{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:37:54Z","timestamp":1792532274217,"version":"4.5.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970785"],"award-info":[{"award-number":["81970785"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.biopha.2020.110573","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T06:53:22Z","timestamp":1596178402000},"page":"110573","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["Therapeutic investigation of quercetin nanomedicine in a zebrafish model of diabetic retinopathy"],"prefix":"10.1016","volume":"130","author":[{"given":"Shuai","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2020.110573_bib0005","article-title":"Pericytes, inflammation, and diabetic retinopathy","author":"Spencer","year":"2019","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.biopha.2020.110573_bib0010","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00125-018-4711-2","article-title":"Global trends in diabetes complications: a review of current evidence","volume":"62","author":"Harding","year":"2019","journal-title":"Diabetologia"},{"key":"10.1016\/j.biopha.2020.110573_bib0015","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-022188","article-title":"Global prevalence of diabetic retinopathy: protocol for a systematic review and meta-analysis","volume":"9","author":"Cheloni","year":"2019","journal-title":"BMJ Open"},{"key":"10.1016\/j.biopha.2020.110573_bib0020","doi-asserted-by":"crossref","DOI":"10.1089\/jop.2019.0028","article-title":"Regression of serous macular detachment after intravitreal dexamethasone implant in patients with diabetic macular edema","author":"Ozdemir","year":"2019","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.biopha.2020.110573_bib0025","doi-asserted-by":"crossref","first-page":"364","DOI":"10.4093\/dmj.2018.0182","article-title":"Pathophysiology of diabetic retinopathy: the old and the new","volume":"42","author":"Kusuhara","year":"2018","journal-title":"Diabetes Metab. J."},{"key":"10.1016\/j.biopha.2020.110573_bib0030","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00592-007-0257-3","article-title":"Induction of hyperglycaemia in zebrafish (Danio rerio) leads to morphological changes in the retina","volume":"44","author":"Gleeson","year":"2007","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.biopha.2020.110573_bib0035","article-title":"Diabetic retinopathy: pathophysiology and treatments","volume":"19","author":"Wang","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2020.110573_bib0040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18092002","article-title":"Zebrafish as a model for the study of microvascular complications of diabetes and their mechanisms","volume":"18","author":"Heckler","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2020.110573_bib0045","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.18240\/ijo.2019.08.04","article-title":"Establishment of an adult zebrafish model of retinal neurodegeneration induced by NMDA","volume":"12","author":"Luo","year":"2019","journal-title":"Int. J. Ophthalmol."},{"key":"10.1016\/j.biopha.2020.110573_bib0050","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3389\/fcell.2018.00110","article-title":"Leveraging zebrafish to study retinal degenerations","volume":"6","author":"Angueyra","year":"2018","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.biopha.2020.110573_bib0055","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s40662-015-0026-2","article-title":"Epidemiology of diabetic retinopathy, diabetic macular edema and related vision loss","volume":"2","author":"Lee","year":"2015","journal-title":"Eye Vis. Lond. (Lond)"},{"key":"10.1016\/j.biopha.2020.110573_bib0060","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.1038\/s41598-019-41009-3","article-title":"High glucose levels affect retinal patterning during zebrafish embryogenesis","volume":"9","author":"Singh","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2020.110573_bib0065","doi-asserted-by":"crossref","first-page":"355","DOI":"10.2174\/0929867323666160909153707","article-title":"The antidiabetic potential of quercetin: underlying mechanisms","volume":"24","author":"Eid","year":"2017","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.biopha.2020.110573_bib0070","doi-asserted-by":"crossref","first-page":"6565","DOI":"10.1111\/jcmm.14455","article-title":"Anti-angiogenic effect of quercetin and its 8-methyl pentamethyl ether derivative in human microvascular endothelial cells","volume":"23","author":"Lupo","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.biopha.2020.110573_bib0075","article-title":"Quercetin-amino acid conjugates are promising anti-cancer agents in drug discovery projects","author":"Dobrydnev","year":"2019","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.biopha.2020.110573_bib0080","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1016\/j.biopha.2018.11.066","article-title":"Neuroprotection of quercetin on central neurons against chronic high glucose through enhancement of