j.phymed.2014.06.005","article-title":"Natural sesquiterpene lactones induce programmed cell death in Trypanosoma cruzi: A new therapeutic target?","volume":"21","author":"Jimenez","year":"2014","journal-title":"Phytomedicine"},{"key":"10.1016\/j.biopha.2020.110178_bib0015","doi-asserted-by":"crossref","first-page":"653","DOI":"10.4269\/ajtmh.17-0657","article-title":"Parasite-vector interaction of chagas disease: a mini-review","volume":"98","author":"de Oliveira","year":"2018","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.biopha.2020.110178_bib0020","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.idc.2012.03.002","article-title":"American trypanosomiasis (Chagas disease)","volume":"26","author":"Rassi","year":"2012","journal-title":"Infect. Dis. Clin. North Am."},{"issue":"10","key":"10.1016\/j.biopha.2020.110178_bib0025","doi-asserted-by":"crossref","first-page":"e0007694","DOI":"10.1371\/journal.pntd.0007694","article-title":"Congenital Chagas disease: updated recommendations for prevention, diagnosis, treatment, and follow-up of newborns and siblings, girls, women of childbearing age, and pregnant women","volume":"13","author":"Carlier","year":"2019","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.biopha.2020.110178_bib0030","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.ejmech.2018.06.040","article-title":"Current advances in drug discovery for Chagas disease","volume":"155","author":"Scarim","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.biopha.2020.110178_bib0035","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.2174\/138920112804724828","article-title":"The potential of microalgae for the production of bioactive molecules of pharmaceutical interest","volume":"13","author":"Mimouni","year":"2012","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.biopha.2020.110178_bib0040","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.fshw.2019.03.001","article-title":"Microalgae: a potential alternative to health supplementation for humans","volume":"8","author":"Koyande","year":"2019","journal-title":"Food Sci. Hum. Wellness"},{"key":"10.1016\/j.biopha.2020.110178_bib0045","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1263\/jbb.101.87","article-title":"Commercial applications of microalgae","volume":"101","author":"Spolaore","year":"2006","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.biopha.2020.110178_bib0050","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2018.00058","article-title":"Trends in microalgae incorporation into innovative food products with potential health benefits","volume":"5","author":"Caporgno","year":"2018","journal-title":"Front. Nutr."},{"key":"10.1016\/j.biopha.2020.110178_bib0055","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.sjbs.2017.11.003","article-title":"Microalgae metabolites: a rich source for food and medicine","volume":"26","author":"Sathasivam","year":"2019","journal-title":"Saudi J. Biol. Sci."},{"key":"10.1016\/j.biopha.2020.110178_bib0060","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1039\/b701534h","article-title":"Marine natural products","volume":"25","author":"Blunt","year":"2008","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.biopha.2020.110178_bib0065","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/835761","article-title":"Biologically active metabolites synthesized by microalgae","volume":"2015","author":"de Morais","year":"2015","journal-title":"Biomed Res. Int."},{"issue":"3","key":"10.1016\/j.biopha.2020.110178_bib0070","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/btpr.575","article-title":"Microalgae as sources of high added-value compounds\u2014a brief review of recent work","volume":"27","author":"Guedes","year":"2011","journal-title":"Biotechnol. Prog."},{"key":"10.1016\/j.biopha.2020.110178_bib0075","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1002\/ptr.3094","article-title":"Antiprotozoal, antimycobacterial and cytotoxic potential of twenty-three British and Irish red algae","volume":"24","author":"Allmendinger","year":"2010","journal-title":"Phytother. Res."},{"key":"10.1016\/j.biopha.2020.110178_bib0080","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.3390\/md8102673","article-title":"Immense essence of excellence: marine microbial bioactive compounds","volume":"8","author":"Bhatnagar","year":"2010","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.biopha.2020.110178_bib0085","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1021\/np800110e","article-title":"Viridamides a and B, lipodepsipeptides with antiprotozoal activity from the marine cyanobacterium Oscillatoria nigro-viridis","volume":"71","author":"Simmons","year":"2008","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.biopha.2020.110178_bib0090","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/dnares\/dsq004","article-title":"Genomic structure of an economically important cyanobacterium, Arthrospira (Spirulina) platensis NIES-39","volume":"17","author":"Fujisawa","year":"2010","journal-title":"DNA Res."