{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T06:40:21Z","timestamp":1794552021891,"version":"4.9.1"},"reference-count":139,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T00:00:00Z","timestamp":1592784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008460","name":"National Center for Complementary and Integrative Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008460","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Northeast Ohio Medical University","id":[{"id":"https:\/\/ror.org\/04q9qf557","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Tariq M Haqqi"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.biopha.2020.110452","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T08:28:25Z","timestamp":1593764905000},"page":"110452","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":686,"special_numbering":"C","title":["Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols"],"prefix":"10.1016","volume":"129","author":[{"given":"Mohammad Yunus","family":"Ansari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nashrah","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq M","family":"Haqqi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10182","key":"10.1016\/j.biopha.2020.110452_bib0005","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","article-title":"Osteoarthritis","volume":"393","author":"Hunter","year":"2019","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.biopha.2020.110452_bib0010","doi-asserted-by":"crossref","first-page":"98","DOI":"10.2174\/1573397113666170807122312","article-title":"Novel insights into the pathogenesis of osteoarthritis","volume":"14","author":"Geyer","year":"2018","journal-title":"Curr. Rheumatol. Rev."},{"key":"10.1016\/j.biopha.2020.110452_bib0015","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.phrs.2016.02.020","article-title":"Acetaminophen from liver to brain: new insights into drug pharmacological action and toxicity","volume":"109","author":"Ghanem","year":"2016","journal-title":"Pharmacol. Res."},{"issue":"7","key":"10.1016\/j.biopha.2020.110452_bib0020","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.3390\/ph3072291","article-title":"Nonsteroidal anti-inflammatory drugs and the kidney","volume":"3","author":"Horl","year":"2010","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.biopha.2020.110452_bib0025","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41413-019-0062-y","article-title":"Sustained Akt signaling in articular chondrocytes causes osteoarthritis via oxidative stress-induced senescence in mice","volume":"7","author":"Xie","year":"2019","journal-title":"Bone Res."},{"key":"10.1016\/j.biopha.2020.110452_bib0030","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.freeradbiomed.2018.08.038","article-title":"Reactive oxygen species, aging and articular cartilage homeostasis","volume":"132","author":"Bolduc","year":"2019","journal-title":"Free Radic. Biol. Med."},{"issue":"8","key":"10.1016\/j.biopha.2020.110452_bib0035","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1089\/ars.2007.1957","article-title":"Redox regulation of cell survival","volume":"10","author":"Trachootham","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.biopha.2020.110452_bib0040","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3389\/fcell.2015.00035","article-title":"Redox interplay between mitochondria and peroxisomes","volume":"3","author":"Lismont","year":"2015","journal-title":"Front. Cell Dev. Biol."},{"issue":"4","key":"10.1016\/j.biopha.2020.110452_bib0045","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.bbadis.2016.01.003","article-title":"ROS\/oxidative stress signaling in osteoarthritis","volume":"1862","author":"Lepetsos","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"issue":"9-10","key":"10.1016\/j.biopha.2020.110452_bib0050","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1089\/ars.2006.8.1485","article-title":"NAD(P)H oxidase activity of Nox4 in chondrocytes is both inducible and involved in collagenase expression","volume":"8","author":"Grange","year":"2006","journal-title":"Antioxid. Redox Signal."},{"issue":"4","key":"10.1016\/j.biopha.2020.110452_bib0055","doi-asserted-by":"crossref","first-page":"R885","DOI":"10.1186\/ar1760","article-title":"NADPH-oxidase-driven oxygen radical production determines chondrocyte death and partly regulates metalloproteinase-mediated cartilage matrix degradation during interferon-gamma-stimulated immune complex arthritis","volume":"7","author":"van Lent","year":"2005","journal-title":"Arthritis Res. Ther."},{"issue":"3","key":"10.1016\/j.biopha.2020.110452_bib0060","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.niox.2008.12.005","article-title":"Plasma 3-nitrotyrosine is a biomarker in animal models of arthritis: pharmacological dissection of iNOS\u2019 role in disease","volume":"20","author":"Nemirovskiy","year":"2009","journal-title":"Nitric Oxide"},{"issue":"10","key":"10.1016\/j.biopha.2020.110452_bib0065","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1007\/s00296-015-3290-5","article-title":"Evaluation of prolidase activity and oxidative status in patients with knee osteoarthritis: relationships with radiographic severity and clinical parameters","volume":"35","author":"Altay","year":"2015","journal-title":"Rheumatol. Int."},{"issue":"1","key":"10.1016\/j.biopha.2020.110452_bib0070","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1177\/0300060513501751","article-title":"Association between severity of knee osteoarthritis and serum and synovial fluid interleukin 17 concentrations","volume":"42","author":"Chen","year":"2014","journal-title":"J. Int. Med. Res."},{"issue":"8","key":"10.1016\/j.biopha.2020.110452_bib0075","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/S0891-5849(02)01004-3","article-title":"Green tea polyphenol epigallocatechin-3-gallate inhibits the IL-1 beta-induced activity and expression of cyclooxygenase-2 and nitric oxide synthase-2 in human chondrocytes","volume":"33","author":"Ahmed","year":"2002","journal-title":"Free Radic. Biol. Med."