{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T11:57:26Z","timestamp":1786622246418,"version":"build-2736575974"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.biopha.2020.110831","type":"journal-article","created":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T22:09:55Z","timestamp":1601762995000},"page":"110831","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["Bifidobacterium adolescentis supplementation attenuates fracture-induced systemic sequelae"],"prefix":"10.1016","volume":"132","author":[{"given":"Joseph L.","family":"Roberts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanglu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor M.","family":"Darby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo M.","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha E.","family":"Diaz-Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rheinallt M.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hicham","family":"Drissi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2020.110831_bib0005","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.injury.2011.03.031","article-title":"The biology of fracture healing","volume":"42","author":"Marsell","year":"2011","journal-title":"Injury"},{"key":"10.1016\/j.biopha.2020.110831_bib0010","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1302\/0301-620X.60B2.350882","article-title":"The biology of fracture healing in long bones","volume":"60-B","author":"McKibbin","year":"1978","journal-title":"J. Bone Joint Surg. Br."},{"key":"10.1016\/j.biopha.2020.110831_bib0015","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrrheum.2014.164","article-title":"Fracture healing: mechanisms and interventions","volume":"11","author":"Einhorn","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.biopha.2020.110831_bib0020","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/jor.24527","article-title":"Advances and promises of nutritional influences on natural bone repair","volume":"38","author":"Roberts","year":"2020","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.biopha.2020.110831_bib0025","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/s11914-018-0423-2","article-title":"The role of the immune cells in fracture healing","volume":"16","author":"Baht","year":"2018","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.biopha.2020.110831_bib0030","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/jbmr.3579","article-title":"Age dependence of systemic bone loss and recovery following femur fracture in mice","volume":"34","author":"Emami","year":"2019","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.biopha.2020.110831_bib0035","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1006\/jsre.1998.5520","article-title":"Femur fracture induces site-specific changes in T-cell immunity","volume":"82","author":"Buzdon","year":"1999","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.biopha.2020.110831_bib0040","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1007\/s11999-013-2908-8","article-title":"Cumulative effects of bone and soft tissue injury on systemic inflammation: a pilot study","volume":"471","author":"Pfeifer","year":"2013","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.biopha.2020.110831_bib0045","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1097\/00024382-199603000-00006","article-title":"The impact of femur fracture with associated soft tissue injury on immune function and intestinal permeability","volume":"5","author":"Napolitano","year":"1996","journal-title":"Shock"},{"key":"10.1016\/j.biopha.2020.110831_bib0050","doi-asserted-by":"crossref","DOI":"10.1136\/tsaco-2017-000108","article-title":"Characterizing the gut microbiome in trauma: significant changes in microbial diversity occur early after severe injury","volume":"2","author":"Howard","year":"2017","journal-title":"Trauma Surg. Acute Care Open."},{"key":"10.1016\/j.biopha.2020.110831_bib0055","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1002\/jbmr.3635","article-title":"Probiotic Lactobacillus reuteri prevents postantibiotic bone loss by reducing intestinal dysbiosis and preventing barrier disruption","volume":"34","author":"Schepper","year":"2019","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.biopha.2020.110831_bib0060","first-page":"5","article-title":"The potential of probiotics as a therapy for osteoporosis","author":"Collins","year":"2017","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.biopha.2020.110831_bib0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0153180","article-title":"Lactobacillus reuteri 6475 increases bone density in intact females only under an inflammatory setting","volume":"11","author":"Collins","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2020.110831_bib0070","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1002\/jcp.24636","article-title":"Probiotic L. reuteri treatment prevents bone loss in a menopausal ovariectomized mouse model","volume":"229","author":"Britton","year":"2014","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.biopha.2020.110831_bib0075","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1172\/JCI86062","article-title":"Sex steroid deficiency\u2013associated bone loss is microbiota dependent and prevented by probiotics","volume":"126","author":"Li","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biopha.2020.110831_bib0080","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.immuni.2018.10.013","article-title":"The