{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T19:55:33Z","timestamp":1793908533808,"version":"4.8.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:00:00Z","timestamp":1594684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LZ17H270001"],"award-info":[{"award-number":["LZ17H270001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.biopha.2020.110527","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T23:54:10Z","timestamp":1595030050000},"page":"110527","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Guanxinshutong capsule ameliorates cardiac function and architecture following myocardial injury by modulating ventricular remodeling in rats"],"prefix":"10.1016","volume":"130","author":[{"given":"Jiaqi","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4349-9011","authenticated-orcid":false,"given":"Yuming","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyang","family":"Shou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minsun","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitong","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiehong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.biopha.2020.110527_bib0005","doi-asserted-by":"crossref","first-page":"e14275","DOI":"10.2196\/14275","article-title":"Investigating the use of mobile health interventions in vulnerable populations for cardiovascular disease management: scoping review","volume":"7","author":"Wali","year":"2019","journal-title":"JMIR Mhealth Uhealth"},{"issue":"6","key":"10.1016\/j.biopha.2020.110527_bib0010","doi-asserted-by":"crossref","first-page":"5093","DOI":"10.3892\/mmr.2016.5178","article-title":"Simvastatin ameliorates ventricular remodeling via the TGF-beta1 signaling pathway in rats following myocardial infarction, macrophage depletion in hypertensive rats accelerates development of cardiomyopathy","volume":"13","author":"Xiao","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.biopha.2020.110527_bib0015","series-title":"Ventricular Remodeling","author":"Selvanayagam","year":"2009"},{"issue":"1","key":"10.1016\/j.biopha.2020.110527_bib0020","first-page":"56","article-title":"Cardioprotective effect of saffron extract and safranal in isoproterenol-induced myocardial infarction in wistar rats","volume":"16","author":"Mehdizadeh","year":"2013","journal-title":"Iran. J. Basic Med. Sci."},{"issue":"25","key":"10.1016\/j.biopha.2020.110527_bib0025","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1161\/CIRCULATIONAHA.110.942268","article-title":"Molecular pathways underlying cardiac remodeling during pathophysiological stimulation","volume":"122","author":"Kehat","year":"2010","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.biopha.2020.110527_bib0030","doi-asserted-by":"crossref","first-page":"e233","DOI":"10.1016\/j.carpath.2009.12.002","article-title":"Remodeling of cardiac fibroblasts following myocardial infarction results in increased gap junction intercellular communication","volume":"19","author":"Zhang","year":"2010","journal-title":"Cardiovasc. Pathol."},{"issue":"7","key":"10.1016\/j.biopha.2020.110527_bib0035","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1016\/j.biomaterials.2010.11.008","article-title":"Integration of multiple cell-matrix interactions into alginate scaffolds for promoting cardiac tissue regeneration","volume":"32","author":"Sapir","year":"2011","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.biopha.2020.110527_bib0040","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/cvr\/cvz179","article-title":"N-cadherin overexpression enhances the reparative potency of human-induced pluripotent stem cell-derived cardiac myocytes in infarcted mouse hearts","volume":"116","author":"Lou","year":"2020","journal-title":"Cardiovasc. Res."},{"issue":"5","key":"10.1016\/j.biopha.2020.110527_bib0045","first-page":"4215","article-title":"Role of blocking ADAM10 hydrolysis site on N-cadherin by single-chain antibody in ventricular remodeling","volume":"14","author":"Li","year":"2017","journal-title":"Exp. Ther. Med."},{"issue":"6","key":"10.1016\/j.biopha.2020.110527_bib0050","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1083\/jcb.151.6.1193","article-title":"N-cadherin extracellular repeat 4 mediates epithelial to mesenchymal transition and increased motility","volume":"151","author":"Kim","year":"2001","journal-title":"J. Cell Biol."