{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:36:02Z","timestamp":1791225362704,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T00:00:00Z","timestamp":1596412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004156","name":"Mahidol University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004071","name":"Khon Kaen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.biopha.2020.110605","type":"journal-article","created":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T23:26:53Z","timestamp":1596929213000},"page":"110605","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["Moringa oleifera leaf extract enhances endothelial nitric oxide production leading to relaxation of resistance artery and lowering of arterial blood pressure"],"prefix":"10.1016","volume":"130","author":[{"given":"Direk","family":"Aekthammarat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panot","family":"Tangsucharit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patchareewan","family":"Pannangpetch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanaporn","family":"Sriwantana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathawut","family":"Sibmooh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.biopha.2020.110605_bib0005","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/cvr\/cvy023","article-title":"Vascular smooth muscle contraction in hypertension","volume":"114","author":"Touyz","year":"2018","journal-title":"Cardiovas. Res."},{"key":"10.1016\/j.biopha.2020.110605_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vph.2017.05.005","article-title":"Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases","volume":"100","author":"Incalza","year":"2018","journal-title":"Vascul. Pharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2020.110605_bib0015","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3400\/avd.ra.17-00134","article-title":"Nitric oxide: from good to bad","volume":"11","author":"Vanhoutte","year":"2018","journal-title":"Ann. Vasc. Dis."},{"key":"10.1016\/j.biopha.2020.110605_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117357","article-title":"Schisantherin A causes endothelium-dependent and -independent vasorelaxation in isolated rat thoracic aorta","volume":"245","author":"Yang","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.biopha.2020.110605_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109022","article-title":"White mulberry fruit polysaccharides enhance endothelial nitric oxide production to relax arteries in vitro and reduce blood pressure in vivo","volume":"116","author":"Wang","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"1548","key":"10.1016\/j.biopha.2020.110605_bib0030","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.3389\/fphar.2019.01548","article-title":"Kang Le Xin reduces blood pressure through inducing endothelial-dependent vasodilation by activating the AMPK-eNOS pathway","volume":"10","author":"Zhao","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.biopha.2020.110605_bib0035","doi-asserted-by":"crossref","first-page":"976","DOI":"10.3390\/molecules25040976","article-title":"A stable isothiocyanate from Moringa oleifera, activates the somatosensory and pain receptor TRPA1 channel in vitro","volume":"25","author":"Borgonovo","year":"2020","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.biopha.2020.110605_bib0040","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1080\/07315724.2019.1608602","article-title":"Consumption of Moringa oleifera Lam leaves lowers postprandial blood pressure","volume":"39","author":"Chan Sun","year":"2020","journal-title":"J. Am. Coll. Nutr."},{"issue":"3","key":"10.1016\/j.biopha.2020.110605_bib0045","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.3892\/ol.2015.3482","article-title":"A potential oral anticancer drug candidate, Moringa oleifera leaf extract, induces the apoptosis of human hepatocellular carcinoma cells","volume":"10","author":"Jung","year":"2015","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.biopha.2020.110605_bib0050","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3389\/fphar.2017.00577","article-title":"Hypoglycemic potential of aqueous extract of Moringa oleifera leaf and in vivo GC-MS metabolomics","volume":"8","author":"Khan","year":"2017","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.biopha.2020.110605_bib0055","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3390\/nu10030343","article-title":"Nutraceutical or pharmacological potential of Moringa oleifera Lam","volume":"10","author":"Kou","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.biopha.2020.110605_bib0060","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2018.00108","article-title":"Moringa Genus: a review of phytochemistry and pharmacology","volume":"9","author":"Abd Rani","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.biopha.2020.110605_bib0065","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.phymed.2018.10.023","article-title":"Moringa oleifera leaf extract lowers high blood pressure by alleviating vascular dysfunction and decreasing oxidative stress in L-NAME hypertensive rats","volume":"54","author":"Aekthammarat","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.biopha.2020.110605_bib0070","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1080\/10641963.2020.1714640","article-title":"Moringa oleifera leaf extract induces vasorelaxation via endothelium-dependent hyperpolarization and calcium channel blockade in mesenteric arterial beds isolated from L-NAME hypertensive rats","volume":"42","author":"Aekthammarat","year":"2020","journal-title":"Clin. Exp. Hypertens."