microbial metabolite butyrate stimulates bone formation via t regulatory cell-mediated regulation of WNT10B expression","volume":"49","author":"Tyagi","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.biopha.2020.110831_bib0085","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/s13018-019-1310-y","article-title":"Oral administration of Lactobacillus casei Shirota improves recovery of hand functions after distal radius fracture among elder patients: a placebo-controlled, double-blind, and randomized trial","volume":"14","author":"Zhang","year":"2019","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.biopha.2020.110831_bib0090","doi-asserted-by":"crossref","first-page":"631","DOI":"10.3920\/BM2016.0067","article-title":"The effect of probiotic treatment on elderly patients with distal radius fracture: a prospective double-blind, placebo-controlled randomised clinical trial","volume":"7","author":"Lei","year":"2016","journal-title":"Benef. Microbes"},{"key":"10.1016\/j.biopha.2020.110831_bib0095","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/j.1365-2036.2005.02615.x","article-title":"Review article: bifidobacteria as probiotic agents -- physiological effects and clinical benefits","volume":"22","author":"Picard","year":"2005","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.biopha.2020.110831_bib0100","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.3389\/fmicb.2016.01204","article-title":"Gut bifidobacteria populations in human health and aging","volume":"7","author":"Arboleya","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.biopha.2020.110831_bib0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0036957","article-title":"Diversity of bifidobacteria within the infant gut microbiota","volume":"7","author":"Turroni","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2020.110831_bib0110","doi-asserted-by":"crossref","first-page":"3490","DOI":"10.1128\/IAI.00119-07","article-title":"Identification of commensal bacterial strains that modulate Yersinia enterocolitica and dextran sodium sulfate-induced inflammatory responses: implications for the development of probiotics","volume":"75","author":"Frick","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.biopha.2020.110831_bib0115","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3389\/fnbeh.2019.00126","article-title":"Prophylactic effects of Bifidobacterium adolescentis on anxiety and depression-like phenotypes after chronic stress: a role of the gut microbiota-inflammation Axis","volume":"13","author":"Guo","year":"2019","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.biopha.2020.110831_bib0120","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1002\/jbmr.3228","article-title":"Fracture Incidence and characteristics in young adults aged 18 to 49 years: a population-based study","volume":"32","author":"Farr","year":"2017","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.biopha.2020.110831_bib0125","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1002\/jbmr.1601","article-title":"Runx1 dose-dependently regulates endochondral ossification during skeletal development and fracture healing","volume":"27","author":"Soung","year":"2012","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.biopha.2020.110831_bib0130","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/jcb.21816","article-title":"Teriparatide (1-34 human PTH) regulation of Osterix during fracture repair","volume":"105","author":"Kaback","year":"2008","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.biopha.2020.110831_bib0135","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1359\/jbmr.081002","article-title":"Reduced COX-2 expression in aged mice is associated with impaired fracture healing","volume":"24","author":"Naik","year":"2009","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.biopha.2020.110831_bib0140","article-title":"Deletion of Runx1 in osteoclasts impairs murine fracture healing through progressive woven bone loss and delayed cartilage remodeling","author":"Paglia","year":"2019","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.biopha.2020.110831_bib0145","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/jbmr.141","article-title":"Guidelines for assessment of bone microstructure in rodents using micro\u2013computed tomography","volume":"25","author":"Bouxsein","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.biopha.2020.110831_bib0150","doi-asserted-by":"crossref","first-page":"14268","DOI":"10.1038\/s41598-018-32532-w","article-title":"Malic Enzyme 1 (ME1) is pro-oncogenic in Apc(Min\/+) mice","volume":"8","author":"Fernandes","year":"2018","journal-title":"SSci. Rep."