},{"issue":"8","key":"10.1016\/j.biopha.2020.110452_bib0080","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1002\/art.10443","article-title":"Epigallocatechin-3-gallate inhibits interleukin-1beta-induced expression of nitric oxide synthase and production of nitric oxide in human chondrocytes: suppression of nuclear factor kappaB activation by degradation of the inhibitor of nuclear factor kappaB","volume":"46","author":"Singh","year":"2002","journal-title":"Arthritis Rheum."},{"issue":"6","key":"10.1016\/j.biopha.2020.110452_bib0085","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1002\/1529-0131(200006)43:6<1290::AID-ANR11>3.0.CO;2-R","article-title":"Selective inhibition of inducible nitric oxide synthase reduces progression of experimental osteoarthritis in vivo: possible link with the reduction in chondrocyte apoptosis and caspase 3 level","volume":"43","author":"Pelletier","year":"2000","journal-title":"Arthritis Rheum."},{"issue":"8","key":"10.1016\/j.biopha.2020.110452_bib0090","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1016\/j.celrep.2017.10.068","article-title":"S-nitrosylation of PINK1 attenuates PINK1\/Parkin-Dependent mitophagy in hiPSC-Based parkinson\u2019s disease models","volume":"21","author":"Oh","year":"2017","journal-title":"Cell Rep."},{"issue":"23","key":"10.1016\/j.biopha.2020.110452_bib0095","doi-asserted-by":"crossref","first-page":"5839","DOI":"10.1073\/pnas.1804932115","article-title":"Oxygen radicals, nitric oxide, and peroxynitrite: redox pathways in molecular medicine","volume":"115","author":"Radi","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.biopha.2020.110452_bib0100","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.29607","article-title":"Role of iNOS in osteoarthritis: pathological and therapeutic aspects","author":"Ahmad","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.biopha.2020.110452_bib0105","doi-asserted-by":"crossref","first-page":"100982","DOI":"10.1016\/j.arr.2019.100982","article-title":"Ageing, age-related diseases and oxidative stress: What to do next?","volume":"57","author":"Luo","year":"2020","journal-title":"Ageing Res. Rev."},{"issue":"6","key":"10.1016\/j.biopha.2020.110452_bib0110","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.freeradbiomed.2009.12.024","article-title":"Mitochondrial superoxide dismutase SOD2, but not cytosolic SOD1, plays a critical role in protection against glutamate-induced oxidative stress and cell death in HT22 neuronal cells","volume":"48","author":"Fukui","year":"2010","journal-title":"Free Radic. Biol. Med."},{"issue":"7","key":"10.1016\/j.biopha.2020.110452_bib0115","doi-asserted-by":"crossref","first-page":"4403","DOI":"10.1074\/jbc.R111.283432","article-title":"Peroxiredoxin functions as a peroxidase and a regulator and sensor of local peroxides","volume":"287","author":"Rhee","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.biopha.2020.110452_bib0120","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1089\/ars.2010.3586","article-title":"Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities","volume":"15","author":"Lubos","year":"2011","journal-title":"Antioxid. Redox Signal."},{"issue":"4","key":"10.1016\/j.biopha.2020.110452_bib0125","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.joca.2007.09.001","article-title":"Joint fluid antioxidants are decreased in osteoarthritic joints compared to joints with macroscopically intact cartilage and subacute injury","volume":"16","author":"Regan","year":"2008","journal-title":"Osteoarthr. Cartil."},{"issue":"2","key":"10.1016\/j.biopha.2020.110452_bib0130","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.joca.2005.08.009","article-title":"Lipid peroxidation and antioxidant enzymes in synovial fluid of patients with primary and secondary osteoarthritis of the knee joint","volume":"14","author":"Ostalowska","year":"2006","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.biopha.2020.110452_bib0135","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1186\/s13075-015-0774-3","article-title":"Histone deacetylase inhibition activates Nrf2 and protects against osteoarthritis","volume":"17","author":"Cai","year":"2015","journal-title":"Arthritis Res. Ther."},{"issue":"13","key":"10.1016\/j.biopha.2020.110452_bib0140","doi-asserted-by":"crossref","first-page":"6641","DOI":"10.1074\/jbc.M115.693523","article-title":"Oxidative stress promotes peroxiredoxin hyperoxidation and attenuates pro-survival signaling in aging chondrocytes","volume":"291","author":"Collins","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.biopha.2020.110452_bib0145","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1002\/art.21387","article-title":"Extracellular superoxide dismutase and oxidant damage in osteoarthritis","volume":"52","author":"Regan","year":"2005","journal-title":"Arthritis Rheum."},{"issue":"8","key":"10.1016\/j.biopha.2020.110452_bib0150","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.joca.2017.07.020","article-title":"Parkin clearance of dysfunctional mitochondria regulates ROS levels and increases survival of human chondrocytes","volume":"26","author":"Ansari","year":"2018","journal-title":"Osteoarthr. Cartil."},{"issue":"Suppl 2","key":"10.1016\/j.biopha.2020.110452_bib0155","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1016\/S1063-4584(08)60008-4","article-title":"Osteoarthritis and nitric oxide","volume":"16","author":"Abramson","year":"2008","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.biopha.2020.110452_bib0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106612","article-title":"Imperatorin suppresses IL-1beta-induced iNOS expression via inhibiting ERK-MAPK\/AP1 signaling in primary human OA chondrocytes","volume":"85","author":"Ahmad","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.biopha.2020.110452_bib0165","first-page":"44","article-title":"The role of aging in the development of osteoarthritis","volume":"128","author":"Loeser","year":"2017","journal-title":"Trans. Am. Clin. Climatol. Assoc."