},{"issue":"3\u20134","key":"10.1016\/j.biopha.2020.110527_bib0055","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s12079-009-0070-6","article-title":"Thrombospondins in the heart: potential functions in cardiac remodeling","volume":"3","author":"Schellings","year":"2009","journal-title":"J. Cell Commun. Signal."},{"issue":"7","key":"10.1016\/j.biopha.2020.110527_bib0060","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/s41419-019-1718-7","article-title":"TLR9 is essential for HMGB1-mediated post-myocardial infarction tissue repair through affecting apoptosis, cardiac healing, and angiogenesis","volume":"10","author":"Liu","year":"2019","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.biopha.2020.110527_bib0065","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1161\/CIRCRESAHA.117.311769","article-title":"Induced pluripotent stem cell (iPSC)-derived extracellular vesicles are safer and more effective for cardiac repair than iPSCs","volume":"122","author":"Adamiak","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.biopha.2020.110527_bib0070","article-title":"Ghrelin ameliorates angiotensin II-Induced myocardial fibrosis by upregulating peroxisome proliferator-activated receptor gamma in young male rats","volume":"2018","author":"Wang","year":"2018","journal-title":"Biomed Res. Int."},{"issue":"1","key":"10.1016\/j.biopha.2020.110527_bib0075","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12968-018-0488-1","article-title":"Cardiovascular magnetic resonance evidence of myocardial fibrosis and its clinical significance in adolescent and adult patients with Ebstein\u2019s anomaly","volume":"20","author":"Yang","year":"2018","journal-title":"J. Cardiovasc. Magn. Reson."},{"issue":"2","key":"10.1016\/j.biopha.2020.110527_bib0080","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/ejhf.696","article-title":"Myocardial fibrosis: biomedical research from bench to bedside","volume":"19","author":"Gyongyosi","year":"2017","journal-title":"Eur. J. Heart Fail."},{"issue":"3","key":"10.1016\/j.biopha.2020.110527_bib0085","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1002\/j.2040-4603.2017.tb00771.x","article-title":"Cardiac fibrosis and arrhythmogenesis","volume":"7","author":"Nguyen","year":"2017","journal-title":"Compr. Physiol."},{"issue":"11","key":"10.1016\/j.biopha.2020.110527_bib0090","doi-asserted-by":"crossref","first-page":"e009915","DOI":"10.1161\/CIRCIMAGING.119.009915","article-title":"Recombinant tissue inhibitor subdues matrix metalloproteinases and produces novel images with new possibilities","volume":"12","author":"Schelbert","year":"2019","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"10.1016\/j.biopha.2020.110527_bib0095","article-title":"Effects of Chaihu-Shugan-San and Shen-Ling-Bai-Zhu-San on p38 MAPK Pathway in Kupffer Cells of Nonalcoholic Steatohepatitis","volume":"2014","author":"Yang","year":"2014","journal-title":"Evid. Complement. Alternat. Med."},{"key":"10.1016\/j.biopha.2020.110527_bib0100","article-title":"Effect of naoxintong capsules on the activities of CYP450 and metabolism of metoprolol tartrate in rats evaluated by probe cocktail and pharmacokinetic methods","volume":"2019","author":"Ouyang","year":"2019","journal-title":"Evid. Complement. Alternat. Med."},{"issue":"3","key":"10.1016\/j.biopha.2020.110527_bib0105","first-page":"225","article-title":"The effects of Guanxinshutong on protection of left ventricular function after acute myocardial infarction in rats","volume":"51","author":"Liang","year":"2012","journal-title":"Chin. J. Intern. Med."},{"issue":"2","key":"10.1016\/j.biopha.2020.110527_bib0110","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3724\/SP.J.1263.2011.11261","article-title":"Cardioprotective effects of Guanxinshutong (GXST) against myocardial ischemia\/ reperfusion injury in rats","volume":"9","author":"Liang","year":"2012","journal-title":"J. Geriatric Cardiol. Jgc"},{"issue":"4","key":"10.1016\/j.biopha.2020.110527_bib0115","first-page":"302","article-title":"Screening and analysis of key active constituents in Guanxinshutong capsule using mass spectrum and integrative network pharmacology","volume":"16","author":"Liu","year":"2018","journal-title":"Chin. J. Nat. Med."