{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:29:13Z","timestamp":1789154953117,"version":"build-2803163510"},"reference-count":98,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T00:00:00Z","timestamp":1600387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012497","name":"Covenant University Centre for Research, Innovation and Discovery","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.biopha.2020.110786","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T20:02:08Z","timestamp":1601496128000},"page":"110786","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Annona senegalensis extract demonstrates anticancer properties in N-diethylnitrosamine-induced hepatocellular carcinoma in male Wistar rats"],"prefix":"10.1016","volume":"131","author":[{"given":"Omolara F.","family":"Yakubu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5787-0475","authenticated-orcid":false,"given":"Damilohun S.","family":"Metibemu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2421-5271","authenticated-orcid":false,"given":"Isaacson B.","family":"Adelani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gbolahan O.","family":"Adesina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chidera B.","family":"Edokwe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oyinkansola E.","family":"Oseha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5135-064X","authenticated-orcid":false,"given":"Abiodun H.","family":"Adebayo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2020.110786_bib0005","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s00432-009-0715-0","article-title":"Chemo-preventive effect of bacoside A on N-nitrosodiethylamine-induced hepatocarcinogenesis in rats","volume":"136","author":"Janani","year":"2010","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.biopha.2020.110786_bib0010","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1002\/ijc.23464","article-title":"Two-dimensional differential gel electrophoresis\/analysis of diethylnitrosamine induced rat hepatocellular carcinoma","volume":"122","author":"Qi","year":"2008","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.biopha.2020.110786_bib0015","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1006\/taap.1996.8089","article-title":"Vitamin E modulation of hepatic focal lesion growth in mice","volume":"143","author":"Kolaja","year":"1997","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.biopha.2020.110786_bib0020","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1002\/mnfr.200900482","article-title":"Dietary antioxidants in the prevention of hepatocarcinogenesis: a review","volume":"54","author":"Glauert","year":"2010","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.biopha.2020.110786_bib0025","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1002\/hep.24516","article-title":"PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice","volume":"54","author":"Qiu","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.biopha.2020.110786_bib0030","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1177\/0192623312467522","article-title":"The chemopreventive capacity of quercetin to induce programmed cell death in hepatocarcinogenesis","volume":"41","author":"V\u00e1squez-Garz\u00f3n","year":"2013","journal-title":"Toxicol. Pathol."},{"issue":"1","key":"10.1016\/j.biopha.2020.110786_bib0035","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1177\/0023677215570086","article-title":"Diethylnitrosamine (DEN)- induced carcinogenic liver injury in mice","volume":"49","author":"Tolba","year":"2015","journal-title":"Lab Anim. (NY)"},{"key":"10.1016\/j.biopha.2020.110786_bib0040","doi-asserted-by":"crossref","first-page":"686","DOI":"10.3889\/oamjms.2017.101","article-title":"Experimental hepatic carcinogenesis: oxidative stress and natural antioxidants","volume":"5","author":"Unsal","year":"2017","journal-title":"Open Access Maced. J. Med. Sci."},{"issue":"5","key":"10.1016\/j.biopha.2020.110786_bib0045","first-page":"473","article-title":"Distinctive gene expression of receptor-type tyrosine kinase families during rat hepatocarcinogenesis","volume":"9","author":"Kuroda","year":"2002","journal-title":"Int. J. Mol. Med."