},{"issue":"4","key":"10.1016\/j.biopha.2020.110452_bib0170","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00296-006-0247-8","article-title":"Increased oxidative stress and its relation with collagen metabolism in knee osteoarthritis","volume":"27","author":"Altindag","year":"2007","journal-title":"Rheumatol. Int."},{"issue":"7","key":"10.1016\/j.biopha.2020.110452_bib0175","first-page":"412","article-title":"Ageing and the pathogenesis of osteoarthritis, Nature reviews","volume":"12","author":"Loeser","year":"2016","journal-title":"Rheumatology"},{"issue":"4","key":"10.1016\/j.biopha.2020.110452_bib0180","first-page":"324","article-title":"Reactive oxygen species and superoxide dismutases: role in joint diseases, Joint, bone","volume":"74","author":"Afonso","year":"2007","journal-title":"spine : revue du rhumatisme"},{"issue":"11","key":"10.1016\/j.biopha.2020.110452_bib0185","doi-asserted-by":"crossref","first-page":"26035","DOI":"10.3390\/ijms161125943","article-title":"Chondrocyte apoptosis in the pathogenesis of osteoarthritis","volume":"16","author":"Hwang","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.biopha.2020.110452_bib0190","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1002\/art.11338","article-title":"Increased oxidative stress with aging reduces chondrocyte survival: correlation with intracellular glutathione levels","volume":"48","author":"Carlo","year":"2003","journal-title":"Arthritis Rheum."},{"issue":"11","key":"10.1016\/j.biopha.2020.110452_bib0195","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1002\/ijc.23192","article-title":"Chronic inflammation and oxidative stress in human carcinogenesis","volume":"121","author":"Federico","year":"2007","journal-title":"Int. J. Cancer"},{"issue":"1","key":"10.1016\/j.biopha.2020.110452_bib0200","first-page":"37","article-title":"Chronic inflammatory systemic diseases: an evolutionary trade-off between acutely beneficial but chronically harmful programs","volume":"2016","author":"Straub","year":"2016","journal-title":"Evolution med. Public Health"},{"issue":"1","key":"10.1016\/j.biopha.2020.110452_bib0205","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/03008207.2016.1208655","article-title":"Inflammation and epigenetic regulation in osteoarthritis","volume":"58","author":"Shen","year":"2017","journal-title":"Connect. Tissue Res."},{"issue":"11","key":"10.1016\/j.biopha.2020.110452_bib0210","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1016\/j.joca.2015.01.008","article-title":"Aging-related inflammation in osteoarthritis","volume":"23","author":"Greene","year":"2015","journal-title":"Osteoarthr. Cartil."},{"issue":"5","key":"10.1016\/j.biopha.2020.110452_bib0215","first-page":"57","article-title":"Innate inflammation and synovial macrophages in osteoarthritis pathophysiology","volume":"37","author":"Griffin","year":"2019","journal-title":"Clin. Exp. Rheumatol."},{"issue":"5","key":"10.1016\/j.biopha.2020.110452_bib0220","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/BOR.0b013e328349c2b1","article-title":"Inflammation in osteoarthritis","volume":"23","author":"Goldring","year":"2011","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.biopha.2020.110452_bib0225","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.freeradbiomed.2017.02.041","article-title":"Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS\/ERK\/Nrf2 signaling pathways in human Osteoarthritis chondrocytes","volume":"106","author":"Khan","year":"2017","journal-title":"Free Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.biopha.2020.110452_bib0230","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1002\/1529-0131(200006)43:6<1300::AID-ANR12>3.0.CO;2-D","article-title":"Reduction of interleukin-17-induced inhibition of chondrocyte proteoglycan synthesis in intact murine articular cartilage by interleukin-4","volume":"43","author":"Lubberts","year":"2000","journal-title":"Arthritis Rheum."},{"issue":"5","key":"10.1016\/j.biopha.2020.110452_bib0235","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1136\/ard.2004.026088","article-title":"Implication of interleukin 18 in production of matrix metalloproteinases in articular chondrocytes in arthritis: direct effect on chondrocytes may not be pivotal","volume":"64","author":"Dai","year":"2005","journal-title":"Ann. Rheum. Dis."},{"issue":"3","key":"10.1016\/j.biopha.2020.110452_bib0240","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1155\/2013\/176278","article-title":"Serum interleukin-15 levels are associated with severity of pain in patients with knee osteoarthritis","volume":"35","author":"Sun","year":"2013","journal-title":"Dis. Markers"},{"issue":"5","key":"10.1016\/j.biopha.2020.110452_bib0245","doi-asserted-by":"crossref","first-page":"e460","DOI":"10.3928\/01477447-20140430-57","article-title":"Tissue levels of leukemia inhibitory factor vary by osteoarthritis grade","volume":"37","author":"Jiang","year":"2014","journal-title":"Orthopedics"},{"issue":"1","key":"10.1016\/j.biopha.2020.110452_bib0250","first-page":"33","article-title":"Role of proinflammatory cytokines in the pathophysiology of osteoarthritis, Nature reviews","volume":"7","author":"Kapoor","year":"2011","journal-title":"Rheumatology"},{"issue":"12","key":"10.1016\/j.biopha.2020.110452_bib0255","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.3899\/jrheum.080346","article-title":"The interleukin 1beta pathway in the pathogenesis of osteoarthritis","volume":"35","author":"Daheshia","year":"2008","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.biopha.2020.110452_bib0260","doi-asserted-by":"crossref","first-page":"27611","DOI":"10.1038\/srep27611","article-title":"Interleukin-1beta induced stress granules sequester COX-2 mRNA and regulates its stability and translation in human OA chondrocytes","volume":"6","author":"Ansari","year":"2016","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.biopha.2020.110452_bib0265","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1093\/rheumatology\/kes363","article-title":"Delphinidin inhibits IL-1beta-induced activation of NF-kappaB by modulating the phosphorylation of IRAK-1(Ser376) in human articular chondrocytes","volume":"52","author":"Haseeb","year":"2013","journal-title":"Rheumatology"},{"issue":"3","key":"10.1016\/j.biopha.2020.110452_bib0270","doi-asserted-by":"crossref","first-page":"R93","DOI":"10.1186\/ar3368","article-title":"Epigallocatechin-3-gallate suppresses the global interleukin-1beta-induced inflammatory response in human chondrocytes","volume":"13","author":"Akhtar","year":"2011","journal-title":"Arthritis Res. Ther."