{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T12:43:17Z","timestamp":1774356197570,"version":"3.50.1"},"reference-count":127,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T00:00:00Z","timestamp":1599523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.biopha.2020.110748","type":"journal-article","created":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T11:34:44Z","timestamp":1599651284000},"page":"110748","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Male predisposition to severe COVID-19: Review of evidence and potential therapeutic prospects"],"prefix":"10.1016","volume":"131","author":[{"given":"Desmond Omane","family":"Acheampong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5813-8481","authenticated-orcid":false,"given":"Isaac Kyei","family":"Barffour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Boye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6489-167X","authenticated-orcid":false,"given":"Enoch","family":"Aninagyei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3992-0969","authenticated-orcid":false,"given":"Stephen","family":"Ocansey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin Tangnaa","family":"Morna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.biopha.2020.110748_bib0005","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1001\/jama.2020.1585","article-title":"Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus\u2013infected pneumonia in Wuhan, China","volume":"323","author":"Wang","year":"2020","journal-title":"Jama"},{"issue":"4","key":"10.1016\/j.biopha.2020.110748_bib0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008520","article-title":"Sex-specific clinical characteristics and prognosis of coronavirus disease-19 infection in Wuhan, China: A retrospective study of 168 severe patients","volume":"16","author":"Meng","year":"2020","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.biopha.2020.110748_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmi.2020.07.024","article-title":"Characteristics and predictors of death among 4,035 consecutively hospitalized patients with COVID-19 in Spain","author":"Berenguer","year":"2020","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.biopha.2020.110748_bib0020","article-title":"Paucity and disparity of publicly available sex-disaggregated data for the COVID-19 epidemic hamper evidence-based decision-making","author":"Kocher","year":"2020","journal-title":"medRxiv"},{"issue":"20","key":"10.1016\/j.biopha.2020.110748_bib0025","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1001\/jama.2020.6775","article-title":"Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area","volume":"323","author":"Richardson","year":"2020","journal-title":"Jama"},{"key":"10.1016\/j.biopha.2020.110748_bib0030","series-title":"Coronavirus Disease 2019 (COVID-19): Situation Report, 72","author":"W.H. Organization","year":"2020"},{"key":"10.1016\/j.biopha.2020.110748_bib0035","series-title":"Men Hit Harder by covid-19","author":"Lawton","year":"2020"},{"key":"10.1016\/j.biopha.2020.110748_bib0040","first-page":"1","article-title":"Coronavirus: Why Men are More Vulnerable to Covid-19 Than Women?","author":"Bwire","year":"2020","journal-title":"Sn Comprehensive Clinical Medicine"},{"issue":"13","key":"10.1016\/j.biopha.2020.110748_bib0045","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/path.5471","article-title":"Angiotensin\u2010converting enzyme\u20102 (ACE2), SARS\u2010CoV\u20102 and pathophysiology of coronavirus disease 2019 (COVID\u201019)","volume":"251","author":"Bourgonje","year":"2020","journal-title":"J. Pathol."},{"key":"10.1016\/j.biopha.2020.110748_bib0050","series-title":"WHO Corona Virus Disease (Covid-19): the Global Situation","author":"World Health Organization","year":"2020"},{"key":"10.1016\/j.biopha.2020.110748_bib0055","series-title":"Tracking Differences in COVID-19 Illness and Death Among Women and Men","author":"Global health 5050","year":"2020"},{"key":"10.1016\/j.biopha.2020.110748_bib0060","series-title":"How Is the Outbreak Growing?","author":"John Hopkins University & Medicine","year":"2020"},{"key":"10.1016\/j.biopha.2020.110748_bib0065","series-title":"Covid-19: Emerging Gender Data and Why It Matters","author":"United Nations Women Organization","year":"2020"},{"key":"10.1016\/j.biopha.2020.110748_bib0070","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3389\/fpubh.2020.00152","article-title":"Gender differences in patients with COVID-19: focus on severity and mortality","volume":"8","author":"Jin","year":"2020","journal-title":"Front. Public Health"},{"issue":"9","key":"10.1016\/j.biopha.2020.110748_bib0075","first-page":"1407","article-title":"Sex Differences in Mortality from COVID-19 Pandemic: Are Men Vulnerable and Women Protected?","volume":"2","author":"Sharma","year":"2020","journal-title":"JACC: Case Reports"},{"key":"10.1016\/j.biopha.2020.110748_bib0080","doi-asserted-by":"crossref","first-page":"75","DOI":"10.18433\/jpps31069","article-title":"Prevention and therapy of COVID-19 via exogenous estrogen treatment for both male and female patients","volume":"23","author":"Suba","year":"2020","journal-title":"J. Pharm. Pharm. Sci."