{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:17:43Z","timestamp":1792034263350,"version":"4.4.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.biopha.2020.110794","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T13:08:16Z","timestamp":1601989696000},"page":"110794","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Topical treatment with a mu opioid receptor agonist alleviates corneal allodynia and corneal nerve sensitization in mice"],"prefix":"10.1016","volume":"132","author":[{"given":"Fanny","family":"Joubert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3235-5469","authenticated-orcid":false,"given":"Adrian","family":"Guerrero-Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darine","family":"Fakih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9264-1133","authenticated-orcid":false,"given":"Elodie","family":"Reboussin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Gaveriaux-Ruff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1759-068X","authenticated-orcid":false,"given":"Maria Carmen","family":"Acosta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3559-3649","authenticated-orcid":false,"given":"Juana","family":"Gallar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4831-1153","authenticated-orcid":false,"given":"Jos\u00e9 Alain","family":"Sahel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0085-9021","authenticated-orcid":false,"given":"Laurence","family":"Bodineau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Baudouin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Rost\u00e8ne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"M\u00e9lik-Parsadaniantz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabelle","family":"R\u00e9aux-Le Goazigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2020.110794_bib0005","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","article-title":"TFOS DEWS II epidemiology report","volume":"15","author":"Stapleton","year":"2017","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.biopha.2020.110794_bib0010","doi-asserted-by":"crossref","DOI":"10.1177\/1744806917729306","article-title":"Evidence that dry eye represents a chronic overlapping pain condition","volume":"13","author":"Levitt","year":"2017","journal-title":"Mol. Pain"},{"key":"10.1016\/j.biopha.2020.110794_bib0015","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jtos.2017.10.001","article-title":"Neuropathic pain and dry eye","volume":"16","author":"Galor","year":"2018","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.biopha.2020.110794_bib0020","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1152\/jn.2000.84.2.1050","article-title":"Cornea-responsive medullary dorsal horn neurons: modulation by local opioids and projections to thalamus and brain stem","volume":"84","author":"Hirata","year":"2000","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.biopha.2020.110794_bib0025","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0304-3959(82)90092-6","article-title":"Density and organization of free nerve endings in the corneal epithelium of the rabbit","volume":"14","author":"Rozsa","year":"1982","journal-title":"Pain"},{"key":"10.1016\/j.biopha.2020.110794_bib0030","first-page":"461","article-title":"Sensory and sympathetic innervation of the mammalian cornea. A retrograde tracing study","volume":"30","author":"Marfurt","year":"1989","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.biopha.2020.110794_bib0035","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1002\/cne.23207","article-title":"Sensory and sympathetic innervation of the mouse and guinea pig corneal epithelium","volume":"521","author":"Ivanusic","year":"2013","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.biopha.2020.110794_bib0040","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/cne.902610309","article-title":"Corneal sensory pathway in the rat: a horseradish peroxidase tracing study","volume":"261","author":"Marfurt","year":"1987","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.biopha.2020.110794_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2015.06.008","article-title":"Reaux-Le Goazigo A: combined 3DISCO clearing method, retrograde tracer and ultramicroscopy to map corneal neurons in a whole adult mouse trigeminal ganglion","author":"Launay","year":"2015","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.biopha.2020.110794_bib0050","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/ejp.1332","article-title":"Reaux-Le Goazigo A: effects of corneal injury on ciliary nerve fibre activity and corneal nociception in mice: a behavioural and electrophysiological study","volume":"23","author":"Joubert","year":"2019","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.biopha.2020.110794_bib0055","doi-asserted-by":"crossref","first-page":"3403","DOI":"10.1167\/iovs.13-13774","article-title":"Corneal sensory nerve activity in an experimental model of UV keratitis","volume":"55","author":"Acosta","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.biopha.2020.110794_bib0060","first-page":"6","article-title":"Polyglycerol-opioid conjugate produces analgesia devoid of side effects","author":"Gonzalez-Rodriguez","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.biopha.2020.110794_bib0065","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3109\/07853899509031962","article-title":"Peripheral opioid receptors","volume":"27","author":"Stein","year":"1995","journal-title":"Ann. Med."