Nrf2\/ARE\/glyoxalase-1 pathway mediated by phosphorylation regulation","volume":"109","author":"Liu","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2020.110573_bib0085","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.lfs.2016.02.080","article-title":"Therapeutic evaluation of rutin in two-kidney one-clip model of renovascular hypertension in rat","volume":"150","author":"Kaur","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.biopha.2020.110573_bib0090","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00210-015-1103-8","article-title":"Investigation of therapeutic potential and molecular mechanism of vitamin P and digoxin in I\/R-induced myocardial infarction in rat","volume":"388","author":"Singh","year":"2015","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.biopha.2020.110573_bib0095","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.lfs.2014.12.022","article-title":"Ameliorative potential of vitamin P and digoxin in ischemic-reperfusion induced renal injury using the Langendorff apparatus","volume":"124","author":"Muthuraman","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.biopha.2020.110573_bib0100","article-title":"The metabolites of the dietary flavonoid quercetin possess potent antithrombotic activity, and interact with aspirin to enhance antiplatelet effects","volume":"3","author":"Stainer","year":"2019","journal-title":"Th Open"},{"key":"10.1016\/j.biopha.2020.110573_bib0105","article-title":"Influence factors of the pharmacokinetics of herbal resourced compounds in clinical practice","volume":"2019","author":"Sun","year":"2019","journal-title":"Evid. Complement. Alternat. Med."},{"key":"10.1016\/j.biopha.2020.110573_bib0110","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.lfs.2018.03.010","article-title":"Therapeutic evaluation of solid lipid nanoparticle of quercetin in pentylenetetrazole induced cognitive impairment of zebrafish","volume":"199","author":"Rishitha","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.biopha.2020.110573_bib0115","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s11892-017-0913-0","article-title":"Animal models of diabetic retinopathy","volume":"17","author":"Olivares","year":"2017","journal-title":"Curr. Diab. Rep."},{"key":"10.1016\/j.biopha.2020.110573_bib0120","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.biopha.2020.110573_bib0125","first-page":"882","article-title":"Improved method for the determination of blood glutathione","volume":"61","author":"Beutler","year":"1963","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.biopha.2020.110573_bib0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042038","article-title":"Local arginase inhibition during early reperfusion mediates cardioprotection via increased nitric oxide production","volume":"7","author":"Gonon","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2020.110573_bib0135","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1161\/01.CIR.0000092948.04444.C7","article-title":"Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels","volume":"108","author":"Berkowitz","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2020.110573_bib0140","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2020.110573_bib0145","article-title":"Phenylthiourea specifically reduces zebrafish eye size","volume":"7","author":"Li","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2020.110573_bib0150","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1089\/zeb.2006.3.191","article-title":"Visual behavior in zebrafish","volume":"3","author":"Fleisch","year":"2006","journal-title":"Zebrafish"},{"key":"10.1016\/j.biopha.2020.110573_bib0155","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ymeth.2005.12.007","article-title":"The zebrafish as a model system for assessing the reinforcing properties of drugs of abuse","volume":"39","author":"Ninkovic","year":"2006","journal-title":"Methods"},{"key":"10.1016\/j.biopha.2020.110573_bib0160","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/eye.2014.19","article-title":"Zebrafish--on the move towards ophthalmological research","volume":"28","author":"Chhetri","year":"2014","journal-title":"Eye Lond. (Lond)"},{"key":"10.1016\/j.biopha.2020.110573_bib0165","first-page":"287","article-title":"Assessing startle responses and their habituation in adult zebrafish, Zebrafish protocols for neurobehavioral research","author":"Chanin","year":"2012","journal-title":"Springer"},{"key":"10.1016\/j.biopha.2020.110573_bib0170","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.neulet.2017.03.002","article-title":"Spectral properties of the zebrafish visual motor response","volume":"646","author":"Burton","year":"2017","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.biopha.2020.110573_bib0175","doi-asserted-by":"crossref","first-page":"5064","DOI":"10.1073\/pnas.0308528101","article-title":"Visual memory task for rats reveals an essential role for hippocampus and perirhinal