},{"issue":"3","key":"10.1016\/j.biopha.2020.110452_bib0275","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/jcb.25750","article-title":"Sucrose, But Not Glucose, Blocks IL1-beta-Induced Inflammatory Response in Human Chondrocytes by Inducing Autophagy via AKT\/mTOR Pathway","volume":"118","author":"Khan","year":"2017","journal-title":"J. Cell. Biochem."},{"issue":"8","key":"10.1016\/j.biopha.2020.110452_bib0280","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1002\/art.20558","article-title":"Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice","volume":"50","author":"Glasson","year":"2004","journal-title":"Arthritis Rheum."},{"issue":"7033","key":"10.1016\/j.biopha.2020.110452_bib0285","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nature03369","article-title":"Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis","volume":"434","author":"Glasson","year":"2005","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.biopha.2020.110452_bib0290","doi-asserted-by":"crossref","first-page":"6706","DOI":"10.1074\/jbc.M708647200","article-title":"Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity","volume":"283","author":"Fushimi","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.biopha.2020.110452_bib0295","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20092260","article-title":"IL-1beta damages fibrocartilage and upregulates MMP-13 expression in Fibrochondrocytes in the condyle of the temporomandibular joint","volume":"20","author":"Tabeian","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.biopha.2020.110452_bib0300","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/ar411","article-title":"Production of interleukin-1 receptor antagonist by human articular chondrocytes","volume":"4","author":"Palmer","year":"2002","journal-title":"Arthritis Res."},{"key":"10.1016\/j.biopha.2020.110452_bib0305","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/561459","article-title":"The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis","volume":"2014","author":"Wojdasiewicz","year":"2014","journal-title":"Mediators Inflamm."},{"issue":"2","key":"10.1016\/j.biopha.2020.110452_bib0310","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1136\/ard.50.2.75","article-title":"In vivo studies of cartilage regeneration after damage induced by catabolin\/interleukin-1","volume":"50","author":"Page Thomas","year":"1991","journal-title":"Ann. Rheum. Dis."},{"issue":"2","key":"10.1016\/j.biopha.2020.110452_bib0315","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2174\/138945007779940061","article-title":"In vivo osteoarthritis target validation utilizing genetically-modified mice","volume":"8","author":"Glasson","year":"2007","journal-title":"Curr. Drug Targets"},{"issue":"12","key":"10.1016\/j.biopha.2020.110452_bib0320","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1002\/art.11355","volume":"48","author":"Clements","year":"2003","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.biopha.2020.110452_bib0325","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3389\/fphar.2017.00282","article-title":"Revisiting the role of Interleukin-1 pathway in osteoarthritis: Interleukin-1alpha and -1beta, and NLRP3 inflammasome are not involved in the pathological features of the murine menisectomy model of osteoarthritis","volume":"8","author":"Nasi","year":"2017","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.biopha.2020.110452_bib0330","first-page":"932","article-title":"Butein activates autophagy through AMPK\/TSC2\/ULK1\/mTOR pathway to inhibit IL-6 expression in IL-1beta stimulated human chondrocytes, cellular physiology and biochemistry : international journal of experimental cellular physiology","volume":"49","author":"Ansari","year":"2018","journal-title":"biochem. pharmacol."},{"issue":"4","key":"10.1016\/j.biopha.2020.110452_bib0335","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/art.40751","article-title":"Genetic inactivation of ZCCHC6 suppresses Interleukin-6 expression and reduces the severity of experimental osteoarthritis in mice","volume":"71","author":"Ansari","year":"2019","journal-title":"Arthritis Rheumatol."},{"issue":"2","key":"10.1016\/j.biopha.2020.110452_bib0340","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/jor.23262","article-title":"Harpagoside suppresses IL-6 expression in primary human osteoarthritis chondrocytes","volume":"35","author":"Haseeb","year":"2017","journal-title":"J. Orthop. Res."},{"issue":"7","key":"10.1016\/j.biopha.2020.110452_bib0345","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1002\/1529-0131(200107)44:7<1620::AID-ART285>3.0.CO;2-B","article-title":"Synergistic effects of glycoprotein 130 binding cytokines in combination with interleukin-1 on cartilage collagen breakdown","volume":"44","author":"Rowan","year":"2001","journal-title":"Arthritis Rheum."},{"issue":"2","key":"10.1016\/j.biopha.2020.110452_bib0350","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/13684730050515796","article-title":"Interleukin-6 and interleukin-8 levels in serum and synovial fluid of patients with osteoarthritis","volume":"6","author":"Kaneko","year":"2000","journal-title":"Cytokines Cell. Molecul. therapy"},{"issue":"4","key":"10.1016\/j.biopha.2020.110452_bib0355","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1136\/annrheumdis-2016-209757","article-title":"Systemic inhibition of IL-6\/Stat3 signalling protects against experimental osteoarthritis","volume":"76","author":"Latourte","year":"2017","journal-title":"Ann. Rheum. Dis."