},{"issue":"8","key":"10.1016\/j.biopha.2020.110786_bib0050","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.31557\/APJCP.2019.20.8.2551","article-title":"The carcinogenic agent diethylnitrosamine induces early oxidative stress, inflammation and proliferation in rat liver, stomach and Colon: protective effect of ginger extract","volume":"20","author":"Dina","year":"2019","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.biopha.2020.110786_bib0055","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3923\/jbs.2008.577.583","article-title":"Comparative phytochemical content of leaves extracts of two Annona senegalensis pers: the one from Togo and the other originates from Burkina Faso","volume":"8","author":"Potchoo","year":"2008","journal-title":"J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.biopha.2020.110786_bib0060","first-page":"139","article-title":"Phytochemical analysis of crude extracts from Annona senegalensis and its Anti-snake Venom potential on Albino Rats","volume":"1","author":"Musa","year":"2017","journal-title":"FUDMA Journal of Sciences"},{"issue":"2","key":"10.1016\/j.biopha.2020.110786_bib0065","article-title":"Phytochemical composition of Annona senegalensis leaf and its antioxidant activity during Trypanosoma brucei brucei induced oxidative stress in mice","volume":"14","author":"Johnson","year":"2017","journal-title":"J. Pharm. Bioresour."},{"issue":"12","key":"10.1016\/j.biopha.2020.110786_bib0070","first-page":"862","article-title":"Annona senegalensis persoon: a multipurpose shrub, its phytotherapic, Phytopharmacological and phytomedicinal uses","volume":"2","author":"Mustapha","year":"2013","journal-title":"Int. J Sci Tech."},{"issue":"2","key":"10.1016\/j.biopha.2020.110786_bib0075","first-page":"211","article-title":"Annona senegalensis Persoon (Annonaceae): a review of its ethnobotanical uses, biological activities and phytocompounds","volume":"5","author":"Okhale","year":"2016","journal-title":"J. Pharmacogn. Phytochem."},{"issue":"1","key":"10.1016\/j.biopha.2020.110786_bib0080","first-page":"16","article-title":"Ethnobotanical potentials of common herbs in Nigeria: a case study of Enugu state","volume":"1","author":"Aiyeloja","year":"2006","journal-title":"Edu. Res. Rev."},{"issue":"2","key":"10.1016\/j.biopha.2020.110786_bib0085","first-page":"28","article-title":"A survey of major Ethno medicinal plants of Kano North, Nigeria, their knowledge and uses by traditional healers, bayero","volume":"4","author":"Dambatta","year":"2011","journal-title":"Int. J. Pure Appl. Sci. Technol."},{"key":"10.1016\/j.biopha.2020.110786_bib0090","first-page":"344","article-title":"Some investigations on the traditional pharmacopoeia about venomous bites and stings from scorpions, snakes and spiders in the Hina Subdivision, Far North, Cameroon","author":"Noumi","year":"2015","journal-title":"British J Pharm Res."},{"issue":"13","key":"10.1016\/j.biopha.2020.110786_bib0095","first-page":"664","article-title":"Ethnobotanical uses of some plants of two ethnoecological regions of Cameroon","volume":"3","author":"Jiofack","year":"2009","journal-title":"Afr. J. Pharm. Pharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2020.110786_bib0100","first-page":"13","article-title":"Herbal approach to the treatment of chicken pox: a case study of giwa local government, Kaduna State, Nigeria","volume":"6","author":"Faleyimu","year":"2010","journal-title":"Int. J Biomed Health Sci"},{"issue":"1","key":"10.1016\/j.biopha.2020.110786_bib0105","doi-asserted-by":"crossref","first-page":"24","DOI":"10.9734\/JABB\/2015\/11884","article-title":"Crude flavonoids isolated from the stem bark of Annona senegalensis have antimicrobial activity","volume":"2","author":"Jada","year":"2015","journal-title":"J of Adv Bio Biotech."},{"issue":"5","key":"10.1016\/j.biopha.2020.110786_bib0110","first-page":"245","article-title":"Phytochemical and anticonvulsant properties of Annona senegalensis pers. (Annonaceae), plant used in Burkina Folk Medicine to treat epilepsy and convulsions","volume":"3","author":"Konate","year":"2012","journal-title":"Br. J Pharmacol Tox."},{"issue":"49","key":"10.1016\/j.biopha.2020.110786_bib0115","first-page":"8435","article-title":"Neuropharmacological evaluation of Annona senegalensis leaves","volume":"9","author":"Okoli","year":"2010","journal-title":"Afr. J Biotech."},{"key":"10.1016\/j.biopha.2020.110786_bib0120","first-page":"25","article-title":"Evaluation of the Anticonvulasant and muscle relaxant effects of the methanol root bark extracts of Annona senegalensis","author":"Okoye","year":"2009","journal-title":"As. Pac. J Trop Med."