{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:25:32Z","timestamp":1788492332853,"version":"build-2803163510"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T00:00:00Z","timestamp":1599523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81560684"],"award-info":[{"award-number":["81560684"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860753"],"award-info":[{"award-number":["81860753"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004772","name":"Natural Science Foundation of Ningxia Province","doi-asserted-by":"publisher","award":["2019AAC03084"],"award-info":[{"award-number":["2019AAC03084"]}],"id":[{"id":"10.13039\/501100004772","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013494","name":"West Light Foundation of the Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013494","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.biopha.2020.110747","type":"journal-article","created":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T11:59:49Z","timestamp":1599911989000},"page":"110747","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Beneficial effect of 2\u2019-acetylacteoside on ovariectomized mice via modulating the function of bone resorption"],"prefix":"10.1016","volume":"131","author":[{"given":"Yanting","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hunter","family":"Snooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changling","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4818-5967","authenticated-orcid":false,"given":"Xueqin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.biopha.2020.110747_bib0005","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/nrrheum.2011.217","article-title":"Osteoporosis, frailty and fracture: implications for case finding and therapy","volume":"8","author":"van den Bergh","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"issue":"14","key":"10.1016\/j.biopha.2020.110747_bib0010","doi-asserted-by":"crossref","DOI":"10.2174\/1389450114666131220160357","article-title":"Beneficial effects of traditional Chinese medicine on the treatment of osteoporosis on ovariectomised rat models","volume":"14","author":"Rufus","year":"2013","journal-title":"Curr. Drug Targets"},{"issue":"2018","key":"10.1016\/j.biopha.2020.110747_bib0015","first-page":"1","article-title":"Prevention and treatment of osteoporosis using Chinese medicinal plants: special emphasis on mechanisms of immune modulation","author":"Zhao","year":"2018","journal-title":"J. Immunol. Res."},{"issue":"1","key":"10.1016\/j.biopha.2020.110747_bib0020","doi-asserted-by":"crossref","DOI":"10.1007\/s11657-016-0301-4","article-title":"New insights into the tonifying kidney-yin herbs and formulas for the treatment of osteoporosis","volume":"12","author":"He","year":"2017","journal-title":"Arch. Osteoporos."},{"issue":"1","key":"10.1016\/j.biopha.2020.110747_bib0025","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1753-4887.2011.00451.x","article-title":"Alternative therapies for the prevention and treatment of osteoporosis","volume":"70","author":"Banu","year":"2012","journal-title":"Nutr. Rev."},{"issue":"5","key":"10.1016\/j.biopha.2020.110747_bib0030","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph15050963","article-title":"Protective effects of selected botanical agents on bone","volume":"15","author":"Jolly","year":"2018","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"13","key":"10.1016\/j.biopha.2020.110747_bib0035","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.2174\/13894501113149990205","article-title":"Beneficial effects of plant sources on the treatment of osteoporosis","volume":"14","author":"Suntar","year":"2013","journal-title":"Curr. Drug Targets"},{"issue":"9773","key":"10.1016\/j.biopha.2020.110747_bib0040","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/S0140-6736(10)62349-5","article-title":"Osteoporosis: now and the future","volume":"377","author":"Rachner","year":"2011","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.biopha.2020.110747_bib0045","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1007\/s00198-006-0187-x","article-title":"Osteoporosis prevention and therapy: preserving and building strength through bone quality","volume":"17","author":"Kleerekoper","year":"2006","journal-title":"Osteoporos. Int."},{"issue":"24","key":"10.1016\/j.biopha.2020.110747_bib0050","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.1101\/gad.11.24.3482","article-title":"Requirement for NF-kappaB in osteoclast and B-cell development","volume":"11","author":"Franzoso","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.biopha.2020.110747_bib0055","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.bone.2015.02.017","article-title":"Leonurine hydrochloride inhibits osteoclastogenesis and prevents osteoporosis associated with estrogen deficiency by inhibiting the NF-\u03baB and PI3K\/Akt signaling pathways","volume":"75","author":"Yuan","year":"2015","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.biopha.2020.110747_bib0060","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S1534-5807(02)00369-6","article-title":"Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts","volume":"3","author":"Takayanagi","year":"2002","journal-title":"Dev. Cell"},{"issue":"11","key":"10.1016\/j.biopha.2020.110747_bib0065","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1016\/j.bcp.2008.03.007","article-title":"Bavachalcone inhibits osteoclast differentiation through suppression of NFATc1 induction by RANKL","volume":"75","author":"Park","year":"2008","journal-title":"Biochem. Pharmacol."