{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:45:07Z","timestamp":1789789507338,"version":"4.0.1"},"reference-count":167,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008402","name":"Chengdu University of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["QNXZ2018025"],"award-info":[{"award-number":["QNXZ2018025"]}],"id":[{"id":"10.13039\/501100008402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2019YJ0492"],"award-info":[{"award-number":["2019YJ0492"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703725"],"award-info":[{"award-number":["81703725"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.biopha.2020.110599","type":"journal-article","created":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T15:33:45Z","timestamp":1597764825000},"page":"110599","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"special_numbering":"C","title":["Pharmacological basis of tanshinone and new insights into tanshinone as a multitarget natural product for multifaceted diseases"],"prefix":"10.1016","volume":"130","author":[{"given":"Zhibei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2020.110599_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.152871","article-title":"Salvia miltiorrhiza in diabetes: a review of its pharmacology, phytochemistry, and safety","volume":"58","author":"Jia","year":"2019","journal-title":"Phytomedicine"},{"issue":"06","key":"10.1016\/j.biopha.2020.110599_bib0010","first-page":"991","article-title":"The Chinese materia medica research of salvia miltiorrhiza","volume":"32","author":"Zhao","year":"2009","journal-title":"Tradit. Chin. Med."},{"key":"10.1016\/j.biopha.2020.110599_bib0015","series-title":"Ben Cao Jing","author":"Mu","year":"2015"},{"issue":"3","key":"10.1016\/j.biopha.2020.110599_bib0020","first-page":"163","article-title":"Salvia miltiorrhiza: traditional medicinal uses, chemistry, and pharmacology","volume":"13","author":"Su","year":"2015","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.biopha.2020.110599_bib0025","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3389\/fphar.2019.00202","article-title":"Tanshinones, critical pharmacological components in salvia miltiorrhiza","volume":"10","author":"Jiang","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2020.110599_bib0030","doi-asserted-by":"crossref","DOI":"10.3390\/molecules21010051","article-title":"Chemical analysis of the herbal medicine salviae miltiorrhizae radix et rhizoma (danshen)","volume":"21","author":"Pang","year":"2016","journal-title":"Molecules"},{"issue":"9","key":"10.1016\/j.biopha.2020.110599_bib0035","doi-asserted-by":"crossref","DOI":"10.3390\/molecules200916235","article-title":"The biosynthetic pathways of tanshinones and phenolic acids in Salvia miltiorrhiza","volume":"20","author":"Ma","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2020.110599_bib0040","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/bs.apha.2019.10.001","article-title":"Pharmacological properties of tanshinones, the natural products from Salvia miltiorrhiza","volume":"87","author":"Wang","year":"2020","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.biopha.2020.110599_bib0045","article-title":"Preventive and therapeutic role of tanshinone IIA in hepatology","volume":"112","author":"Shi","year":"2019","journal-title":"Biomed. pharmacotherpy"},{"issue":"4","key":"10.1016\/j.biopha.2020.110599_bib0050","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22267","article-title":"Tanshinone I attenuates proliferation and chemoresistance of cervical cancer in a KRAS-dependent manner","volume":"33","author":"Dun","year":"2019","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.biopha.2020.110599_bib0055","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ejphar.2019.03.021","article-title":"Tanshinone I inhibits vascular smooth muscle cell proliferation by targeting insulin-like growth factor-1 receptor\/phosphatidylinositol-3-kinase signaling pathway","volume":"853","author":"Wu","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2020.110599_bib0060","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ejphar.2017.09.047","article-title":"Tanshinone IIA sodium sulfonate regulates antioxidant system, inflammation, and endothelial dysfunction in atherosclerosis by downregulation of CLIC1","volume":"815","author":"Zhu","year":"2017","journal-title":"Eur. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.biopha.2020.110599_bib0065","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.3390\/molecules23051132","article-title":"Salvia castanea hairy roots are more tolerant to phosphate deficiency than salvia miltiorrhiza hairy roots based on the secondary metabolism and antioxidant defenses","volume":"23","author":"Liu","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2020.110599_bib0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2020.104633","article-title":"Cryptotanshinone: a review of its pharmacology activities and molecular mechanisms","volume":"145","author":"Wu","year":"2020","journal-title":"Fitoterapia"},{"issue":"1","key":"10.1016\/j.biopha.2020.110599_bib0075","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.atherosclerosis.2011.06.041","article-title":"Cardiovascular actions and therapeutic potential of tanshinone IIA","volume":"220","author":"Gao","year":"2012","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.biopha.2020.110599_bib0080","doi-asserted-by":"crossref","first-page":"753","DOI":"10.3389\/fphar.2019.00753","article-title":"Salvia miltiorrhiza in treating cardiovascular diseases: a review on its pharmacological and clinical applications","volume":"10","author":"Ren","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"12","key":"10.1016\/j.biopha.2020.110599_bib0085","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1002\/gcc.22805","article-title":"The cell of origin and the leukemia stem cell in acute myeloid leukemia","volume":"58","author":"Martin","year":"2019","journal-title":"Genes Chromosomes Cancer"},{"issue":"6","key":"10.1016\/j.biopha.2020.110599_bib0090","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s11373-006-9110-x","article-title":"Induction of apoptosis and inhibition of cell adhesive and invasive effects by tanshinone IIA in acute promyelocytic leukemia cells in vitro","volume":"13","author":"Liu","year":"2006","journal-title":"J. Biomed. Sci."},{"issue":"1","key":"10.1016\/j.biopha.2020.110599_bib0095","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.bcmd.2015.10.007","article-title":"Tanshinone IIA inhibits acute promyelocytic leukemia cell proliferation and induces their apoptosis in vivo","volume":"56","author":"Zhang","year":"2016","journal-title":"Blood Cells Mol. Dis."},{"issue":"4","key":"10.1016\/j.biopha.2020.110599_bib0100","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s12185-010-0686-6","article-title":"C\/EBP\u03b2 and CHOP participate in tanshinone IIA-induced differentiation and apoptosis of acute promyelocytic leukemia cells in vitro","volume":"92","author":"Zhang","year":"2010","journal-title":"Int. J. Hematol."