{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:23:58Z","timestamp":1793741038603,"version":"4.6.1"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:00:00Z","timestamp":1594684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2018ZX09201017-005"],"award-info":[{"award-number":["2018ZX09201017-005"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2018ZX09711001-002-001"],"award-info":[{"award-number":["2018ZX09711001-002-001"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2018ZX09735006"],"award-info":[{"award-number":["2018ZX09735006"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703665"],"award-info":[{"award-number":["81703665"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773874"],"award-info":[{"award-number":["81773874"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903807"],"award-info":[{"award-number":["81903807"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973476"],"award-info":[{"award-number":["81973476"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.biopha.2020.110524","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T04:48:09Z","timestamp":1600922889000},"page":"110524","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["In vivo hepatotoxicity screening of different extracts, components, and constituents of Polygoni Multiflori Thunb. in zebrafish (Danio rerio) larvae"],"prefix":"10.1016","volume":"131","author":[{"given":"Hong-Ying","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Bo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Fang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai-Xia","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Ting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Fei","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Yu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Long","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Tao","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang-Cheng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2020.110524_bib0005","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jep.2005.08.054","article-title":"Protective effect of Polygonum multiflorum Thunb on amyloid \u03b2-peptide 25\u201335 induced cognitive deficits in mice","volume":"104","author":"Um","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2020.110524_bib0010","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jpba.2017.03.016","article-title":"Rapid profiling and pharmacokinetic studies of major compounds in crude extract from Polygonum multiflorum by UHPLC-Q-TOF-MS and UPLC\u2013MS\/MS","volume":"140","author":"Wang","year":"2017","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.biopha.2020.110524_bib0015","doi-asserted-by":"crossref","first-page":"364","DOI":"10.3389\/fphar.2018.00364","article-title":"Polygonum multiflorum Thunb.: a review on chemical analysis, processing mechanism, quality evaluation, and hepatotoxicity","volume":"9","author":"Liu","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.biopha.2020.110524_bib0020","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1080\/10286020.2016.1171758","article-title":"Polygonumnolides C1-C4; minor dianthrone glycosides from the roots of Polygonum multiflorum Thunb","volume":"18","author":"Yang","year":"2016","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.biopha.2020.110524_bib0025","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.fitote.2016.11.009","article-title":"a-glucosidase inhibitors extracted from the roots of Polygonum multiflorum Thunb","volume":"117","author":"Yang","year":"2017","journal-title":"Fitoterapia"},{"key":"10.1016\/j.biopha.2020.110524_bib0030","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s12272-016-0816-7","article-title":"Polygonumnolides A1\u2013B3, minor dianthrone derivatives from the roots of Polygonum multiflorum Thunb","volume":"41","author":"Yang","year":"2018","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.biopha.2020.110524_bib0035","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jpba.2019.03.049","article-title":"Characterization and identification of the chemical constituents of Polygonum multiflorum Thunb. by high-performance liquid chromatography coupled with ultraviolet detection and linear ion trap FT-ICR hybrid mass spectrometry","volume":"172","author":"Yang","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.biopha.2020.110524_bib0040","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.jep.2014.03.042","article-title":"In vitro effects of active components of Polygonum multiflorum Radix on enzymes involved in the lipid metabolism","volume":"153","author":"Wang","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2020.110524_bib0045","doi-asserted-by":"crossref","first-page":"112232","DOI":"10.1016\/j.jep.2019.112232","article-title":"Inflammation inhibition and gut microbiota regulation by TSG to combat atherosclerosis in ApoE-\/- mice","volume":"247","author":"Li","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2020.110524_bib0050","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ejphar.2017.05.037","article-title":"Current pharmacological developments in 2,3,4\u2019,5-tetrahydroxystilbene 2-O-\u03b2-D-glucoside (TSG)","volume":"811","author":"Wu","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2020.110524_bib0055","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1016\/j.foodchem.2007.03.022","article-title":"Antioxidant activity of stilbene glycoside from Polygonum multiflorum Thunb in vivo","volume":"104","author":"Lv","year":"2007","journal-title":"Food Chem."