},{"issue":"5","key":"10.1016\/j.biopha.2020.110747_bib0070","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.3390\/molecules23051213","article-title":"Echinacoside, an inestimable natural product in treatment of neurological and other disorders","volume":"23","author":"Liu","year":"2018","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.biopha.2020.110747_bib0075","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s11418-014-0837-9","article-title":"Acylated phenylethanoid glycosides, echinacoside and acteoside from Cistanche tubulosa, improve glucose tolerance in mice","volume":"68","author":"Morikawa","year":"2014","journal-title":"J. Nat. Med. Tokyo"},{"key":"10.1016\/j.biopha.2020.110747_bib0080","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jpba.2015.10.038","article-title":"Screening and identification of three typical phenylethanoid glycosides metabolites from Cistanches Herba by human intestinal bacteria using UPLC\/Q-TOF-MS","volume":"118","author":"Li","year":"2016","journal-title":"J. Pharmaceut. Biomed."},{"issue":"7","key":"10.1016\/j.biopha.2020.110747_bib0085","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1248\/cpb.c16-00033","article-title":"Changes in levels of phenylethanoid glycosides, antioxidant activity, and other quality traits in Cistanche deserticola slices by steam processing","volume":"64","author":"Peng","year":"2016","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"10.1016\/j.biopha.2020.110747_bib0090","article-title":"Acute and subacute toxicity and chemical constituents of the hydroethanolic extract of Verbena litoralis Kunth","volume":"224","author":"Rachel De Lima","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2020.110747_bib0095","series-title":"Pharmacopoeia, \"Editorial Committee of Chinese Pharmacopoeia. Pharmacopoeia of the People's Republic of China\"","first-page":"178","year":"2015"},{"issue":"06","key":"10.1016\/j.biopha.2020.110747_bib0100","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1142\/S0192415X12500838","article-title":"Cistanche deserticola Y. C. Ma, \"Desert Ginseng\": a review","volume":"40","author":"Wang","year":"2012","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.biopha.2020.110747_bib0105","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2019.01412","article-title":"Anti-osteoporotic activity of an edible traditional Chinese medicine Cistanche deserticola on bone metabolism of ovariectomized rats through RANKL\/RANK\/TRAF6-mediated signaling pathways","volume":"10","author":"Zhang","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"9","key":"10.1016\/j.biopha.2020.110747_bib0110","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.4314\/tjpr.v15i9.17","article-title":"Anti-osteoporosis effect of Cistanche deserticola Ma extract in ovariectomized rats","volume":"15","author":"Zhang","year":"2016","journal-title":"Trop. J. Pharm. Res."},{"issue":"9","key":"10.1016\/j.biopha.2020.110747_bib0115","first-page":"1630","article-title":"Caffeoyl phenylethanoid glycosides from Callicarpa kwangtungensis","volume":"39","author":"Hu","year":"2014","journal-title":"China J. Chin. Mater. Med."},{"issue":"5","key":"10.1016\/j.biopha.2020.110747_bib0120","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nm.4076","article-title":"LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption","volume":"22","author":"Luo","year":"2016","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.biopha.2020.110747_bib0125","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40199-017-0167-z","article-title":"New horizons in treatment of osteoporosis","volume":"25","author":"Tabatabaei-Malazy","year":"2017","journal-title":"DARU J. Pharm. Sci."},{"issue":"70","key":"10.1016\/j.biopha.2020.110747_bib0130","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1753-4887.2011.00451.x","article-title":"Alternative therapies for the prevention and treatment of osteoporosis","volume":"1","author":"Banu","year":"2012","journal-title":"Nutr. Rev."},{"issue":"4","key":"10.1016\/j.biopha.2020.110747_bib0135","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1080\/01480545.2016.1242013","article-title":"Safety assessment of powdered Cistanche deserticola Y. C. Ma by a 90-day feeding test in Sprague-Dawley rats","volume":"40","author":"Gao","year":"2017","journal-title":"Drug Chem. Toxicol."