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Bull."},{"key":"10.1016\/j.biopha.2020.110263_bib0530","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1002\/bmc.1000","article-title":"Identification of major alkaloids and steroidal saponins in rat serum by HPLC\u2010diode array detection\u2010MS\/MS following oral administration of Huangbai\u2010Zhimu herb\u2010pair Extract","volume":"22","author":"Ma","year":"2008","journal-title":"Biomed. 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Res."},{"key":"10.1016\/j.biopha.2020.110263_bib0550","doi-asserted-by":"crossref","first-page":"R75","DOI":"10.1530\/JOE-14-0024","article-title":"Metabolic profiling in diabetes","volume":"221","author":"Suhre","year":"2014","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.biopha.2020.110263_bib0555","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1055\/s-0029-1186218","article-title":"Goji (Lycium barbarum and L. chinense): phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity","volume":"76","author":"Potterat","year":"2010","journal-title":"Planta Med."},{"key":"10.1016\/j.biopha.2020.110263_bib0560","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S0254-6272(13)60137-5","article-title":"Retrospective study on Professor Zhongying Zhou\u2019s experience in Traditional Chinese Medicine treatment on diabetic nephropathy","volume":"33","author":"Su","year":"2013","journal-title":"J. Tradit. Chin. 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Lipid Res."},{"key":"10.1016\/j.biopha.2020.110263_bib0590","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2337\/db12-0466","article-title":"Acylcarnitines: reflecting or inflicting insulin resistance?","volume":"62","author":"Schooneman","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.biopha.2020.110263_bib0595","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1038\/oby.2009.510","article-title":"Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity","volume":"18","author":"Mihalik","year":"2010","journal-title":"Obes."},{"key":"10.1016\/j.biopha.2020.110263_bib0600","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.2337\/db09-1679","article-title":"Role of KLF15 in regulation of hepatic gluconeogenesis and metformin action","volume":"59","author":"Takashima","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.biopha.2020.110263_bib0605","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1042\/CS20110386","article-title":"Cellular and molecular mechanisms of metformin: an overview","volume":"122","author":"Viollet","year":"2012","journal-title":"Clin. 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Med."},{"key":"10.1016\/j.biopha.2020.110263_bib0660","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.fitote.2018.02.004","article-title":"Isoprenylated flavonoids from Morus nigra and their PPAR \u03b3 agonistic activities","volume":"127","author":"Xu","year":"2018","journal-title":"Fitoterapia"},{"key":"10.1016\/j.biopha.2020.110263_bib0665","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1007\/s00394-016-1197-x","article-title":"A meta-analysis of efficacy of Morus alba Linn. To improve blood glucose and lipid profile","volume":"56","author":"Phimarn","year":"2017","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.biopha.2020.110263_bib0670","first-page":"217","article-title":"Phytochemicals from mulberry extract (Morus sp.): antioxidant and neuroprotective potentials","volume":"7","author":"Rebai","year":"2017","journal-title":"Int. J. Appl. Pharm. Sci. 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