},{"key":"10.1016\/j.biopha.2020.110831_bib0155","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.1128\/AEM.01541-09","article-title":"Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities","volume":"75","author":"Schloss","year":"2009","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.biopha.2020.110831_bib0160","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s41038-019-0162-3","article-title":"Intestinal barrier dysfunction in severe burn injury","volume":"7","author":"He","year":"2019","journal-title":"Burns Trauma"},{"key":"10.1016\/j.biopha.2020.110831_bib0165","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1097\/SHK.0000000000001271","article-title":"Remote intestinal injury early after experimental polytrauma and hemorrhagic shock","volume":"52","author":"Wrba","year":"2019","journal-title":"Shock"},{"key":"10.1016\/j.biopha.2020.110831_bib0170","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0020-1383(96)00055-1","article-title":"Prolonged alteration in gut permeability following nonthermal injury","volume":"27","author":"Walsh","year":"1996","journal-title":"Injury"},{"key":"10.1016\/j.biopha.2020.110831_bib0175","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2174\/1573401311309020004","article-title":"Protection and restitution of gut barrier by probiotics: nutritional and clinical implications","volume":"9","author":"Rao","year":"2013","journal-title":"Curr. Nutr. Food Sci."},{"key":"10.1016\/j.biopha.2020.110831_bib0180","doi-asserted-by":"crossref","first-page":"G807","DOI":"10.1152\/ajpgi.00243.2009","article-title":"Probiotic bacteria and intestinal epithelial barrier function","volume":"298","author":"Ohland","year":"2010","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.biopha.2020.110831_bib0185","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12979-014-0020-x","article-title":"The immune response after fracture trauma is different in old compared to young patients","volume":"11","author":"Vester","year":"2014","journal-title":"Immun. Ageing"},{"key":"10.1016\/j.biopha.2020.110831_bib0190","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1093\/advances\/nmy063","article-title":"Mechanisms of action of probiotics","volume":"10","author":"Plaza-Diaz","year":"2019","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.biopha.2020.110831_bib0195","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1097\/00003246-199808000-00006","article-title":"Synergy of bone fractures, soft tissue disruption, and hemorrhagic shock in the genesis of postinjury immunochaos: the pathway to multiple organ failure","volume":"26","author":"Moore","year":"1998","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.biopha.2020.110831_bib0200","first-page":"G827","article-title":"Alterations in intestinal bacterial flora modulate the systemic cytokine response to hemorrhagic shock","volume":"269","author":"Guo","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.biopha.2020.110831_bib0205","doi-asserted-by":"crossref","first-page":"R970","DOI":"10.1152\/ajpregu.00793.2005","article-title":"Systemic inflammation and remote organ damage following bilateral femur fracture requires Toll-like receptor 4","volume":"291","author":"Levy","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.biopha.2020.110831_bib0210","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1097\/00005373-199806000-00016","article-title":"Intestinal permeability correlates with severity of injury in trauma patients","volume":"44","author":"Faries","year":"1998","journal-title":"J. Trauma"},{"key":"10.1016\/j.biopha.2020.110831_bib0215","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jnutbio.2013.09.011","article-title":"Bifidobacterium adolescentis protects from the development of nonalcoholic steatohepatitis in a mouse model","volume":"25","author":"Reichold","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.biopha.2020.110831_bib0220","doi-asserted-by":"crossref","first-page":"3930","DOI":"10.1091\/mbc.e09-04-0320","article-title":"ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeleton","volume":"20","author":"Van Itallie","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.biopha.2020.110831_bib0225","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/labinvest.2008.78","article-title":"Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation","volume":"88","author":"Weber","year":"2008","journal-title":"Lab. Invest."},{"key":"10.1016\/j.biopha.2020.110831_bib0230","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1136\/gut.2006.094375","article-title":"Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn\u2019s disease","volume":"56","author":"Zeissig","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.biopha.2020.110831_bib0235","doi-asserted-by":"crossref","first-page":"31263","DOI":"10.1074\/jbc.M111.238147","article-title":"Interleukin-6 (IL-6) regulates claudin-2 expression and tight junction permeability in intestinal epithelium","volume":"286","author":"Suzuki","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2020.110831_bib0240","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0085345","article-title":"Interleukin-6 modulation of intestinal epithelial tight junction permeability is mediated by JNK pathway activation of claudin-2 gene","volume":"9","author":"Al-Sadi","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2020.110831_bib0245","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00441-009-0751-8","article-title":"TNFalpha up-regulates claudin-2 expression in epithelial HT-29\/B6 cells via phosphatidylinositol-3-kinase signaling","volume":"336","author":"Mankertz","year":"2009","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.biopha.2020.110831_bib0250","doi-asserted-by":"crossref","first-page":"12037","DOI":"10.1074\/jbc.M109.064808","article-title":"Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity","volume":"285","author":"Weber","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2020.110831_bib0255","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1242\/jcs.021485","article-title":"The