},{"key":"10.1016\/j.biopha.2020.110794_bib0070","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00429-014-0717-9","article-title":"A mu-delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks","volume":"220","author":"Erbs","year":"2015","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.biopha.2020.110794_bib0075","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.neuron.2018.03.002","article-title":"Functional divergence of Delta and mu opioid receptor organization in CNS pain circuits","volume":"98","author":"Wang","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.biopha.2020.110794_bib0080","doi-asserted-by":"crossref","first-page":"7373","DOI":"10.2174\/138161281942140105163727","article-title":"Opiate-induced analgesia: contributions from mu, delta and kappa opioid receptors mouse mutants","volume":"19","author":"Gaveriaux-Ruff","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.biopha.2020.110794_bib0085","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.pain.2012.05.002","article-title":"Tolerance and opioid-induced hyperalgesia. Is a divorce imminent?","volume":"153","author":"Richebe","year":"2012","journal-title":"Pain"},{"key":"10.1016\/j.biopha.2020.110794_bib0090","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1097\/ICO.0000000000001328","article-title":"Codeine plus acetaminophen for pain after photorefractive keratectomy: a randomized, double-blind, placebo-controlled add-on trial","volume":"36","author":"Pereira","year":"2017","journal-title":"Cornea"},{"key":"10.1016\/j.biopha.2020.110794_bib0095","doi-asserted-by":"crossref","first-page":"S34","DOI":"10.1016\/j.ophtha.2017.08.004","article-title":"Neuropathic corneal pain: approaches for management","volume":"124","author":"Dieckmann","year":"2017","journal-title":"Ophthalmology"},{"key":"10.1016\/j.biopha.2020.110794_bib0100","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jtos.2019.12.004","article-title":"Ocular pain response to treatment in dry eye patients","volume":"18","author":"Siedlecki","year":"2020","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.biopha.2020.110794_bib0105","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/j.pain.0000000000001419","article-title":"Melik Parsadaniantz S: dual enkephalinase inhibitor PL265: a novel topical treatment to alleviate corneal pain and inflammation","volume":"160","author":"Reaux-Le Goazigo","year":"2019","journal-title":"Pain"},{"key":"10.1016\/j.biopha.2020.110794_bib0110","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0304-3959(03)00260-4","article-title":"Effect of morphine sulphate eye drops on hyperalgesia in the rat cornea","volume":"105","author":"Wenk","year":"2003","journal-title":"Pain"},{"key":"10.1016\/j.biopha.2020.110794_bib0115","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/vaa.12069","article-title":"Preliminary investigations into the analgesic effects of topical ocular 1% morphine solution in dogs and cats","volume":"40","author":"Thomson","year":"2013","journal-title":"Vet. Anaesth. Analg."},{"key":"10.1016\/j.biopha.2020.110794_bib0120","doi-asserted-by":"crossref","first-page":"813","DOI":"10.2460\/ajvr.2003.64.813","article-title":"Effect of topical administration of 1% morphine sulfate solution on signs of pain and corneal wound healing in dogs","volume":"64","author":"Stiles","year":"2003","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.biopha.2020.110794_bib0125","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1136\/bjo.78.2.138","article-title":"Effects of morphine on corneal sensitivity and epithelial wound healing: implications for topical ophthalmic analgesia","volume":"78","author":"Peyman","year":"1994","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.biopha.2020.110794_bib0130","doi-asserted-by":"crossref","first-page":"934","DOI":"10.3928\/1081597X-20100212-06","article-title":"Effect of topical 0.5% morphine on postoperative pain after photorefractive keratectomy","volume":"26","author":"Faktorovich","year":"2010","journal-title":"J. Refract. Surg."