{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:17:29Z","timestamp":1791227849773,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T00:00:00Z","timestamp":1588204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.biopha.2020.110218","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T06:15:03Z","timestamp":1589782503000},"page":"110218","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Downregulation of the GLP-1\/CREB\/adiponectin pathway is partially responsible for diabetes-induced dysregulated vascular tone and VSMC dysfunction"],"prefix":"10.1016","volume":"127","author":[{"given":"Xiaowei","family":"Xiong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weimin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"24","key":"10.1016\/j.biopha.2020.110218_bib0005","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1001\/jama.2017.7596","article-title":"Prevalence and Ethnic Pattern of Diabetes and Prediabetes in China in 2013","volume":"317","author":"Wang","year":"2017","journal-title":"JAMA"},{"issue":"8","key":"10.1016\/j.biopha.2020.110218_bib0010","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.jacc.2013.03.089","article-title":"Diabetes mellitus-associated vascular impairment: novel circulating biomarkers and therapeutic approaches","volume":"62","author":"Tousoulis","year":"2013","journal-title":"J Am Coll Cardiol"},{"issue":"12","key":"10.1016\/j.biopha.2020.110218_bib0015","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1016\/j.bbadis.2013.08.006","article-title":"Endothelial dysfunction - a major mediator of diabetic vascular disease","volume":"1832","author":"Sena","year":"2013","journal-title":"Biochim Biophys Acta"},{"issue":"6","key":"10.1016\/j.biopha.2020.110218_bib0020","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2217\/fca-2018-0045","article-title":"Type-2 diabetes mellitus and cardiovascular disease","volume":"14","author":"Henning","year":"2018","journal-title":"Future Cardiol"},{"issue":"6","key":"10.1016\/j.biopha.2020.110218_bib0025","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1159\/000051094","article-title":"Influence of type II diabetes on arterial tone and endothelial function in murine mesenteric resistance arteries","volume":"38","author":"Lagaud","year":"2001","journal-title":"J Vasc Res"},{"issue":"8","key":"10.1016\/j.biopha.2020.110218_bib0030","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.2337\/diabetes.54.8.2415","article-title":"Compromised arterial function in human type 2 diabetic patients","volume":"54","author":"Okon","year":"2005","journal-title":"Diabetes"},{"issue":"6","key":"10.1016\/j.biopha.2020.110218_bib0035","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1159\/000075238","article-title":"Augmented contractile response of vascular smooth muscle in a diabetic mouse model","volume":"40","author":"Okon","year":"2003","journal-title":"J Vasc Res"},{"issue":"6","key":"10.1016\/j.biopha.2020.110218_bib0040","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.cmet.2013.04.008","article-title":"Pharmacology, physiology, and mechanisms of incretin hormone action","volume":"17","author":"Campbell","year":"2013","journal-title":"Cell Metab"},{"issue":"3","key":"10.1016\/j.biopha.2020.110218_bib0045","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.regpep.2004.10.002","article-title":"Effect of GLP-1 on glucose transport and its cell signalling in human myocytes","volume":"126","author":"Gonzalez","year":"2005","journal-title":"Regul Pept"},{"issue":"9","key":"10.1016\/j.biopha.2020.110218_bib0050","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1161\/CIRCULATIONAHA.117.028136","article-title":"Cardiovascular Actions and Clinical Outcomes With Glucagon-Like Peptide-1 Receptor Agonists and Dipeptidyl Peptidase-4 Inhibitors","volume":"136","author":"Nauck","year":"2017","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.biopha.2020.110218_bib0055","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s11906-015-0621-6","article-title":"GLP-1 Agonists and Blood Pressure: A Review of the Evidence","volume":"18","author":"Goud","year":"2016","journal-title":"Curr Hypertens Rep"},{"issue":"1","key":"10.1016\/j.biopha.2020.110218_bib0060","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1024\/0301-1526\/a000243","article-title":"Influence of glucose metabolism on vascular smooth muscle cell proliferation","volume":"42","author":"Chiong","year":"2013","journal-title":"Vasa"},{"issue":"1","key":"10.1016\/j.biopha.2020.110218_bib0065","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.bbrc.2014.03.004","article-title":"GLP-1 promotes mitochondrial metabolism in vascular smooth muscle cells by enhancing endoplasmic reticulum-mitochondria coupling","volume":"446","author":"Morales","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"10.1016\/j.biopha.2020.110218_bib0070","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18061321","article-title":"Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction","volume":"18","author":"Achari","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.biopha.2020.110218_bib0075","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1002\/j.2040-4603.2018.tb00036.x","article-title":"Adiponectin Regulation and Function","volume":"8","author":"Fang","year":"2018","journal-title":"Compr