},{"issue":"1","key":"10.1016\/j.biopha.2020.110599_bib0105","first-page":"57","article-title":"Apoptosis of NB4 cells induced by Tanshinone II A combined with arsenic trioxide","volume":"41","author":"Zhang","year":"2010","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"issue":"4","key":"10.1016\/j.biopha.2020.110599_bib0110","doi-asserted-by":"crossref","DOI":"10.1097\/MAJ.0b013e318240bca6","article-title":"Tanshinone IIA in acute promyelocytic leukemia","volume":"344","author":"Li","year":"2012","journal-title":"Am. J. Med. Sci."},{"issue":"4","key":"10.1016\/j.biopha.2020.110599_bib0115","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/ptr.6013","article-title":"Antiproliferative activity and apoptosis induction by trijuganone C isolated from the root of Salvia miltiorrhiza Bunge (danshen)","volume":"32","author":"Uto","year":"2018","journal-title":"Phytother. Res."},{"issue":"4","key":"10.1016\/j.biopha.2020.110599_bib0120","first-page":"1075","article-title":"Tanshinone IIA inhibits leukemia THP-1 cell growth by induction of apoptosis","volume":"21","author":"Liu","year":"2009","journal-title":"Oncol. Rep."},{"issue":"2","key":"10.1016\/j.biopha.2020.110599_bib0125","doi-asserted-by":"crossref","DOI":"10.1248\/bpb.b12-00537","article-title":"Activation of c-Jun N-terminal kinase mediates tanshinone IIA-induced apoptosis in KBM-5 chronic myeloid leukemia cells","volume":"36","author":"Yun","year":"2013","journal-title":"Biol. Pharm. Bull."},{"issue":"5","key":"10.1016\/j.biopha.2020.110599_bib0130","first-page":"2995","article-title":"Tanshinone IIA induces apoptosis and autophagy in acute monocytic leukemia via downregulation of PI3K\/Akt pathway","volume":"11","author":"Zhang","year":"2019","journal-title":"Am. J. Transl. Res."},{"issue":"2","key":"10.1016\/j.biopha.2020.110599_bib0135","first-page":"503","article-title":"Tanshinone IIA enhances the inhibitory effect of Imatinib on proliferation and motility of acute leukemia cell line TIB\u2011152 in vivo and in vitro by inhibiting the PI3K\/AKT\/mTOR","volume":"43","author":"Teng","year":"2020","journal-title":"Signaling Pathway Oncol. Rep."},{"key":"10.1016\/j.biopha.2020.110599_bib0140","doi-asserted-by":"crossref","DOI":"10.1007\/s10616-020-00389-5","article-title":"miR-497 plays a key role in Tanshinone IIA-attenuated proliferation in OCI-AML3 cells via the MAPK\/ERK1\/2 pathway","author":"Kang","year":"2020","journal-title":"Cytotechnology"},{"key":"10.1016\/j.biopha.2020.110599_bib0145","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.biocel.2018.10.008","article-title":"The combination of Nutlin-3 and Tanshinone IIA promotes synergistic cytotoxicity in acute leukemic cells expressing wild-type p53 by co-regulating MDM2-P53 and the AKT\/mTOR pathway","volume":"106","author":"Guo","year":"2019","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"24","key":"10.1016\/j.biopha.2020.110599_bib0150","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.1042\/BCJ20170386","article-title":"Nutlin-3 plus tanshinone IIA exhibits synergetic anti-leukemia effect with imatinib by reactivating p53 and inhibiting the AKT\/mTOR pathway in Ph+ ALL","volume":"474","author":"Guo","year":"2017","journal-title":"Biochem. J."},{"key":"10.1016\/j.biopha.2020.110599_bib0155","doi-asserted-by":"crossref","DOI":"10.1186\/1472-6882-12-5","article-title":"Analysis of tanshinone IIA induced cellular apoptosis in leukemia cells by genome-wide expression profiling","author":"Liu","year":"2012","journal-title":"BMC Complementary Med. Ther."},{"issue":"1","key":"10.1016\/j.biopha.2020.110599_bib0160","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1080\/21691401.2019.1709862","article-title":"Tanshinone I induces cell apoptosis by reactive oxygen species-mediated endoplasmic reticulum stress and by suppressing p53\/DRAM-mediated autophagy in human hepatocellular carcinoma","volume":"48","author":"Liu","year":"2020","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"issue":"1","key":"10.1016\/j.biopha.2020.110599_bib0165","first-page":"282","article-title":"Tanshinone IIA inhibits human hepatocellular carcinoma J5 cell growth by increasing Bax and caspase 3 and decreasing CD31 expression in vivo","volume":"5","author":"Chien","year":"2012","journal-title":"Mol. Med. Rep."},{"issue":"6","key":"10.1016\/j.biopha.2020.110599_bib0170","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1177\/030089160909500623","article-title":"Tanshinone II-A inhibits invasion and metastasis of human hepatocellular carcinoma cells in vitro and in vivo","volume":"95","author":"Yuxian","year":"2009","journal-title":"Tumori"},{"issue":"1","key":"10.1016\/j.biopha.2020.110599_bib0175","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s11418-011-0576-0","article-title":"Tanshinone IIA activates calcium-dependent apoptosis signaling pathway in human hepatoma cells","volume":"66","author":"Dai","year":"2012","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.biopha.2020.110599_bib0180","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ejphar.2016.11.046","article-title":"Tanshinone IIA induced cell death via miR30b-p53-PTPN11\/SHP2 signaling pathway in human hepatocellular carcinoma cells","volume":"796","author":"Ren","year":"2017","journal-title":"Eur. J. Pharmacol."},{"issue":"21","key":"10.1016\/j.biopha.2020.110599_bib0185","doi-asserted-by":"crossref","first-page":"9719","DOI":"10.18632\/aging.102420","article-title":"Tanshinone IIA mediates SMAD7-YAP interaction to inhibit liver cancer growth by inactivating the transforming growth factor beta signaling pathway","volume":"11","author":"Ma","year":"2019","journal-title":"Aging"},{"issue":"1","key":"10.1016\/j.biopha.2020.110599_bib0190","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12864-015-1230-0","article-title":"Integrating transcriptomics and proteomics to show that tanshinone IIA suppresses cell growth by blocking glucose metabolism in gastric cancer cells","volume":"16","author":"Lin","year":"2015","journal-title":"BMC Genomics"},{"issue":"2","key":"10.1016\/j.biopha.2020.110599_bib0195","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.3892\/mmr.2015.4658","article-title":"Tanshinone IIA decreases the migratory ability of ags cells by decreasing the protein expression of matrix metalloproteinases, nuclear factor \u03baB-p65 and cyclooxygenase-2","volume":"13","author":"Su","year":"2016","journal-title":"Mol. Med. Rep."},{"issue":"2","key":"10.1016\/j.biopha.2020.110599_bib0200","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.3892\/or.2016.4857","article-title":"Tanshinone IIA decreases the protein expression of egfr, and igfr blocking the PI3K\/Akt\/mTOR pathway in gastric carcinoma AGS cells both in vitro and in vivo","volume":"36","author":"Su","year":"2016","journal-title":"Oncol. Rep."},{"issue":"4","key":"10.1016\/j.biopha.2020.110599_bib0205","first-page":"2389","article-title":"Tanshinone IIA inhibits gastric carcinoma ags cells by decreasing the protein expression of VEGFR and blocking Ras\/Raf\/MEK\/ERK pathway","volume":"41","author":"Su","year":"2018","journal-title":"Int. J. Mol. Med."},{"issue":"3","key":"10.1016\/j.biopha.2020.110599_bib0210","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.3892\/or.2017.5408","article-title":"Tanshinone IIA suppresses gastric cancer cell proliferation and migration by downregulation of FOXM1","volume":"37","author":"Yu","year":"2017","journal-title":"Oncol. Rep."