},{"key":"10.1016\/j.biopha.2020.110748_bib0085","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/294278","article-title":"Sex hormones and their receptors regulate liver energy homeostasis","volume":"2015","author":"Shen","year":"2015","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.biopha.2020.110748_bib0090","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3389\/fped.2020.00206","article-title":"COVID-19 infection and circulating ACE2 levels: protective role in women and children","volume":"8","author":"Ciaglia","year":"2020","journal-title":"Front. Pediatr."},{"issue":"8","key":"10.1016\/j.biopha.2020.110748_bib0095","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.annonc.2020.04.479","article-title":"Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (n= 4532)","volume":"31","author":"Montopoli","year":"2020","journal-title":"Ann. Oncol."},{"issue":"6","key":"10.1016\/j.biopha.2020.110748_bib0100","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1530\/ERC-20-0133","article-title":"Androgen hazards with COVID-19","volume":"27","author":"Sharifi","year":"2020","journal-title":"Endocr. Relat. Cancer"},{"issue":"2","key":"10.1016\/j.biopha.2020.110748_bib0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.02.058","article-title":"Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein","volume":"281","author":"Walls","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2020.110748_bib0110","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1146\/annurev-virology-110615-042301","article-title":"Structure, function, and evolution of coronavirus spike proteins","volume":"3","author":"Li","year":"2016","journal-title":"Annu. Rev. Virol."},{"key":"10.1016\/j.biopha.2020.110748_bib0115","series-title":"TMPRSS2 Contributes to Virus Spread and Immunopathology in the Airways of Murine Models After Coronavirus Infection","author":"Iwata-Yoshikawa","year":"2019"},{"issue":"22","key":"10.1016\/j.biopha.2020.110748_bib0120","doi-asserted-by":"crossref","first-page":"4397","DOI":"10.1038\/s41388-019-0730-9","article-title":"TMPRSS2-ERG activates NO-cGMP signaling in prostate cancer cells","volume":"38","author":"Zhou","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.biopha.2020.110748_bib0125","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.mce.2017.02.009","article-title":"Emerging aspects of microRNA interaction with TMPRSS2-ERG and endocrine therapy","volume":"462","author":"Zoni","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"issue":"4","key":"10.1016\/j.biopha.2020.110748_bib0130","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/j.1464-410X.2012.11774.x","article-title":"Androgen deprivation therapy: evidence\u2010based management of side effects","volume":"111","author":"Ahmadi","year":"2013","journal-title":"BJU Int."},{"issue":"5","key":"10.1016\/j.biopha.2020.110748_bib0135","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.eururo.2014.07.010","article-title":"Adverse effects of androgen deprivation therapy and strategies to mitigate them","volume":"67","author":"Nguyen","year":"2015","journal-title":"Eur. Urol."},{"key":"10.1016\/j.biopha.2020.110748_bib0140","first-page":"133","article-title":"Integrating diet and exercise into care of prostate cancer patients on androgen deprivation therapy","volume":"8","author":"Moyad","year":"2016","journal-title":"Res. Rep. Urol."},{"issue":"10","key":"10.1016\/j.biopha.2020.110748_bib0145","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.3390\/ijms21103474","article-title":"COVID-19 and individual genetic Susceptibility\/Receptivity: role of ACE1\/ACE2 genes, immunity, inflammation and coagulation. Might the double X-Chromosome in females Be protective against SARS-CoV-2 compared to the single X-Chromosome in males?","volume":"21","author":"Gemmati","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2020.110748_bib0150","series-title":"Mayo Clinic Proceedings","article-title":"Sex differences in COVID-19 case fatality rate: insights from a multinational registry","author":"Alkhouli","year":"2020"},{"issue":"3","key":"10.1016\/j.biopha.2020.110748_bib0155","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1210\/jc.2017-02060","article-title":"Genetic determinants of circulating estrogen levels and evidence of a causal effect of estradiol on bone density in men","volume":"103","author":"Eriksson","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2020.110748_bib0160","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ygcen.2015.12.019","article-title":"Characterization of estrogens, testosterone, and cortisol in normal bottlenose dolphin (Tursiops truncatus) pregnancy","volume":"226","author":"Steinman","year":"2016","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.biopha.2020.110748_bib0165","series-title":"The Reproductive System, The Zebrafish in Biomedical