{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:05:24Z","timestamp":1785888324044,"version":"3.56.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002630","name":"Ewha Womans University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002630","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["2018R1A2B6003074"],"award-info":[{"award-number":["2018R1A2B6003074"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["2020R1A5A2019210"],"award-info":[{"award-number":["2020R1A5A2019210"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.biopha.2020.110576","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T13:53:16Z","timestamp":1596635596000},"page":"110576","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Papaverine inhibits \u03b1-synuclein aggregation by modulating neuroinflammation and matrix metalloproteinase-3 expression in the subacute MPTP\/P mouse model of Parkinson\u2019s disease"],"prefix":"10.1016","volume":"130","author":[{"given":"Yea-Hyun","family":"Leem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Sun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Eun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do-Yeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihee Lee","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1889-8739","authenticated-orcid":false,"given":"Hee-Sun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2020.110576_bib0005","doi-asserted-by":"crossref","first-page":"17013","DOI":"10.1038\/nrdp.2017.13","article-title":"Parkinson disease","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.biopha.2020.110576_bib0010","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00702-017-1686-y","article-title":"Epidemiology of Parkinson\u2019s disease","volume":"124","author":"Tysnes","year":"2017","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.biopha.2020.110576_bib0015","doi-asserted-by":"crossref","first-page":"612","DOI":"10.3389\/fnins.2018.00612","article-title":"Parkinson\u2019s disease: biomarkers, treatment, and risk factors","volume":"12","author":"Emamzadeh","year":"2018","journal-title":"Front. Neurosci."},{"issue":"2","key":"10.1016\/j.biopha.2020.110576_bib0020","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/ncb748","article-title":"Alpha-synuclein is phosphorylated in synucleinopathy lesions","volume":"4","author":"Fujiwara","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.biopha.2020.110576_bib0025","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.bbr.2017.10.021","article-title":"Are rodent models of Parkinson\u2019s disease behaving as they should?","volume":"352","author":"Vingill","year":"2018","journal-title":"Behav. Brain Res."},{"issue":"4","key":"10.1016\/j.biopha.2020.110576_bib0030","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3233\/JPD-150642","article-title":"The synaptic function of \u03b1-synuclein","volume":"5","author":"Burr\u00e9","year":"2015","journal-title":"J. Parkinson\u2019s Dis."},{"issue":"1","key":"10.1016\/j.biopha.2020.110576_bib0035","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/nrn3406","article-title":"The many faces of \u03b1-synuclein: from structure and toxicity to therapeutic target","volume":"14","author":"Lashuel","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"issue":"9996","key":"10.1016\/j.biopha.2020.110576_bib0040","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson\u2019s disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet."},{"issue":"5","key":"10.1016\/j.biopha.2020.110576_bib0045","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/jnc.14779","article-title":"Spreading of alpha-synuclein - relevant or epiphenomenon?","volume":"150","author":"Killinger","year":"2019","journal-title":"J. Neurochem."},{"issue":"7","key":"10.1016\/j.biopha.2020.110576_bib0050","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1002\/emmm.201302475","article-title":"Caudo-rostral brain spreading of \u03b1-synuclein through vagal connections","volume":"5","author":"Ulusoy","year":"2013","journal-title":"EMBO Mol. Med."},{"issue":"12","key":"10.1016\/j.biopha.2020.110576_bib0055","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.1523\/JNEUROSCI.0285-07.2007","article-title":"Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo","volume":"27","author":"Periquet","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.biopha.2020.110576_bib0060","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/ncomms1453","article-title":"Parkinson\u2019s disease induced pluripotent stem cells with triplication of the \u03b1-synuclein locus","volume":"2","author":"Devine","year":"2011","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.biopha.2020.110576_bib0065","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3233\/JPD-130216","article-title":"Limelight on alpha-synuclein: pathological and mechanistic implications in neurodegeneration","volume":"3","author":"Wales","year":"2013","journal-title":"J. Parkinson\u2019s Dis."