},{"issue":"3","key":"10.1016\/j.biopha.2020.110786_bib0125","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.jep.2008.07.001","article-title":"Antimicrobial activity of medicinal plants against oral microorganisms","volume":"119","author":"More","year":"2008","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2020.110786_bib0130","first-page":"137","article-title":"In vivo antimalarial and cytotoxic properties of Annona senegalensis extract","volume":"3","author":"Ajaiyeoba","year":"2006","journal-title":"Afr. J Trad CAM."},{"key":"10.1016\/j.biopha.2020.110786_bib0135","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.jep.2004.09.055","article-title":"Effect of Annona senegalensis rootbark extracts on Naja nigricotlis nigricotlis venom in rats","volume":"96","author":"Adzu","year":"2005","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.biopha.2020.110786_bib0140","first-page":"93","article-title":"Detoxification of Echis ocellatus venom induced toxicity by Annona senegalensis pers","volume":"11","author":"Amlabu","year":"2014","journal-title":"J Comp Integ Med."},{"issue":"8","key":"10.1016\/j.biopha.2020.110786_bib0145","first-page":"409","article-title":"Effect of aqueous extract of Annona senegalensis leaves on the spermiogram of male albino rats","volume":"3","author":"Oladele","year":"2014","journal-title":"World J Pharmacy Pharm Sci."},{"issue":"1","key":"10.1016\/j.biopha.2020.110786_bib0150","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2515\/therapie\/2010076","article-title":"Evaluation of the anti-inflammatory activity and phytochemical screening of Annona senegalensis leaves","volume":"66","author":"Yeo","year":"2011","journal-title":"Therapie."},{"issue":"2","key":"10.1016\/j.biopha.2020.110786_bib0155","first-page":"88","article-title":"Evaluation of analgesic and anti-inflammatory effects of the crude methanol extract of the stem-bark of Annona senegalensis pers","volume":"4","author":"Suleiman","year":"2014","journal-title":"Int. J Med Arom Plants."},{"issue":"1","key":"10.1016\/j.biopha.2020.110786_bib0160","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0304-4017(03)00040-2","article-title":"In vitro screening of two nigerian medicinal plants (Vernonia amygdalina and Annona senegalensis) for anthelmintic activity","volume":"113","author":"Alawa","year":"2003","journal-title":"Vet. Parasit"},{"issue":"1","key":"10.1016\/j.biopha.2020.110786_bib0165","first-page":"61","article-title":"Enhancing the anthelminthic activity roots of Annona senegalensis","volume":"53","author":"Fall","year":"2008","journal-title":"Dakar Med."},{"key":"10.1016\/j.biopha.2020.110786_bib0170","doi-asserted-by":"crossref","DOI":"10.4137\/IJIS.S37188","article-title":"Toxicity of Boswellia dalzielii (Burseraceae) leaf fractions against immature stages of Anopheles gambiae (Giles) and Culex quinquefasciatus (say) (Diptera: culicidae)","volume":"8","author":"Younoussa","year":"2016","journal-title":"Int. J. Insect Sci."},{"key":"10.1016\/j.biopha.2020.110786_bib0175","series-title":"Guide for the Care and Use of Laboratory Animals","first-page":"85","author":"National Institute of Health (NIH)","year":"2011"},{"key":"10.1016\/j.biopha.2020.110786_bib0180","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.ccr.2012.02.007","article-title":"Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4","volume":"21","author":"Dapito","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.biopha.2020.110786_bib0185","first-page":"481","volume":"24","author":"Bergmeyer","year":"1986","journal-title":"J. Clin. Chem. Clin. Biochem."},{"key":"10.1016\/j.biopha.2020.110786_bib0190","first-page":"497","volume":"24","author":"Bergmeyer","year":"1986","journal-title":"J. Clin. Chem. Clin. Biochem."},{"key":"10.1016\/j.biopha.2020.110786_bib0195","first-page":"731","article-title":"IFCC methods for the measurement of catalytic concentration of enzymes, Part 5. IFCC method for alkaline phosphatase (orthophosphoric-monoester phosphohydrolase, alkaline optimum, EC 3.1.3.1)","volume":"21","author":"Tietz","year":"1983","journal-title":"J. Clin. Chem. Clin. Biochem."},{"key":"10.1016\/j.biopha.2020.110786_bib0200","series-title":"Practical Clinical Enzymology","first-page":"83","article-title":"The dehydrogenases or oxidoreductase-lactate dehydrogenase","author":"King","year":"1965"},{"key":"10.1016\/j.biopha.2020.110786_bib0205","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(78)52032-6","volume":"52","author":"Buege","year":"1978","journal-title":"Methods Enzymol."