Research","first-page":"151","author":"Siegfried","year":"2020"},{"key":"10.1016\/j.biopha.2020.110748_bib0170","series-title":"Skeletal Tissue and Ovarian Function: Puberty and Menopause, Multidisciplinary Approach to Osteoporosis","first-page":"129","author":"Colao","year":"2018"},{"issue":"10","key":"10.1016\/j.biopha.2020.110748_bib0175","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1007\/s00204-019-02564-w","article-title":"Qualitative and quantitative differences in estrogen biotransformation in human breast glandular and adipose tissues: implications for studies using mammary biospecimens","volume":"93","author":"Pemp","year":"2019","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.biopha.2020.110748_bib0180","series-title":"Investigating the Mechanism of Action of Hormones Used in Hormone Replacement Therapy Via Estrogen Receptor Subtypes and the Influence of the Progesterone Receptor","author":"Perkins","year":"2018"},{"key":"10.1016\/j.biopha.2020.110748_bib0185","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.maturitas.2017.11.006","article-title":"Sex hormone levels and change in left ventricular structure among men and post-menopausal women: the Multi-Ethnic Study of Atherosclerosis (MESA)","volume":"108","author":"Subramanya","year":"2018","journal-title":"Maturitas"},{"key":"10.1016\/j.biopha.2020.110748_bib0190","article-title":"A Multi-hospital Study in Wuhan, China: Protective Effects of Non-menopause and Female Hormones on SARS-CoV-2 infection","author":"Ding","year":"2020","journal-title":"medRxiv"},{"issue":"6","key":"10.1016\/j.biopha.2020.110748_bib0195","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.jinf.2020.03.037","article-title":"Cytokine storm in COVID-19 and treatment","volume":"80","author":"Ye","year":"2020","journal-title":"J. Infect."},{"key":"10.1016\/j.biopha.2020.110748_bib0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2020.102537","article-title":"Interleukin-6 use in COVID-19 pneumonia related macrophage activation syndrome","author":"McGonagle","year":"2020","journal-title":"Autoimmun. Rev."},{"issue":"1","key":"10.1016\/j.biopha.2020.110748_bib0205","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s10528-018-9871-8","article-title":"Gene expression of ABHD6, a key factor in the endocannabinoid system, can Be modulated by female hormones in human immune cells","volume":"57","author":"Drehmer","year":"2019","journal-title":"Biochem. Genet."},{"issue":"4","key":"10.1016\/j.biopha.2020.110748_bib0210","doi-asserted-by":"crossref","first-page":"434","DOI":"10.7150\/ijbs.18278","article-title":"Estradiol suppresses TLR4-triggered apoptosis of decidual stromal cells and drives an anti-inflammatory TH2 shift by activating SGK1","volume":"13","author":"Lou","year":"2017","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.biopha.2020.110748_bib0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-08631-5","article-title":"Balance between estrogens and proinflammatory cytokines regulates chemokine production involved in thymic germinal center formation","volume":"7","author":"Dragin","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2020.110748_bib0220","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.clinbiochem.2018.05.014","article-title":"Measuring estrogens in women, men, and children: recent advances 2012\u20132017","volume":"62","author":"Smy","year":"2018","journal-title":"Clin. Biochem."},{"issue":"10","key":"10.1016\/j.biopha.2020.110748_bib0225","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.4049\/jimmunol.1601896","article-title":"Sex-based differences in susceptibility to severe acute respiratory syndrome coronavirus infection","volume":"198","author":"Channappanavar","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.biopha.2020.110748_bib0230","first-page":"383","article-title":"Understanding immune effects of oestrogens to explain the reduced morbidity and mortality in female versus male COVID-19 patients. Comparisons with autoimmunity and vaccination","volume":"38","author":"Cutolo","year":"2020","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.biopha.2020.110748_bib0235","series-title":"Sex Hormones and Novel Corona Virus Infectious Disease (COVID-19), Mayo Clinic Proceedings","author":"Al-Lami","year":"2020"},{"issue":"10","key":"10.1016\/j.biopha.2020.110748_bib0240","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1210\/jc.2016-3476","article-title":"Third trimester estrogens and maternal breast cancer: prospective evidence","volume":"102","author":"Cohn","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"6","key":"10.1016\/j.biopha.2020.110748_bib0245","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41568-018-0001-z","article-title":"Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance","volume":"18","author":"Katzenellenbogen","year":"2018","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.biopha.2020.110748_bib0250","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3389\/fimmu.2017.00108","article-title":"Estrogen receptor-dependent regulation of dendritic cell development and