{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T01:12:47Z","timestamp":1787620367191,"version":"build-2736575974"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T00:00:00Z","timestamp":1591056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Chinese National Science Foundation","doi-asserted-by":"publisher","award":["81560682"],"award-info":[{"award-number":["81560682"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010828","name":"Guizhou Provincial Department of Education","doi-asserted-by":"publisher","award":["(2012) 055"],"award-info":[{"award-number":["(2012) 055"]}],"id":[{"id":"10.13039\/501100010828","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Major Project of Guizhou Education Department","award":["2015-6010"],"award-info":[{"award-number":["2015-6010"]}]},{"name":"Guizhou Province Education Department Tutor Studio","award":["99-030"],"award-info":[{"award-number":["99-030"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.biopha.2020.110351","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T23:06:09Z","timestamp":1591916769000},"page":"110351","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"special_numbering":"C","title":["Dendrobium nobile Lindl. alkaloids-mediated protection against CCl4-induced liver mitochondrial oxidative damage is dependent on the activation of Nrf2 signaling pathway"],"prefix":"10.1016","volume":"129","author":[{"given":"Jinxin","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanfu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingshan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2020.110351_bib0005","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18112353","article-title":"Hepatotoxicity of herbal supplements mediated by modulation of cytochrome P450","volume":"18","author":"Brewer","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2020.110351_bib0010","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.fct.2013.08.050","article-title":"Protective effects of the total saponins from rosa laevigata michx fruit against carbon tetrachloride-induced acute liver injury in mice","volume":"62","author":"Dong","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2020.110351_bib0015","doi-asserted-by":"crossref","first-page":"299","DOI":"10.35946\/arcr.v37.2.13","article-title":"Alcohol and viral hepatitis: role of lipid rafts","volume":"37","author":"Dolganiuc","year":"2015","journal-title":"Alcohol Res."},{"key":"10.1016\/j.biopha.2020.110351_bib0020","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S2221-1691(11)60013-0","article-title":"Hepatoprotective activity of hepax-a polyherbal formulation","volume":"2","author":"Devaraj","year":"2011","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"10.1016\/j.biopha.2020.110351_bib0025","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1136\/gutjnl-2016-313369","article-title":"Drug-induced liver injury: recent advances in diagnosis and risk assessment","volume":"66","author":"Kullak-Ublick","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.biopha.2020.110351_bib0030","doi-asserted-by":"crossref","first-page":"947","DOI":"10.7326\/0003-4819-137-12-200212170-00007","article-title":"Acute liver failure study group. Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States","volume":"137","author":"Ostapowicz","year":"2002","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.biopha.2020.110351_bib0035","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3390\/ijms17020224","article-title":"Hepatotoxicity by drugs: the most common implicated agents","volume":"17","author":"Bj\u00f6rnsson","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2020.110351_bib0040","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3350\/cmh.2012.18.3.249","article-title":"Drug-induced liver injury: present and future","volume":"18","author":"Suk","year":"2012","journal-title":"Clin. Mol. Hepatol."},{"key":"10.1016\/j.biopha.2020.110351_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109073","article-title":"Induction of Nrf2 pathway by Dendrobium nobile Lindl. alkaloids protects against carbon tetrachloride induced acute liver injury","volume":"117","author":"Li","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2020.110351_bib0050","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1006\/taap.1998.8547","article-title":"Resistance to carbon tetrachloride-induced hepatotoxicity in mice which lack CYP2E1 expression","volume":"152","author":"Wong","year":"1998","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.biopha.2020.110351_bib0055","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3109\/03602532.2011.602688","article-title":"Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity","volume":"44","author":"Jaeschke","year":"2012","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.biopha.2020.110351_bib0060","first-page":"157","article-title":"Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology","volume":"3","author":"Ramachandran","year":"2017","journal-title":"J. Clin. Transl. Res."