},{"key":"10.1016\/j.biopha.2020.110524_bib0060","doi-asserted-by":"crossref","first-page":"S356","DOI":"10.1016\/S0168-8278(08)60953-8","article-title":"951 Twelve cases of toxic hepatitis related to the root of Polygonum multiflorum Thunb","volume":"48","author":"Min","year":"2008","journal-title":"J. Hepatol."},{"key":"10.1016\/j.biopha.2020.110524_bib0065","doi-asserted-by":"crossref","first-page":"W30","DOI":"10.7326\/0003-4819-140-7-200404060-00042-w3","article-title":"New case of acute hepatitis following the consumption of Shou Wu Pian, a Chinese herbal product derived from Polygonum multiflorum","volume":"140","author":"Mazzanti","year":"2004","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.biopha.2020.110524_bib0070","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1046\/j.1440-1746.2001.02309.x","article-title":"Acute hepatitis induced by Shou-Wu-Pian, a herbal product derived from Polygonum multiflorum","volume":"16","author":"Park","year":"2001","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.biopha.2020.110524_bib0075","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ctim.2013.12.008","article-title":"Eighteen cases of liver injury following ingestion of Polygonum multiflorum","volume":"22","author":"Dong","year":"2014","journal-title":"Complement. Ther. Med."},{"key":"10.1016\/j.biopha.2020.110524_bib0080","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jep.2014.11.009","article-title":"Traditional usages, botany, phytochemistry, pharmacology and toxicology of Polygonum multiflorum Thunb.: a review","volume":"159","author":"Lin","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2020.110524_bib0085","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.jpba.2018.11.034","article-title":"Pharmacokinetic studies unveiled the drug\u2013drug interaction between trans-2,3,5,4\u2032-tetrahydroxystilbene-2-O-\u03b2-d-glucopyranoside and emodin that may contribute to the idiosyncratic hepatotoxicity of Polygoni Multiflori Radix","volume":"164","author":"Xing","year":"2019","journal-title":"J. Pharm. Biomed."},{"key":"10.1016\/j.biopha.2020.110524_bib0090","first-page":"451","article-title":"Enhanced absorption and inhibited metabolism of emodin by 2, 3, 5, 4\u2032-tetrahydroxystilbene-2-O-\u03b2-D-glucopyranoside: possible mechanisms for Polygoni Multiflori Radix-induced liver injury","volume":"15","author":"Yu","year":"2017","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.biopha.2020.110524_bib0095","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.bbrc.2016.03.084","article-title":"Rhein triggers apoptosis via induction of endoplasmic reticulum stress, caspase-4 and intracellular calcium in primary human hepatic HL-7702 cells","volume":"473","author":"KoraMagazi","year":"2016","journal-title":"Biochem. Biophys. Res. Co."},{"key":"10.1016\/j.biopha.2020.110524_bib0100","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s11655-017-2543-9","article-title":"Idiosyncratic drug-induced liver injury linked to Polygonum multiflorum: a case study by pharmacognosy","volume":"23","author":"Li","year":"2017","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.biopha.2020.110524_bib0105","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1038\/aps.2017.32","article-title":"Cis-stilbene glucoside in Polygonum multiflorum induces immunological idiosyncratic hepatotoxicity in LPS-treated rats by suppressing PPAR-\u03b3","volume":"38","author":"Meng","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.biopha.2020.110524_bib0110","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.biopha.2018.01.033","article-title":"Acute toxicity screening of different extractions, components and constituents ofPolygonum multiflorum Thunb. on zebrafish (Danio rerio) embryos in vivo","volume":"99","author":"Yang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2020.110524_bib0115","doi-asserted-by":"crossref","first-page":"125129","DOI":"10.1016\/j.chemosphere.2019.125129","article-title":"Tebuconazole induced oxidative stress related hepatotoxicity in adult and larval zebrafish (Danio