},{"issue":"3","key":"10.1016\/j.biopha.2020.110786_bib0210","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","article-title":"Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase","volume":"47","author":"Marklund","year":"1974","journal-title":"Eur. J. Biochem."},{"issue":"1","key":"10.1016\/j.biopha.2020.110786_bib0215","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"issue":"4073","key":"10.1016\/j.biopha.2020.110786_bib0220","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1126\/science.179.4073.588","article-title":"Selenium: biochemical role as a component of glutathione peroxidase","volume":"179","author":"Rotruck","year":"1973","journal-title":"Science."},{"key":"10.1016\/j.biopha.2020.110786_bib0225","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.biopha.2018.02.116","article-title":"Naringin enhances reverse cholesterol transport in high fat\/low streptozocin induced diabetic rats","volume":"101","author":"Rotimi","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2020.110786_bib0230","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3923\/jpt.2007.373.379","article-title":"The effects of ethanolic leaf extract of Commiphora africana (Burseraceae) on rat liver and kidney functions","volume":"2","author":"Aliyu","year":"1998","journal-title":"J Pharmacol Toxicol."},{"key":"10.1016\/j.biopha.2020.110786_bib0235","first-page":"404","article-title":"The effect of chronic ingestion of crude Garcinia kola on the histology of the liver","volume":"2","author":"Osifo","year":"2012","journal-title":"Eur. J. Exp. Biol."},{"issue":"6","key":"10.1016\/j.biopha.2020.110786_bib0240","doi-asserted-by":"crossref","first-page":"383","DOI":"10.22159\/ajpcr.2017.v10i6.17350","article-title":"Gas chromatography- mass spectrometry analysis of Viburnum opulus (L) extract and its toxicity studies in rats","volume":"10","author":"Adebayo","year":"2017","journal-title":"Asian J Pharm Clin Res."},{"issue":"6","key":"10.1016\/j.biopha.2020.110786_bib0245","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1128\/AAC.49.6.2307-2313.2005","article-title":"Combination of antimicrobial and endotoxin-neutralizing activities of novel oleoylamines","volume":"49","author":"Zorko","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"issue":"4439","key":"10.1016\/j.biopha.2020.110786_bib0250","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/S0140-6736(01)79937-0","article-title":"The formic acid derivatives in the treatment of cancer","volume":"172","author":"Evans","year":"1908","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.biopha.2020.110786_bib0255","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0922-338X(98)80053-6","article-title":"Antitumor activity of (10E, 12Z)-9-hydroxy-10, 12-octadecadienoic acid from rice bran","volume":"86","author":"Hayshi","year":"1998","journal-title":"J. Ferment. Bioeng."},{"key":"10.1016\/j.biopha.2020.110786_bib0260","first-page":"670","article-title":"Characterization of anticancer, antimicrobial, antioxidant properties and chemical compositions of Peperomia pellucida leaf extract","author":"Wei","year":"2011","journal-title":"Acta Med. Iran."},{"issue":"8","key":"10.1016\/j.biopha.2020.110786_bib0265","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.31557\/APJCP.2019.20.8.2551","article-title":"The carcinogenic agent Diethylnitrosamine induces early oxidative stress, inflammation and proliferation in rat liver, stomach and colon: protective effect of ginger extract","volume":"20","author":"Mansour","year":"2019","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.biopha.2020.110786_bib0270","article-title":"Is liver enzyme release really associated with cell necrosis induced by oxidant stress?","volume":"3529149","author":"Contreras-Zentella","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.biopha.2020.110786_bib0275","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the Warburg effect: the metabolic requirements of cell proliferation","volume":"324","author":"Vander","year":"2009","journal-title":"Science."},{"issue":"3","key":"10.1016\/j.biopha.2020.110786_bib0280","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s11523-011-0184-7","article-title":"LDH-A infl uences hypoxia-inducible factor 1alpha (HIF1 alpha) and is critical for growth of HT29 colon carcinoma cells in vivo","volume":"6","author":"Langhammer","year":"2011","journal-title":"Target. Oncol."