{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T13:41:24Z","timestamp":1769607684873,"version":"3.49.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T00:00:00Z","timestamp":1601942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001664","name":"John Randolph and Dora Haynes Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001664","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001779","name":"Monash University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001779","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.biopha.2020.110860","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T13:19:10Z","timestamp":1602508750000},"page":"110860","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Visualising functional 5-HT3 receptors containing A and C subunits at or near the cell surface"],"prefix":"10.1016","volume":"132","author":[{"given":"Isaiah P.L.","family":"Abad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ray L.","family":"Fam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan-Thanh","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cameron J.","family":"Nowell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phuc N.H.","family":"Trinh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David T.","family":"Manallack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lubna A.","family":"Freihat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay","family":"Chakrabarti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aamani","family":"Jamil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betty","family":"Exintaris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nor S.","family":"Yaakob","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1514-0909","authenticated-orcid":false,"given":"Helen R.","family":"Irving","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2020.110860_bib0005","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.neuropharm.2008.08.003","article-title":"The 5-HT3 receptor - the relationship between structure and function","volume":"56","author":"Barnes","year":"2009","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.biopha.2020.110860_bib0010","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1124\/pr.118.015487","article-title":"5-HT3 receptor antagonists in neurologic and neuropsychiatric disorders: the iceberg still lies beneath the surface","volume":"71","author":"Fakhfouri","year":"2019","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.biopha.2020.110860_bib0015","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.pharmthera.2010.07.001","article-title":"5-HT3 receptors: role in disease and target of drugs","volume":"128","author":"Walstab","year":"2010","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.biopha.2020.110860_bib0020","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2174\/156652411794474392","article-title":"Heterogeneity amongst 5 HT3 receptor subunits: is this significant?","volume":"11","author":"Yaakob","year":"2011","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.biopha.2020.110860_bib0025","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0378-1119(03)00803-5","article-title":"A cluster of novel serotonin receptor 3-like genes on human chromosome 3","volume":"319","author":"Karnovsky","year":"2003","journal-title":"Gene"},{"key":"10.1016\/j.biopha.2020.110860_bib0030","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0378-1119(03)00503-1","article-title":"Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E","volume":"310","author":"Niesler","year":"2003","journal-title":"Gene"},{"key":"10.1016\/j.biopha.2020.110860_bib0035","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/16941","article-title":"The 5-HT3B subunit is a major determinant of serotonin-receptor function","volume":"397","author":"Davies","year":"1999","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.biopha.2020.110860_bib0040","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1471-4159.2008.05775.x","article-title":"Characterisation of 5-HT3C, 5-HT3D and 5-HT3E receptor subunits: evolution, distribution and function","volume":"108","author":"Holbrook","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.biopha.2020.110860_bib0045","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1124\/mol.106.032144","article-title":"Characterization of the novel human serotonin receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E","volume":"72","author":"Niesler","year":"2007","journal-title":"Mol. Pharmacol."},{"issue":"5","key":"10.1016\/j.biopha.2020.110860_bib0050","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1021\/acschemneuro.6b00416","article-title":"Subtle differences among 5-HT3AC, 5-HT3AD, and 5-HT3AE receptors are revealed by partial agonists","volume":"8","author":"Price","year":"2017","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.biopha.2020.110860_bib0055","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1006\/mcne.2002.1160","article-title":"Assembly and cell surface expression of homomeric and heteromeric 5-HT3 receptors: the role of oligomerization and chaperone proteins","volume":"21","author":"Boyd","year":"2002","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.biopha.2020.110860_bib0060","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/nature13552","article-title":"X-ray structure of the mouse serotonin 5-HT3 receptor","volume":"512","author":"Hassaine","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2020.110860_bib0065","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/s41467-018-02997-4","article-title":"Cryo-EM structure of 5-HT3A receptor in its resting conformation","volume":"9","author":"Basak","year":"2018","journal-title":"Nature Commun."