},{"issue":"3","key":"10.1016\/j.biopha.2020.110527_bib0120","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1161\/CIRCRESAHA.116.304510","article-title":"MicroRNA induced cardiac reprogramming in vivo: evidence for mature cardiac myocytes and improved cardiac function","volume":"116","author":"Jayawardena","year":"2015","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.biopha.2020.110527_bib0125","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1186\/s12906-019-2778-z","article-title":"Efficacy and safety of oral Guanxinshutong capsules in patients with stable angina pectoris in China: a prospective, multicenter, double-blind, placebo-controlled, randomized clinical trial","volume":"19","author":"Li","year":"2019","journal-title":"BMC Complement. Altern. Med."},{"issue":"9","key":"10.1016\/j.biopha.2020.110527_bib0130","doi-asserted-by":"crossref","DOI":"10.3390\/nu10091304","article-title":"Cardioprotective effects of nanoemulsions loaded with anti-inflammatory nutraceuticals against doxorubicin-induced cardiotoxicity","volume":"10","author":"Quagliariello","year":"2018","journal-title":"Nutrients"},{"issue":"5","key":"10.1016\/j.biopha.2020.110527_bib0135","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s10741-018-9716-x","article-title":"Role of cytokines and inflammation in heart function during health and disease","volume":"23","author":"Bartekova","year":"2018","journal-title":"Heart Fail. Rev."},{"issue":"4","key":"10.1016\/j.biopha.2020.110527_bib0140","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1056\/NEJM199007263230405","article-title":"Elevated circulating levels of tumor necrosis factor in severe chronic heart failure","volume":"323","author":"Levine","year":"1990","journal-title":"N. Engl. J. Med."},{"issue":"11","key":"10.1016\/j.biopha.2020.110527_bib0145","first-page":"5063","article-title":"Systemic inflammation is associated with myocardial fibrosis, diastolic dysfunction, and cardiac hypertrophy in patients with hypertrophic cardiomyopathy","volume":"9","author":"Fang","year":"2017","journal-title":"Am. J. Transl. Res."},{"issue":"5","key":"10.1016\/j.biopha.2020.110527_bib0150","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.jacc.2009.08.064","article-title":"Rac1-induced connective tissue growth factor regulates connexin 43 and N-cadherin expression in atrial fibrillation","volume":"55","author":"Adam","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"issue":"4","key":"10.1016\/j.biopha.2020.110527_bib0155","doi-asserted-by":"crossref","first-page":"e94722","DOI":"10.1371\/journal.pone.0094722","article-title":"Assembly of the cardiac intercalated disk during pre- and postnatal development of the human heart","volume":"9","author":"Arnold","year":"2014","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.biopha.2020.110527_bib0160","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/bit.10506","article-title":"Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomers","volume":"81","author":"Gopalan","year":"2003","journal-title":"Biotechnol. Bioeng."},{"issue":"8","key":"10.1016\/j.biopha.2020.110527_bib0165","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1161\/CIRCULATIONAHA.119.039767","article-title":"Endothelial forkhead box transcription factor P1 regulates pathological cardiac remodeling through transforming growth factor-beta1-endothelin-1 signal pathway","volume":"140","author":"Liu","year":"2019","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.biopha.2020.110527_bib0170","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1093\/eurheartj\/ehy188","article-title":"Deletion of delta-like 1 homologue accelerates fibroblast-myofibroblast differentiation and induces myocardial fibrosis","volume":"40","author":"Rodriguez","year":"2019","journal-title":"Eur. Heart J."},{"issue":"1","key":"10.1016\/j.biopha.2020.110527_bib0175","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1093\/eurheartj\/ehw119","article-title":"Hypercoagulability causes atrial fibrosis and promotes atrial fibrillation","volume":"38","author":"Spronk","year":"2017","journal-title":"Eur. Heart J."