cortex","volume":"101","author":"Prusky","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biopha.2020.110573_bib0180","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.bbr.2009.03.003","article-title":"Zebrafish (Danio rerio) responds to the animated image of a predator: towards the development of an automated aversive task","volume":"201","author":"Gerlai","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.biopha.2020.110573_bib0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0214374","article-title":"Rapid habituation of a touch-induced escape response in Zebrafish (Danio rerio) Larvae","volume":"14","author":"Roberts","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2020.110573_bib0190","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1111\/acer.13249","article-title":"Behavioral responses to novelty or to a predator stimulus are not altered in adult zebrafish by early embryonic alcohol exposure","volume":"40","author":"Seguin","year":"2016","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.biopha.2020.110573_bib0195","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.bbr.2010.07.028","article-title":"An automated predator avoidance task in zebrafish","volume":"216","author":"Ahmed","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.biopha.2020.110573_bib0200","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1177\/147470491301100308","article-title":"Antipredatory behavior of zebrafish: adaptive function and a tool for translational research","volume":"11","author":"Gerlai","year":"2013","journal-title":"Evol. Psychol."},{"key":"10.1016\/j.biopha.2020.110573_bib0205","first-page":"e3865","article-title":"Blood collection for biochemical analysis in adult zebrafish","author":"Pedroso","year":"2012","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.biopha.2020.110573_bib0210","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1021\/pr3009226","article-title":"Novel blood collection method allows plasma proteome analysis from single zebrafish","volume":"12","author":"Babaei","year":"2013","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.biopha.2020.110573_bib0215","series-title":"Abnormalities of Vascular System., Abnormalities of Vascular System","first-page":"1","article-title":"Chapter 02: ameliorative potential of curcumin phytosome in streptozotocin induced vascular dementia in danio rerio","author":"Muthuraman","year":"2018"},{"key":"10.1016\/j.biopha.2020.110573_bib0220","series-title":"Abnormalities of Vascular System","first-page":"1","article-title":"Chapter 03: therapeutic evaluation of solid lipid nanoparticle of cycloastragenol in streptozotocin induced vascular dementia in Danio rerio","author":"Rishitha","year":"2019"},{"key":"10.1016\/j.biopha.2020.110573_bib0225","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0377-1237(17)30502-6","article-title":"Methods for estimation of blood glucose: a comparative evaluation","volume":"54","author":"Ambade","year":"1998","journal-title":"Med. J. Armed Forces India"},{"key":"10.1016\/j.biopha.2020.110573_bib0230","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/BF02759895","article-title":"Evaluation of total plasma homocysteine in Indian newborns using heel-prick samples","volume":"73","author":"Radha Rama Devi","year":"2006","journal-title":"Indian J. Pediatr."},{"key":"10.1016\/j.biopha.2020.110573_bib0235","first-page":"79","article-title":"Preventative effects of alpha-naphtho flavone in vascular dementia","volume":"12","author":"Rishitha","year":"2020","journal-title":"Front. Biosci. Elite Ed. (Elite Ed)"},{"key":"10.1016\/j.biopha.2020.110573_bib0240","first-page":"4753","article-title":"Astaxanthin inhibits homocysteine induced endothelial cell dysfunction via the regulation of the reactive oxygen speciesdependent VEGFVEGFR2FAK signaling pathway","volume":"19","author":"Wang","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.biopha.2020.110573_bib0245","doi-asserted-by":"crossref","first-page":"89","DOI":"10.5717\/jenb.2014.18.1.89","article-title":"Effects of treadmill exercise on brain insulin signaling and \u03b2-amyloid in intracerebroventricular streptozotocin induced-memory impairment in rats","volume":"18","author":"Kang","year":"2014","journal-title":"J. Exerc. Nutrition Biochem."},{"key":"10.1016\/j.biopha.2020.110573_bib0250","doi-asserted-by":"crossref","first-page":"58264","DOI":"10.18632\/oncotarget.16811","article-title":"Homocysteine-induced peripheral microcirculation dysfunction in zebrafish and its attenuation by L-arginine","volume":"8","author":"Lee","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.biopha.2020.110573_bib0255","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.eplepsyres.2008.04.008","article-title":"Hyperhomocysteinemia and retinal vascular changes in patients with epilepsy","volume":"81","author":"Belcastro","year":"2008","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.biopha.2020.110573_bib0260","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3892\/ijmm.2012.1177","article-title":"Quercetin and quercitrin protect against cytokineinduced injuries in RINm5F beta-cells via the mitochondrial