},{"issue":"9","key":"10.1016\/j.biopha.2020.110452_bib0360","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1002\/art.30451","article-title":"Interleukin-6 plays an essential role in hypoxia-inducible factor 2alpha-induced experimental osteoarthritic cartilage destruction in mice","volume":"63","author":"Ryu","year":"2011","journal-title":"Arthritis Rheum."},{"issue":"1","key":"10.1016\/j.biopha.2020.110452_bib0365","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.joca.2004.09.011","article-title":"Male IL-6 gene knock out mice developed more advanced osteoarthritis upon aging","volume":"13","author":"de Hooge","year":"2005","journal-title":"Osteoarthr. Cartil."},{"issue":"2","key":"10.1016\/j.biopha.2020.110452_bib0370","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1124\/jpet.103.059220","article-title":"Green tea polyphenol epigallocatechin-3-gallate (EGCG) differentially inhibits interleukin-1 beta-induced expression of matrix metalloproteinase-1 and -13 in human chondrocytes","volume":"308","author":"Ahmed","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"5","key":"10.1016\/j.biopha.2020.110452_bib0375","doi-asserted-by":"crossref","first-page":"R195","DOI":"10.1186\/ar3166","article-title":"Pomegranate extract inhibits the interleukin-1beta-induced activation of MKK-3, p38alpha-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes","volume":"12","author":"Rasheed","year":"2010","journal-title":"Arthritis Res. Ther."},{"issue":"2","key":"10.1016\/j.biopha.2020.110452_bib0380","doi-asserted-by":"crossref","first-page":"305","DOI":"10.2174\/138945007779940115","article-title":"Inflammatory signaling in cartilage: MAPK and NF-kappaB pathways in chondrocytes and the use of inhibitors for research into pathogenesis and therapy of osteoarthritis","volume":"8","author":"Saklatvala","year":"2007","journal-title":"Curr. Drug Targets"},{"issue":"11","key":"10.1016\/j.biopha.2020.110452_bib0385","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1016\/j.biocel.2013.08.018","article-title":"The NF-kappaB signalling pathway in osteoarthritis","volume":"45","author":"Rigoglou","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"9","key":"10.1016\/j.biopha.2020.110452_bib0390","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11926-017-0679-z","article-title":"Wnt\/beta-catenin signaling in osteoarthritis and in other forms of arthritis","volume":"19","author":"Zhou","year":"2017","journal-title":"Curr. Rheumatol. Rep."},{"issue":"10","key":"10.1016\/j.biopha.2020.110452_bib0395","first-page":"550","article-title":"Wnt-beta-catenin signaling in the pathogenesis of osteoarthritis, Nature clinical practice","volume":"4","author":"Corr","year":"2008","journal-title":"Rheumatology"},{"issue":"3","key":"10.1016\/j.biopha.2020.110452_bib0400","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/labinvest.3700747","article-title":"Wnt\/beta-catenin signaling stimulates matrix catabolic genes and activity in articular chondrocytes: its possible role in joint degeneration","volume":"88","author":"Yuasa","year":"2008","journal-title":"Lab. Invest."},{"issue":"3","key":"10.1016\/j.biopha.2020.110452_bib0405","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.96308","article-title":"Inhibition of Wnt\/beta-catenin signaling ameliorates osteoarthritis in a murine model of experimental osteoarthritis","volume":"3","author":"Lietman","year":"2018","journal-title":"JCI Insight"},{"issue":"46","key":"10.1016\/j.biopha.2020.110452_bib0410","doi-asserted-by":"crossref","first-page":"31972","DOI":"10.1074\/jbc.M109.056838","article-title":"Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways","volume":"284","author":"Yin","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"20","key":"10.1016\/j.biopha.2020.110452_bib0415","doi-asserted-by":"crossref","first-page":"11727","DOI":"10.1074\/jbc.270.20.11727","article-title":"Involvement of reactive oxygen species in cytokine and growth factor induction of c-fos expression in chondrocytes","volume":"270","author":"Lo","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.biopha.2020.110452_bib0420","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/(SICI)1097-4644(19980401)69:1<19::AID-JCB3>3.0.CO;2-Y","article-title":"Interleukin-1 beta induction of c-fos and collagenase expression in articular chondrocytes: involvement of reactive oxygen species","volume":"69","author":"Lo","year":"1998","journal-title":"J. Cell. Biochem."},{"issue":"26","key":"10.1016\/j.biopha.2020.110452_bib0425","doi-asserted-by":"crossref","first-page":"15703","DOI":"10.1074\/jbc.271.26.15703","article-title":"Reactive oxygen species mediate cytokine activation of c-Jun NH2-terminal kinases","volume":"271","author":"Lo","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.biopha.2020.110452_bib0430","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1002\/art.39547","article-title":"JNK-2 controls aggrecan degradation in murine articular cartilage and the development of experimental osteoarthritis","volume":"68","author":"Ismail","year":"2016","journal-title":"Arthritis Rheumatol."},{"issue":"3","key":"10.1016\/j.biopha.2020.110452_bib0435","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/1759720X11436238","article-title":"Current nutraceuticals in the management of osteoarthritis: a review","volume":"4","author":"Akhtar","year":"2012","journal-title":"Ther. Adv. Musculoskelet. Dis."},{"issue":"5","key":"10.1016\/j.biopha.2020.110452_bib0440","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1002\/jsfa.8664","article-title":"Anti-inflammatory effects of polyphenols in arthritis","volume":"98","author":"Oliviero","year":"2018","journal-title":"J. Sci. Food Agric."