},{"issue":"2","key":"10.1016\/j.biopha.2020.110786_bib0285","doi-asserted-by":"crossref","first-page":"e57697","DOI":"10.1371\/journal.pone.0057697","article-title":"Lactate dehydrogenase- B is silenced by promoter methylation in a high frequency of human breast cancers","volume":"8","author":"Brown","year":"2013","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.biopha.2020.110786_bib0290","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1002\/iub.1216","article-title":"Lactate dehydrogenase A in cancer: a promising target for diagnosis and therapy","volume":"65","author":"Miao","year":"2013","journal-title":"IUBMB Life"},{"key":"10.1016\/j.biopha.2020.110786_bib0295","doi-asserted-by":"crossref","first-page":"6124","DOI":"10.1002\/cam4.1820","article-title":"Lactate dehydrogenase A: a key player in carcinogenesis and potential target in cancer therapy","volume":"7","author":"Feng","year":"2018","journal-title":"Cancer Med."},{"key":"10.1016\/j.biopha.2020.110786_bib0300","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.jhep.2012.08.018","article-title":"CYP2E1 and oxidant stress in alcoholic and non- alcoholic fatty liver disease","volume":"58","author":"Leung","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.biopha.2020.110786_bib0305","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3390\/antiox8030072","article-title":"Measurement and clinical significance of lipid peroxidation as a biomarker of oxidative stress: oxidative stress in diabetes, atherosclerosis, and chronic inflammation","volume":"8","author":"Ito","year":"2019","journal-title":"Antioxidants."},{"key":"10.1016\/j.biopha.2020.110786_bib0310","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0009-8981(02)00292-9","article-title":"Tissue lipid peroxidation and antioxidant status in patients with adenocarcinoma of the breast","volume":"325","author":"Kumaraguruparan","year":"2002","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.biopha.2020.110786_bib0315","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.kjms.2010.11.003","article-title":"Expression of manganese superoxide dismutase in patients with breast cancer","volume":"27","author":"Tsai","year":"2011","journal-title":"Kaohsiung J. Med. Sci."},{"key":"10.1016\/j.biopha.2020.110786_bib0320","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/BF01247464","article-title":"Antioxidant enzyme activities and oxidative stress in human breast cancer","volume":"120","author":"Punnonen","year":"1994","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.biopha.2020.110786_bib0325","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.1128\/MCB.15.8.4489","article-title":"Identification of a novel p53 promoter element involved in genotoxic stressinducible p53 gene expression","volume":"15","author":"Sun","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.biopha.2020.110786_bib0330","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1089\/152308604773934242","article-title":"Mitochondria, manganese superoxide dismutase, and cancer","volume":"6","author":"Oberley","year":"2004","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.biopha.2020.110786_bib0335","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.molcatb.2010.11.007","article-title":"The basic and applied aspects of superoxide dismutase","volume":"68","author":"Bafana","year":"2011","journal-title":"J. Mol. Catal., B Enzym."},{"key":"10.1016\/j.biopha.2020.110786_bib0340","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0304-3835(00)00391-8","article-title":"Salvia miltiorrhiza inhibits cell growth and induces apoptosis in human hepatoma HepG (2) cells","volume":"153","author":"Liu","year":"2000","journal-title":"Cancer Lett."},{"key":"10.1016\/j.biopha.2020.110786_bib0345","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.phymed.2004.02.013","article-title":"Tinospora cordifolia induces enzymes of carcinogen\/drug metabolism and antioxidant system, and inhibits lipid peroxidation in mice","volume":"13","author":"Singh","year":"2006","journal-title":"Phytomedicine"},{"issue":"10","key":"10.1016\/j.biopha.2020.110786_bib0350","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a016295","article-title":"IL-6 in inflammation, immunity, and disease","volume":"6","author":"Tanaka","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"3","key":"10.1016\/j.biopha.2020.110786_bib0355","doi-asserted-by":"crossref","first-page":"182","DOI":"10.5114\/ceh.2018.78122","article-title":"Evaluation of serum interleukin-6 levels in hepatocellular carcinoma patients: a systematic review","volume":"4","author":"Shakiba","year":"2018","journal-title":"Clin Exp Hepatol."