},{"issue":"4","key":"10.1016\/j.biopha.2020.110599_bib0215","first-page":"2931","article-title":"Tanshinone IIA inhibits cell proliferation and tumor growth by downregulating STAT3 in human gastric cancer","volume":"16","author":"Zhang","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.biopha.2020.110599_bib0220","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.phymed.2018.05.012","article-title":"Potentiation of the anticancer effect of doxorubicinin drug-resistant gastric cancer cells by tanshinone IIA","volume":"51","author":"Xu","year":"2018","journal-title":"Phytomedicine"},{"issue":"6","key":"10.1016\/j.biopha.2020.110599_bib0225","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1142\/S0192415X1650066X","article-title":"Inflammatory and apoptotic regulatory activity of tanshinone IIA in helicobacter pylori-infected cells","volume":"44","author":"Chen","year":"2016","journal-title":"Am. J. Chin. Med."},{"issue":"6","key":"10.1016\/j.biopha.2020.110599_bib0230","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1007\/s00280-016-3034-6","article-title":"Tanshinone I induces apoptosis and pro-survival autophagy in gastric cancers","volume":"77","author":"Jing","year":"2016","journal-title":"Cancer Chemtherapy Pharmacol."},{"key":"10.1016\/j.biopha.2020.110599_bib0235","doi-asserted-by":"crossref","first-page":"4793","DOI":"10.12659\/MSM.914446","article-title":"Effects and mechanism of tanshinone ii a in proliferation, apoptosis, and migration of human colon cancer cells","volume":"25","author":"Xue","year":"2019","journal-title":"Med. Sci. Monit."},{"issue":"3","key":"10.1016\/j.biopha.2020.110599_bib0240","doi-asserted-by":"crossref","first-page":"555","DOI":"10.3892\/etm.2011.441","article-title":"Tanshinone IIA potentiates the efficacy of 5-FU in Colo205 colon cancer cells in vivo through downregulation of P-gp and LC3-II","volume":"3","author":"Su","year":"2012","journal-title":"Exp. Ther. Med."},{"issue":"11","key":"10.1016\/j.biopha.2020.110599_bib0245","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1038\/aps.2009.139","article-title":"Inhibitory effects of tanshinone II-A on invasion and metastasis of human colon carcinoma cells","volume":"30","author":"Shan","year":"2009","journal-title":"Acta Pharmacol. Sin."},{"issue":"4","key":"10.1016\/j.biopha.2020.110599_bib0250","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.intimp.2012.08.015","article-title":"TanshinoneIIA ameliorates inflammatory microenvironment of colon cancer cells via repression of microRNA-155","volume":"14","author":"Tu","year":"2012","journal-title":"Int. Immunopharmacol."},{"issue":"3","key":"10.1016\/j.biopha.2020.110599_bib0255","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.3892\/etm.2016.2984","article-title":"Tanshinone IIA enhances chemosensitivity of colon cancer cells by suppressing nuclear factor-\u03baB","volume":"11","author":"Bai","year":"2016","journal-title":"Exp. Ther. Med."},{"issue":"3","key":"10.1016\/j.biopha.2020.110599_bib0260","article-title":"In vitro inhibition of invasion and metastasis in colon cancer cells by TanIIA","volume":"15","author":"Zhang","year":"2016","journal-title":"Genet. Med. Res."},{"key":"10.1016\/j.biopha.2020.110599_bib0265","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.canlet.2017.05.013","article-title":"Tanshinone IIA inhibits \u03b2-catenin\/VEGF-mediated angiogenesis by targeting TGF-\u03b21 in normoxic and HIF-1\u03b1 in hypoxic microenvironments in human colorectal cancer","volume":"403","author":"Sui","year":"2017","journal-title":"Cancer Lett."},{"issue":"2","key":"10.1016\/j.biopha.2020.110599_bib0270","first-page":"1692","article-title":"Tanshinone IIA regulates colorectal cancer apoptosis via attenuation of Parkin\u2011mediated mitophagy by suppressing AMPK\/Skp2 pathways","volume":"18","author":"He","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"5","key":"10.1016\/j.biopha.2020.110599_bib0275","first-page":"1337","article-title":"Research on the inhibiting effect of tanshinone IIA on colon cancer cell gowth via COX-2-Wnt\/\u03b2-catenin signaling pathway","volume":"23","author":"Ma","year":"2018","journal-title":"J. BUON"},{"key":"10.1016\/j.biopha.2020.110599_bib0280","doi-asserted-by":"crossref","first-page":"4793","DOI":"10.12659\/MSM.914446","article-title":"Effects and mechanism of Tanshinone II A in proliferation, apoptosis, and migration of human colon cancer cells","volume":"25","author":"Xue","year":"2019","journal-title":"Med. Sci. Monit."},{"issue":"6","key":"10.1016\/j.biopha.2020.110599_bib0285","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1002\/ptr.6353","article-title":"Combination of tanshinone iia and doxorubicin possesses synergism and attenuation effects on doxorubicin in the treatment of breast cancer","volume":"33","author":"Li","year":"2019","journal-title":"Phytother. Res."},{"issue":"4","key":"10.1016\/j.biopha.2020.110599_bib0290","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/ptr.6014","article-title":"Cytotoxicity of Tanshinone IIA combined with taxol on drug-resist breast cancer cells MCF-7 through inhibition of Tau","volume":"32","author":"Lin","year":"2018","journal-title":"Phytother. Res."},{"issue":"2","key":"10.1016\/j.biopha.2020.110599_bib0295","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0117440","article-title":"Tanshinone IIA inhibits hif-1\u03b1 and vegf expression in breast cancer cells via mTOR\/p70S6K\/RPS6\/4E-BP1 signaling pathway","volume":"10","author":"Li","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.biopha.2020.110599_bib0300","first-page":"38","article-title":"Effect of Tanshinone II on cell growth of breast cancer cell line type MCF-7 and MD-MB-231","volume":"119","author":"Nicolin","year":"2014","journal-title":"Ital. J. Anat. Embryol."},{"issue":"6","key":"10.1016\/j.biopha.2020.110599_bib0305","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.3892\/or.2014.3140","article-title":"Tanshinone iia blocks epithelial-mesenchymal transition through hif-1\u03b1 downregulation, reversing hypoxia-induced chemotherapy resistance in breast cancer cell lines","volume":"31","author":"Fu","year":"2014","journal-title":"Oncol. Rep."},{"issue":"9","key":"10.1016\/j.biopha.2020.110599_bib0310","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1002\/jcb.24553","article-title":"Tanshinone IIA inhibits breast cancer stem cells growth in vitro and in vivo through attenuation of IL-6\/STAT3\/NF-kB signaling pathways","volume":"114","author":"Lin","year":"2013","journal-title":"J. Cell. Biochem."},{"issue":"4","key":"10.1016\/j.biopha.2020.110599_bib0315","article-title":"Tanshinone I attenuates proliferation and chemoresistance of cervical cancer in a KRAS-dependent manner","volume":"33","author":"Dun","year":"2019","journal-title":"J. Biochem. Mol. Toxiol."},{"key":"10.1016\/j.biopha.2020.110599_bib0320","doi-asserted-by":"crossref","first-page":"9355","DOI":"10.2147\/OTT.S221228","article-title":"Tanshinone IIA reverses gefitinib-resistance in human non-small-cell lung cancer via regulation of VEGFR\/Akt pathway","volume":"12","author":"Wang","year":"2019","journal-title":"Onco Targets Ther."},{"issue":"9","key":"10.1016\/j.biopha.2020.110599_bib0325","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1002\/ptr.6392","article-title":"Tanshinone IIA combined with cisplatin synergistically inhibits non\u2010small\u2010cell lung cancer in vitro and in vivo via down\u2010regulating the phosphatidylinositol 3\u2010kinase\/Akt signalling pathway","volume":"33","author":"Liao","year":"2019","journal-title":"Phytother. Res."