Physiol"},{"issue":"7293","key":"10.1016\/j.biopha.2020.110218_bib0080","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/nature08991","article-title":"Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK\/SIRT1","volume":"464","author":"Iwabu","year":"2010","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.biopha.2020.110218_bib0085","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/MOL.0000000000000431","article-title":"Adiponectin, lipids and atherosclerosis","volume":"28","author":"Katsiki","year":"2017","journal-title":"Curr Opin Lipidol"},{"issue":"7","key":"10.1016\/j.biopha.2020.110218_bib0090","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.005812","article-title":"Enhanced Mitochondrial Transient Receptor Potential Channel, Canonical Type 3-Mediated Calcium Handling in the Vasculature From Hypertensive Rats","volume":"6","author":"Wang","year":"2017","journal-title":"J Am Heart Assoc"},{"issue":"3","key":"10.1016\/j.biopha.2020.110218_bib0095","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/s41374-019-0331-9","article-title":"ETS2 promotes epithelial-to-mesenchymal transition in renal fibrosis by targeting JUNB transcription","volume":"100","author":"Yao","year":"2019","journal-title":"Lab Invest"},{"issue":"2","key":"10.1016\/j.biopha.2020.110218_bib0100","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/s12020-015-0799-z","article-title":"The pivotal role of high glucose-induced overexpression of PKCbeta in the appearance of glucagon-like peptide-1 resistance in endothelial cells","volume":"54","author":"Pujadas","year":"2016","journal-title":"Endocrine"},{"issue":"1","key":"10.1016\/j.biopha.2020.110218_bib0105","doi-asserted-by":"crossref","first-page":"H124","DOI":"10.1152\/ajpheart.00218.2011","article-title":"Calcium homeostasis in vascular smooth muscle cells is altered in type 2 diabetes by Bcl-2 protein modulation of InsP3R calcium release channels","volume":"302","author":"Velmurugan","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"8","key":"10.1016\/j.biopha.2020.110218_bib0110","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/dom.12085","article-title":"Blood pressure-lowering effects of GLP-1 receptor agonists exenatide and liraglutide: a meta-analysis of clinical trials","volume":"15","author":"Wang","year":"2013","journal-title":"Diabetes Obes Metab"},{"issue":"3","key":"10.1016\/j.biopha.2020.110218_bib0115","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1080\/14740338.2017.1281246","article-title":"Cardiovascular safety and benefits of GLP-1 receptor agonists","volume":"16","author":"Dalsgaard","year":"2017","journal-title":"Expert Opin Drug Saf"},{"issue":"7","key":"10.1016\/j.biopha.2020.110218_bib0120","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.2337\/dc13-2618","article-title":"Simultaneous GLP-1 and insulin administration acutely enhances their vasodilatory, antiinflammatory, and antioxidant action in type 2 diabetes","volume":"37","author":"Ceriello","year":"2014","journal-title":"Diabetes Care"},{"issue":"3","key":"10.1016\/j.biopha.2020.110218_bib0125","first-page":"1693","article-title":"Cardioprotection by exenatide: A novel mechanism via improving mitochondrial function involving the GLP-1 receptor\/cAMP\/PKA pathway","volume":"41","author":"Chang","year":"2018","journal-title":"Int J Mol Med"},{"issue":"9","key":"10.1016\/j.biopha.2020.110218_bib0130","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/j.1463-1326.2010.01238.x","article-title":"Exendin-4 protects pancreatic beta cells from human islet amyloid polypeptide-induced cell damage: potential involvement of AKT and mitochondria biogenesis","volume":"12","author":"Fan","year":"2010","journal-title":"Diabetes Obes Metab"},{"issue":"1","key":"10.1016\/j.biopha.2020.110218_bib0135","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.bbrc.2013.06.035","article-title":"LOX-1, a bridge between GLP-1R and mitochondrial ROS generation in human vascular smooth muscle cells","volume":"437","author":"Dai","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.biopha.2020.110218_bib0140","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.cytogfr.2019.06.002","article-title":"The potential of adipokines as biomarkers and therapeutic agents for vascular complications in type 2 diabetes mellitus","volume":"48","author":"Liang","year":"2019","journal-title":"Cytokine Growth Factor Rev"},{"issue":"1","key":"10.1016\/j.biopha.2020.110218_bib0145","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1161\/HYPERTENSIONAHA.113.01453","article-title":"Adiponectin levels and the risk of hypertension: a systematic review and meta-analysis","volume":"62","author":"Kim","year":"2013","journal-title":"Hypertension"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220304108?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220304108?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:00:43Z","timestamp":1760097643000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332220304108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":29,"alternative-id":["S0753332220304108"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110218","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Downregulation of the GLP-1\/CREB\/adiponectin pathway is partially responsible for diabetes-induced dysregulated vascular tone and VSMC dysfunction","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110218","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"110218"}}