function","volume":"8","author":"Laffont","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.biopha.2020.110748_bib0255","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.31159","article-title":"ER\u03b1 promotes murine hematopoietic regeneration through the Ire1\u03b1-mediated unfolded protein response","volume":"7","author":"Chapple","year":"2018","journal-title":"Elife"},{"issue":"2","key":"10.1016\/j.biopha.2020.110748_bib0260","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1189\/jlb.3A0914-430RR","article-title":"Estrogen anti\u2010inflammatory activity on human monocytes is mediated through cross\u2010talk between estrogen receptor ER\u03b136 and GPR30\/GPER1","volume":"99","author":"Pelekanou","year":"2016","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.biopha.2020.110748_bib0265","series-title":"Macrophages, Extracellular Matrix, and Estrogens in Breast Cancer Risk, Systems Biology of Tumor Physiology","first-page":"1","author":"Nguyen","year":"2016"},{"issue":"1","key":"10.1016\/j.biopha.2020.110748_bib0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13046-019-1461-z","article-title":"Acetyl-L-Carnitine downregulates invasion (CXCR4\/CXCL12, MMP-9) and angiogenesis (VEGF, CXCL8) pathways in prostate cancer cells: rationale for prevention and interception strategies","volume":"38","author":"Baci","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.biopha.2020.110748_bib0275","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jep.2017.08.034","article-title":"Anti-inflammatory sesquiterpenoids from the Traditional Chinese Medicine Salvia plebeia: Regulates pro-inflammatory mediators through inhibition of NF-\u03baB and Erk1\/2 signaling pathways in LPS-induced Raw264. 7 cells","volume":"210","author":"Zou","year":"2018","journal-title":"J. Ethnopharmacol."},{"issue":"526","key":"10.1016\/j.biopha.2020.110748_bib0280","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aap9415","article-title":"Estrogen receptor \u03b1 contributes to T cell\u2013mediated autoimmune inflammation by promoting T cell activation and proliferation","volume":"11","author":"Mohammad","year":"2018","journal-title":"Sci. Signal."},{"issue":"6","key":"10.1016\/j.biopha.2020.110748_bib0285","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.ajpath.2017.02.012","article-title":"Interferon-\u03b3 released by activated CD8+ T lymphocytes impairs the calcium resorption potential of osteoclasts in calcified human aortic valves","volume":"187","author":"Nagy","year":"2017","journal-title":"Am. J. Pathol."},{"issue":"2","key":"10.1016\/j.biopha.2020.110748_bib0290","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1159\/000077436","article-title":"Hormonal therapy with letrozole for relapsed epithelial ovarian cancer","volume":"66","author":"Papadimitriou","year":"2004","journal-title":"Oncology"},{"issue":"7","key":"10.1016\/j.biopha.2020.110748_bib0295","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1038\/s41375-018-0376-6","article-title":"Inflammation-induced glycolytic switch controls suppressivity of mesenchymal stem cells via STAT1 glycosylation","volume":"33","author":"Jitschin","year":"2019","journal-title":"Leukemia"},{"issue":"5","key":"10.1016\/j.biopha.2020.110748_bib0300","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.4049\/jimmunol.1601166","article-title":"Sex drives dimorphic immune responses to viral infections","volume":"198","author":"Ghosh","year":"2017","journal-title":"J. Immunol."},{"issue":"8-9","key":"10.1016\/j.biopha.2020.110748_bib0305","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.imbio.2017.05.007","article-title":"Ovarian hormones in innate inflammation","volume":"222","author":"Stubelius","year":"2017","journal-title":"Immunobiology"},{"issue":"5","key":"10.1016\/j.biopha.2020.110748_bib0310","doi-asserted-by":"crossref","first-page":"708","DOI":"10.3390\/jcm8050708","article-title":"Systemic inflammation in metabolic syndrome: increased platelet and leukocyte activation, and key role of CX3CL1\/CX3CR1 and CCL2\/CCR2 axes in arterial platelet-proinflammatory monocyte adhesion","volume":"8","author":"Marques","year":"2019","journal-title":"J. Clin. Med."},{"issue":"6","key":"10.1016\/j.biopha.2020.110748_bib0315","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008570","article-title":"Biological sex impacts COVID-19 outcomes","volume":"16","author":"Klein","year":"2020","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.biopha.2020.110748_bib0320","series-title":"Seminars in Immunopathology","first-page":"239","article-title":"Sex differences in vaccine-induced humoral immunity","author":"Fischinger","year":"2019"},{"issue":"14","key":"10.1016\/j.biopha.2020.110748_bib0325","doi-asserted-by":"crossref","first-page":"E2029","DOI":"10.1073\/pnas.1520113113","article-title":"Unusual maintenance of X chromosome inactivation predisposes female lymphocytes for increased expression from the inactive X","volume":"113","author":"Wang","year":"2016","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"19","key":"10.1016\/j.biopha.2020.110748_bib0330","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aap8855","article-title":"TLR7 escapes X chromosome inactivation in immune cells","volume":"3","author":"Souyris","year":"2018","journal-title":"Sci. Immunol."