},{"issue":"5","key":"10.1016\/j.biopha.2020.110599_bib0330","first-page":"3102","article-title":"Tanshinone IIA can inhibit MiaPaCa\u20112 human pancreatic cancer cells by dual blockade of the Ras\/Raf\/MEK\/ERK and PI3K\/AKT\/mTOR pathways","volume":"40","author":"Su","year":"2018","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.biopha.2020.110599_bib0335","doi-asserted-by":"crossref","first-page":"7667","DOI":"10.1007\/s13277-015-4602-9","article-title":"The interplay between autophagy and apoptosis induced by tanshinone IIA in prostate cancer cells","volume":"37","author":"Li","year":"2016","journal-title":"Tumour Biol."},{"issue":"9","key":"10.1016\/j.biopha.2020.110599_bib0340","doi-asserted-by":"crossref","first-page":"6454","DOI":"10.1111\/jcmm.14539","article-title":"Tanshinone I inhibits the growth and metastasis of osteosarcoma via suppressing JAK\/STAT3 signalling pathway","volume":"23","author":"Wang","year":"2019","journal-title":"J. Cell. Mol. Med."},{"issue":"S3","key":"10.1016\/j.biopha.2020.110599_bib0345","doi-asserted-by":"crossref","first-page":"S707","DOI":"10.1080\/21691401.2018.1508028","article-title":"Nanoparticle-mediated delivery of Tanshinone IIA reduces adverse cardiac remodeling following myocardial infarctions in a mice model: role of NF-\u03baB pathway","volume":"46","author":"Mao","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"issue":"6","key":"10.1016\/j.biopha.2020.110599_bib0350","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1111\/jcmm.13557","article-title":"Tanshinone IIA prevents left ventricular remodelling via the TLR4\/MyD88\/NF-\u03baB signalling pathway in rats with myocardial infarction","volume":"22","author":"Wu","year":"2018","journal-title":"J. Cell. Mol. Med."},{"issue":"1","key":"10.1016\/j.biopha.2020.110599_bib0355","first-page":"351","article-title":"Protective effects of sodium tanshinone IIA sulfonate on cardiac function after myocardial infarction in mice","volume":"11","author":"Wu","year":"2019","journal-title":"Am. J. Transl. Res."},{"issue":"1","key":"10.1016\/j.biopha.2020.110599_bib0360","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.atherosclerosis.2013.07.005","article-title":"Regulation of antioxidant system, lipids and fatty acid \u03b2-oxidation contributes to the cardioprotective effect of sodium tanshinone IIA sulphonate in isoproterenol-induced myocardial infarction in rats","volume":"230","author":"Wei","year":"2013","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.biopha.2020.110599_bib0365","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3389\/fphar.2019.00779","article-title":"Exploration of multiple signaling pathways through which sodium tanshinone IIA sulfonate attenuates pathologic remodeling experimental infarction","volume":"10","author":"Ma","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"7","key":"10.1016\/j.biopha.2020.110599_bib0370","doi-asserted-by":"crossref","first-page":"4592","DOI":"10.1111\/jcmm.14306","article-title":"Sodium tanshinone IIA sulfonate prevents the adverse left ventricular remodelling: focus on polymorphonuclear neutrophil-derived granule components","volume":"23","author":"Mao","year":"2019","journal-title":"J. Cell. Mol. Med."},{"issue":"6","key":"10.1016\/j.biopha.2020.110599_bib0375","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s10557-015-6625-2","article-title":"Rationale and design of sodium tanshinone IIA sulfonate in left ventricular remodeling secondary to acute myocardial infarction (STAMP-REMODELING) trial: a randomized controlled study","volume":"29","author":"Mao","year":"2015","journal-title":"Cardiovasc. Drugs Ther."},{"issue":"1","key":"10.1016\/j.biopha.2020.110599_bib0380","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.phymed.2010.06.002","article-title":"Tanshinone II-A attenuates cardiac fibrosis and modulates collagen metabolism in rats with renovascular hypertension","volume":"18","author":"Fang","year":"2010","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.biopha.2020.110599_bib0385","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jep.2012.10.044","article-title":"Hydrogen peroxide-mediated oxidative stress and collagen synthesis in cardiac fibroblasts: blockade by tanshinone IIA","volume":"145","author":"Wang","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2020.110599_bib0390","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/6712585","article-title":"Sodium tanshinone IIA sulfonate prevents angiotensin ii-induced differentiation of human atrial fibroblasts into myofibroblasts","volume":"2018","author":"Chen","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"3","key":"10.1016\/j.biopha.2020.110599_bib0395","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0092216","article-title":"The complex regulation of tanshinone IIA in rats with hypertension-induced left ventricular hypertrophy","volume":"9","author":"Pang","year":"2014","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.biopha.2020.110599_bib0400","doi-asserted-by":"crossref","first-page":"633","DOI":"10.4103\/0253-7613.144933","article-title":"Effects of tanshinone IIA on the transforming growth factor \u03b21\/smad signaling pathway in rat cardiac fibroblasts","volume":"46","author":"Zhan","year":"2014","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.biopha.2020.110599_bib0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108599","article-title":"Tanshinone IIA protects against heart failure post-myocardial infarction via AMPKs\/mTOR-dependent autophagy pathway","volume":"112","author":"Zhang","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"6","key":"10.1016\/j.biopha.2020.110599_bib0410","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.hjc.2017.11.011","article-title":"Tanshinone modulates the expression of bcl-2 and bax in cardiomyocytes and has a protective effect in a rat model of myocardial ischemia-reperfusion","volume":"59","author":"Guo","year":"2018","journal-title":"Hellenic J. Cardiol."},{"key":"10.1016\/j.biopha.2020.110599_bib0415","doi-asserted-by":"crossref","first-page":"3583921","DOI":"10.1155\/2018\/3583921","article-title":"Tanshinone IIA pretreatment protects h9c2 cells against anoxia\/reoxygenation injury: involvement of the translocation of bcl-2 to mitochondria mediated by 14-3-3\u03b7","volume":"2018","author":"Zhang","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"2","key":"10.1016\/j.biopha.2020.110599_bib0420","first-page":"167","article-title":"Tanshinone attenuates myocardial injury via activating JAK2\/STAT1 pathway in a murine model of viral myocarditis","volume":"43","author":"Xia","year":"2015","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi"},{"issue":"12","key":"10.1016\/j.biopha.2020.110599_bib0425","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.3109\/13880209.2015.1005753","article-title":"Protective effects of tanshinone IIA on myocardial ischemia reperfusion injury by reducing oxidative stress, HMGB1 expression, and inflammatory reaction","volume":"53","author":"Hu","year":"2015","journal-title":"Pharm. Biol."