{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T02:18:38Z","timestamp":1780366718997,"version":"3.54.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671832"],"award-info":[{"award-number":["81671832"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31470918"],"award-info":[{"award-number":["31470918"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health Industry Scientific Research Project of Gansu Province","award":["GSWSKY2018-49"],"award-info":[{"award-number":["GSWSKY2018-49"]}]},{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu Province","doi-asserted-by":"publisher","award":["18JR3RA349"],"award-info":[{"award-number":["18JR3RA349"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Innovation Program of Lanzhou University","award":["20200060086"],"award-info":[{"award-number":["20200060086"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.biopha.2020.110382","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T13:09:14Z","timestamp":1592917754000},"page":"110382","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Local intramyocardial delivery of bioglass with alginate hydrogels for post-infarct myocardial regeneration"],"prefix":"10.1016","volume":"129","author":[{"given":"Quan","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhize","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2020.110382_bib0005","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.actbio.2016.10.013","article-title":"Dual delivery of VEGF and ANG-1 in ischemic hearts using an injectable hydrogel","volume":"48","author":"Rufaihah","year":"2017","journal-title":"Acta Biomater."},{"issue":"5","key":"10.1016\/j.biopha.2020.110382_bib0010","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/ejhf.486","article-title":"Thirty-year trends in heart failure hospitalization and mortality rates and the prognostic impact of co-morbidity: a Danish nationwide cohort study","volume":"18","author":"Schmidt","year":"2016","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.biopha.2020.110382_bib0015","article-title":"Contributions of BMPs in cardiac repair cells in 3D in vitro models and angiogenesis","author":"Pallotta","year":"2017","journal-title":"J. Tissue Eng. Regen. Med."},{"issue":"9","key":"10.1016\/j.biopha.2020.110382_bib0020","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/adhm.201500861","article-title":"Gelatin microspheres as vehicle for cardiac progenitor cells delivery to the myocardium","volume":"5","author":"Feyen","year":"2016","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.biopha.2020.110382_bib0025","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.biomaterials.2016.03.046","article-title":"In vitro and in vivo assessment of heart-homing porous silicon nanoparticles","volume":"94","author":"Ferreira","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.biopha.2020.110382_bib0030","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.actbio.2016.05.039","article-title":"An injectable silk sericin hydrogel promotes cardiac functional recovery after ischemic myocardial infarction","volume":"41","author":"Song","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biopha.2020.110382_bib0035","article-title":"Combinatorial therapy with three-dimensionally cultured adipose-derived stromal cells and self-assembling peptides to enhance angiogenesis and preserve cardiac function in infarcted hearts","author":"Kim","year":"2016","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"10.1016\/j.biopha.2020.110382_bib0040","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jconrel.2016.10.017","article-title":"Simultaneous regulation of apoptotic gene silencing and angiogenic gene expression for myocardial infarction therapy: Single-carrier delivery of SHP-1 siRNA and VEGF-expressing pDNA","volume":"243","author":"Kim","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.biopha.2020.110382_bib0045","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.biomaterials.2017.02.020","article-title":"A single injection of protein-loaded coacervate-gel significantly improves cardiac function post infarction","volume":"125","author":"Awada","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.biopha.2020.110382_bib0050","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.actbio.2016.11.036","article-title":"Improved vascularization of porous scaffolds through growth factor delivery from heparinized polyethylene glycol hydrogels","volume":"49","author":"Janse van Rensburg","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biopha.2020.110382_bib0055","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jconrel.2015.02.009","article-title":"Heart regeneration after myocardial infarction using synthetic biomaterials","volume":"203","author":"Pascual-Gil","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.biopha.2020.110382_bib0060","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.biomaterials.2018.01.055","article-title":"\"All-in-one\" in vitro selection of collagen-binding vascular endothelial growth factor","volume":"161","author":"Park","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.biopha.2020.110382_bib0065","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.actbio.2016.12.015","article-title":"Biohybrid cardiac ECM-based hydrogels improve long term cardiac function post myocardial infarction","volume":"50","author":"Efraim","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biopha.2020.110382_bib0070","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.biomaterials.2018.11.017","article-title":"An injectable continuous stratified structurally and functionally biomimetic construct for enhancing osteochondral regeneration","volume":"192","author":"Zhu","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.biopha.2020.110382_bib0075","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.biomaterials.2016.01.033","article-title":"Bioglass promotes wound healing by affecting gap junction connexin 43 mediated endothelial cell behavior","volume":"84","author":"Li","year":"2016","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.biopha.2020.110382_bib0080","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1016\/j.biomaterials.2011.01.004","article-title":"A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics","volume":"32","author":"Hoppe","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.biopha.2020.110382_bib0085","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.actbio.2014.12.016","article-title":"Injectable biodegradable hybrid hydrogels based on thiolated collagen and oligo(acryloyl carbonate)-poly(ethylene glycol)-oligo(acryloyl carbonate) copolymer for functional cardiac regeneration","volume":"15","author":"Xu","year":"2015","journal-title":"Acta Biomater."},{"issue":"2","key":"10.1016\/j.biopha.2020.110382_bib0090","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.actbio.2013.10.027","article-title":"Evaluation of polyelectrolyte complex-based scaffolds for mesenchymal stem cell therapy in cardiac ischemia treatment","volume":"10","author":"Ceccaldi","year":"2014","journal-title":"Acta Biomater."