rerio)","volume":"241","author":"Li","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.biopha.2020.110524_bib0120","doi-asserted-by":"crossref","first-page":"125941","DOI":"10.1016\/j.chemosphere.2020.125941","article-title":"Thiophanate-methyl induces severe hepatotoxicity in zebrafish","volume":"248","author":"Jia","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.biopha.2020.110524_bib0125","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.toxlet.2019.02.007","article-title":"Aloe emodin induces hepatotoxicity by activating NF-\u03baB inflammatory pathway and P53 apoptosis pathway in zebrafish","volume":"306","author":"Quan","year":"2019","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.biopha.2020.110524_bib0130","doi-asserted-by":"crossref","first-page":"D152","DOI":"10.1093\/nar\/gkq1027","article-title":"miRBase: integrating microRNA annotation and deep-sequencing data","volume":"39","author":"Kozomara","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.biopha.2020.110524_bib0135","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jhep.2014.10.004","article-title":"miR-122 \u2013 a key factor and therapeutic target in liver disease","volume":"62","author":"Bandiera","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.biopha.2020.110524_bib0140","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ajg.2015.06.004","article-title":"Relation of ALT and AST levels to the histopathological changes in liver biopsies of patients with chronic hepatitis C genotype 4","volume":"16","author":"Khattab","year":"2015","journal-title":"Arab J. Gastroenterol."},{"key":"10.1016\/j.biopha.2020.110524_bib0145","doi-asserted-by":"crossref","first-page":"547","DOI":"10.5604\/01.3001.0012.0916","article-title":"New insights about albumin and liver disease","volume":"17","author":"Carvalho","year":"2018","journal-title":"Ann. Hepatol."},{"key":"10.1016\/j.biopha.2020.110524_bib0150","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/hep.510230104","article-title":"The hepatic microcirculation in the isolated perfused human liver","volume":"23","author":"Villeneuve","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.biopha.2020.110524_bib0155","first-page":"221","article-title":"Experimental methods in hepatology: Guidelines of the German Association for the Study of the Liver (GASL). Liver perfusion - Technique and applications","volume":"35","author":"vom Dahl","year":"1997","journal-title":"Z. Gastroenterol."},{"key":"10.1016\/j.biopha.2020.110524_bib0160","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.yexcr.2018.11.020","article-title":"Albumin uptake and distribution in the zebrafish liver as observed via correlative imaging","volume":"374","author":"Cheng","year":"2019","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.biopha.2020.110524_bib0165","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/9781118102138.ch8","article-title":"Hepatotoxicity testing in larval zebrafish","volume":"8","author":"Hill","year":"2011","journal-title":"Zebrafish"},{"key":"10.1016\/j.biopha.2020.110524_bib0170","doi-asserted-by":"crossref","first-page":"134490","DOI":"10.1016\/j.scitotenv.2019.134490","article-title":"DMSO effects larval zebrafish (Danio rerio) behavior, with additive and interaction effects when combined with positive controls","volume":"709","author":"Christou","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.biopha.2020.110524_bib0175","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3109\/15569543.2014.986282","article-title":"Study on early biomarkers of zebrafish liver injury induced by acetaminophen","volume":"34","author":"Guo","year":"2015","journal-title":"Toxin Rev."},{"key":"10.1016\/j.biopha.2020.110524_bib0180","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.biomaterials.2015.11.047","article-title":"A two-photon fluorescent sensor revealing drug-induced liver injury via tracking \u03b3-glutamyltranspeptidase (GGT) level in vivo","volume":"80","author":"Zhang","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.biopha.2020.110524_bib0185","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.toxlet.2014.06.844","article-title":"Gene expression markers in the zebrafish embryo reflect a hepatotoxic response in animal models and humans","volume":"230","author":"Driessen","year":"2014","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.biopha.2020.110524_bib0190","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.vascn.2012.10.003","article-title":"A zebrafish phenotypic assay for assessing drug-induced hepatotoxicity","volume":"67","author":"He","year":"2013","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.biopha.2020.110524_bib0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2019.105324","article-title":"Developmental toxicity and angiogenic defects of etoxazole exposed zebrafish (Danio rerio) larvae","volume":"217","author":"Park","year":"2019","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.biopha.2020.110524_bib0200","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.chemosphere.2019.05.261","article-title":"Developmental toxicity and alteration of gene expression in zebrafish embryo exposed to 6-benzylaminopurine","volume":"233","author":"Wang","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.biopha.2020.110524_bib0205","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1743-7075-5-23","article-title":"A high throughput live transparent animal bioassay to identify non-toxic small molecules or genes that regulate vertebrate fat metabolism for obesity drug development","volume":"5","author":"Jones","year":"2008","journal-title":"Nutr. Metab."