},{"issue":"3","key":"10.1016\/j.biopha.2020.110599_bib0430","first-page":"308","article-title":"Protective effects of tanshinone IIA sodium sulfonate on ischemia-reperfusion-induced myocardial injury in rats","volume":"20","author":"Pan","year":"2017","journal-title":"Iran. J. Basic Med. Sci."},{"issue":"2","key":"10.1016\/j.biopha.2020.110599_bib0435","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1177\/1753944710396538","article-title":"Salvianolic acid B and tanshinone IIA attenuate myocardial ischemia injury in mice by NO production through multiple pathways","volume":"5","author":"Pan","year":"2011","journal-title":"Ther. Adv. Cardiovasc. Dis."},{"issue":"3","key":"10.1016\/j.biopha.2020.110599_bib0440","doi-asserted-by":"crossref","first-page":"973","DOI":"10.3892\/etm.2014.1820","article-title":"Pharmacological postconditioning with tanshinone IIA attenuates myocardial ischemia-reperfusion injury in rats by activating the phosphatidylinositol 3-kinase pathway","volume":"8","author":"Yuan","year":"2014","journal-title":"Exp. Ther. Med."},{"issue":"4","key":"10.1016\/j.biopha.2020.110599_bib0445","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0254-6272(10)60053-2","article-title":"Study of anti-myocardial cell oxidative stress action and effect of tanshinone IIA on prohibitin expression","volume":"30","author":"Yang","year":"2010","journal-title":"J. Traditionnal Chin. Med."},{"key":"10.1016\/j.biopha.2020.110599_bib0450","first-page":"610694","article-title":"Tanshinone IIA and cryptotanshinone prevent mitochondrial dysfunction in hypoxia-induced h9c2 cells: association to mitochondrial ROS, intracellular nitric oxide, and calcium levels","volume":"2013","author":"Jin","year":"2013","journal-title":"Evid. Complement. Alternat. Med."},{"issue":"11","key":"10.1016\/j.biopha.2020.110599_bib0455","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1038\/aps.2013.91","article-title":"Sodium tanshinone IIA sulfonate protects rat myocardium against ischemia-reperfusion injury via activation of PI3K\/AKT\/FOXO3A\/BIM pathway","volume":"34","author":"Zhang","year":"2013","journal-title":"Acta Pharmacol. Sin."},{"issue":"1","key":"10.1016\/j.biopha.2020.110599_bib0460","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12860-020-00264-3","article-title":"Tanshinone IIA alleviates hypoxia\/reoxygenation induced cardiomyocyte injury via lncRNA AK003290\/miR-124-5p signaling","volume":"21","author":"Chen","year":"2020","journal-title":"BMC Mol. Cell Biol."},{"issue":"6","key":"10.1016\/j.biopha.2020.110599_bib0465","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1159\/000324012","article-title":"Tanshinone IIA inhibits miR-1 expression through p38 MAPK signal pathway in post-infarction rat cardiomyocytes","volume":"26","author":"Zhang","year":"2010","journal-title":"Cell. Physiol. Biochem."},{"issue":"5","key":"10.1016\/j.biopha.2020.110599_bib0470","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1111\/bph.12185","article-title":"Sodium tanshinone IIA silate inhibits oxygen-glucose deprivation\/recovery-induced cardiomyocyte apoptosis via suppression of the NF-\u03baB\/TNF-\u03b1 pathway","volume":"169","author":"Wu","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.biopha.2020.110599_bib0475","doi-asserted-by":"crossref","first-page":"e51720","DOI":"10.1371\/journal.pone.0051720","article-title":"TanshinoneIIA and cryptotanshinone protect against hypoxia-induced mitochondrial apoptosis in h9c2 cells","volume":"8 (1","author":"Jin","year":"2013","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.biopha.2020.110599_bib0480","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1139\/cjpp-2016-0036","article-title":"The cardioprotection of dihydrotanshinone I against myocardial ischemia-reperfusion injury via inhibition of arachidonic acid \u03c9-hydroxylase","volume":"94","author":"Wei","year":"2016","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"14","key":"10.1016\/j.biopha.2020.110599_bib0485","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.3390\/molecules24142584","article-title":"Rapid identification of tanshinone IIA metabolites in an amyloid-\u03b21-42 induced alzherimer\u2019s disease rat model using uhplc-q-exactive qrbitrap mass spectrometry","volume":"24","author":"Liang","year":"2019","journal-title":"Molecules"},{"issue":"13","key":"10.1016\/j.biopha.2020.110599_bib0490","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1097\/WNR.0000000000000419","article-title":"Upregulation effects of tanshinone IIA on the expressions of neun, nissl body, and i\u03bab and downregulation effects on the expressions of GFAP and NF-\u03baB in the brain tissues of rat models of alzheimer\u2019s disease","volume":"26","author":"Li","year":"2015","journal-title":"Neuroreport"},{"issue":"12","key":"10.1016\/j.biopha.2020.110599_bib0495","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1097\/WNR.0000000000000618","article-title":"Tanshinone IIA decreases the levels of inflammation induced by A\u03b21-42 in brain tissues of alzheimer\u2019s disease model rats","volume":"27","author":"Lu","year":"2016","journal-title":"Neuroreport"},{"issue":"2","key":"10.1016\/j.biopha.2020.110599_bib0500","doi-asserted-by":"crossref","first-page":"689","DOI":"10.3892\/mmr.2014.2254","article-title":"Tanshinone IIA reduces the risk of Alzheimer\u2019s disease by inhibiting iNOS, MMP\u20112 and NF\u2011\u03baBp65 transcription and translation in the temporal lobes of rat models of Alzheimer\u2019s disease","volume":"10","author":"Jiang","year":"2014","journal-title":"Mol. Med. Rep."},{"issue":"11","key":"10.1016\/j.biopha.2020.110599_bib0505","first-page":"1210","article-title":"Effects of tanshinone IIA on the expressions of p53, pp53 and apoptosis in the rats with Alzheimer\u2019s disease","volume":"40","author":"Li","year":"2015","journal-title":"ZHong nan da xue xue bao. Yi xue bao"},{"key":"10.1016\/j.biopha.2020.110599_bib0510","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.brainres.2015.11.040","article-title":"Treatment effects of tanshinone IIA against intracerebroventricular streptozotocin induced memory deficits in mice","volume":"1631","author":"Liu","year":"2016","journal-title":"Brain Res."},{"issue":"7","key":"10.1016\/j.biopha.2020.110599_bib0515","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1007\/s11064-014-1312-4","article-title":"Anti-inflammatory effect of tanshinone i in neuroprotection against cerebral ischemia-reperfusion injury in the gerbil hippocampus","volume":"39","author":"Park","year":"2014","journal-title":"Neurochem. Res."},{"issue":"8","key":"10.1016\/j.biopha.2020.110599_bib0520","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1016\/j.fitote.2012.09.020","article-title":"Comparison of neuroprotective effects of five major lipophilic diterpenoids from danshen extract against experimentally induced transient cerebral ischemic damage","volume":"83","author":"Park","year":"2012","journal-title":"Fitoterapia"},{"issue":"9","key":"10.1016\/j.biopha.2020.110599_bib0525","first-page":"940","article-title":"Effect of tanshinone IIA on phosphorylated nmda receptor 1 expression and intracellular free calcium concentration in neonatal sd rats with hypoxic ischemic brain damage","volume":"35","author":"Hei","year":"2010","journal-title":"ZHong nan da xue xue bao. Yi xue bao"},{"issue":"12","key":"10.1016\/j.biopha.2020.110599_bib0530","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1002\/ptr.3500","article-title":"Tanshinone IIA alleviates the biochemical changes associated with hypoxic ischemic brain damage in a rat","volume":"25","author":"Hei","year":"2011","journal-title":"Model Phytotherapy Res.