},{"issue":"2","key":"10.1016\/j.biopha.2020.110748_bib0335","first-page":"71","article-title":"Coronavirus COV-19\/SARS-CoV-2 affects women less than men: clinical response to viral infection","volume":"34","author":"Conti","year":"2020","journal-title":"J. Biol. Regul. Homeost. Agents"},{"issue":"4\u20135","key":"10.1016\/j.biopha.2020.110748_bib0340","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.micinf.2020.04.009","article-title":"Bioinformatic analysis and identification of single-stranded RNA sequences recognized by TLR7\/8 in the SARS-CoV-2, SARS-CoV, and MERS-CoV genomes","volume":"22","author":"Moreno-Eutimio","year":"2020","journal-title":"Microbes Infect."},{"issue":"1","key":"10.1016\/j.biopha.2020.110748_bib0345","doi-asserted-by":"crossref","first-page":"253","DOI":"10.4049\/jimmunol.1602020","article-title":"CXCL4 exposure potentiates TLR-driven polarization of human monocyte-derived dendritic cells and increases stimulation of T cells","volume":"199","author":"Silva-Cardoso","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.biopha.2020.110748_bib0350","article-title":"Non-white ethnicity, male sex, and higher body mass index, but not medications acting on the renin-angiotensin system are associated with coronavirus disease 2019 (covid-19) hospitalisation: review of the first 669 cases from the uk biobank","author":"Raisi-Estabragh","year":"2020","journal-title":"medRxiv"},{"issue":"6","key":"10.1016\/j.biopha.2020.110748_bib0355","doi-asserted-by":"crossref","first-page":"e351","DOI":"10.1016\/j.jsxm.2017.04.007","article-title":"001 sexual activity changes patterns of inflammation in healthy women","volume":"14","author":"Lorenz","year":"2017","journal-title":"J. Sex. Med."},{"key":"10.1016\/j.biopha.2020.110748_bib0360","doi-asserted-by":"crossref","first-page":"330","DOI":"10.3389\/fimmu.2018.00330","article-title":"Src family kinases regulate interferon regulatory factor 1 K63 ubiquitination following activation by TLR7\/8 vaccine adjuvant in human monocytes and B cells","volume":"9","author":"Tulli","year":"2018","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.biopha.2020.110748_bib0365","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1177\/1753425916642615","article-title":"Altered molecular expression of TLR-signaling pathways affects the steady-state release of IL-12p70 and IFN-\u03b1 in patients with relapsing-remitting multiple sclerosis","volume":"22","author":"Deckx","year":"2016","journal-title":"Innate Immun."},{"issue":"1","key":"10.1016\/j.biopha.2020.110748_bib0370","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/mrd.22590","article-title":"The effects of 2, 4\u2010dinitrophenol and d\u2010glucose concentration on the development, sex ratio, and interferon\u2010tau (IFNT) production of bovine blastocysts","volume":"83","author":"Green","year":"2016","journal-title":"Mol. Reprod. Dev."},{"issue":"1","key":"10.1016\/j.biopha.2020.110748_bib0375","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-28438-2","article-title":"Efficient production of human interferon beta in the white of eggs from ovalbumin gene\u2013targeted hens","volume":"8","author":"Oishi","year":"2018","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.biopha.2020.110748_bib0380","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13293-019-0278-y","article-title":"SeXY chromosomes and the immune system: reflections after a comparative study","volume":"11","author":"Meester","year":"2020","journal-title":"Biol. Sex Differ."},{"issue":"10","key":"10.1016\/j.biopha.2020.110748_bib0385","first-page":"10534","article-title":"HIV-derived microRNA-99 reduces phagocytic function of macrophages and enhances the release of cytokines via the TLR8 signaling pathway","volume":"11","author":"Zhao","year":"2018","journal-title":"Int. J. Clin. Exp. Med."},{"issue":"1","key":"10.1016\/j.biopha.2020.110748_bib0390","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1189\/jlb.5A1016-444R","article-title":"Elevated interferon\u2010\u03b3\u2013induced protein 10 and its receptor CXCR3 impair NK cell function during HIV infection","volume":"102","author":"Wang","year":"2017","journal-title":"J. Leukoc. Biol."},{"issue":"5","key":"10.1016\/j.biopha.2020.110748_bib0395","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s12264-019-00366-9","article-title":"MicroRNA21 meets neuronal TLR8: non-canonical functions of MicroRNA in neuropathic pain","volume":"35","author":"Wang","year":"2019","journal-title":"Neurosci. Bull."