},{"key":"10.1016\/j.biopha.2020.110860_bib0070","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s00432-008-0387-1","article-title":"Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy","volume":"134","author":"Fasching","year":"2008","journal-title":"J. Can. Res. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.biopha.2020.110860_bib0075","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3109\/00016340903322727","article-title":"Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy","volume":"89","author":"Goecke","year":"2010","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"10.1016\/j.biopha.2020.110860_bib0080","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1111\/apt.15420","article-title":"Abnormalities of mucosal serotonin metabolism and 5\u2010HT3 receptor subunit 3C polymorphism in irritable bowel syndrome with diarrhoea predict responsiveness to ondansetron","volume":"50","author":"Gunn","year":"2019","journal-title":"Ali. Pharmacol. Therap."},{"key":"10.1016\/j.biopha.2020.110860_bib0085","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.euroneuro.2013.07.003","article-title":"5-HT3 receptor influences the washing phenotype and visual organization in obsessive-compulsive disorder supporting 5-HT3 receptor antagonists as novel treatment option","volume":"24","author":"Lennertz","year":"2014","journal-title":"Eur. J. Neuropsychopharmacol."},{"key":"10.1016\/j.biopha.2020.110860_bib0090","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s10549-014-2832-y","article-title":"Association between variants of 5-hydroxytrptamine receptor 3C (HTR3C) and chemotherapy-induced symptoms in women receiving adjuvant treatment for breast cancer","volume":"144","author":"Pud","year":"2014","journal-title":"Breast Can. Res. Treat."},{"key":"10.1016\/j.biopha.2020.110860_bib0095","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/ajmg.b.30882","article-title":"Allelic variants in HTR3C show association with autism, A","volume":"150B","author":"Rehnstr\u00f6m","year":"2009","journal-title":"J. Med. Genet. Part B Neuropsych. Genet."},{"key":"10.1016\/j.biopha.2020.110860_bib0100","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.biopsych.2010.06.025","article-title":"Early life stress combined with serotonin 3A receptor and brain-derived growth factor valine 66 to methionine genotypes impacts emotional brain and arousal correlates of risk for depression","volume":"68","author":"Gatt","year":"2011","journal-title":"Biol. Psych."},{"key":"10.1016\/j.biopha.2020.110860_bib0105","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1002\/da.20726","article-title":"Impact of the HTR3A gene with early life trauma on emotional brain networks and depressed mood","volume":"27","author":"Gatt","year":"2010","journal-title":"Depression Anxiety"},{"key":"10.1016\/j.biopha.2020.110860_bib0110","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1097\/FPC.0b013e32830500e2","article-title":"Association between a polymorphism of the HTR3A gene and therapeutic response to riseridone tretment in drug-naive Chinese schizophrenia patients","volume":"18","author":"Gu","year":"2008","journal-title":"Pharmocogenet. Genom."},{"key":"10.1016\/j.biopha.2020.110860_bib0115","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.schres.2014.12.031","article-title":"Evidence for schizophrenia susceptibility alleles in the Indian population: an association of neurodevelopmental genes in case-control and familial samples","volume":"162","author":"Jajodia","year":"2015","journal-title":"Schizophrenia Res."},{"key":"10.1016\/j.biopha.2020.110860_bib0120","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1176\/appi.ajp.2013.12091163","article-title":"Determination of genotype combinations that can predict the outcome of the treatment of alcohol dependence using the 5-HT3 antagonist ondansetron","volume":"170","author":"Johnson","year":"2013","journal-title":"Am. J. Psych."},{"key":"10.1016\/j.biopha.2020.110860_bib0125","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1159\/000094727","article-title":"Effects of the serotonin type 2A, 3A and 3B receptor and the seotonin transporter genes on paroxetine and fluvoxamine efficiacy and adverse drug reactions in depressed Japanese patients","volume":"53","author":"Kato","year":"2006","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.biopha.2020.110860_bib0130","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/00008571-200108000-00002","article-title":"Association between the 5\u2019-UTR variant C178T of the the serotonin receptor gene HTR3A and bipolar affective disorder","volume":"11","author":"Niesler","year":"2001","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.biopha.2020.110860_bib0135","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/00008571-200102000-00003","article-title":"Serotonin receptor gene HTR3A variants in schizophrenic and bipolar affective patients","volume":"11","author":"Niesler","year":"2001","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.biopha.2020.110860_bib0140","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00213-012-2773-2","article-title":"Outcome definitions and clinical predictors influence pharmacogenetic associations between HTR3A gene polymorphisms and response to clozapine in patients with schizophrenia","volume":"224","author":"Rajkumar","year":"2012","journal-title":"Psychopharmacology"},{"issue":"4","key":"10.1016\/j.biopha.2020.110860_bib0145","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/FPC.0b013e328337ce3e","article-title":"Influence of serotonin 3A and 3B receptor genes on clozapine treatment response in schizophrenia","volume":"20","author":"Souza","year":"2010","journal-title":"Pharmocogenet. Genom."