\u202f: PTR"},{"issue":"1","key":"10.1016\/j.biopha.2020.110599_bib0535","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13041-017-0332-9","article-title":"Tanshinone I alleviates motor and cognitive impairments via suppressing oxidative stress in the neonatal rats after hypoxic-ischemic brain damage","volume":"10","author":"Dai","year":"2017","journal-title":"Mol. Brain"},{"issue":"2","key":"10.1016\/j.biopha.2020.110599_bib0540","first-page":"1899","article-title":"Tanshinone IIA improves hypoxic ischemic encephalopathy through TLR\u20114\u2011mediated NF\u2011\u03baB signal pathway","volume":"18","author":"Fang","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"11","key":"10.1016\/j.biopha.2020.110599_bib0545","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s11655-012-1266-9","article-title":"Neutroprotective efficacy of sodium Tanshinone B on hippocampus neuron in a rat model of focal cerebral ischemia","volume":"18","author":"Cai","year":"2012","journal-title":"Chin. J. Integr. Med."},{"issue":"2","key":"10.1016\/j.biopha.2020.110599_bib0550","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1177\/0394632017703274","article-title":"Tanshinone inhibits neuronal cell apoptosis and inflammatory response in cerebral infarction rat model Intermational","volume":"30","author":"Zhou","year":"2017","journal-title":"J. Immunopathol. Pharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2020.110599_bib0555","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000325202","article-title":"Tanshinone IIA prevented brain iron dyshomeostasis in cerebral ischemic rats","volume":"27","author":"Yang","year":"2011","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.biopha.2020.110599_bib0560","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.brainres.2009.12.046","article-title":"Tanshinone IIA down-regulates HMGB1, RAGE, TLR4, NF-kappaB expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemia","volume":"1321","author":"Wang","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.biopha.2020.110599_bib0565","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jep.2017.06.023","article-title":"Salvia Miltiorrhiza Bunge (Danshen) extract attenuates permanent cerebral ischemia through inhibiting platelet activation in rats","volume":"207","author":"Fei","year":"2017","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.biopha.2020.110599_bib0570","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s11064-013-1221-y","article-title":"Protective effect of tanshinone IIA against infarct size and increased HMGB1, NF\u03baB, GFAP and apoptosis consequent to transient middle cerebral artery occlusion","volume":"39","author":"Wang","year":"2014","journal-title":"Neurochem. Res."},{"issue":"6","key":"10.1016\/j.biopha.2020.110599_bib0575","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/WNR.0000000000000559","article-title":"Tanshinone IIA increases levels of neun, protein disulfide isomerase, and Na+\/K+-ATPase and decreases evidence of microglial activation after cerebral ischemic injury","volume":"27","author":"Wen","year":"2016","journal-title":"Neuroreport"},{"issue":"3\u20134","key":"10.1016\/j.biopha.2020.110599_bib0580","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.brainresbull.2010.04.005","article-title":"The neuroprotective effects of tanshinone iia are associated with induced nuclear translocation of torc1 and upregulated expression of TORC1, pCREB and BDNF in the acute stage of ischemic stroke","volume":"82","author":"Liu","year":"2010","journal-title":"Brain Res. Bull."},{"issue":"2","key":"10.1016\/j.biopha.2020.110599_bib0585","doi-asserted-by":"crossref","first-page":"132","DOI":"10.2174\/1567202614666170306105315","article-title":"Tanshinone IIA protects hippocampal neuronal cells from reactive oxygen species through Changes in Autophagy and Activation of Phosphatidylinositol 3-kinase, protein kinas B, and mechanistic target of rapamycin pathways","volume":"14","author":"Zhu","year":"2017","journal-title":"Curr. Neurovasc. Res."},{"issue":"4","key":"10.1016\/j.biopha.2020.110599_bib0590","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/s12975-017-0526-6","article-title":"Sodium tanshinone IIA sulfonate enhances effectiveness Rt-PA treatment in acute ischemic stroke patients associated with ameliorating blood-brain barrier damage","volume":"8","author":"Ji","year":"2017","journal-title":"Transl. Stroke Res."},{"issue":"4","key":"10.1016\/j.biopha.2020.110599_bib0595","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s11064-015-1751-6","article-title":"Neuroprotective effects of tanshinone i against 6-ohda-induced oxidative stress in cellular and mouse model of Parkinson\u2019s disease through upregulating Nrf2","volume":"41","author":"Jing","year":"2016","journal-title":"Neurochem. Res."},{"issue":"8","key":"10.1016\/j.biopha.2020.110599_bib0600","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1007\/s11064-016-1906-0","article-title":"Tanshinone I enhances neurogenesis in the mouse hippocampal dentate gyrus via increasing Wnt-3, phosphorylated glycogen synthase kinase-3\u03b2 and \u03b2-catenin immunoreactivities","volume":"41","author":"Chen","year":"2016","journal-title":"Neurochem. Res."},{"issue":"2","key":"10.1016\/j.biopha.2020.110599_bib0605","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/jphp.12650","article-title":"Tanshinone IIA attenuates A\u03b225-35 -induced spatial memory impairment via upregulating receptors for activated c kinase1 and inhibiting autophagy in hippocampus","volume":"69","author":"Zhu","year":"2017","journal-title":"J. Pharm. Pharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2020.110599_bib0610","first-page":"2012","article-title":"Neuroprotective effect of Tanshinone IIA weakens spastic cerebral palsy through inflammation, p38MAPK and VEGF in neonatal rats","volume":"17","author":"Zhang","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"8","key":"10.1016\/j.biopha.2020.110599_bib0615","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.kjms.2018.03.005","article-title":"Neuroprotective effect of tanshinone IIA against neuropathic pain in diabetic rats through the Nrf2\/ARE and NF-\u03baB signaling pathways","volume":"34","author":"Feng","year":"2018","journal-title":"Kaohsiung J. Med. Sci."