},{"issue":"11","key":"10.1016\/j.biopha.2020.110452_bib0445","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s11926-018-0782-9","article-title":"Natural products for promoting joint health and managing osteoarthritis","volume":"20","author":"Henrotin","year":"2018","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.biopha.2020.110452_bib0450","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.biopha.2017.09.140","article-title":"A standardized extract of Butea monosperma (Lam.) flowers suppresses the IL-1beta-induced expression of IL-6 and matrix-metalloproteases by activating autophagy in human osteoarthritis chondrocytes","volume":"96","author":"Ansari","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2020.110452_bib0455","doi-asserted-by":"crossref","first-page":"43789","DOI":"10.1038\/srep43789","article-title":"A wogonin-rich-fraction of Scutellaria baicalensis root extract exerts chondroprotective effects by suppressing IL-1beta-induced activation of AP-1 in human OA chondrocytes","volume":"7","author":"Khan","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2020.110452_bib0460","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.lfs.2015.03.012","article-title":"Chondroprotective effects of a new glucosamine combination in rats: gene expression, biochemical and histopathological evaluation","volume":"130","author":"Ucuncu","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.biopha.2020.110452_bib0465","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1476-9255-5-9","article-title":"Bioavailable constituents\/metabolites of pomegranate (Punica granatum L) preferentially inhibit COX2 activity ex vivo and IL-1beta-induced PGE2 production in human chondrocytes in vitro","volume":"5","author":"Shukla","year":"2008","journal-title":"J. Inflamm."},{"issue":"9","key":"10.1016\/j.biopha.2020.110452_bib0470","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1093\/jn\/135.9.2096","article-title":"extract inhibits IL-1beta-induced expression of matrix metalloproteinases by inhibiting the activation of MAP kinases and NF-kappaB in human chondrocytes in vitro","volume":"135","author":"Ahmed","year":"2005","journal-title":"J. Nutr."},{"issue":"3","key":"10.1016\/j.biopha.2020.110452_bib0475","doi-asserted-by":"crossref","first-page":"R71","DOI":"10.1186\/ar2700","article-title":"Green tea polyphenol epigallocatechin-3-gallate inhibits advanced glycation end product-induced expression of tumor necrosis factor-alpha and matrix metalloproteinase-13 in human chondrocytes","volume":"11","author":"Rasheed","year":"2009","journal-title":"Arthritis Res. Ther."},{"issue":"6","key":"10.1016\/j.biopha.2020.110452_bib0480","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0127165","article-title":"Intra-articular injections of polyphenols protect articular cartilage from inflammation-induced degradation: suggesting a potential role in cartilage therapeutics","volume":"10","author":"Natarajan","year":"2015","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.biopha.2020.110452_bib0485","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1186\/s13075-014-0508-y","article-title":"Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse post-traumatic osteoarthritis model","volume":"16","author":"Leong","year":"2014","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.biopha.2020.110452_bib0490","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3389\/fphar.2013.00051","article-title":"Epigallocatechin-3-gallate reduces inflammation induced by calcium pyrophosphate crystals in vitro","volume":"4","author":"Oliviero","year":"2013","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.biopha.2020.110452_bib0495","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/j.biopha.2018.05.003","article-title":"Quercetin attenuates mitochondrial dysfunction and biogenesis via upregulated AMPK\/SIRT1 signaling pathway in OA rats","volume":"103","author":"Qiu","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"7","key":"10.1016\/j.biopha.2020.110452_bib0500","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1002\/jor.22339","article-title":"EGb761 inhibits inflammatory responses in human chondrocytes and shows chondroprotection in osteoarthritic rat knee","volume":"31","author":"Chen","year":"2013","journal-title":"J. Orthop. Res."},{"issue":"10","key":"10.1016\/j.biopha.2020.110452_bib0505","doi-asserted-by":"crossref","first-page":"18192","DOI":"10.1002\/jcp.28452","article-title":"Quercetin attenuates oxidative stress-induced apoptosis via SIRT1\/AMPK-mediated inhibition of ER stress in rat chondrocytes and prevents the progression of osteoarthritis in a rat model","volume":"234","author":"Feng","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.biopha.2020.110452_bib0510","article-title":"Intra-articular delivery of quercetin using thermosensitive hydrogel attenuate cartilage degradation in an osteoarthritis rat model","author":"Mok","year":"2018","journal-title":"Cartilage"},{"key":"10.1016\/j.biopha.2020.110452_bib0515","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.freeradbiomed.2019.09.024","article-title":"Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages","volume":"145","author":"Hu","year":"2019","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.biopha.2020.110452_bib0520","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1159\/000495684","article-title":"Morin exhibits anti-inflammatory effects on IL-1beta-Stimulated human osteoarthritis chondrocytes by activating the Nrf2 signaling pathway","volume":"51","author":"Qu","year":"2018","journal-title":"cellular physiol. biochem."