},{"key":"10.1016\/j.biopha.2020.110605_bib0075","first-page":"1","article-title":"Seperation of phenolic compounds from food by reversed\u2010phase high performance liquid chromatography","volume":"24","author":"Penarrieta","year":"2007","journal-title":"Rev. Bol. Quim."},{"issue":"9","key":"10.1016\/j.biopha.2020.110605_bib0080","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1139\/cjpp-2018-0012","article-title":"Deferiprone increases endothelial nitric oxide synthase phosphorylation and nitric oxide production","volume":"96","author":"Sriwantana","year":"2018","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2020.110605_bib0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/1071576021000033112","article-title":"Methodologies for the sensitive and specific measurement of S-nitrosothiols, iron-nitrosyls, and nitrite in biological samples","volume":"37","author":"Yang","year":"2003","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.biopha.2020.110605_bib0090","doi-asserted-by":"crossref","DOI":"10.1186\/1472-6882-14-150","article-title":"Polygonum viviparum L. induces vasorelaxation in the rat thoracic aorta via activation of nitric oxide synthase in endothelial cells","volume":"14","author":"Chang","year":"2014","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.biopha.2020.110605_bib0095","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1016\/j.biopha.2018.07.107","article-title":"The protective effects of a novel synthetic \u03b2-elemene derivative on human umbilical vein endothelial cells against oxidative stress-induced injury: involvement of antioxidation and PI3k\/Akt\/eNOS\/NO signaling pathways","volume":"106","author":"Ahmad","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2020.110605_bib0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phymed.2018.05.005","article-title":"Lespedeza cuneata protects the endothelial dysfunction via eNOS phosphorylation of PI3K\/Akt signaling pathway in HUVECs","volume":"48","author":"Lee","year":"2018","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.biopha.2020.110605_bib0105","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.jep.2012.03.022","article-title":"Effect on blood pressure of a dietary supplement containing traditional medicinal plants of C\u00f4te d\u2019Ivoire","volume":"141","author":"Abrogoua","year":"2012","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2020.110605_bib0110","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3390\/ijms19010120","article-title":"Overview of the microenvironment of vasculature in vascular tone regulation","volume":"19","author":"Loh","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.biopha.2020.110605_bib0115","doi-asserted-by":"crossref","first-page":"5814","DOI":"10.3390\/molecules18055814","article-title":"Vasodilator compounds derived from plants and their mechanisms of action","volume":"18","author":"Luna-V\u00e1zquez","year":"2013","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.biopha.2020.110605_bib0120","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1089\/jmf.2015.0113","article-title":"The antiproliferative effect of Moringa oleifera crude aqueous leaf extract on human esophageal cancer cells","volume":"19","author":"Tiloke","year":"2016","journal-title":"J. Med. Food"},{"issue":"3","key":"10.1016\/j.biopha.2020.110605_bib0125","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.3892\/ol.2015.3482","article-title":"A potential oral anticancer drug candidate, Moringa oleifera leaf extract, induces the apoptosis of human hepatocellular carcinoma cells","volume":"10","author":"Jung","year":"2015","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.biopha.2020.110605_bib0130","doi-asserted-by":"crossref","DOI":"10.1186\/1472-6882-13-212","article-title":"Moringa oleifera aqueous leaf extract down-regulates nuclear factor-kappaB and increases cytotoxic effect of chemotherapy in pancreatic cancer cells","volume":"13","author":"Berkovich","year":"2013","journal-title":"BMC Complement. Altern. Med."},{"issue":"4","key":"10.1016\/j.biopha.2020.110605_bib0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095492","article-title":"Soluble extract from Moringa oleifera leaves with a new anticancer activity","volume":"9","author":"Jung","year":"2014","journal-title":"PLoS One"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220307988?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220307988?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T18:01:38Z","timestamp":1766080898000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332220307988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":27,"alternative-id":["S0753332220307988"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110605","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Moringa oleifera leaf extract enhances endothelial nitric oxide production leading to relaxation of resistance artery and lowering of arterial blood pressure","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110605","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"110605"}}