},{"issue":"1","key":"10.1016\/j.biopha.2020.110527_bib0180","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s11897-005-0002-6","article-title":"Disruptions and detours in the myocardial matrix highway and heart failure","volume":"2","author":"Deschamps","year":"2005","journal-title":"Curr. Heart Fail. Rep."},{"issue":"11","key":"10.1016\/j.biopha.2020.110527_bib0185","doi-asserted-by":"crossref","first-page":"E3611","DOI":"10.3390\/ijms19113611","article-title":"The role of TGF-\u03b2 signaling in lung cancer associated with idiopathic pulmonary fibrosis","volume":"19","author":"Akira","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2020.110527_bib0190","first-page":"46","article-title":"5-aminolaevulinic acid-based photodynamic therapy restrains pathological hyperplasia of fibroblasts","volume":"23","author":"Wang","year":"2017","journal-title":"Med. Sci. Monit. Int. Med. J. Exp. Clin. Res."},{"issue":"9","key":"10.1016\/j.biopha.2020.110527_bib0195","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1038\/jcbfm.2012.94","article-title":"Chronic cerebral hypoxia promotes arteriogenic remodeling events that can be identified by reduced endoglin (CD105) expression and a switch in \u03b21 integrins","volume":"32","author":"Boroujerdi","year":"2012","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.biopha.2020.110527_bib0200","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.3389\/fphar.2019.01142","article-title":"AFC1 compound attenuated MI\/R-induced ventricular remodeling via inhibiting PDGFR and STAT pathway","volume":"10","author":"Liu","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.biopha.2020.110527_bib0205","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.jtcvs.2012.05.018","article-title":"Optimized ventricular restraint therapy: adjustable restraint is superior to standard restraint in an ovine model of ischemic cardiomyopathy","volume":"145","author":"Lee","year":"2013","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"6","key":"10.1016\/j.biopha.2020.110527_bib0210","doi-asserted-by":"crossref","first-page":"e00442","DOI":"10.1002\/prp2.442","article-title":"Utility of glycosylated TIMP3 molecules: inhibition of MMPs and TACE to improve cardiac function in rat myocardial infarct model","volume":"6","author":"Chintalgattu","year":"2018","journal-title":"Pharmacol. Res. Perspect."},{"issue":"3","key":"10.1016\/j.biopha.2020.110527_bib0215","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.yjmcc.2007.11.013","article-title":"N-cadherin haploinsufficiency affects cardiac gap junctions and arrhythmic susceptibility","volume":"44","author":"Li","year":"2008","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"2","key":"10.1016\/j.biopha.2020.110527_bib0220","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jjcc.2016.10.004","article-title":"Evidence of epigenetic tags in cardiac fibrosis","volume":"69","author":"Grimaldi","year":"2017","journal-title":"J. Cardiol."},{"key":"10.1016\/j.biopha.2020.110527_bib0225","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/bs.apha.2017.08.002","article-title":"Matrix metalloproteinases, vascular remodeling, and vascular disease","volume":"81","author":"Wang","year":"2018","journal-title":"Adv. Pharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2020.110527_bib0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijcard.2003.06.039","article-title":"Cardiovascular pharmacotherapy and herbal medicines: the risk of drug interaction","volume":"98","author":"Izzo","year":"2005","journal-title":"Int. J. Cardiol."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220307204?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220307204?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T18:06:46Z","timestamp":1766081206000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332220307204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":46,"alternative-id":["S0753332220307204"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110527","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Guanxinshutong capsule ameliorates cardiac function and architecture following myocardial injury by modulating ventricular remodeling in rats","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110527","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"110527"}}