},{"key":"10.1016\/j.biopha.2020.110599_bib0620","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.ejphar.2015.09.006","article-title":"a multiple target neuroprotectant, promotes caveolae-dependent neuronal differentiation","volume":"765","author":"Zhao","year":"2015","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.biopha.2020.110599_bib0625","first-page":"196","article-title":"Tanshinone IIA ameliorates lead (Pb)-induced cognitive deficits and oxidative stress in a rat pup model","volume":"118","author":"Tang","year":"2017","journal-title":"Bratisl. Lek. Listy"},{"issue":"4","key":"10.1016\/j.biopha.2020.110599_bib0630","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1213\/ANE.0000000000001942","article-title":"Tanshinone IIA attenuates sevoflurane neurotoxicity in neonatal mice","volume":"124","author":"Xia","year":"2017","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.biopha.2020.110599_bib0635","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.biopha.2018.05.040","article-title":"Tanshinone IIA exerts neuroprotective effects on hippocampus-dependent cognitive impairments in diabetic rats by attenuating ER stress-induced apoptosis","volume":"104","author":"Chen","year":"2018","journal-title":"Biomed. Pharmacotherapy"},{"issue":"1","key":"10.1016\/j.biopha.2020.110599_bib0640","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s10753-018-0899-z","article-title":"The protective effects and the involved mechanisms of tanshinone IIA on sepsis-induced brain damage in mice","volume":"42","author":"Xiong","year":"2019","journal-title":"Inflammation"},{"issue":"7","key":"10.1016\/j.biopha.2020.110599_bib0645","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1007\/s11064-015-1624-z","article-title":"Tanshinone IIA rescued the impairments of primary hippocampal neurons induced by BV2 microglial over-activation","volume":"40","author":"Wang","year":"2015","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.biopha.2020.110599_bib0650","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ejphar.2015.12.014","article-title":"Treatment with tanshinone IIA suppresses disruption of the blood-brain barrier and reduces expression of adhesion molecules and chemokines in experimental autoimmune encephalomyelitis","volume":"771","author":"Yang","year":"2016","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.biopha.2020.110599_bib0655","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1142\/S0192415X16500403","article-title":"Tanshinone IIA protects against folic acid-induced acute kidney injury","volume":"44","author":"Jiang","year":"2016","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.biopha.2020.110599_bib0660","article-title":"Tanshinone IIA attenuates renal fibrosis after acute kidney injury in a mouse model through inhibition of fibrocytes recruitment","volume":"2015","author":"Jiang","year":"2016","journal-title":"Biomed Res. Int."},{"issue":"6","key":"10.1016\/j.biopha.2020.110599_bib0665","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1159\/000489688","article-title":"Tanshinone IIA attenuates contrast-induced nephropathy via Nrf2 activation in rats","volume":"46","author":"Liang","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"issue":"9","key":"10.1016\/j.biopha.2020.110599_bib0670","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1055\/s-0031-1298487","article-title":"Tanshinone IIA prevents uric acid nephropathy in rats through NF-\u03baB inhibition","volume":"78","author":"Wu","year":"2012","journal-title":"Planta Med."},{"issue":"2","key":"10.1016\/j.biopha.2020.110599_bib0675","first-page":"405","article-title":"Protective effect of tanshinone IIA on rat kidneys during hypothermic preservation","volume":"5","author":"Zhang","year":"2011","journal-title":"Mol. Med. Rep."},{"issue":"3","key":"10.1016\/j.biopha.2020.110599_bib0680","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.etap.2013.07.017","article-title":"Tanshinone I protects mice from aristolochic acid I-induced kidney injury by induction of CYP1A","volume":"36","author":"Feng","year":"2013","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"2","key":"10.1016\/j.biopha.2020.110599_bib0685","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1248\/bpb.32.220","article-title":"Protective effect of Tanshinone IIA on the early stage of experimental diabetic nephropathy","volume":"32","author":"Kim","year":"2009","journal-title":"Biol. Pharm. Bull."},{"issue":"19","key":"10.1016\/j.biopha.2020.110599_bib0690","doi-asserted-by":"crossref","first-page":"31915","DOI":"10.18632\/oncotarget.16651","article-title":"Tanshinone IIA attenuates renal damage in STZ-induced diabetic rats via inhibiting oxidative stress and inflammation","volume":"8","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"issue":"7","key":"10.1016\/j.biopha.2020.110599_bib0695","first-page":"965","article-title":"Effects of tanshinone IIA on Wnt\/beta-catenin signaling pathway of high glucose induced renal tubular epithelial cell transdifferentiation","volume":"32","author":"Huang","year":"2012","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"issue":"5","key":"10.1016\/j.biopha.2020.110599_bib0700","first-page":"4639","article-title":"Effect of tanshinone IIA on oxidative stress and apoptosis in a rat model of fatty liver","volume":"14","author":"Yang","year":"2017","journal-title":"Environ. Therapeutic Med."},{"key":"10.1016\/j.biopha.2020.110599_bib0705","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.biopha.2018.12.019","article-title":"Sodium tanshinone IIA sulfonate ameliorates hepatic steatosis by inhibiting lipogenesis and inflammation","volume":"111","author":"Li","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.biopha.2020.110599_bib0710","first-page":"379","article-title":"Tanshinone IIA inhibits Hep-J5 cells by increasing calreticulin, caspase 12 and GADD153 protein expression","volume":"26","author":"Cheng","year":"2010","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.biopha.2020.110599_bib0715","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.biopha.2017.03.022","article-title":"Pre-conditioning with tanshinone IIA attenuates the ischemia\/reperfusion injury caused by liver grafts via regulation of HMGB1 in rat Kupffer cells","volume":"89","author":"Li","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.biopha.2020.110599_bib0720","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.3892\/mmr.2015.4696","article-title":"Tanshinone IIA promotes the proliferation of WB-F344 hepatic oval cells via Wnt\/\u03b2-catenin signaling","volume":"13","author":"Ze","year":"2016","journal-title":"Mol. Med. Rep."},{"issue":"6","key":"10.1016\/j.biopha.2020.110599_bib0725","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.phymed.2016.02.022","article-title":"Tanshinone IIA protects against acetaminophen-induced hepatotoxicity via activating the Nrf2 pathway","volume":"23","author":"Wang","year":"2016","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.biopha.2020.110599_bib0730","doi-asserted-by":"crossref","first-page":"620","DOI":"10.3390\/ijms18030620","article-title":"A biomedical investigation of the hepatoprotective effect of radix salviae miltiorrhizae and network pharmacology-based prediction of the active compounds and molecular targets","volume":"18","author":"Hong","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.biopha.2020.110599_bib0735","first-page":"484","article-title":"Tanshinone IIA protects rat primary hepatocytes against carbon tetrachloride toxicity via inhibiting mitochondria permeability transition","volume":"48","author":"Zhu","year":"2010","journal-title":"Comp. Study"},{"key":"10.1016\/j.biopha.2020.110599_bib0740","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jep.2015.01.047","article-title":"Tanshinone IIA exerts protective effects in a LCA-induced cholestatic liver model associated with participation of pregnane X receptor","volume":"164","author":"Zhang","year":"2015","journal-title":"J. Ethnopharmacol."