},{"issue":"1","key":"10.1016\/j.biopha.2020.110576_bib0070","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.semcdb.2007.06.003","article-title":"MMPs in the central nervous system: where the good guys go bad","volume":"19","author":"Agrawal","year":"2008","journal-title":"Semin. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.biopha.2020.110576_bib0075","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0003-9861(02)00664-1","article-title":"Effect of \u03b3-synuclein overexpression on matrix metalloproteinases in retinoblastoma Y79 cells","volume":"410","author":"Surgucheva","year":"2003","journal-title":"Arch. Biochem. Biophys."},{"issue":"16","key":"10.1016\/j.biopha.2020.110576_bib0080","doi-asserted-by":"crossref","first-page":"14168","DOI":"10.1074\/jbc.M111.222430","article-title":"Role of matrix metalloproteinase 3-mediated alpha-synuclein cleavage in dopaminergic cell death","volume":"286","author":"Choi","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2020.110576_bib0085","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/370526","article-title":"MMP-3 contributes to nigrostriatal dopaminergic neuronal loss, BBB damage, and neuroinflammation in an MPTP mouse model of Parkinson\u2019s disease","volume":"2013","author":"Chung","year":"2013","journal-title":"Mediators Inflamm."},{"issue":"15","key":"10.1016\/j.biopha.2020.110576_bib0090","doi-asserted-by":"crossref","first-page":"3942","DOI":"10.1523\/JNEUROSCI.4965-05.2006","article-title":"Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein (1-120): implications for Lewy body disorders","volume":"26","author":"Tofaris","year":"2006","journal-title":"J. Neurosci."},{"issue":"11","key":"10.1016\/j.biopha.2020.110576_bib0095","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.3390\/molecules24112182","article-title":"Lycopodium atenuates loss of dopaminergic neurons by suppressing oxidative stress and neuroinflammation in a rat model of Parkinson\u2019s disease","volume":"24","author":"Jayaraj","year":"2019","journal-title":"Molecules"},{"issue":"11\u201312","key":"10.1016\/j.biopha.2020.110576_bib0100","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.phytochem.2010.04.022","article-title":"The biosynthesis of papaverine proceeds via (S)-reticuline","volume":"71","author":"Han","year":"2010","journal-title":"Phytochemistry"},{"key":"10.1016\/j.biopha.2020.110576_bib0105","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s10072-013-1589-0","article-title":"Effectiveness of papaverine cisternal irrigation for cerebral vasospasm after aneurysmal subarachnoid hemorrhage and measurement of biomarkers","volume":"35","author":"Kim","year":"2014","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.biopha.2020.110576_bib0110","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1016\/j.actbio.2014.03.023","article-title":"Highly flexible and rapidly degradable papaverine-loaded electrospun fibrous membranes for preventing vasospasm and repairing vascular tissue","volume":"10","author":"Zhu","year":"2014","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biopha.2020.110576_bib0115","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0006-8993(03)02754-9","article-title":"Immunohistochemical localization of PDE10A in the rat brain","volume":"985","author":"Seeger","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.biopha.2020.110576_bib0120","doi-asserted-by":"crossref","first-page":"378","DOI":"10.2174\/1381612820666140826114744","article-title":"Emerging biology of PDE10A","volume":"21","author":"Wilson","year":"2015","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.biopha.2020.110576_bib0125","article-title":"Inhibition of the striatal specific phosphodiesterase PDE10A ameliorates striatal and cortical pathology in R6\/2 mouse model of Huntington\u2019s disease","volume":"5","author":"Giampa","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2020.110576_bib0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/0929867325666180309110629","article-title":"Phosphodiesterase 10 inhibitors - novel perspectives for psychiatric and neurodegenerative drug discovery","volume":"25","author":"Zagorska","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.biopha.2020.110576_bib0135","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1186\/s12974-019-1649-3","article-title":"The phosphodiesterase 10 inhibitor papaverine exerts anti-inflammatory and neuroprotective effects via the PKA signaling pathway in neuroinflammation and Parkinson\u2019s disease mouse models","volume":"16","author":"Lee","year":"2019","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.biopha.2020.110576_bib0140","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jchemneu.2015.12.002","article-title":"Ursolic acid attenuates oxidative stress in nigrostriatal tissue and improves neurobehavioral activity in MPTP-induced Parkinsonian mouse model","volume":"71","author":"Rai","year":"2016","journal-title":"J. Chem. Neuroanat."