},{"key":"10.1016\/j.biopha.2020.110860_bib0150","first-page":"4581","article-title":"Association of genetic polymorphisms in HTR3A and HTR3E with diarrhea predominant irritable bowel syndrome","volume":"8","author":"Gu","year":"2015","journal-title":"Int. J. Chem. Exper. Med."},{"key":"10.1016\/j.biopha.2020.110860_bib0155","doi-asserted-by":"crossref","first-page":"100459","DOI":"10.18632\/oncotarget.19682","article-title":"HTR3A and HTR3E gene polymorphisms and diarrhea predominnat irritiable bowel syndrome risk: evidence from a meta-analysis","volume":"8","author":"Guan","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.biopha.2020.110860_bib0160","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/cne.22525","article-title":"Serotonin receptor diversity in the human colon: expression of serotonin type 3 receptor subunits 5-HT32, 5-HT3D, and 5-HT3E","volume":"519","author":"Kapeller","year":"2011","journal-title":"J. Compar. Neurol."},{"key":"10.1016\/j.biopha.2020.110860_bib0165","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/1471-2350-12-140","article-title":"Serotonin receptor 3A polymorphism c.-42C & T is associated with severe dysepsia","volume":"12","author":"Mujakovic","year":"2011","journal-title":"BMC Med. Genetics"},{"key":"10.1016\/j.biopha.2020.110860_bib0170","article-title":"Distribution of serotonin receptors and interacting proteins in the human sigmoid colon","volume":"21","author":"Chetty","year":"2009","journal-title":"Neurogastroent. Mot."},{"key":"10.1016\/j.biopha.2020.110860_bib0175","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/j.1365-2982.2006.00891.x","article-title":"Regional differences in expression of TPH-1, SERT, 5-HT3 and 5-HT4 receptors in the human stomach and duodenum","volume":"19","author":"Van Lelyveld","year":"2007","journal-title":"Neurogastroent. Mot."},{"key":"10.1016\/j.biopha.2020.110860_bib0180","doi-asserted-by":"crossref","first-page":"361","DOI":"10.5056\/jnm14157","article-title":"Distribution of 5-HT3, 5-HT4 and 5-HT7 receptors along the human colon","volume":"21","author":"Yaakob","year":"2015","journal-title":"J. Neurogastroent. Mot."},{"key":"10.1016\/j.biopha.2020.110860_bib0185","doi-asserted-by":"crossref","first-page":"26956","DOI":"10.1074\/jbc.M110.122838","article-title":"RIC-3 exclusively enhances the surface expressionof human homomeric 5-hydroxytryptamine type 3A (5-HT3A) receptors despite direct interactions with 5-HT3A, -C, -D and -E subunits","volume":"285","author":"Walstab","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2020.110860_bib0190","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.biopha.2017.12.010","article-title":"The C and E subnits of the serotonin 5-HT3 receptor subtly modulate the electrical properties of the receptor","volume":"97","author":"Yaakob","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2020.110860_bib0195","doi-asserted-by":"crossref","first-page":"30799","DOI":"10.1074\/jbc.274.43.30799","article-title":"The pharmacological and functional characterisation of the 5-HT3A receptor are specifically modified by a 5-HT3B receptor subunit","volume":"274","author":"Dubin","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.biopha.2020.110860_bib0200","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1016\/S0006-3495(03)74980-7","article-title":"Co-expression of the 5-HT3B serotonin receptor subunit alters the biophysics of the 5-HT3 receptor","volume":"84","author":"Hapfelmeier","year":"2003","journal-title":"Biophys. J."},{"key":"10.1016\/j.biopha.2020.110860_bib0205","doi-asserted-by":"crossref","first-page":"6826","DOI":"10.1074\/jbc.M707571200","article-title":"The 5-HT3B subunit confers spontaneous channel opening and altered ligand properties of the 5-HT3 receptor","volume":"283","author":"Hu","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2020.110860_bib0210","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.bpj.2013.07.015","article-title":"The 5-HT3AB receptor shows an A3B2 stoichometry at the plasma membrane","volume":"105","author":"Miles","year":"2013","journal-title":"Biophys. J."},{"key":"10.1016\/j.biopha.2020.110860_bib0215","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/j.bpj.2009.12.4313","article-title":"Agonists and antagonists bind to an A-A interface in the heteromeric 5-HT3AB receptor","volume":"98","author":"Lochner","year":"2010","journal-title":"Biophys. J."},{"key":"10.1016\/j.biopha.2020.110860_bib0220","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.1113\/jphysiol.2011.208439","article-title":"Cysteine modification reveals which subunits form the ligand binding site in human heteromeric 5-HT3AB receptors","volume":"589","author":"Thompson","year":"2011","journal-title":"J. Physiol."},{"key":"10.1016\/j.biopha.2020.110860_bib0225","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nmeth.1318","article-title":"Enzymatic assembly of DNA molecules up to several hundred kilobases","volume":"6","author":"Gibson","year":"2009","journal-title":"Nat. Meth."