{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:00:15Z","timestamp":1778742015545,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T00:00:00Z","timestamp":1602720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.biopha.2020.110896","type":"journal-article","created":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T20:44:10Z","timestamp":1604263450000},"page":"110896","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Over-expression of Kv4.3 gene reverses cardiac remodeling and transient-outward K+ current (Ito) reduction via CaMKII inhibition in myocardial infarction"],"prefix":"10.1016","volume":"132","author":[{"given":"Bo","family":"Tao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhebo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzhen","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengyu","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.biopha.2020.110896_bib0005","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1161\/01.CIR.0000117090.01718.2A","article-title":"Mortality in patients after a recent myocardial infarction - A randomized, placebo-controlled trial of azimilide using heart rate variability for risk stratification","volume":"109","author":"Camm","year":"2004","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.biopha.2020.110896_bib0010","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0008-6363(00)00308-4","article-title":"Sympathetic nerve sprouting, electrical remodeling and the mechanisms of sudden cardiac death","volume":"50","author":"Chen","year":"2001","journal-title":"Cardiovasc. Res."},{"issue":"23","key":"10.1016\/j.biopha.2020.110896_bib0015","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1161\/01.CIR.103.23.2845","article-title":"Combined angiotensin II receptor antagonism and angiotensin-converting enzyme inhibition further attenuates postinfarction left ventricular remodeling","volume":"103","author":"Mankad","year":"2001","journal-title":"Circulation"},{"issue":"24","key":"10.1016\/j.biopha.2020.110896_bib0020","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1093\/eurheartj\/ehm489","article-title":"Quantitative relationship between resting heart rate reduction and magnitude of clinical benefits in post-myocardial infarction: a meta-regression of randomized clinical trials","volume":"28","author":"Cucherat","year":"2007","journal-title":"Eur. Heart J."},{"issue":"1","key":"10.1016\/j.biopha.2020.110896_bib0025","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1161\/CIRCRESAHA.116.303577","article-title":"The biological basis for cardiac repair after myocardial infarction: from inflammation to fibrosis","volume":"119","author":"Prabhu","year":"2016","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.biopha.2020.110896_bib0030","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nm1215","article-title":"Calmodulin kinase II inhibition protects against structural heart disease","volume":"11","author":"Zhang","year":"2005","journal-title":"Nat. Med."},{"issue":"12","key":"10.1016\/j.biopha.2020.110896_bib0035","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1002\/ejhf.163","article-title":"Ca(2+) \/calmodulin-dependent protein kinase II equally induces sarcoplasmic reticulum Ca(2+) leak in human ischaemic and dilated cardiomyopathy","volume":"16","author":"Fischer","year":"2014","journal-title":"Eur. J. Heart Fail."},{"issue":"6","key":"10.1016\/j.biopha.2020.110896_bib0040","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1161\/CIRCRESAHA.113.301651","article-title":"Mechanisms of altered Ca2+ handling in heart failure","volume":"113","author":"Luo","year":"2013","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.biopha.2020.110896_bib0045","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1161\/01.RES.79.3.461","article-title":"Cellular and ionic basis of arrhythmias in postinfarction remodeled ventricular myocardium","volume":"79","author":"Qin","year":"1996","journal-title":"Circ. Res."},{"issue":"14","key":"10.1016\/j.biopha.2020.110896_bib0050","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1161\/01.CIR.98.14.1383","article-title":"Molecular basis of transient outward potassium current downregulation in human heart failure: a decrease in Kv4.3 mRNA correlates with a reduction in current density","volume":"98","author":"K\u00e4\u00e4b","year":"1998","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.biopha.2020.110896_bib0055","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1161\/01.RES.0000128406.08418.34","article-title":"NFATc3-induced reductions in voltage-gated K+ currents after myocardial infarction","volume":"94","author":"Rossow","year":"2004","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.biopha.2020.110896_bib0060","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1124\/jpet.105.097618","article-title":"KN-93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium\/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated potassium channels","volume":"317","author":"Rezazadeh","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"2","key":"10.1016\/j.biopha.2020.110896_bib0065","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1161\/01.RES.0000200739.90811.9f","article-title":"Increased sarcoplasmic reticulum calcium leak but unaltered contractility by acute CaMKII overexpression in isolated rabbit cardiac