},{"key":"10.1016\/j.biopha.2020.110524_bib0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125704","article-title":"Changes in lipid profiles induced by bisphenol A (BPA) in zebrafish eleutheroembryos during the yolk sac absorption stage","volume":"246","author":"Mart\u00ednez","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.biopha.2020.110524_bib0215","article-title":"Carboxyl ester lipase is highly conserved in utilizing maternal supplied lipids during early development of zebrafish and human","volume":"1865","author":"Qiu","year":"2020","journal-title":"Biochim. Biophys. Acta. Mol. Cell. Biol. Lipids"},{"key":"10.1016\/j.biopha.2020.110524_bib0220","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.fsi.2019.11.066","article-title":"Effects of spinetoram on the developmental toxicity and immunotoxicity of zebrafish","volume":"96","author":"Cheng","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.biopha.2020.110524_bib0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113517","article-title":"Monobutyl phthalate (MBP) can dysregulate the antioxidant system and induce apoptosis of zebrafish liver","volume":"257","author":"Jiao","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.biopha.2020.110524_bib0230","first-page":"1747","article-title":"Toxic effects of water extract of Genkwa Flos on liver of juvenile zebra fish","volume":"34","author":"Li","year":"2019","journal-title":"Chin. J. Trad. Chin. Med. Pharm."},{"key":"10.1016\/j.biopha.2020.110524_bib0235","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/1473578","article-title":"Expression of miRNA-122 induced by liver toxicants in zebrafish","volume":"2016","author":"Nam","year":"2016","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.biopha.2020.110524_bib0240","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.chemosphere.2019.04.026","article-title":"Mechanism of isoniazid-induced hepatotoxicity in zebrafish larvae: activation of ROS-mediated ERS, apoptosis and the Nrf2 pathway","volume":"227","author":"Jia","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.biopha.2020.110524_bib0245","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/pca.963","article-title":"Identification and determination of the major constituents in traditional Chinese medicinal plant Polygonum multiflorum Thunb by HPLC coupled with PAD and ESI\/MS","volume":"18","author":"Yi","year":"2007","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.biopha.2020.110524_bib0250","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1055\/s-0028-1088349","article-title":"Maillard reaction involved in the steaming process of the root of Polygonum multiflorum","volume":"75","author":"Liu","year":"2009","journal-title":"Planta Med."},{"key":"10.1016\/j.biopha.2020.110524_bib0255","first-page":"37","article-title":"Influence of high pressure processing on contents of active ingredients from Polygoni Multiflori Radix","volume":"19","author":"Liu","year":"2013","journal-title":"Chin. J. Exp. Trad. Med. Formulae"},{"key":"10.1016\/j.biopha.2020.110524_bib0260","first-page":"78","article-title":"Effect of high pressure processing on stilbene glycoside and phosphatidylcholine in Polygoni Multiflori Radix","volume":"42","author":"Xu","year":"2011","journal-title":"Chin. Trad. Herb. Drugs"},{"key":"10.1016\/j.biopha.2020.110524_bib0265","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.jep.2011.07.055","article-title":"Hepatoxicity of major constituents and extractions of Radix Polygoni Multiflori and Radix Polygoni Multiflori Praeparata","volume":"137","author":"Yu","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2020.110524_bib0270","first-page":"66","article-title":"Content changes of 5 components in Polygohum muhiflorum during processing","volume":"18","author":"Chen","year":"2012","journal-title":"Chin. J. Exp. Trad. Med. Formulae"},{"key":"10.1016\/j.biopha.2020.110524_bib0275","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.fitote.2011.12.012","article-title":"Toxicity of raw and processed roots of Polygonum multiflorum","volume":"83","author":"Wu","year":"2012","journal-title":"Fitoterapia"},{"key":"10.1016\/j.biopha.2020.110524_bib0280","first-page":"2414","article-title":"Quality changes of root of Polygonum multiflorum during a nine-time repeat of the steaming and sun-drying process","volume":"26","author":"Yang","year":"2015","journal-title":"Lishizhen Med. Mater. Med. Res."