},{"key":"10.1016\/j.biopha.2020.110178_bib0095","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.biortech.2016.01.103","article-title":"Cultivation of scenedesmus obliquus in liquid hydrolysate from flash hydrolysis for nutrient recycling","volume":"207","author":"Barbera","year":"2016","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.biopha.2020.110178_bib0100","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/tpj.12780","article-title":"Chlamydomonas as a model for biofuels and bio-products production","volume":"82","author":"Scranton","year":"2015","journal-title":"Plant J."},{"key":"10.1016\/j.biopha.2020.110178_bib0105","doi-asserted-by":"crossref","first-page":"41215","DOI":"10.1038\/srep41215","article-title":"The green microalga Tetraselmis suecica reduces oxidative stress and induces repairing mechanisms in human cells","volume":"7","author":"Sansone","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2020.110178_bib0110","article-title":"Long-duration effect of multi-factor stresses on the cellular biochemistry, oil-yielding performance and morphology of Nannochloropsis oculata","volume":"12","author":"Wei","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2020.110178_bib0115","first-page":"229","article-title":"Studies of marine planktonic diatoms","volume":"8","author":"GUILLARD","year":"1962","journal-title":"I. Cyclotella nana Hustedt, and Detonula confervacea (cleve) Gran. Can. J. Microbiol."},{"key":"10.1016\/j.biopha.2020.110178_bib0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0097269","article-title":"Flow cytometry pulse width data enables rapid and sensitive estimation of biomass dry weight in the microalgae chlamydomonas reinhardtii and chlorella vulgaris","volume":"9","author":"Chioccioli","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2020.110178_bib0125","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1128\/br.35.2.171-205.1971","article-title":"Purification and properties of unicellular blue-green algae (order Chroococcales)","volume":"35","author":"Stanier","year":"1971","journal-title":"Bacteriol. Rev."},{"key":"10.1016\/j.biopha.2020.110178_bib0130","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.biortech.2005.09.030","article-title":"Production of biomass and nutraceutical compounds by Spirulina platensis under different temperature and nitrogen regimes","volume":"98","author":"Colla","year":"2007","journal-title":"Bioresour. Technol."},{"issue":"8","key":"10.1016\/j.biopha.2020.110178_bib0135","doi-asserted-by":"crossref","DOI":"10.3390\/md17080453","article-title":"Identification of antimicrobial peptides from the microalgae Tetraselmis suecica (Kylin) butcher and bactericidal activity improvement","volume":"17","author":"Guzm\u00e1n","year":"2019","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.biopha.2020.110178_bib0140","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/j.1550-7408.1982.tb01338.x","article-title":"Growth of isolated amastigotes of Trypanosoma cruzi in cell-free medium","volume":"29","author":"Villalta","year":"1982","journal-title":"J. Protozool."},{"key":"10.1016\/j.biopha.2020.110178_bib0145","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.actatropica.2014.12.006","article-title":"Trypanosoma cruzi infectivity assessment in \u201cin vitro\u201d culture systems by automated cell counting","volume":"143","author":"Liempi","year":"2015","journal-title":"Acta Trop."},{"key":"10.1016\/j.biopha.2020.110178_bib0150","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.exppara.2016.10.007","article-title":"Pentamidine antagonizes the benznidazole\u2019s effect in vitro, and lacks of synergy in vivo: implications about the polyamine transport as an anti-Trypanosoma cruzi target","volume":"171","author":"Seguel","year":"2016","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.biopha.2020.110178_bib0155","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1093\/bioinformatics\/btw230","article-title":"Combenefit: an interactive platform for the analysis and visualization of drug combinations","volume":"32","author":"Di Veroli","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.biopha.2020.110178_bib0160","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.placenta.2012.10.004","article-title":"Role of matrix metalloproteinases 2 and 9 in ex vivo Trypanosoma cruzi infection of human placental chorionic villi","volume":"33","author":"Castillo","year":"2012","journal-title":"Placenta"},{"key":"10.1016\/j.biopha.2020.110178_bib0165","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0166-6851(03)00093-8","article-title":"Rapid quantitation of Trypanosoma cruzi in host tissue by real-time PCR","volume":"129","author":"Cummings","year":"2003","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.biopha.2020.110178_bib0170","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/758357","article-title":"Reorganization of extracellular matrix in placentas from women with asymptomatic chagas disease: mechanism of parasite invasion or local placental defense?","volume":"2012","author":"Duaso","year":"2012","journal-title":"J. Trop. Med."},{"key":"10.1016\/j.biopha.2020.110178_bib0175","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.biopha.2020.110178_bib0180","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/nprot.2007.102","article-title":"Estimation of total phenolic content and other oxidation substrates in plant tissues using Folin-Ciocalteu reagent","volume":"2","author":"Ainsworth","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.biopha.2020.110178_bib0185","first-page":"462","article-title":"[Standardization of propolis extract and identification of principal constituents]","volume":"49","author":"Arvouet-Grand","year":"2020","journal-title":"J. Pharm. Belg."