},{"issue":"1","key":"10.1016\/j.biopha.2020.110748_bib0400","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cell.2020.05.025","article-title":"Potent neutralizing antibodies against SARS-CoV-2 identified by high-throughput single-cell sequencing of convalescent patients\u2019 B cells","volume":"182","author":"Cao","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2020.110748_bib0405","doi-asserted-by":"crossref","first-page":"814","DOI":"10.3389\/fimmu.2018.00814","article-title":"Tribody [(HER2) 2xCD16] is more effective than trastuzumab in enhancing \u03b3\u03b4 T cell and natural killer cell cytotoxicity against HER2-expressing cancer cells","volume":"9","author":"Oberg","year":"2018","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.biopha.2020.110748_bib0410","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3892\/ol.2014.2099","article-title":"Effects of complement and serum IgG on rituximab\u2011dependent natural killer cell\u2011mediated cytotoxicity against Raji cells","volume":"17","author":"Li","year":"2018","journal-title":"Oncol. Lett."},{"issue":"1","key":"10.1016\/j.biopha.2020.110748_bib0415","first-page":"1","article-title":"Age-associated changes in the impact of sex steroids on influenza vaccine responses in males and females","volume":"4","author":"Potluri","year":"2019","journal-title":"Npj Vaccines"},{"key":"10.1016\/j.biopha.2020.110748_bib0420","series-title":"The Effect of Donor Sex on Influenza A Infection in Primary Human Nasal Epithelial Cell Cultures","author":"Bochnowski","year":"2016"},{"issue":"11","key":"10.1016\/j.biopha.2020.110748_bib0425","first-page":"11159","article-title":"Interactions between angiotensin-converting enzyme-2 polymorphisms and high salt intake increase the risk of hypertension in the Chinese Wa population","volume":"10","author":"He","year":"2017","journal-title":"Int. J. Clin. Exp. Pathol."},{"issue":"Suppl_1","key":"10.1016\/j.biopha.2020.110748_bib0430","doi-asserted-by":"crossref","DOI":"10.1161\/hyp.74.suppl_1.099","article-title":"Novel angiotensin-converting-Enzyme 2 (ACE2) truncates to target the kidney renin-angiotensin-System (RAS)","volume":"74","author":"Wysocki","year":"2019","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.biopha.2020.110748_bib0435","doi-asserted-by":"crossref","first-page":"4403","DOI":"10.3892\/mmr.2017.7168","article-title":"Role of the ACE2\u2011Ang\u2011(1\u20117)\u2011Mas axis in blood pressure regulation and its potential as an antihypertensive in functional foods","volume":"16","author":"Lin","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.biopha.2020.110748_bib0440","first-page":"1","article-title":"Compensation of ACE2 function for possible clinical management of 2019-nCoV-induced acute lung injury","author":"Wu","year":"2020","journal-title":"Virol. Sin."},{"issue":"19","key":"10.1016\/j.biopha.2020.110748_bib0445","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.3748\/wjg.v23.i19.3396","article-title":"Renin angiotensin system in liver diseases: Friend or foe?","volume":"23","author":"e Silva","year":"2017","journal-title":"World J. Gastroenterol."},{"issue":"84","key":"10.1016\/j.biopha.2020.110748_bib0450","doi-asserted-by":"crossref","first-page":"35500","DOI":"10.18632\/oncotarget.26174","article-title":"Renin-angiotensin inhibitors reprogram tumor immune microenvironment: a comprehensive view of the influences on anti-tumor immunity","volume":"9","author":"Vallejo-Ardila","year":"2018","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.biopha.2020.110748_bib0455","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s10741-019-09837-7","article-title":"Angiotensin II and angiotensin 1\u20137: which is their role in atrial fibrillation?","volume":"25","author":"Mascolo","year":"2020","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.biopha.2020.110748_bib0460","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.metabol.2019.03.006","article-title":"Angiotensin-(1-7), adipokines and inflammation","volume":"95","author":"de Farias Lelis","year":"2019","journal-title":"Metabolism"},{"key":"10.1016\/j.biopha.2020.110748_bib0465","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.matbio.2020.04.005","article-title":"Targeting the renin-angiotensin-Aldosterone system in fibrosis","volume":"91-92","author":"AlQudah","year":"2020","journal-title":"Matrix Biol."},{"key":"10.1016\/j.biopha.2020.110748_bib0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2020.102463","article-title":"Assessing ACE2 expression patterns in lung tissues in the pathogenesis of COVID-19","author":"Li","year":"2020","journal-title":"J. Autoimmun."},{"issue":"1","key":"10.1016\/j.biopha.2020.110748_bib0475","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13054-020-02942-2","article-title":"Age and sex differences in soluble ACE2 may give insights for COVID-19","volume":"24","author":"Sw\u00e4rd","year":"2020","journal-title":"Crit. Care"},{"issue":"5","key":"10.1016\/j.biopha.2020.110748_bib0480","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1042\/CS20200163","article-title":"Soluble angiotensin-converting enzyme 2: a potential approach for coronavirus infection therapy?","volume":"134","author":"Batlle","year":"2020","journal-title":"Clin. Sci."