},{"key":"10.1016\/j.biopha.2020.110794_bib0135","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1152\/jn.00082.2012","article-title":"Fentanyl decreases discharges of C and A nociceptors to suprathreshold mechanical stimulation in chronic inflammation","volume":"108","author":"Moshourab","year":"2012","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.biopha.2020.110794_bib0140","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.nbd.2015.12.017","article-title":"Ocular inflammation induces trigeminal pain, peripheral and central neuroinflammatory mechanisms","volume":"88","author":"Launay","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.biopha.2020.110794_bib0145","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1016\/j.pain.2013.07.012","article-title":"Changes in sensory activity of ocular surface sensory nerves during allergic keratoconjunctivitis","volume":"154","author":"Acosta","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.biopha.2020.110794_bib0150","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/s12974-019-1656-4","article-title":"Chronic dry eye induced corneal hypersensitivity, neuroinflammatory responses, and synaptic plasticity in the mouse trigeminal brainstem","volume":"16","author":"Fakih","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.biopha.2020.110794_bib0155","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1167\/iovs.18-24007","article-title":"Functional and morphologic alterations in mechanical, polymodal, and cold sensory nerve fibers of the Cornea Following Photorefractive Keratectomy","volume":"59","author":"Bech","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.biopha.2020.110794_bib0160","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1167\/iovs.18-26384","article-title":"Remodeling of substance P sensory nerves and transient receptor potential melastatin 8 (TRPM8) cold receptors after corneal experimental surgery","volume":"60","author":"He","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.biopha.2020.110794_bib0165","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3389\/fnana.2015.00071","article-title":"Transient receptor potential cation channel subfamily V member 1 expressing corneal sensory neurons can be subdivided into at least three subpopulations","volume":"9","author":"Alamri","year":"2015","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.biopha.2020.110794_bib0170","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.regpep.2010.09.004","article-title":"UMB-3, a novel rabbit monoclonal antibody, for assessing mu-opioid receptor expression in mouse, rat and human formalin-fixed and paraffin-embedded tissues","volume":"167","author":"Lupp","year":"2011","journal-title":"Regul. Pept."},{"key":"10.1016\/j.biopha.2020.110794_bib0175","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/nn.3622","article-title":"Targeted expression of mu-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward","volume":"17","author":"Cui","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.biopha.2020.110794_bib0180","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.tips.2013.03.006","article-title":"Targeting inflammation and wound healing by opioids","volume":"34","author":"Stein","year":"2013","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.biopha.2020.110794_bib0185","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF00506644","article-title":"Side-effects of local anesthetics on the corneal epithelium of the rabbit eye","volume":"197","author":"Harnisch","year":"1975","journal-title":"Albrecht Von Graefes Arch. Klin. Exp. Ophthalmol."},{"key":"10.1016\/j.biopha.2020.110794_bib0190","first-page":"198","article-title":"Severe toxic keratopathy secondary to topical anesthetic abuse","volume":"30","author":"Rocha","year":"1995","journal-title":"Can. J. Ophthalmol."},{"key":"10.1016\/j.biopha.2020.110794_bib0195","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1097\/AJP.0b013e318175929e","article-title":"Topical fentanyl in a randomized, double-blind study in patients with corneal damage","volume":"24","author":"Zollner","year":"2008","journal-title":"Clin. J. Pain"},{"key":"10.1016\/j.biopha.2020.110794_bib0200","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.neures.2004.12.014","article-title":"Effect of Brn-3a deficiency on primary nociceptors in the trigeminal ganglion","volume":"51","author":"Ichikawa","year":"2005","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.biopha.2020.110794_bib0205","first-page":"8","article-title":"Mu opioid receptors on primary afferent nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice","author":"Weibel","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2020.110794_bib0210","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jchemneu.2007.05.005","article-title":"Morphological and immunohistochemical characterization of the trigeminal ganglion neurons innervating the cornea and upper eyelid of the rat","volume":"34","author":"Nakamura","year":"2007","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.biopha.2020.110794_bib0215","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.jtos.2017.05.002","article-title":"TFOS DEWS II pain and sensation