density of small tight junction pores varies among cell types and is increased by expression of claudin-2","volume":"121","author":"Van Itallie","year":"2008","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.biopha.2020.110831_bib0260","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/mi.2015.32","article-title":"New developments in goblet cell mucus secretion and function","volume":"8","author":"Birchenough","year":"2015","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.biopha.2020.110831_bib0265","doi-asserted-by":"crossref","first-page":"761","DOI":"10.4161\/19490976.2014.972238","article-title":"Antimicrobial peptides and the enteric mucus layer act in concert to protect the intestinal mucosa","volume":"5","author":"Dupont","year":"2014","journal-title":"Gut Microbes"},{"key":"10.1016\/j.biopha.2020.110831_bib0270","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1053\/j.gastro.2012.10.043","article-title":"IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells","volume":"144","author":"Hasnain","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biopha.2020.110831_bib0275","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-9255-9-1","article-title":"LPS induced inflammatory responses in human peripheral blood mononuclear cells is mediated through NOX4 and Gialpha dependent PI-3kinase signalling","volume":"9","author":"Ngkelo","year":"2012","journal-title":"J Inflamm (Lond)"},{"key":"10.1016\/j.biopha.2020.110831_bib0280","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1038\/s41598-017-03147-4","article-title":"Lipopolysaccharides induced inflammatory responses and electrophysiological dysfunctions in human-induced pluripotent stem cell derived cardiomyocytes","volume":"7","author":"Yucel","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2020.110831_bib0285","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1007\/s11999-016-5159-7","article-title":"Defective bone repair in C57Bl6 mice with acute systemic inflammation","volume":"475","author":"Behrends","year":"2017","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.biopha.2020.110831_bib0290","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1080\/17453670510045327","article-title":"Lipopolysaccharide impairs fracture healing: an experimental study in rats","volume":"76","author":"Reikeras","year":"2005","journal-title":"Acta Orthop."},{"key":"10.1016\/j.biopha.2020.110831_bib0295","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1007\/s00198-018-4606-6","article-title":"Study of Osteoporotic Fractures Research G. Incident fracture is associated with a period of accelerated loss of hip BMD: the Study of Osteoporotic Fractures","volume":"29","author":"Christiansen","year":"2018","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.biopha.2020.110831_bib0300","doi-asserted-by":"crossref","first-page":"7223","DOI":"10.1038\/s41598-017-07511-2","article-title":"Calcium and vitamin-D deficiency marginally impairs fracture healing but aggravates posttraumatic bone loss in osteoporotic mice","volume":"7","author":"Fischer","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2020.110831_bib0305","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1615\/CritRevEukarGeneExpr.v20.i2.20","article-title":"Recent advances in the use of serological bone formation markers to monitor callus development and fracture healing","volume":"20","author":"Coulibaly","year":"2010","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"10.1016\/j.biopha.2020.110831_bib0310","doi-asserted-by":"crossref","first-page":"E8141","DOI":"10.1073\/pnas.1617460113","article-title":"Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice","volume":"113","author":"Tan","year":"2016","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.biopha.2020.110831_bib0315","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1348-0421.1998.tb02294.x","article-title":"Culture supernatants of Lactobacillus acidophilus and Bifidobacterium adolescentis repress ileal ulcer formation in rats treated with a nonsteroidal antiinflammatory drug by suppressing unbalanced growth of aerobic bacteria and lipid peroxidation","volume":"42","author":"Kinouchi","year":"1998","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.biopha.2020.110831_bib0320","first-page":"3","article-title":"Strengthening of the intestinal epithelial tight junction by Bifidobacterium bifidum","author":"Hsieh","year":"2015","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.biopha.2020.110831_bib0325","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/biof.1081","article-title":"Flavonols enhanced production of anti-inflammatory substance(s) by Bifidobacterium adolescentis: prebiotic actions of galangin, quercetin, and fisetin","volume":"39","author":"Kawabata","year":"2013","journal-title":"Biofactors."},{"key":"10.1016\/j.biopha.2020.110831_bib0330","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1080\/09168451.2017.1401916","article-title":"Functional properties of anti-inflammatory substances from quercetin-treated Bifidobacterium adolescentis","volume":"82","author":"Kawabata","year":"2018","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.biopha.2020.110831_bib0335","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.copbio.2014.10.006","article-title":"Novel opportunities for next-generation probiotics targeting metabolic syndrome","volume":"32","author":"Cani","year":"2015","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.biopha.2020.110831_bib0340","first-page":"25877","article-title":"Manipulating the gut microbiota to maintain health and treat disease","volume":"26","author":"Scott","year":"2015","journal-title":"Microb. Ecol. Health Dis."