},{"issue":"12","key":"10.1016\/j.biopha.2020.110747_bib0140","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20122974","article-title":"Protective effect of acteoside on ovariectomy-induced bone loss in mice","volume":"20","author":"Yang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.biopha.2020.110747_bib0145","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.phymed.2008.12.006","article-title":"Antiosteoporotic activity of icariin in ovariectomized rats","volume":"16","author":"Nian","year":"2009","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.biopha.2020.110747_bib0150","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.jep.2011.07.017","article-title":"Anti-osteoporosis activity of Cibotium barometz extract on ovariectomy-induced bone loss in rats","volume":"137","author":"Zhao","year":"2011","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.biopha.2020.110747_bib0155","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00198-004-1780-5","article-title":"Assessment of fracture risk","volume":"16","author":"Kanis","year":"2005","journal-title":"Osteoporos. Int."},{"issue":"6","key":"10.1016\/j.biopha.2020.110747_bib0160","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.phymed.2013.01.001","article-title":"Antiosteoporotic activity of echinacoside in ovariectomized rats","volume":"20","author":"Li","year":"2013","journal-title":"Phytomedicine"},{"key":"10.1016\/j.biopha.2020.110747_bib0165","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.phymed.2018.03.020","article-title":"Syringin prevents bone loss in ovariectomized mice via TRAF6 mediated inhibition of NF-kappaB and stimulation of PI3K\/AKT","volume":"42","author":"Liu","year":"2018","journal-title":"Phytomedicine"},{"issue":"5","key":"10.1016\/j.biopha.2020.110747_bib0170","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/BF00316875","article-title":"Bone strength the bottom line","volume":"51","author":"E.T. A","year":"1992","journal-title":"Calcif. Tissue Int."},{"issue":"8","key":"10.1016\/j.biopha.2020.110747_bib0175","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1101\/gad.13.8.1015","article-title":"TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling","volume":"13","author":"Lomaga","year":"1999","journal-title":"Genes Dev."},{"issue":"3","key":"10.1016\/j.biopha.2020.110747_bib0180","first-page":"65","article-title":"Osteoclast formation and differentiation: an overview","volume":"59","author":"Niroshani Surangika Soysa","year":"2012","journal-title":"J. Med. Dent. Sci."},{"issue":"1","key":"10.1016\/j.biopha.2020.110747_bib0185","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1146\/annurev.immunol.20.100301.064753","article-title":"RANK-L and RANK: T cells, bone loss, and mammalian evolution","volume":"20","author":"Theill","year":"2002","journal-title":"Annu. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.biopha.2020.110747_bib0190","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3892\/ijmm.2013.1557","article-title":"Increased OPG\/RANKL ratio in the conditioned medium of soybean-treated osteoblasts suppresses RANKL-induced osteoclast differentiation","volume":"33","author":"Park","year":"2014","journal-title":"Int. J. Mol. Med."},{"issue":"4","key":"10.1016\/j.biopha.2020.110747_bib0195","first-page":"846","article-title":"TRAF6 mediates suppression of osteoclastogenesis and prevention of ovariectomy-induced bone loss by a novel prenylflavonoid","volume":"32","author":"L.L.I.I","year":"2016","journal-title":"J. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.biopha.2020.110747_bib0200","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1128\/MCB.22.4.992-1000.2002","article-title":"Receptor activator of NF-\u03baB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6","volume":"22","author":"Junko Mizukami","year":"2002","journal-title":"Mol. Cell. Biol."},{"issue":"4","key":"10.1016\/j.biopha.2020.110747_bib0205","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21041347","article-title":"Ethyl acetate fraction of aqueous extract of Lentinula edodes inhibits osteoclastogenesis by suppressing NFATc1 expression","volume":"21","author":"Lee","year":"2020","journal-title":"Int. J. Mol. Sci."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220309409?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220309409?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T18:28:25Z","timestamp":1766082505000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332220309409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":41,"alternative-id":["S0753332220309409"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110747","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Beneficial effect of 2\u2019-acetylacteoside on ovariectomized mice via modulating the function of bone resorption","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110747","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"110747"}}