},{"key":"10.1016\/j.biopha.2020.110178_bib0190","doi-asserted-by":"crossref","first-page":"F4.3.1","DOI":"10.1002\/0471142913.faf0403s01","article-title":"Chlorophylls and carotenoids: measurement and characterization by UV\u2010VIS spectroscopy","volume":"1","author":"Lichtenthaler","year":"2001","journal-title":"Curr. Protoc. Food Anal. Chem."},{"key":"10.1016\/j.biopha.2020.110178_bib0195","first-page":"571","article-title":"Phytochemical screening and evaluation of analgesic activity of Oroxylum indicum","volume":"76","author":"Das","year":"2014","journal-title":"Indian J. Pharm. Sci."},{"key":"10.1016\/j.biopha.2020.110178_bib0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.actatropica.2019.105107","article-title":"Drug discovery for chagas disease: a viewpoint","volume":"198","author":"Kratz","year":"2019","journal-title":"Acta Trop."},{"key":"10.1016\/j.biopha.2020.110178_bib0205","first-page":"1","article-title":"Research priorities for chagas disease, human african trypanosomiasis and leishmaniasis","author":"WHO Press","year":"2012","journal-title":"World Health Organ. Tech. Rep. Ser. v\u2013xii"},{"key":"10.1016\/j.biopha.2020.110178_bib0210","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.actatropica.2014.01.002","article-title":"Toxic and therapeutic effects of Nifurtimox and Benznidazol on Trypanosoma cruzi ex vivo infection of human placental chorionic villi explants","volume":"132","author":"Rojo","year":"2014","journal-title":"Acta Trop."},{"issue":"10","key":"10.1016\/j.biopha.2020.110178_bib0215","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1017\/S0031182017000634","article-title":"Applicability of plant-based products in the treatment of Trypanosoma cruzi and Trypanosoma brucei infections: a systematic review of preclinical in vivo evidence","volume":"144","author":"Pereira","year":"2017","journal-title":"Parasitology"},{"key":"10.1016\/j.biopha.2020.110178_bib0220","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jep.2012.02.035","article-title":"In vitro antiprotozoal and cytotoxic activity of 33 ethonopharmacologically selected medicinal plants from Democratic Republic of Congo","volume":"141","author":"Musuyu Muganza","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2020.110178_bib0225","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.actatropica.2014.04.006","article-title":"Anti-Trypanosoma cruzi activity of 10 medicinal plants used in northeast Mexico","volume":"136","author":"Molina-Garza","year":"2014","journal-title":"Acta Trop."},{"issue":"October","key":"10.1016\/j.biopha.2020.110178_bib0230","article-title":"Cameroonian medicinal plants: pharmacology and derived natural products","volume":"123","author":"Kuete","year":"2010","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.biopha.2020.110178_bib0235","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jep.2018.09.029","article-title":"In vitro antiplasmodial, antitrypanosomal and antileishmanial activities of selected medicinal plants from Ugandan flora: refocusing into multi-component potentials","volume":"229","author":"Obbo","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2020.110178_bib0240","article-title":"Antitrypanosomal effects of zanthoxylum zanthoxyloides (lam.) zepern. & timler extracts on African trypanosomes","volume":"2019","author":"Dofuor","year":"2019","journal-title":"Evid. Complement. Alternat. Med."},{"key":"10.1016\/j.biopha.2020.110178_bib0245","first-page":"89","article-title":"Antitrypanosomal screening and cytotoxic effects of selected medicinal plants","volume":"31","author":"Dyary","year":"2014","journal-title":"Trop. Biomed."},{"key":"10.1016\/j.biopha.2020.110178_bib0250","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/1087057114550585","article-title":"Chagas disease drug discovery","volume":"20","author":"Chatelain","year":"2015","journal-title":"J. Biomol. Screen."},{"key":"10.1016\/j.biopha.2020.110178_bib0255","first-page":"e571","volume":"3","author":"Dauby","year":"2009","journal-title":"No Title"},{"key":"10.1016\/j.biopha.2020.110178_bib0260","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.actatropica.2013.04.003","article-title":"Nifurtimox therapy for Chagas disease does not cause hypersensitivity reactions in patients with such previous adverse reactions during benznidazole treatment","volume":"127","author":"P\u00e9rez-Molina","year":"2013","journal-title":"Acta Trop."},{"key":"10.1016\/j.biopha.2020.110178_bib0265","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.149","article-title":"Analysis of drug combinations: current methodological landscape","volume":"3","author":"Foucquier","year":"2015","journal-title":"Pharmacol. Res. Perspect."