},{"issue":"9","key":"10.1016\/j.biopha.2020.110786_bib0360","first-page":"1873","article-title":"Interleukin-6 enhances cancer stemness and promotes metastasis of hepatocellular carcinoma via up-regulating osteopontin expression","volume":"6","author":"Wang","year":"2016","journal-title":"Am. J. Cancer Res."},{"issue":"13","key":"10.1016\/j.biopha.2020.110786_bib0365","doi-asserted-by":"crossref","first-page":"17021","DOI":"10.18632\/oncotarget.7740","article-title":"Chronic inflammation contributes to the development of hepatocellular carcinoma by decreasing miR-122 levels","volume":"7","author":"Li","year":"2016","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.biopha.2020.110786_bib0370","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/0471141755.ph1430s66","article-title":"The DEN and CCL4\u2010induced mouse model of fibrosis and inflammation\u2010associated hepatocellular carcinoma","volume":"66","author":"Uehara","year":"2014","journal-title":"Curr. Protoc. Pharmacol."},{"issue":"10","key":"10.1016\/j.biopha.2020.110786_bib0375","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1038\/ncb3031","article-title":"EGFR has a tumor-promoting role in liver macrophages during hepatocellular carcinoma formation","volume":"16","author":"Lanaya","year":"2014","journal-title":"Nat. Cell Biol."},{"issue":"6","key":"10.1016\/j.biopha.2020.110786_bib0380","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.jhep.2016.02.004","article-title":"IL-6 pathway in the liver: from physiopathology to therapy","volume":"64","author":"Schmidt-Arras","year":"2016","journal-title":"J. Hepatol."},{"issue":"1421","key":"10.1016\/j.biopha.2020.110786_bib0385","first-page":"1","article-title":"Predisposition to apoptosis in hepatocellular carcinoma: from mechanistic insights to therapeutic strategies","volume":"9","author":"Marquardt","year":"2019","journal-title":"Front. Oncol."},{"issue":"2","key":"10.1016\/j.biopha.2020.110786_bib0390","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/hep.22393","article-title":"Expression of X-linked inhibitor-of-apoptosis protein in hepatocellular carcinoma promotes metastasis and tumor recurrence","volume":"48","author":"Shi","year":"2008","journal-title":"Hepatology."},{"issue":"10","key":"10.1016\/j.biopha.2020.110786_bib0395","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/sj.embor.7400795","article-title":"Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family","volume":"7","author":"Eckelman","year":"2006","journal-title":"EMBO Rep."},{"issue":"1","key":"10.1016\/j.biopha.2020.110786_bib0400","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1186\/1471-2407-10-379","article-title":"Simultaneous gene silencing of Bcl-2, XIAP and Survivin re-sensitizes pancreatic cancer cells towards apoptosis","volume":"10","author":"R\u00fcckert","year":"2010","journal-title":"BMC Cancer"},{"issue":"180002","key":"10.1016\/j.biopha.2020.110786_bib0405","first-page":"1","article-title":"Targeting BCL-2 regulated apoptosis in cancer","volume":"8","author":"Campbell","year":"2018","journal-title":"Open Biol."},{"key":"10.1016\/j.biopha.2020.110786_bib0410","first-page":"155","article-title":"Drug resistance and molecular cancer therapy: apoptosis versus autophagy","author":"Marquez","year":"2013","journal-title":"Apoptosis."},{"key":"10.1016\/j.biopha.2020.110786_bib0415","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1096\/fasebj.31.1_supplement.774.18","article-title":"Antioxidant and anti-proliferative activity of fractions from Annona senegalensis pers (Annonaceae) stem bark on HeLa cells","volume":"31","author":"Adisa","year":"2017","journal-title":"Faseb J."},{"issue":"5","key":"10.1016\/j.biopha.2020.110786_bib0420","doi-asserted-by":"crossref","first-page":"5085","DOI":"10.1007\/s11033-011-1304-2","article-title":"VEGF is essential for the growth and migration of human hepatocellular carcinoma cells","volume":"39","author":"Zhang","year":"2012","journal-title":"Mol. Biol. Rep."},{"issue":"3","key":"10.1016\/j.biopha.2020.110786_bib0425","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1158\/1078-0432.CCR-18-1254","article-title":"The role of angiogenesis in hepatocellular carcinoma","volume":"25","author":"Morse","year":"2019","journal-title":"Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.biopha.2020.110786_bib0430","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1136\/gut.48.1.87","article-title":"Dual mechanism of vascular endothelial growth factor upregulation by hypoxia in human hepatocellular carcinoma","volume":"48","author":"Von Marschall","year":"2001","journal-title":"Gut."