},{"issue":"2","key":"10.1016\/j.biopha.2020.110452_bib0525","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.intimp.2011.12.024","article-title":"Morin inhibits interleukin-1beta-induced nitric oxide and prostaglandin E2 production in human chondrocytes","volume":"12","author":"Chen","year":"2012","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.biopha.2020.110452_bib0530","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1258\/ebm.2011.011271","article-title":"Morin exerts antiosteoarthritic properties: an in vitro and in vivo study","volume":"237","author":"Chen","year":"2012","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.biopha.2020.110452_bib0535","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12263-016-0520-4","article-title":"Curcumin and tetrahydrocurcumin both prevent osteoarthritis symptoms and decrease the expressions of pro-inflammatory cytokines in estrogen-deficient rats","volume":"11","author":"Park","year":"2016","journal-title":"Genes Nutr."},{"issue":"1","key":"10.1016\/j.biopha.2020.110452_bib0540","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s13075-016-1025-y","article-title":"Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model","volume":"18","author":"Zhang","year":"2016","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.biopha.2020.110452_bib0545","doi-asserted-by":"crossref","DOI":"10.1016\/j.semarthrit.2018.03.001","article-title":"Efficacy of curcumin and Boswellia for knee osteoarthritis: systematic review and meta-analysis","author":"Bannuru","year":"2018","journal-title":"Seminars in Arthritis and Rheumatism"},{"key":"10.1016\/j.biopha.2020.110452_bib0550","article-title":"Oral administration of a chemically modified curcumin, TRB-N0224, reduced inflammatory cytokines and cartilage Erosion in a rabbit ACL transection injury model","author":"Coury","year":"2018","journal-title":"Cartilage"},{"issue":"8","key":"10.1016\/j.biopha.2020.110452_bib0555","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s00011-010-0165-9","article-title":"The chondroprotective effects of ferulic acid on hydrogen peroxide-stimulated chondrocytes: inhibition of hydrogen peroxide-induced pro-inflammatory cytokines and metalloproteinase gene expression at the mRNA level","volume":"59","author":"Chen","year":"2010","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.biopha.2020.110452_bib0560","doi-asserted-by":"crossref","DOI":"10.1002\/term.3031","article-title":"Resveratrol counteracts IL-1beta-mediated impairment of extracellular matrix deposition in 3D articular chondrocyte constructs","author":"Frischholz","year":"2020","journal-title":"J. Tissue Eng. Regen. Med."},{"issue":"6","key":"10.1016\/j.biopha.2020.110452_bib0565","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1007\/s00296-010-1720-y","article-title":"Effect of resveratrol on cartilage protection and apoptosis inhibition in experimental osteoarthritis of rabbit","volume":"32","author":"Wang","year":"2012","journal-title":"Rheumatol. Int."},{"issue":"1","key":"10.1016\/j.biopha.2020.110452_bib0570","first-page":"1493","article-title":"Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis","volume":"17","author":"Wei","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"5","key":"10.1016\/j.biopha.2020.110452_bib0575","doi-asserted-by":"crossref","first-page":"R167","DOI":"10.1186\/ar3127","article-title":"Chondroprotective effects and mechanisms of resveratrol in advanced glycation end products-stimulated chondrocytes","volume":"12","author":"Liu","year":"2010","journal-title":"Arthritis Res. Ther."},{"issue":"2-3","key":"10.1016\/j.biopha.2020.110452_bib0580","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ejphar.2011.10.015","article-title":"Resveratrol inhibits interleukin 1beta-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-kappaB activity","volume":"674","author":"Lei","year":"2012","journal-title":"Eur. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.biopha.2020.110452_bib0585","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1002\/jor.22859","article-title":"Intra-articular resveratrol injection prevents osteoarthritis progression in a mouse model by activating SIRT1 and thereby silencing HIF-2alpha","volume":"33","author":"Li","year":"2015","journal-title":"J. Orthop. Res."},{"issue":"9","key":"10.1016\/j.biopha.2020.110452_bib0590","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1007\/s10495-014-1012-1","article-title":"Resveratrol protects rabbit articular chondrocyte against sodium nitroprusside-induced apoptosis via scavenging ROS","volume":"19","author":"Liang","year":"2014","journal-title":"Apoptosis"},{"key":"10.1016\/j.biopha.2020.110452_bib0595","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/7659023","article-title":"Oral administration of resveratrol alleviates osteoarthritis pathology in C57BL\/6J mice model induced by a high-fat diet","volume":"2017","author":"Jiang","year":"2017","journal-title":"Mediators Inflamm."},{"issue":"3","key":"10.1016\/j.biopha.2020.110452_bib0600","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19030686","article-title":"Potential health benefits of olive oil and plant polyphenols","volume":"19","author":"Gorzynik-Debicka","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.biopha.2020.110452_bib0605","doi-asserted-by":"crossref","first-page":"255","DOI":"10.5312\/wjo.v9.i11.255","article-title":"Recently highlighted nutraceuticals for preventive management of osteoarthritis","volume":"9","author":"Ravalli","year":"2018","journal-title":"World J. Orthop."},{"issue":"12","key":"10.1016\/j.biopha.2020.110452_bib0610","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17122042","article-title":"Nutraceutical supplements in the management and prevention of osteoarthritis","volume":"17","author":"Castrogiovanni","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.biopha.2020.110452_bib0615","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.bbagen.2016.03.002","article-title":"Hydroxytyrosol prevents chondrocyte death under oxidative stress by inducing autophagy through sirtuin 1-dependent and -independent mechanisms","volume":"1860","author":"Cetrullo","year":"2016","journal-title":"Biochim. Biophys. Acta."},{"issue":"2","key":"10.1016\/j.biopha.2020.110452_bib0620","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00394-018-1632-2","article-title":"Physical activity and Mediterranean diet based on olive tree phenolic compounds from two different geographical areas have protective effects on early osteoarthritis, muscle atrophy and hepatic steatosis","volume":"58","author":"Szychlinska","year":"2019","journal-title":"Eur. J. Nutr."