},{"issue":"465","key":"10.1016\/j.biopha.2020.110576_bib0145","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aar5280","article-title":"The vermiform appendix impacts the risk of developing Parkinson\u2019s disease","volume":"10","author":"Killinger","year":"2018","journal-title":"Sci. Transl. Med."},{"issue":"7","key":"10.1016\/j.biopha.2020.110576_bib0150","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1111\/j.1742-4658.2012.08491.x","article-title":"Animal models of Parkinson\u2019s disease","volume":"279","author":"Blandini","year":"2012","journal-title":"FEBS J."},{"key":"10.1016\/j.biopha.2020.110576_bib0155","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.neuroscience.2011.10.057","article-title":"Neurotoxin-based models of Parkinson\u2019s disease","volume":"211","author":"Bov\u00e9","year":"2012","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.biopha.2020.110576_bib0160","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0306-3623(90)90898-V","article-title":"Effects of probenecid on striatal dopamine depletion in acute and long-term 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice","volume":"21","author":"Lau","year":"1990","journal-title":"Gen. Pharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2020.110576_bib0165","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S0006-8993(02)03514-X","article-title":"Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson\u2019s disease","volume":"956","author":"Meredith","year":"2002","journal-title":"Brain Res."},{"issue":"10","key":"10.1016\/j.biopha.2020.110576_bib0170","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1038\/aps.2017.49","article-title":"Reassessment of subacute MPTP-treated mice as animal model of Parkinson\u2019s disease","volume":"38","author":"Zhang","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.biopha.2020.110576_bib0175","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1016\/j.neuropharm.2012.01.028","article-title":"Contributions of central and systemic inflammation to the pathophysiology of Parkinson\u2019s disease","volume":"62","author":"Collins","year":"2012","journal-title":"Neuropharmacology"},{"issue":"9","key":"10.1016\/j.biopha.2020.110576_bib0180","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1073\/pnas.0409713102","article-title":"Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein","volume":"102","author":"Fornai","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"Suppl. 2","key":"10.1016\/j.biopha.2020.110576_bib0185","doi-asserted-by":"crossref","first-page":"S112","DOI":"10.1016\/j.parkreldis.2008.04.012","article-title":"Modeling PD pathogenesis in mice: advantages of a chronic MPTP protocol","author":"Meredith","year":"2008","journal-title":"Parkinson. Relat. Disord."},{"key":"10.1016\/j.biopha.2020.110576_bib0190","first-page":"132","article-title":"New \u03b1- and \u03b3-synuclein immunopathological lesions in human brain","volume":"2","author":"Surgucheva","year":"2014","journal-title":"Acta Neuropathol. Commun."},{"issue":"1","key":"10.1016\/j.biopha.2020.110576_bib0195","doi-asserted-by":"crossref","first-page":"8362","DOI":"10.1038\/s41598-019-42847-x","article-title":"GM1 ganglioside modifies \u03b1-dynuclein toxicity and is neuroprotective in a rat \u03b1-synuclein model of Parkinson\u2019s disease","volume":"9","author":"Schneider","year":"2019","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.biopha.2020.110576_bib0200","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/ana.24066","article-title":"Lewy body extracts from Parkinson disease brains trigger \u03b1-synuclein pathology and neurodegeneration in mice and monkeys","volume":"75","author":"Recasens","year":"2014","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.biopha.2020.110576_bib0205","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3389\/fnins.2019.00381","article-title":"The roles of post-translational modifications on \u03b1-synuclein in the