},{"key":"10.1016\/j.biopha.2020.110178_bib0270","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1128\/AAC.01454-07","article-title":"Buthionine sulfoximine has anti-Trypanosoma cruzi activity in a murine model of acute Chagas\u2019 disease and enhances the efficacy of nifurtimox","volume":"52","author":"Fa\u00fandez","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.biopha.2020.110178_bib0275","doi-asserted-by":"crossref","first-page":"323","DOI":"10.4067\/S0716-97602010000300009","article-title":"Chagas disease: present status of pathogenic mechanisms and chemotherapy","volume":"43","author":"Maya","year":"2010","journal-title":"Biol. Res."},{"key":"10.1016\/j.biopha.2020.110178_bib0280","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.exppara.2018.04.016","article-title":"In vitro and in vivo drug combination for the treatment of Trypanosoma cruzi infection: a multivariate approach","volume":"189","author":"Strauss","year":"2018","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.biopha.2020.110178_bib0285","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.fct.2018.12.023","article-title":"Trypanocidal and toxicological assessment in vitro and in silico of three sesquiterpene lactones from Asteraceae plant species","volume":"125","author":"Sep\u00falveda-Robles","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2020.110178_bib0290","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.carbpol.2018.07.012","article-title":"Chemical structure and biological properties of sulfated fucan from the sequential extraction of subAntarctic Lessonia sp (Phaeophyceae)","volume":"199","author":"Leal","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.biopha.2020.110178_bib0295","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.copbio.2010.09.019","article-title":"Biologically active secondary metabolites from marine cyanobacteria","volume":"21","author":"Nunnery","year":"2010","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.biopha.2020.110178_bib0300","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1017\/S003118201000034X","article-title":"In vitro anti-trypanosomal activity of elatol isolated from red seaweed Laurencia dendroidea","volume":"137","author":"Veiga-Santos","year":"2010","journal-title":"Parasitology"},{"key":"10.1016\/j.biopha.2020.110178_bib0305","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1080\/10408398.2013.764841","article-title":"Availability and utilization of pigments from microalgae","volume":"56","author":"Begum","year":"2016","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.biopha.2020.110178_bib0310","doi-asserted-by":"crossref","first-page":"7339","DOI":"10.3390\/md13127069","article-title":"Carotenoids, phenolic compounds and tocopherols contribute to the antioxidative properties of some microalgae species grown on industrial wastewater","volume":"13","author":"Safafar","year":"2015","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.biopha.2020.110178_bib0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2017.05.002","article-title":"Mining terpenoids production and biosynthetic pathway in thraustochytrids","author":"Xie","year":"2017","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.biopha.2020.110178_bib0320","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.chom.2012.12.003","article-title":"Combined action of nucleic acid-sensing toll-like receptors and TLR11\/TLR12 heterodimers imparts resistance to toxoplasma gondii in mice","volume":"13","author":"Andrade","year":"2013","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.biopha.2020.110178_bib0325","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1080\/10408398.2010.513779","article-title":"Updated knowledge about polyphenols: functions, bioavailability, metabolism, and health","volume":"52","author":"Landete","year":"2012","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.biopha.2020.110178_bib0330","doi-asserted-by":"crossref","first-page":"e2617","DOI":"10.1371\/journal.pntd.0002617","article-title":"Phytol, a diterpene alcohol from chlorophyll, as a drug against neglected tropical disease Schistosomiasis mansoni","volume":"8","author":"de Moraes","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.biopha.2020.110178_bib0335","doi-asserted-by":"crossref","first-page":"8232","DOI":"10.1016\/j.biortech.2011.06.010","article-title":"Properties of oil and char derived from slow pyrolysis of Tetraselmis chui","volume":"102","author":"Grierson","year":"2011","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.biopha.2020.110178_bib0340","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002494","article-title":"Natural terpenoids from Ambrosia species are active in vitro and in vivo against human pathogenic trypanosomatids","volume":"7","author":"S\u00fclsen","year":"2013","journal-title":"PLoS Negl. Trop. Dis."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S075333222030370X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S075333222030370X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:55:28Z","timestamp":1760097328000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S075333222030370X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":68,"alternative-id":["S075333222030370X"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110178","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microalgae extracts: Potential anti-Trypanosoma cruzi agents?","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110178","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"110178"}}