},{"key":"10.1016\/j.biopha.2020.110351_bib0065","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3109\/03602532.2011.602688","article-title":"Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity","volume":"44","author":"Jaeschke","year":"2012","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.biopha.2020.110351_bib0070","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1084\/jem.185.8.1481","article-title":"Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis","volume":"185","author":"Leist","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.biopha.2020.110351_bib0075","article-title":"Activation of the Nrf2\/HO-1 antioxidant pathway contributes to the protective effects of lycium barbarum polysaccharides in the rodent retina after ischemia-reperfusion-induced damage","volume":"9","author":"He","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2020.110351_bib0080","doi-asserted-by":"crossref","first-page":"i19","DOI":"10.1093\/ndt\/gft224","article-title":"The Nrf2 pathway in the progression of renal disease","volume":"1","author":"Zoja","year":"2014","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.biopha.2020.110351_bib0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0045870","article-title":"Dimethylfumarate attenuates renal fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-\u03b2\/Smad signaling","volume":"7","author":"Oh","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2020.110351_bib0090","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/4820414","article-title":"Liver injury induced by chronic plus binge ethanol feeding by modulating oxidative stress and inflammation via CYP2E1 and NRF2 in mice","volume":"2017","author":"He","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.biopha.2020.110351_bib0095","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/cns.12678","article-title":"Dendrobium nobile Lindl alkaloid, a novel autophagy inducer, protects against axonal degeneration induced by A\u03b2 (25-35) in hippocampus neurons in vitro","volume":"23","author":"Li","year":"2017","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.biopha.2020.110351_bib0100","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.3389\/fphar.2018.01479","article-title":"Dendrobium nobile Lindl. Alkaloids decreases the level of intracellular \u03b2-amyloid by improving impaired autolysosomal proteolysis in APP\/PS1 mice","volume":"9","author":"Nie","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.biopha.2020.110351_bib0105","doi-asserted-by":"crossref","first-page":"e7627","DOI":"10.7717\/peerj.7627","article-title":"Dendrobium alkaloids decrease A\u03b2 by regulating \u03b1- and \u03b2-secretases in hippocampal neurons of SD rats","volume":"7","author":"Huang","year":"2019","journal-title":"PeerJ."},{"key":"10.1016\/j.biopha.2020.110351_bib0110","doi-asserted-by":"crossref","first-page":"e2739","DOI":"10.7717\/peerj.2739","article-title":"Dendrobium alkaloids prevent A\u03b2(25-35)-induced neuronal and synaptic loss via promoting neurotrophic factors expression in mice","volume":"4","author":"Nie","year":"2016","journal-title":"PeerJ"},{"key":"10.1016\/j.biopha.2020.110351_bib0115","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.biopha.2020.110351_bib0120","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.taap.2018.09.014","article-title":"Regulatory crosstalk between the oxidative stress-related transcription factor Nfe2l2\/Nrf2 and mitochondria","volume":"359","author":"Ryoo","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.biopha.2020.110351_bib0125","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1021\/jf9709919","article-title":"Measurement of malondialdehyde levels in food by high-performance liquid chromatography with fluorometric detection","volume":"46","author":"Bergamo","year":"1998","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.biopha.2020.110351_bib0130","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1093\/carcin\/7.11.1849","article-title":"Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair","volume":"7","author":"Kasai","year":"1986","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.biopha.2020.110351_bib0135","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.cell.2012.02.035","article-title":"Mitochondria: in sickness and in health","volume":"148","author":"Nunnari","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2020.110351_bib0140","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tox.2017.07.019","article-title":"Mitochondrial fusion, fission, and mitochondrial toxicity","volume":"391","author":"Meyer","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.biopha.2020.110351_bib0145","doi-asserted-by":"crossref","first-page":"782","DOI":"10.3389\/fphar.2019.00782","article-title":"The essential oils and eucalyptol from artemisia vulgaris L. Prevent acetaminophen-induced liver injury by activating Nrf2-Keap1 and enhancing APAP clearance through non-toxic metabolic pathway","volume":"10","author":"Jiang","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.biopha.2020.110351_bib0150","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1089\/ars.2017.7342","article-title":"Transcriptional regulation by Nrf2","volume":"29","author":"Tonelli","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.biopha.2020.110351_bib0155","first-page":"19","article-title":"The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders","volume":"6","author":"Gao","year":"2014","journal-title":"Clin. Pharmacol."