},{"key":"10.1016\/j.biopha.2020.110748_bib0485","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3389\/fphys.2016.00469","article-title":"A disintegrin and metalloprotease 17 in the cardiovascular and central nervous systems","volume":"7","author":"Xu","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.biopha.2020.110748_bib0490","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3389\/fcell.2018.00153","article-title":"Renal ADAM10 and 17: their physiological and medical meanings","volume":"6","author":"Kato","year":"2018","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.biopha.2020.110748_bib0495","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.virol.2018.02.001","article-title":"Metalloprotease ADAM17 regulates porcine epidemic diarrhea virus infection by modifying aminopeptidase N","volume":"517","author":"Zhang","year":"2018","journal-title":"Virology"},{"key":"10.1016\/j.biopha.2020.110748_bib0500","doi-asserted-by":"crossref","first-page":"7027","DOI":"10.1038\/srep07027","article-title":"Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury","volume":"4","author":"Yang","year":"2014","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.biopha.2020.110748_bib0505","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms4594","article-title":"Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections","volume":"5","author":"Zou","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biopha.2020.110748_bib0510","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev-med-041717-085955","article-title":"New and emerging therapies for pulmonary arterial hypertension","volume":"70","author":"Spiekerkoetter","year":"2019","journal-title":"Annu. Rev. Med."},{"issue":"9","key":"10.1016\/j.biopha.2020.110748_bib0515","doi-asserted-by":"crossref","first-page":"H1171","DOI":"10.1152\/ajpheart.00897.2014","article-title":"Differences in angiotensin (1\u20137) between men and women","volume":"308","author":"Sullivan","year":"2015","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"key":"10.1016\/j.biopha.2020.110748_bib0520","series-title":"ACE2 And TMPRSS2 Variants and Expression As Candidates to Sex and Country Differences in COVID-19 Severity in Italy","author":"Asselta","year":"2020"},{"key":"10.1016\/j.biopha.2020.110748_bib0525","article-title":"Plasma levels of soluble ACE2 are associated with sex, Metabolic Syndrome, and its biomarkers in a large cohort, pointing to a possible mechanism for increased severity in COVID-19","author":"Kornilov","year":"2020","journal-title":"medRxiv"},{"key":"10.1016\/j.biopha.2020.110748_bib0530","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ejim.2020.04.037","article-title":"The pivotal link between ACE2 deficiency and SARS-CoV-2 infection","volume":"76","author":"Verdecchia","year":"2020","journal-title":"Eur. J. Intern. Med."},{"issue":"1\u20132","key":"10.1016\/j.biopha.2020.110748_bib0535","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0303-7207(00)00305-1","article-title":"The expression of the ADAMs proteases in prostate cancer cell lines and their regulation by dihydrotestosterone","volume":"167","author":"McCulloch","year":"2000","journal-title":"Mol. Cell. Endocrinol."},{"issue":"6","key":"10.1016\/j.biopha.2020.110748_bib0540","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/cmi.2014.101","article-title":"Estrogen upregulates MICA\/B expression in human non-small cell lung cancer through the regulation of ADAM17","volume":"12","author":"Ren","year":"2015","journal-title":"Cell. Mol. Immunol."},{"issue":"3","key":"10.1016\/j.biopha.2020.110748_bib0545","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1042\/BJ20100568","article-title":"ADAMs and protein disulfide isomerase: the key to regulated cell-surface protein ectodomain shedding?","volume":"428","author":"Bass","year":"2010","journal-title":"Biochem. J."},{"issue":"3","key":"10.1016\/j.biopha.2020.110748_bib0550","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.tibs.2012.12.002","article-title":"Who decides when to cleave an ectodomain?","volume":"38","author":"Hartmann","year":"2013","journal-title":"Trends Biochem. Sci."},{"issue":"9","key":"10.1016\/j.biopha.2020.110748_bib0555","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1210\/me.2006-0006","article-title":"Protein disulfide isomerase serves as a molecular chaperone to maintain estrogen receptor \u03b1 structure and function","volume":"20","author":"Schultz-Norton","year":"2006","journal-title":"Mol. Endocrinol."},{"issue":"6","key":"10.1016\/j.biopha.2020.110748_bib0560","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1530\/eje.0.1400608","article-title":"17beta-estradiol induces protein thiol\/disulfide oxidoreductases and protects cultured bovine aortic endothelial cells from oxidative stress","volume":"140","author":"Ejima","year":"1999","journal-title":"Eur. J. Endocrinol."