},{"key":"10.1016\/j.biopha.2020.110860_bib0230","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Meth."},{"key":"10.1016\/j.biopha.2020.110860_bib0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047132","article-title":"Crystal structure of enhanced green fluorescent protein to 1.35 \u00c5 resolution reveals alternative conformations for Glu222","volume":"7","author":"Arpino","year":"2012","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.biopha.2020.110860_bib0240","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1016\/j.bcp.2004.06.034","article-title":"Identification and importance of N-glycosylation of the human 5-hydroxytryptamine 3A receptor subunit","volume":"68","author":"Monk","year":"2004","journal-title":"Biochem. Pharmacol."},{"issue":"4","key":"10.1016\/j.biopha.2020.110860_bib0245","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1017\/S0033583510000168","article-title":"The structural basis of function in Cys-loop receptors","volume":"43","author":"Thompson","year":"2010","journal-title":"Quart. Rev. Biophys."},{"key":"10.1016\/j.biopha.2020.110860_bib0250","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1002\/pmic.200300772","article-title":"PhosphoSite: a bioinformatics resource dedicated to physiological protein phosphorylation","volume":"4","author":"Hornbeck","year":"2004","journal-title":"Proteomics"},{"key":"10.1016\/j.biopha.2020.110860_bib0255","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/msb.2011.75","article-title":"Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega","volume":"7","author":"Sievers","year":"2011","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.biopha.2020.110860_bib0260","doi-asserted-by":"crossref","DOI":"10.1038\/srep23921","article-title":"Pentameric quaternary structure of the intracellular domain of serotonin type 3A receptors","volume":"6","author":"Pandhare","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2020.110860_bib0265","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/jphp.12522","article-title":"Tropisetron inhibits high glucose-induced calcineurin\/NFAT hypertrophic pathway in H9c2 myocardial cells","volume":"68","author":"Asadi","year":"2016","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.biopha.2020.110860_bib0270","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ejphar.2015.10.019","article-title":"Inhibition of calcineurin\/NFAT pathway plays an essential role in renoprotective effect of tropisetron in early stage of diabetic nephropathy","volume":"767","author":"Barzegar-Fallah","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2020.110860_bib0275","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.bcp.2005.04.031","article-title":"The 5-HT3 receptor antagonist tropisetron inhibits T cell activation by targeting the calcineurin pathway","volume":"70","author":"de la Vega","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biopha.2020.110860_bib0280","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.biopha.2018.11.142","article-title":"Tropisetron inhibits sepsis by repressing hyper-inflammation and regulating the cardiac action potential in rat models","volume":"110","author":"Liu","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2020.110860_bib0285","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.1242\/jcs.056218","article-title":"Imaging with total internal reflection fluorescence microscopy for the cell biologist","volume":"123","author":"Mattheyeses","year":"2010","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.biopha.2020.110860_bib0290","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1085\/jgp.201010532","article-title":"Nicotine up-regulates \u03b14\u03b22 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoning","volume":"137","author":"Srinivasan","year":"2011","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.biopha.2020.110860_bib0295","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1007\/s12035-014-8957-5","article-title":"From chemotherapy-induced emesis to neuroprotection: therapeutic opportunities for 5-HT3 receptor antagonists","volume":"52","author":"Fakhfouri","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.biopha.2020.110860_bib0300","doi-asserted-by":"crossref","first-page":"14082","DOI":"10.1038\/s41598-017-13968-y","article-title":"Organelle membrane derived patches: reshaping classical methods for new targets","volume":"7","author":"Shapovalov","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2020.110860_bib0305","doi-asserted-by":"crossref","first-page":"37336","DOI":"10.1038\/srep37336","article-title":"5-HTR3 and 5-HTR4 located on the mitochondrial membrane and functional regulated mitochonrial functions","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220310520?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220310520?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:01:19Z","timestamp":1760097679000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332220310520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":61,"alternative-id":["S0753332220310520"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110860","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Visualising functional 5-HT3 receptors containing A and C subunits at or near the cell surface","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110860","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"110860"}}