},{"issue":"28","key":"10.1016\/j.biopha.2020.110786_bib0435","doi-asserted-by":"crossref","first-page":"46691","DOI":"10.18632\/oncotarget.17358","article-title":"Oncotarget 46691 www.impactjournals.com\/oncotarget Hypoxia inducible factors in hepatocellular carcinoma","volume":"8","author":"Chen","year":"2017","journal-title":"Oncotarget [Internet]"},{"key":"10.1016\/j.biopha.2020.110786_bib0440","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1186\/1471-2407-13-518","article-title":"Identification of the angiogenic gene signature induced by EGF and hypoxia in colorectal cancer","volume":"13","author":"Khong","year":"2013","journal-title":"BMC Cancer"},{"key":"10.1016\/j.biopha.2020.110786_bib0445","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1186\/1472-6882-14-353","article-title":"Anti-angiogenic potential of an ethanol extract of Annona atemoya seeds in vitro and in vivo","volume":"14","author":"Yi","year":"2014","journal-title":"BMC Complement. Altern. Med."},{"issue":"20","key":"10.1016\/j.biopha.2020.110786_bib0450","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.4161\/cc.8.20.9565","article-title":"Nrf2 and p21 regulate the fine balance between life and death by controlling ROS levels","volume":"8","author":"Villeneuve","year":"2009","journal-title":"Cell Cycle"},{"issue":"8","key":"10.1016\/j.biopha.2020.110786_bib0455","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.3390\/cancers11081178","article-title":"p21 in Cancer research","volume":"11","author":"Shamloo","year":"2019","journal-title":"Cancers."},{"issue":"8","key":"10.1016\/j.biopha.2020.110786_bib0460","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1038\/cdd.2015.53","article-title":"TP53: an oncogene in disguise","volume":"22","author":"Soussi","year":"2015","journal-title":"Cell Death Differ."},{"issue":"24","key":"10.1016\/j.biopha.2020.110786_bib0465","first-page":"6788","article-title":"Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome","volume":"60","author":"Sigal","year":"2000","journal-title":"Cancer Res."},{"issue":"8","key":"10.1016\/j.biopha.2020.110786_bib0470","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1038\/sj.cdd.4401962","article-title":"The p53\u2013Bcl-2 connection","volume":"13","author":"Hemann","year":"2006","journal-title":"Cell Death Differ."},{"issue":"4","key":"10.1016\/j.biopha.2020.110786_bib0475","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.3892\/ol.2017.6681","article-title":"Relationship of the expression levels of XIAP and p53 genes in hepatocellular carcinoma and the prognosis of patients","volume":"14","author":"Li","year":"2017","journal-title":"Oncol. Lett."},{"issue":"11","key":"10.1016\/j.biopha.2020.110786_bib0480","first-page":"775","article-title":"Targeting protein prenylation for cancer therapy, Nature reviews","volume":"11","author":"Berndt","year":"2011","journal-title":"Cancer"},{"issue":"8","key":"10.1016\/j.biopha.2020.110786_bib0485","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1634\/theoncologist.10-8-565","article-title":"Development of farnesyl transferase inhibitors: a review","volume":"10","author":"Appels","year":"2005","journal-title":"Oncologist"},{"key":"10.1016\/j.biopha.2020.110786_bib0490","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1179299X16684640","article-title":"Biomarkers for hepatocellular carcinoma","volume":"9","author":"Lou","year":"2017","journal-title":"Biomark. Cancer"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220309793?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220309793?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T18:51:13Z","timestamp":1766083873000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332220309793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":98,"alternative-id":["S0753332220309793"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110786","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Annona senegalensis extract demonstrates anticancer properties in N-diethylnitrosamine-induced hepatocellular carcinoma in male Wistar rats","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110786","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"110786"}}