pathogenesis of Parkinson\u2019s disease","volume":"13","author":"Zhang","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.biopha.2020.110576_bib0210","doi-asserted-by":"crossref","first-page":"29739","DOI":"10.1074\/jbc.M600933200","article-title":"Phosphorylation of Ser-129 is dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease","volume":"281","author":"Anderson","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.biopha.2020.110576_bib0215","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.1007\/s12035-018-1316-1","article-title":"\u03b4-Opioid receptor activation attenuates the oligomer formation induced by hypoxia and\/or \u03b1-synuclein overexpression\/mutation through dual signaling pathways","volume":"56","author":"Chen","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.biopha.2020.110576_bib0220","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.expneurol.2014.02.022","article-title":"\u03b4-Opioid receptor activation reduces \u03b1-synuclein overexpression and oligomer formation induced by MPP(+) and\/or hypoxia","volume":"255","author":"Chen","year":"2014","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.biopha.2020.110576_bib0225","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s40478-020-00969-8","article-title":"Phosphorylation and oligomerization of \u03b1-synuclein associated with GSK-3\u03b2 activation in the rTg4510 mouse model of taupathy","volume":"8","author":"Takaichi","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"issue":"1","key":"10.1016\/j.biopha.2020.110576_bib0230","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1096\/fj.06-5865com","article-title":"A pivotal role of matrix metalloproteinase-3 activity in dopaminergic neuronal degeneration via microglial activation","volume":"21","author":"Kim","year":"2007","journal-title":"FASEB J."},{"key":"10.1016\/j.biopha.2020.110576_bib0235","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.expneurol.2008.10.010","article-title":"Increased \u03b1-synuclein aggregation following limited cleavage by certain matrix metalloproteinases","volume":"215","author":"Levin","year":"2009","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.biopha.2020.110576_bib0240","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1111\/j.1471-4159.2008.05430.x","article-title":"Inhibition of MMP-3 or -9 suppresses lipopolysaccharide-induced expression of proinflammatory cytokines and iNOS in microglia","volume":"106","author":"Woo","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.biopha.2020.110576_bib0245","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1186\/s12974-018-1363-6","article-title":"Anti-inflammatory and anti-oxidant mechanisms of an MMP-8 inhibitor in lipoteichoic acid-stimulated rat primary astrocytes: involvement of NF-\u03baB, Nrf2, and PPAR-\u03b3 signaling pathways","volume":"15","author":"Lee","year":"2018","journal-title":"J. Neuroinflamm."},{"issue":"1","key":"10.1016\/j.biopha.2020.110576_bib0250","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s40199-015-0101-1","article-title":"Non-addictive opium alkaloids selectively induce apoptosis in cancer cells compared to normal cells","volume":"23","author":"Afzali","year":"2015","journal-title":"Daru"},{"key":"10.1016\/j.biopha.2020.110576_bib0255","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1042\/bse0330065","article-title":"A molecular basis for opiate action","volume":"33","author":"Massotte","year":"1998","journal-title":"Essays Biochem."},{"issue":"5","key":"10.1016\/j.biopha.2020.110576_bib0260","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.euroneuro.2007.08.002","article-title":"Phosphodiesterase 10A inhibition is associated with locomotor and cognitive deficits and increased anxiety in mice","volume":"18","author":"Hebb","year":"2008","journal-title":"Eur. Neuropsychopharmacol."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220307691?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220307691?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T18:08:29Z","timestamp":1766081309000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332220307691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":52,"alternative-id":["S0753332220307691"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110576","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Papaverine inhibits \u03b1-synuclein aggregation by modulating neuroinflammation and matrix metalloproteinase-3 expression in the subacute MPTP\/P mouse model of Parkinson\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110576","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"110576"}}