pathway and NF-kappaB signaling","volume":"31","author":"Dai","year":"2013","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.biopha.2020.110573_bib0265","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20133177","article-title":"The anti-cancer effect of quercetin: molecular implications in cancer metabolism","volume":"20","author":"Reyes-Farias","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2020.110573_bib0270","doi-asserted-by":"crossref","first-page":"3952","DOI":"10.1210\/jc.2016-2007","article-title":"Arginase inhibition improves microvascular endothelial function in patients with type 2 diabetes mellitus","volume":"101","author":"Kovamees","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2020.110573_bib0275","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19041215","article-title":"Mechanisms of diabetes-induced endothelial cell senescence: role of arginase 1","volume":"19","author":"Shosha","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2020.110573_bib0280","doi-asserted-by":"crossref","DOI":"10.1093\/jn\/134.10.2760S","article-title":"Structure and function of arginases","volume":"134","author":"Ash","year":"2004","journal-title":"J. Nutr."},{"key":"10.1016\/j.biopha.2020.110573_bib0285","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3233\/JAD-170427","article-title":"Altered expression of urea cycle enzymes in amyloid-beta protein precursor overexpressing PC12 cells and in sporadic Alzheimer\u2019s disease brain","volume":"62","author":"Jesko","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.biopha.2020.110573_bib0290","doi-asserted-by":"crossref","DOI":"10.21767\/2171-6625.100088","article-title":"Protective role of arginase II in cerebral ischemia and excitotoxicity","volume":"7","author":"Ahmad","year":"2016","journal-title":"J. Neurol. Neurosci."},{"key":"10.1016\/j.biopha.2020.110573_bib0295","doi-asserted-by":"crossref","first-page":"e2483","DOI":"10.1038\/cddis.2016.295","article-title":"Arginase 2 promotes neurovascular degeneration during ischemia\/reperfusion injury","volume":"7","author":"Shosha","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.biopha.2020.110573_bib0300","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3389\/fendo.2019.00050","article-title":"Plasma levels of amino acids related to urea cycle and risk of type 2 diabetes mellitus in Chinese adults","volume":"10","author":"Cao","year":"2019","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.biopha.2020.110573_bib0305","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1258\/acb.2007.007125","article-title":"Homocysteine enhances LDL fatty acid peroxidation, promoting microalbuminuria in type 2 diabetes","volume":"45","author":"Kassab","year":"2008","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.biopha.2020.110573_bib0310","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0006-291X(82)92054-X","article-title":"Effect of streptozotocin diabetes on some urea cycle enzymes","volume":"106","author":"Jorda","year":"1982","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2020.110573_bib0315","doi-asserted-by":"crossref","DOI":"10.3390\/md16100353","article-title":"Targeting hepatic protein carbonylation and oxidative stress occurring on diet-induced metabolic diseases through the supplementation with fish oils","volume":"16","author":"Munoz","year":"2018","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.biopha.2020.110573_bib0320","doi-asserted-by":"crossref","first-page":"127","DOI":"10.5213\/inj.2011.15.3.127","article-title":"Exploring the potential of flunarizine for Cisplatin-induced painful uremic neuropathy in rats","volume":"15","author":"Muthuraman","year":"2011","journal-title":"Int. Neurourol. J."},{"key":"10.1016\/j.biopha.2020.110573_bib0325","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1159\/000494018","article-title":"Homocysteine aggravates intestinal epithelial barrier dysfunction in rats with experimental uremia","volume":"43","author":"Liang","year":"2018","journal-title":"Kidney Blood Press. Res."},{"key":"10.1016\/j.biopha.2020.110573_bib0330","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/ar4450","article-title":"Mechanisms of endothelial dysfunction in rheumatoid arthritis: lessons from animal studies","volume":"16","author":"Totoson","year":"2014","journal-title":"Arthritis Res. Ther."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220307666?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220307666?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T18:16:02Z","timestamp":1766081762000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332220307666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":66,"alternative-id":["S0753332220307666"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110573","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic investigation of quercetin nanomedicine in a zebrafish model of diabetic retinopathy","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110573","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"110573"}}