},{"key":"10.1016\/j.biopha.2020.110351_bib0160","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.bcp.2008.12.028","article-title":"Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes","volume":"77","author":"Reisman","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biopha.2020.110351_bib0165","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.bcp.2015.07.024","article-title":"Withaferin-A Reduces Acetaminophen-induced liver injury in mice","volume":"97","author":"Jadeja","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biopha.2020.110351_bib0170","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1093\/toxsci\/kfu244","article-title":"Cyclooxygenase-1 serves a vital hepato-protective function in chemically induced acute liver injury","volume":"143","author":"Xiao","year":"2015","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.biopha.2020.110351_bib0175","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23010215","article-title":"Curcumin attenuates on carbon tetrachloride-induced acute liver injury in mice via modulation of the Nrf2\/HO-1 and TGF-\u03b21\/Smad3 pathway","volume":"23","author":"Peng","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2020.110351_bib0180","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.toxrep.2015.05.012","article-title":"A single acute hepatotoxic dose of CCl4 causes oxidative stress in the rat brain","volume":"2","author":"Ritesh","year":"2015","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.biopha.2020.110351_bib0185","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1196\/annals.1427.015","article-title":"The role of mitochondria in reactive oxygen species metabolism and signaling","volume":"1147","author":"Starkov","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.biopha.2020.110351_bib0190","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1104\/pp.010999","article-title":"Oxidative stress increased respiration and generation of reactive oxygen species, resulting in ATP depletion, opening of mitochondrial permeability transition, and programmed cell death","volume":"128","author":"Tiwari","year":"2002","journal-title":"Plant Physiol."},{"key":"10.1016\/j.biopha.2020.110351_bib0195","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1016\/j.bbamcr.2016.09.012","article-title":"Activation of apoptosis signalling pathways by reactive oxygen species","volume":"1863","author":"Redza-Dutordoir","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biopha.2020.110351_bib0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/782497","article-title":"NRF2 Protection against Liver Injury Produced by Various Hepatotoxicants","volume":"2013","author":"Liu","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.biopha.2020.110351_bib0205","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1111\/j.1476-5381.2010.01095.x","article-title":"Nrf2-mediated liver protection by sauchinone, an antioxidant lignan, from acetaminophen toxicity through the PKC\u03b4-GSK3\u03b2 pathway","volume":"163","author":"Kay","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.biopha.2020.110351_bib0210","doi-asserted-by":"crossref","first-page":"S417","DOI":"10.33549\/physiolres.933506","article-title":"In vitro and in vivo experimental hepatotoxic models in liver research: applications to the assessment of potential hepatoprotective drugs","volume":"65","author":"Farghali","year":"2016","journal-title":"Physiol. Res."},{"key":"10.1016\/j.biopha.2020.110351_bib0215","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.cotox.2016.10.002","article-title":"The multifaceted role of Nrf2 in mitochondrial function","volume":"1","author":"Holmstr\u00f6m","year":"2016","journal-title":"Curr. Opin. Toxicol."},{"key":"10.1016\/j.biopha.2020.110351_bib0220","first-page":"1269","article-title":"Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network","author":"Scarpulla","year":"2011","journal-title":"Biochim Biophys Acta.1813"},{"key":"10.1016\/j.biopha.2020.110351_bib0225","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1111\/jphp.12778","article-title":"Dendrobium nobile Lindl. Alkaloids regulate metabolism gene expression in livers of mice","volume":"69","author":"Xu","year":"2017","journal-title":"J. Pharm. Pharmacol."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220305448?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220305448?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:55:32Z","timestamp":1760097332000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332220305448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":45,"alternative-id":["S0753332220305448"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110351","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dendrobium nobile Lindl. alkaloids-mediated protection against CCl4-induced liver mitochondrial oxidative damage is dependent on the activation of Nrf2 signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110351","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"110351"}}