},{"key":"10.1016\/j.biopha.2020.110524_bib0285","first-page":"704","article-title":"Characteristic chemical components in unprocessed and processed Polygonum multiflorum","volume":"14","author":"Zhai","year":"2016","journal-title":"Cent. S. Pharm."},{"key":"10.1016\/j.biopha.2020.110524_bib0290","first-page":"2194","article-title":"Research on processing of Radix based on UPLC fingerprints and chemometrics Polygoni Multiflori based on UPLC fingerprints and chemometrics","volume":"32","author":"Sun","year":"2017","journal-title":"Chin. J. Trad. Chin. Med. Pharm."},{"key":"10.1016\/j.biopha.2020.110524_bib0295","first-page":"1344","article-title":"Effect of processing time of Polygoni Multiflori Radix on content changes of 16 components","volume":"42","author":"Zhao","year":"2017","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"10.1016\/j.biopha.2020.110524_bib0300","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.taap.2018.09.029","article-title":"Emodin-induced hepatotoxicity was exacerbated by probenecid through inhibiting UGTs and MRP2","volume":"359","author":"Wu","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.biopha.2020.110524_bib0305","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jep.2009.04.018","article-title":"Assessment of the renal protection and hepatotoxicity of rhubarb extract in rats","volume":"124","author":"Wang","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2020.110524_bib0310","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jep.2017.03.046","article-title":"The assessment of the chronic hepatotoxicity induced by Polygoni Multiflori Radix in rats: a pilot study by using untargeted metabolomics method","volume":"203","author":"Xia","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2020.110524_bib0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109531","article-title":"Hepatotoxicity and mechanism study of chrysophanol-8-O-glucoside in vitro","volume":"120","author":"Lin","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2020.110524_bib0320","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.fct.2017.10.033","article-title":"Gallic acid, a natural polyphenol, protects against tert -butyl hydroperoxide- induced hepatotoxicity by activating ERK-Nrf2-Keap1-mediated antioxidative response","volume":"119","author":"Feng","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2020.110524_bib0325","first-page":"694","article-title":"Study on the effect of Polygonum multiflorum and its main components on normal human L02 hepatocyte injury","volume":"35","author":"Song","year":"2016","journal-title":"Beijing J. Trad. Chin. Med."},{"key":"10.1016\/j.biopha.2020.110524_bib0330","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.phymed.2016.08.001","article-title":"Sennoside A derived from the traditional Chinese medicine plant Rheum L., is a new dual HIV-1 inhibitor effective on HIV-1 replication","volume":"23","author":"Esposito","year":"2016","journal-title":"Phytomedicine"},{"key":"10.1016\/j.biopha.2020.110524_bib0335","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.toxlet.2020.01.026","article-title":"Classification, hepatotoxic mechanisms, and targets of the risk ingredients in traditional Chinese medicine-induced liver injury","volume":"323","author":"Pan","year":"2020","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.biopha.2020.110524_bib0340","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ddmod.2017.04.003","article-title":"Systems pharmacology of hepatic metabolism in zebrafish larvae","volume":"22","author":"van Wijk","year":"2016","journal-title":"Drug Discov. Today Dis. Models"},{"key":"10.1016\/j.biopha.2020.110524_bib0345","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.jhazmat.2019.01.079","article-title":"Evaluation of the developmental toxicity of 2,7-dibromocarbazole to zebrafish based on transcriptomics assay","volume":"368","author":"Ji","year":"2019","journal-title":"J. Hazard. Mater."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220307174?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220307174?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T18:37:30Z","timestamp":1766083050000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332220307174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":69,"alternative-id":["S0753332220307174"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110524","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vivo hepatotoxicity screening of different extracts, components, and constituents of Polygoni Multiflori Thunb. in zebrafish (Danio rerio) larvae","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110524","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"110524"}}