report","volume":"15","author":"Belmonte","year":"2017","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.biopha.2020.110794_bib0220","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.neuropharm.2017.10.016","article-title":"Fentanyl, fentanyl analogs and novel synthetic opioids: a comprehensive review","volume":"134","author":"Armenian","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.biopha.2020.110794_bib0225","doi-asserted-by":"crossref","first-page":"13068","DOI":"10.1523\/JNEUROSCI.1817-11.2011","article-title":"Activation of spinal mu- and delta-opioid receptors potently inhibits substance P release induced by peripheral noxious stimuli","volume":"31","author":"Beaudry","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.biopha.2020.110794_bib0230","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1124\/mol.106.026740","article-title":"Mu-opioid receptor activation modulates transient receptor potential vanilloid 1 (TRPV1) currents in sensory neurons in a model of inflammatory pain","volume":"71","author":"Endres-Becker","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.biopha.2020.110794_bib0235","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/j.peptides.2010.03.029","article-title":"Analytical characterization and comparison of the blood-brain barrier permeability of eight opioid peptides","volume":"31","author":"Van Dorpe","year":"2010","journal-title":"Peptides"},{"key":"10.1016\/j.biopha.2020.110794_bib0240","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1097\/j.pain.0000000000000898","article-title":"Hyperalgesic priming (type II) induced by repeated opioid exposure: maintenance mechanisms","volume":"158","author":"Araldi","year":"2017","journal-title":"Pain"},{"key":"10.1016\/j.biopha.2020.110794_bib0245","doi-asserted-by":"crossref","first-page":"12502","DOI":"10.1523\/JNEUROSCI.1673-15.2015","article-title":"Repeated mu-opioid exposure induces a novel form of the hyperalgesic priming model for transition to chronic pain","volume":"35","author":"Araldi","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.biopha.2020.110794_bib0250","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev-neuro-080317-061522","article-title":"Endogenous and exogenous opioids in pain","volume":"41","author":"Corder","year":"2018","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.biopha.2020.110794_bib0255","doi-asserted-by":"crossref","first-page":"8177","DOI":"10.1523\/JNEUROSCI.0654-19.2019","article-title":"Role of TRPM8 channels in altered cold sensitivity of corneal primary sensory neurons induced by axonal damage","volume":"39","author":"Pina","year":"2019","journal-title":"J. Neurosci."},{"key":"10.1016\/j.biopha.2020.110794_bib0260","first-page":"1169","article-title":"LPS-stimulated inflammation and apoptosis in corneal injury models","volume":"13","author":"Liang","year":"2007","journal-title":"Mol. Vis."},{"key":"10.1016\/j.biopha.2020.110794_bib0265","doi-asserted-by":"crossref","first-page":"14415","DOI":"10.1523\/JNEUROSCI.4569-09.2009","article-title":"T-cell infiltration and signaling in the adult dorsal spinal cord is a major contributor to neuropathic pain-like hypersensitivity","volume":"29","author":"Costigan","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.biopha.2020.110794_bib0270","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1097\/j.pain.0000000000000455","article-title":"Abnormal activity of corneal cold thermoreceptors underlies the unpleasant sensations in dry eye disease","volume":"157","author":"Kovacs","year":"2016","journal-title":"Pain"},{"key":"10.1016\/j.biopha.2020.110794_bib0275","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.brainres.2014.01.042","article-title":"Morphine inhibits acid-sensing ion channel currents in rat dorsal root ganglion neurons","volume":"1554","author":"Cai","year":"2014","journal-title":"Brain Res."},{"key":"10.1016\/j.biopha.2020.110794_bib0280","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3389\/fnmol.2017.00242","article-title":"Peripheral interaction of resolvin D1 and E1 with opioid receptor antagonists for antinociception in inflammatory pain in rats","volume":"10","author":"Oehler","year":"2017","journal-title":"Front. Mol. Neurosci."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220309872?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220309872?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:58:03Z","timestamp":1760097483000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332220309872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":56,"alternative-id":["S0753332220309872"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110794","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Topical treatment with a mu opioid receptor agonist alleviates corneal allodynia and corneal nerve sensitization in mice","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110794","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"110794"}}