},{"key":"10.1016\/j.biopha.2020.110831_bib0345","first-page":"6","article-title":"Functional dynamics of the gut microbiome in elderly people during probiotic consumption","author":"Eloe-Fadrosh","year":"2015","journal-title":"mBio."},{"key":"10.1016\/j.biopha.2020.110831_bib0350","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1128\/AEM.72.5.3593-3599.2006","article-title":"Two routes of metabolic cross-feeding between Bifidobacterium adolescentis and butyrate-producing anaerobes from the human gut","volume":"72","author":"Belenguer","year":"2006","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.biopha.2020.110831_bib0355","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1757-4749-5-23","article-title":"Commensal Clostridia: leading players in the maintenance of gut homeostasis","volume":"5","author":"Lopetuso","year":"2013","journal-title":"Gut Pathog."},{"key":"10.1016\/j.biopha.2020.110831_bib0360","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.3389\/fmicb.2017.01666","article-title":"Secretome of intestinal Bacilli: a natural guard against pathologies","volume":"8","author":"Ilinskaya","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.biopha.2020.110831_bib0365","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1093\/ndt\/gfy238","article-title":"Sodium butyrate ameliorates insulin resistance and renal failure in CKD rats by modulating intestinal permeability and mucin expression","volume":"34","author":"Gonzalez","year":"2019","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.biopha.2020.110831_bib0370","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1159\/000490981","article-title":"Sodium butyrate attenuates diarrhea in weaned piglets and promotes tight junction protein expression in Colon in a GPR109A-Dependent manner","volume":"47","author":"Feng","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.biopha.2020.110831_bib0375","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cellimm.2018.03.003","article-title":"High fiber dietary and sodium butyrate attenuate experimental autoimmune hepatitis through regulation of immune regulatory cells and intestinal barrier","volume":"328","author":"Hu","year":"2018","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.biopha.2020.110831_bib0380","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1177\/1535370217708188","article-title":"Butyrate reduces high-fat diet-induced metabolic alterations, hepatic steatosis and pancreatic beta cell and intestinal barrier dysfunctions in prediabetic mice","volume":"242","author":"Matheus","year":"2017","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.biopha.2020.110831_bib0385","first-page":"4000","article-title":"Sodium butyrate protects the intestinal barrier function in peritonitic mice","volume":"8","author":"Han","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.biopha.2020.110831_bib0390","doi-asserted-by":"crossref","DOI":"10.4161\/21688370.2014.982426","article-title":"Roles and regulation of the mucus barrier in the gut","volume":"3","author":"Cornick","year":"2015","journal-title":"Tissue Barriers"},{"key":"10.1016\/j.biopha.2020.110831_bib0395","first-page":"54","article-title":"Bacteroides ovatus as the predominant commensal intestinal microbe causing a systemic antibody response in inflammatory bowel disease","volume":"9","author":"Saitoh","year":"2002","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"10.1016\/j.biopha.2020.110831_bib0400","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1348-0421.2003.tb03368.x","article-title":"The suppressive effect of bifidobacteria on Bacteroides vulgatus, a putative pathogenic microbe in inflammatory bowel disease","volume":"47","author":"Shiba","year":"2003","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.biopha.2020.110831_bib0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.chom.2020.01.016","article-title":"Fecal IgA levels are determined by strain-level differences in Bacteroides ovatus and are modifiable by gut microbiota manipulation","author":"Yang","year":"2020","journal-title":"Cell Host Microbe."},{"key":"10.1016\/j.biopha.2020.110831_bib0410","article-title":"Involvement of the gut microbiota and barrier function in glucocorticoid-induced osteoporosis","author":"Schepper","year":"2019","journal-title":"J. Bone Miner. Res."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220310246?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220310246?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:56:24Z","timestamp":1760097384000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332220310246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":82,"alternative-id":["S0753332220310246"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110831","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bifidobacterium adolescentis supplementation attenuates fracture-induced systemic sequelae","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110831","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"110831"}}