{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T20:35:05Z","timestamp":1794083705645,"version":"4.8.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T00:00:00Z","timestamp":1592179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Brazilian agencies Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004916","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Amazonas","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004916","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006181","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado da Bahia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006181","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.biopha.2020.110402","type":"journal-article","created":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T17:04:44Z","timestamp":1592672684000},"page":"110402","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Essential oil from leaves of Conobea scoparioides (Cham. &amp; Schltdl.) Benth. (Plantaginaceae) causes cell death in HepG2 cells and inhibits tumor development in a xenograft model"],"prefix":"10.1016","volume":"129","author":[{"given":"Emilly J.S.P. de","family":"Lima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4925-0660","authenticated-orcid":false,"given":"Sheila S.","family":"Fontes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateus L.","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdenizia R.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano de S.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gigliola M.A.","family":"D\u2019Elia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosane B.","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline B.S.","family":"Sales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa A. Gurgel","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos A.","family":"Vannier-Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena B.P.","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanoel V.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe M.A. da","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector H.F.","family":"Koolen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6774-2063","authenticated-orcid":false,"given":"Daniel P.","family":"Bezerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2020.110402_bib0005","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.biopha.2020.110402_bib0010","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1056\/NEJMoa0708857","article-title":"SHARP investigators study group. Sorafenib in advanced hepatocellular carcinoma","volume":"359","author":"Llovet","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biopha.2020.110402_bib0015","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/14728214.2017.1336538","article-title":"Emerging tyrosine kinase inhibitors for the treatment of hepatocellular carcinoma","volume":"22","author":"Rosamel","year":"2017","journal-title":"Expert Opin. Emerg. Drugs"},{"key":"10.1016\/j.biopha.2020.110402_bib0020","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S2468-1253(17)30255-8","article-title":"Treatment of advanced hepatocellular carcinoma: beyond sorafenib","volume":"3","author":"Meyer","year":"2018","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.biopha.2020.110402_bib0025","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/1099-1026(200011\/12)15:6<413::AID-FFJ931>3.0.CO;2-H","article-title":"Essential oils from Conobea scoparioides (Cham. & Schltdl.) Benth","volume":"15","author":"Maia","year":"2000","journal-title":"Flavour Fragr. J."},{"key":"10.1016\/j.biopha.2020.110402_bib0030","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0378-8741(01)00346-4","article-title":"Antiprotozoal activities of Colombian plants","volume":"78","author":"Weniger","year":"2001","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2020.110402_bib0035","series-title":"Flora Medicinal de Colombia","author":"Garc\u0131a-Barriga","year":"1992"},{"key":"10.1016\/j.biopha.2020.110402_bib0040","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1021\/np50113a004","article-title":"ucurbitacins, cell adhesion inhibitors from Conobea scoparioides","volume":"57","author":"Musza","year":"1994","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.biopha.2020.110402_bib0045","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1590\/S0103-50532009000600005","article-title":"Antioxidant capacity and biological activity of essential oil and methanol extract of Conobea scoparioides (Cham. & Schltdl.) Benth","volume":"20","author":"Rebelo","year":"2009","journal-title":"J. Braz. Chem. Soc."},{"key":"10.1016\/j.biopha.2020.110402_bib0050","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0021-9673(01)80947-X","article-title":"Generalization of the retention index system including linear temperature programmed gas-liquid partition chromatography","volume":"11","author":"Van Den Dool","year":"1963","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.biopha.2020.110402_bib0055","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0022-1759(94)90396-4","article-title":"new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: an alternative to [3H]-thymidine incorporation assay","volume":"170","author":"Ahmed","year":"1994","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.biopha.2020.110402_bib0060","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/7126872","article-title":"Xylopine induces oxidative stress and causes G2\/M phase arrest, triggering caspase-mediated apoptosis by p53-independent pathway in HCT116 cells","volume":"2017","author":"Santos","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.biopha.2020.110402_bib0065","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/s41598-017-18639-6","article-title":"A ruthenium-based 5-fluorouracil complex with enhanced cytotoxicity and apoptosis induction action in HCT116 cells","volume":"8","author":"Silva","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2020.110402_bib0070","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0022-1759(91)90198-O","article-title":"A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry","volume":"139","author":"Nicoletti","year":"1991","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.biopha.2020.110402_bib0075","doi-asserted-by":"crossref","first-page":"E2974","DOI":"10.3390\/molecules23112974","article-title":"Antitumor effect of the essential oil from the leaves of Croton matourensisAubl. (Euphorbiaceae)","volume":"23","author":"Lima","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2020.110402_bib0080","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1055\/s-0035-1546130","article-title":"Antitumor properties of the essential oil from the leaves of Duguetia gardneriana","volume":"81","author":"Rodrigues","year":"2015","journal-title":"Planta Med."},{"key":"10.1016\/j.biopha.2020.110402_bib0085","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1146\/annurev-immunol-042617-053010","article-title":"Apoptosis and clearance of apoptotic cells","volume":"36","author":"Nagata","year":"2018","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.biopha.2020.110402_bib0090","doi-asserted-by":"crossref","first-page":"15787","DOI":"10.1038\/s41598-018-34055-w","article-title":"In-vitro evaluation of apoptotic effect of OEO and thymol in 2D and 3D cell cultures and the study of their interaction mode with DNA","volume":"8","author":"Jamali","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2020.110402_bib0095","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.phymed.2013.01.015","article-title":"Cytotoxic effect of leaf essential oil of Lippia gracilis Schauer (Verbenaceae)","volume":"20","author":"Ferraz","year":"2013","journal-title":"Phytomedicine"},{"key":"10.1016\/j.biopha.2020.110402_bib0100","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.fct.2013.08.037","article-title":"Disruption of the PI3K\/AKT\/mTOR signaling cascade and induction of apoptosis in HL-60 cells by an essential oil from Monarda citriodora","volume":"62","author":"Pathania","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2020.110402_bib0105","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/bcpt.12488","article-title":"Antitumour activity of the microencapsulation of Annona vepretorum essential oil","volume":"118","author":"Bomfim","year":"2016","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.biopha.2020.110402_bib0110","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1515\/znc-2014-4138","article-title":"Chemical composition, antitumor activity, and toxicity of essential oil from the leaves of Lippia microphylla","volume":"70","author":"Xavier","year":"2015","journal-title":"Z. Naturforsch. C"},{"key":"10.1016\/j.biopha.2020.110402_bib0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109713","article-title":"In vitro and in vivo growth inhibition of human acute promyelocytic leukemia HL-60 cells by Guatteria megalophylla Diels (Annonaceae) leaf essential oil","volume":"122","author":"Costa","year":"2020","journal-title":"Biomed. Pharmacother."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220305953?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220305953?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:05:43Z","timestamp":1760097943000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332220305953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":23,"alternative-id":["S0753332220305953"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110402","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Essential oil from leaves of Conobea scoparioides (Cham. & Schltdl.) Benth. (Plantaginaceae) causes cell death in HepG2 cells and inhibits tumor development in a xenograft model","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110402","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"110402"}}