},{"issue":"12","key":"10.1016\/j.biopha.2020.110452_bib0625","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1016\/j.jnutbio.2013.07.007","article-title":"Extra-virgin olive oil diet and mild physical activity prevent cartilage degeneration in an osteoarthritis model: an in vivo and in vitro study on lubricin expression","volume":"24","author":"Musumeci","year":"2013","journal-title":"J. Nutr. Biochem."},{"issue":"9","key":"10.1016\/j.biopha.2020.110452_bib0630","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.jnutbio.2006.11.006","article-title":"Genistein reduces the production of proinflammatory molecules in human chondrocytes","volume":"18","author":"Hooshmand","year":"2007","journal-title":"J. Nutr. Biochem."},{"issue":"4","key":"10.1016\/j.biopha.2020.110452_bib0635","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s10787-017-0432-2","article-title":"Java Tea (Orthosiphon stamineus) protected against osteoarthritis by mitigating inflammation and cartilage degradation: a preclinical study","volume":"26","author":"Bokhari","year":"2018","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.biopha.2020.110452_bib0640","doi-asserted-by":"crossref","first-page":"33527","DOI":"10.1038\/srep33527","article-title":"Olive and grape seed extract prevents post-traumatic osteoarthritis damages and exhibits in vitro anti IL-1beta activities before and after oral consumption","volume":"6","author":"Mevel","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.biopha.2020.110452_bib0645","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.joca.2014.08.016","article-title":"Oleuropein or rutin consumption decreases the spontaneous development of osteoarthritis in the Hartley guinea pig","volume":"23","author":"Horcajada","year":"2015","journal-title":"Osteoarthr. Cartil."},{"issue":"12","key":"10.1016\/j.biopha.2020.110452_bib0650","first-page":"8797","article-title":"Chlorogenic acid suppresses interleukin-1beta-induced inflammatory mediators in human chondrocytes","volume":"7","author":"Chen","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.biopha.2020.110452_bib0655","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1186\/1472-6882-12-256","article-title":"Standardized butanol fraction of WIN-34B suppresses cartilage destruction via inhibited production of matrix metalloproteinase and inflammatory mediator in osteoarthritis human cartilage explants culture and chondrocytes","volume":"12","author":"Huh","year":"2012","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.biopha.2020.110452_bib0660","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.biopha.2018.04.183","article-title":"Chondroprotective effects of aqueous extract of Anthriscus sylvestris leaves on osteoarthritis in vitro and in vivo through MAPKs and NF-kappaB signaling inhibition","volume":"103","author":"Lee","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.biopha.2020.110452_bib0665","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/jmf.2017.0015","article-title":"Review on sustained relief of osteoarthritis symptoms with a proprietary extract from pine bark, pycnogenol","volume":"21","author":"Rohdewald","year":"2018","journal-title":"J. Med. Food"},{"issue":"8","key":"10.1016\/j.biopha.2020.110452_bib0670","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1002\/ptr.2461","article-title":"Effect of pine bark extract (Pycnogenol) on symptoms of knee osteoarthritis","volume":"22","author":"Cisar","year":"2008","journal-title":"Phytother. Res."},{"key":"10.1016\/j.biopha.2020.110452_bib0675","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2020.109136","article-title":"Stachydrine attenuates IL-1beta-induced inflammatory response in osteoarthritis chondrocytes through the NF-kappaB signaling pathway","volume":"326","author":"Wu","year":"2020","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.biopha.2020.110452_bib0680","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1472-6882-6-13","article-title":"The chrondoprotective actions of a natural product are associated with the activation of IGF-1 production by human chondrocytes despite the presence of IL-1beta","volume":"6","author":"Miller","year":"2006","journal-title":"BMC Complement. Altern. Med."},{"issue":"1","key":"10.1016\/j.biopha.2020.110452_bib0685","doi-asserted-by":"crossref","first-page":"17173","DOI":"10.1038\/s41598-018-35455-8","article-title":"Identifying chondroprotective diet-derived bioactives and investigating their synergism","volume":"8","author":"Davidson","year":"2018","journal-title":"Sci. Rep."},{"issue":"3-4","key":"10.1016\/j.biopha.2020.110452_bib0690","first-page":"268","article-title":"Suppression of cartilage degradation by zingerone involving the p38 and JNK MAPK signaling pathway","volume":"83","author":"Ruangsuriya","year":"2017","journal-title":"Planta Med."},{"issue":"12","key":"10.1016\/j.biopha.2020.110452_bib0695","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1006\/cyto.1999.0505","article-title":"Differential effects of IL-8, LIF (pro-inflammatory) and IL-11 (anti-inflammatory) on TNF-alpha-induced PGE(2)release and on signalling pathways in human OA synovial fibroblasts","volume":"11","author":"Alaaeddine","year":"1999","journal-title":"Cytokine"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220306454?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220306454?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:13:12Z","timestamp":1760098392000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332220306454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":139,"alternative-id":["S0753332220306454"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110452","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110452","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"110452"}}