},{"issue":"10","key":"10.1016\/j.biopha.2020.110599_bib0745","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.3109\/13880209.2014.889720","article-title":"Salvia miltiorrhiza compounds protect the liver from acute injury by regulation of P38 and NFKB signaling in kupffer cells","volume":"52","author":"Yue","year":"2014","journal-title":"Pharm. Biol."},{"issue":"5","key":"10.1016\/j.biopha.2020.110599_bib0750","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/emm.2006.31","article-title":"Tanshinone IIA inhibits osteoclast differentiation through down-regulation of c-Fos and NFATc1","volume":"10","author":"Kwak","year":"2006","journal-title":"Exp. Mol. Med."},{"issue":"5","key":"10.1016\/j.biopha.2020.110599_bib0755","first-page":"6969","article-title":"Tanshinone\u2011IIA attenuates the deleterious effects of oxidative stress in osteoporosis through the NF\u2011\u03baB signaling pathway","volume":"17","author":"Zhu","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"5","key":"10.1016\/j.biopha.2020.110599_bib0760","first-page":"1457","article-title":"Tanshinone IIA attenuates osteoclastogenesis in ovariectomized mice by inactivating NF-kB and akt signaling pathways","volume":"10","author":"Cheng","year":"2018","journal-title":"Am. J. Transl. Res."},{"issue":"1","key":"10.1016\/j.biopha.2020.110599_bib0765","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1080\/13880209.2020.1738502","article-title":"Inhibition of tanshinone IIA on renin activity protected against osteoporosis in diabetic mice","volume":"58","author":"Zhang","year":"2020","journal-title":"Pharm. Biol."},{"issue":"2","key":"10.1016\/j.biopha.2020.110599_bib0770","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jep.2010.03.021","article-title":"Tanshinone IIA inhibits smooth muscle proliferation and intimal hyperplasia in the rat carotid balloon-injured model through inhibition of MAPK signaling pathway","volume":"129","author":"Li","year":"2010","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.biopha.2020.110599_bib0775","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1159\/000358682","article-title":"Tanshinone IIA promotes pulmonary artery smooth muscle cell apoptosis in vitro by inhibiting the JAK2\/STAT3 signaling pathway","volume":"33","author":"Chen","year":"2014","journal-title":"Cell. Physiol. Biochem."},{"issue":"6","key":"10.1016\/j.biopha.2020.110599_bib0780","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1177\/1074248415574743","article-title":"Tanshinone IIA prevents rat basilar artery smooth muscle cells proliferation by inactivation of PDK1 during the development of hypertension","volume":"20","author":"Yu","year":"2015","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"issue":"4","key":"10.1016\/j.biopha.2020.110599_bib0785","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1242\/bio.024133","article-title":"Tanshinone IIA suppresses the progression of atherosclerosis by inhibiting the apoptosis of vascular smooth muscle cells and the proliferation and migration of macrophages induced by ox-LDL","volume":"6","author":"Wang","year":"2017","journal-title":"Biol. Open"},{"issue":"1","key":"10.1016\/j.biopha.2020.110599_bib0790","first-page":"83","article-title":"Tanshinone IIA inhibits AGEs-induced proliferation and migration of cultured vascular smooth muscle cells by suppressing ERK1\/2 MAPK signaling Iranian","volume":"21","author":"Lu","year":"2018","journal-title":"J. Basic Med. Sci."},{"issue":"4","key":"10.1016\/j.biopha.2020.110599_bib0795","first-page":"1847","article-title":"Tanshinone IIA inhibits lipopolysaccharide\u2011induced inflammatory responses through the TLR4\/TAK1\/NF\u2011\u03baB signaling pathway in vascular smooth muscle cells intermational","volume":"43","author":"Meng","year":"2019","journal-title":"J. Mol. Med."},{"issue":"11","key":"10.1016\/j.biopha.2020.110599_bib0800","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1248\/bpb.b19-00053","article-title":"Tanshinone IIA can inhibit angiotensin ii-induced proliferation and autophagy of vascular smooth muscle cells via regulating the MAPK signaling pathway","volume":"42","author":"Lu","year":"2019","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.biopha.2020.110599_bib0805","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.abb.2019.108154","article-title":"Tanshinone IIA attenuates high glucose induced human vsmc proliferation and migration through miR-21-5p-mediated tropomyosin 1 downregulation","volume":"677","author":"Jia","year":"2019","journal-title":"Arch. Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.biopha.2020.110599_bib0810","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.bbrc.2019.11.055","article-title":"Tanshinone \u2161A inhibits homocysteine-induced proliferation of vascular smooth muscle cells via miR-145\/CD40 signaling","volume":"522","author":"Li","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2020.110599_bib0815","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ejphar.2019.03.021","article-title":"Tanshinone I inhibits vascular smooth muscle cell proliferation by targeting insulin-like growth factor-1 receptor\/phosphatidylinositol-3-kinase signaling pathway","volume":"853","author":"Wu","year":"2019","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.biopha.2020.110599_bib0820","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1089\/rej.2016.1912","article-title":"Tanshinone iia elicits neuroprotective effect through activating the nuclear factor erythroid 2-related factor-dependent antioxidant response","volume":"20","author":"Cai","year":"2017","journal-title":"Rejuvenation Res."},{"issue":"2","key":"10.1016\/j.biopha.2020.110599_bib0825","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1177\/0394632017703274","article-title":"Tanshinone inhibits neuronal cell apoptosis and inflammatory response in cerebral infarction rat model","volume":"30","author":"Zhou","year":"2017","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.biopha.2020.110599_bib0830","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.biopha.2018.05.040","article-title":"Tanshinone IIA exerts neuroprotective effects on hippocampus-dependent cognitive impairments in diabetic rats by attenuating ER stress-induced apoptosis","volume":"104","author":"Chen","year":"2018","journal-title":"Biomed. Pharmacotherapy"},{"key":"10.1016\/j.biopha.2020.110599_bib0835","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2020.01.026","article-title":"Tanshinone IIA improves depression-like behavior in mice by activating the ERK-CREB-BDNF signaling pathway","volume":"430","author":"Lu","year":"2020","journal-title":"Neuroscience"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220307927?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220307927?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T18:19:49Z","timestamp":1766081989000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332220307927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":167,"alternative-id":["S0753332220307927"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110599","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacological basis of tanshinone and new insights into tanshinone as a multitarget natural product for multifaceted diseases","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110599","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"110599"}}