},{"issue":"8","key":"10.1016\/j.biopha.2020.110382_bib0095","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1016\/j.biomaterials.2013.12.011","article-title":"Regeneration of chronic myocardial infarction by injectable hydrogels containing stem cell homing factor SDF-1 and angiogenic peptide Ac-SDKP","volume":"35","author":"Song","year":"2014","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.biopha.2020.110382_bib0100","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1021\/acsbiomaterials.7b00502","article-title":"Evaluation of hydrogels presenting extracellular matrix-derived adhesion peptides and encapsulating cardiac progenitor cells for cardiac repair","volume":"4","author":"Bhutani","year":"2018","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"12","key":"10.1016\/j.biopha.2020.110382_bib0105","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1021\/acsbiomaterials.7b00734","article-title":"Methods to assess shear-thinning hydrogels for application As injectable biomaterials","volume":"3","author":"Chen","year":"2017","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"11","key":"10.1016\/j.biopha.2020.110382_bib0110","doi-asserted-by":"crossref","first-page":"9107","DOI":"10.1016\/j.actbio.2013.06.022","article-title":"The calcium silicate\/alginate composite: preparation and evaluation of its behavior as bioactive injectable hydrogels","volume":"9","author":"Han","year":"2013","journal-title":"Acta Biomater."},{"issue":"2","key":"10.1016\/j.biopha.2020.110382_bib0115","doi-asserted-by":"crossref","first-page":"5379","DOI":"10.1016\/j.actbio.2012.10.019","article-title":"Stimulation of proangiogenesis by calcium silicate bioactive ceramic","volume":"9","author":"Li","year":"2013","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biopha.2020.110382_bib0120","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.biomaterials.2016.04.025","article-title":"Human relaxin gene expression delivered by bioreducible dendrimer polymer for post-infarct cardiac remodeling in rats","volume":"97","author":"Lee","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.biopha.2020.110382_bib0125","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.biomaterials.2016.07.035","article-title":"Functional engineered human cardiac patches prepared from nature's platform improve heart function after acute myocardial infarction","volume":"105","author":"Wang","year":"2016","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.biopha.2020.110382_bib0130","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.biomaterials.2010.08.097","article-title":"The promotion of myocardial repair by the sequential delivery of IGF-1 and HGF from an injectable alginate biomaterial in a model of acute myocardial infarction","volume":"32","author":"Ruvinov","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.biopha.2020.110382_bib0135","article-title":"Macrophage Smad3 protects the infarcted heart, stimulating phagocytosis and regulating inflammation","author":"Chen","year":"2019","journal-title":"Circ. Res."},{"issue":"36","key":"10.1016\/j.biopha.2020.110382_bib0140","doi-asserted-by":"crossref","first-page":"30103","DOI":"10.1021\/acsami.8b09191","article-title":"Bioactive Injectable Hydrogels Containing Desferrioxamine and Bioglass for Diabetic Wound Healing","volume":"10","author":"Kong","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.biopha.2020.110382_bib0145","article-title":"Electrospun chitosan\/PVA\/bioglass Nanofibrous membrane with spatially designed structure for accelerating chronic wound healing, Materials science & engineering","volume":"105","author":"Chen","year":"2019","journal-title":"C, Materials for biological applications"},{"issue":"5","key":"10.1016\/j.biopha.2020.110382_bib0150","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.jacc.2018.05.034","article-title":"Left ventricular unloading before reperfusion promotes functional recovery after acute myocardial infarction","volume":"72","author":"Esposito","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.biopha.2020.110382_bib0155","doi-asserted-by":"crossref","first-page":"4835","DOI":"10.2147\/IJN.S132064","article-title":"Spatiotemporal delivery of nanoformulated liraglutide for cardiac regeneration after myocardial infarction","volume":"12","author":"Qi","year":"2017","journal-title":"Int. J. Nanomedicine"},{"issue":"13","key":"10.1016\/j.biopha.2020.110382_bib0160","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1161\/CIRCULATIONAHA.118.036344","article-title":"Endothelial C-Type natriuretic peptide is a critical regulator of angiogenesis and vascular remodeling","volume":"139","author":"Bubb","year":"2019","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.biopha.2020.110382_bib0165","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jacc.2018.09.086","article-title":"Multitarget Strategies to Reduce Myocardial Ischemia\/Reperfusion Injury: JACC Review Topic of the Week","volume":"73","author":"Davidson","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.biopha.2020.110382_bib0170","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.actbio.2016.09.009","article-title":"VEGF-loaded microsphere patch for local protein delivery to the ischemic heart","volume":"45","author":"Rodness","year":"2016","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.biopha.2020.110382_bib0175","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1161\/CIRCRESAHA.115.305373","article-title":"Emerging concepts in paracrine mechanisms in regenerative cardiovascular medicine and biology","volume":"118","author":"Hodgkinson","year":"2016","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.biopha.2020.110382_bib0180","first-page":"199","article-title":"Effect of bioactive glasses on angiogenesis: a review of in vitro and in vivo evidences, Tissue engineering","volume":"16","author":"Gorustovich","year":"2010","journal-title":"Part B, Reviews"},{"issue":"1","key":"10.1016\/j.biopha.2020.110382_bib0185","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1161\/CIRCRESAHA.117.311504","article-title":"CCND2 Overexpression enhances the regenerative potency of human induced pluripotent stem cell-derived cardiomyocytes: remuscularization of injured ventricle","volume":"122","author":"Zhu","year":"2018","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.biopha.2020.110382_bib0190","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.cardiores.2006.10.011","article-title":"Myocardial angiogenesis after plasmid or adenoviral VEGF-A(165) gene transfer in rat myocardial infarction model","volume":"73","author":"Hao","year":"2007","journal-title":"Cardiovasc. Res."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220305758?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220305758?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:06:14Z","timestamp":1760097974000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332220305758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":38,"alternative-id":["S0753332220305758"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110382","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Local intramyocardial delivery of bioglass with alginate hydrogels for post-infarct myocardial regeneration","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110382","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"110382"}}