},{"issue":"2","key":"10.1016\/j.biopha.2020.110748_bib0565","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.bbrc.2007.10.194","article-title":"Decreased enzyme activities of chaperones PDI and BiP in aged mouse livers","volume":"365","author":"Nuss","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.biopha.2020.110748_bib0570","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1046\/j.1471-4159.2001.00271.x","article-title":"Estradiol protects against ATP depletion, mitochondrial membrane potential decline and the generation of reactive oxygen species induced by 3\u2010nitroproprionic acid in SK\u2010N\u2010SH human neuroblastoma cells","volume":"77","author":"Wang","year":"2001","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.biopha.2020.110748_bib0575","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1124\/jpet.107.130351","volume":"324","author":"Chen","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"6","key":"10.1016\/j.biopha.2020.110748_bib0580","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.kint.2020.04.009","article-title":"Blockade of SARS-CoV-2 infection by recombinant soluble ACE2","volume":"97","author":"Alhenc-Gelas","year":"2020","journal-title":"Kidney Int."},{"issue":"5","key":"10.1016\/j.biopha.2020.110748_bib0585","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1152\/ajpheart.00217.2020","article-title":"COVID-19, ACE2, and the cardiovascular consequences","volume":"318","author":"South","year":"2020","journal-title":"Am. J. of Physiol. Heart Circulatory Physiol."},{"key":"10.1016\/j.biopha.2020.110748_bib0590","series-title":"Dissertationes Scholae Doctoralis Ad Sanitatem Investigandam Universitatis Helsinkiensis","article-title":"Regulation of angiotensin II type receptor by its messenger RNA-binding proteins","author":"Backlund","year":"2016"},{"issue":"5","key":"10.1016\/j.biopha.2020.110748_bib0595","doi-asserted-by":"crossref","first-page":"R898","DOI":"10.1152\/ajpregu.00415.2015","article-title":"Effects of estrogen replacement on stress-induced cardiovascular responses via renin-angiotensin system in ovariectomized rats, American Journal of Physiology-Regulatory","volume":"311","author":"Tazumi","year":"2016","journal-title":"Integrative Comparative Physiol."},{"issue":"1","key":"10.1016\/j.biopha.2020.110748_bib0600","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1161\/HYPERTENSIONAHA.120.15291","article-title":"ACE2, COVID-19, and ACE Inhibitor and ARB Use during the Pandemic: The Pediatric Perspective","volume":"76","author":"South","year":"2020","journal-title":"Hypertension"},{"key":"10.1016\/j.biopha.2020.110748_bib0605","article-title":"Smoking, SARS-CoV-2 and COVID-19: A review of reviews considering implications for public health policy and practice","volume":"18","author":"Grundy","year":"2020","journal-title":"Tob. Induc. Dis."},{"issue":"7","key":"10.1016\/j.biopha.2020.110748_bib0610","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/S2213-2600(20)30239-3","article-title":"Tobacco smoking and COVID-19 infection","volume":"8","author":"van Zyl-Smit","year":"2020","journal-title":"Lancet Respir. Med."},{"issue":"1","key":"10.1016\/j.biopha.2020.110748_bib0615","doi-asserted-by":"crossref","first-page":"C73","DOI":"10.1152\/ajpcell.00110.2016","article-title":"Cigarette smoke-induced autophagy impairment accelerates lung aging, COPD-emphysema exacerbations and pathogenesis","volume":"314","author":"Vij","year":"2018","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.biopha.2020.110748_bib0620","article-title":"Worse progression of COVID\u201019 in men: Is Testosterone a key factor?","author":"Giagulli","year":"2020","journal-title":"Andrology"},{"issue":"5","key":"10.1016\/j.biopha.2020.110748_bib0625","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1097\/AOG.0b013e318189a8e2","article-title":"Cigarette smoking, androgen levels, and hot flushes in midlife women","volume":"112","author":"Cochran","year":"2008","journal-title":"Obstet. Gynecol."},{"issue":"10","key":"10.1016\/j.biopha.2020.110748_bib0630","doi-asserted-by":"crossref","first-page":"3184","DOI":"10.1210\/jc.2011-1165","article-title":"Cigarette smoking and endogenous sex hormones in postmenopausal women","volume":"96","author":"Brand","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"10","key":"10.1016\/j.biopha.2020.110748_bib0635","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.3390\/ijms21103627","article-title":"Smoking-mediated upregulation of the androgen pathway leads to increased SARS-CoV-2 susceptibility","volume":"21","author":"Chakladar","year":"2020","journal-title":"Int. J. Mol. Sci."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220309410?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220309410?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T18:30:16Z","timestamp":1766082616000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332220309410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":127,"alternative-id":["S0753332220309410"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110748","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Male predisposition to severe COVID-19: Review of evidence and potential therapeutic prospects","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110748","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"110748"}}