myocytes","volume":"98","author":"Kohlhaas","year":"2006","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.biopha.2020.110896_bib0070","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/eurheartj\/ehq469","article-title":"Dynamic Kv4.3-CaMKII unit in heart: an intrinsic negative regulator for CaMKII activation","volume":"32","author":"Keskanokwong","year":"2011","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.biopha.2020.110896_bib0075","doi-asserted-by":"crossref","first-page":"538","DOI":"10.3389\/fphar.2019.00538","article-title":"Stachydrine ameliorates cardiac fibrosis through inhibition of angiotensin II\/transformation growth factor \u03b21 fibrogenic axis","volume":"10","author":"Liu","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"6","key":"10.1016\/j.biopha.2020.110896_bib0080","first-page":"2104","article-title":"Myocardial infarct size measurement in the mouse chronic infarction model: comparison of area- and length-based approaches","volume":"102","author":"Takagawa","year":"2007","journal-title":"J. Appl. Phys."},{"issue":"1","key":"10.1016\/j.biopha.2020.110896_bib0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000336148","article-title":"Risk of ventricular arrhythmias after myocardial infarction with diabetes associated with sympathetic neural remodeling in rabbits","volume":"121","author":"Wang","year":"2012","journal-title":"Cardiology"},{"issue":"19","key":"10.1016\/j.biopha.2020.110896_bib0090","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1161\/01.CIR.98.19.2074","article-title":"Postinfarction survival and inducibility of ventricular arrhythmias in the spontaneously hypertensive rat: effects of ramipril and hydralazine","volume":"98","author":"Nguyen","year":"1998","journal-title":"Circulation"},{"issue":"22","key":"10.1016\/j.biopha.2020.110896_bib0095","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1161\/01.CIR.0000148176.33730.3F","article-title":"In vivo cardiac gene transfer of Kv4.3 abrogates the hypertrophic response in rats after aortic stenosis","volume":"110","author":"Lebeche","year":"2004","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.biopha.2020.110896_bib0100","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1042\/BJ20111604","article-title":"Large T-antigen up-regulates Kv4.3 K+ channels through Sp1, and Kv4.3 K+ channels contribute to cell apoptosis and necrosis through activation of calcium\/calmodulin-dependent protein kinase II","volume":"441","author":"Li","year":"2012","journal-title":"Biochem. J."},{"issue":"10","key":"10.1016\/j.biopha.2020.110896_bib0105","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.15252\/emmm.201403848","article-title":"CaM Kinase II mediates maladaptive post-infarct remodeling and pro-inflammatory chemoattractant signaling but not acute myocardial ischemia\/reperfusion injury","volume":"6","author":"Weinreuter","year":"2014","journal-title":"EMBO Mol. Med."},{"issue":"Pt1","key":"10.1016\/j.biopha.2020.110896_bib0110","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1469-7793.1999.0229z.x","article-title":"Relationship between K+ channel down-regulation and [Ca2+]i in rat ventricular myocytes following myocardial infarction","volume":"517","author":"Kaprielian","year":"1999","journal-title":"J. Physiol."},{"issue":"11","key":"10.1016\/j.biopha.2020.110896_bib0115","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1046\/j.1540-8167.2000.01252.x","article-title":"Early down-regulation of K+ channel genes and currents in the postinfarction heart","volume":"11","author":"Huang","year":"2000","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"10.1016\/j.biopha.2020.110896_bib0120","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.yjmcc.2018.11.011","article-title":"Kv4.3 expression abrogates and reverses norepinephrine-induced myocyte hypertrophy by CaMKII inhibition","volume":"126","author":"Wang","year":"2019","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.biopha.2020.110896_bib0125","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1146\/annurev.physiol.63.1.391","article-title":"Cytoplasmic signaling pathways that regulate cardiac hypertrophy","volume":"63","author":"Molkentin","year":"2001","journal-title":"Annu. Rev. Physiol."},{"issue":"11","key":"10.1016\/j.biopha.2020.110896_bib0130","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1161\/01.RES.85.11.1067","article-title":"Targeted expression of a dominant-negative K(v)4.2 K(+) channel subunit in the mouse heart","volume":"85","author":"Wickenden","year":"1999","journal-title":"Circ. Res."},{"issue":"12","key":"10.1016\/j.biopha.2020.110896_bib0135","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1161\/01.RES.0000194329.41863.89","article-title":"Ca2+\/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure","volume":"97","author":"Ai","year":"2005","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.biopha.2020.110896_bib0140","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1161\/CIRCRESAHA.110.222562","article-title":"Alterations of L-type calcium current and cardiac function in CaMKII{delta} knockout mice","volume":"107","author":"Xu","year":"2010","journal-title":"Circ. Res."},{"issue":"7","key":"10.1016\/j.biopha.2020.110896_bib0145","doi-asserted-by":"crossref","first-page":"H1454","DOI":"10.1152\/ajpheart.00812.2011","article-title":"CaMKII inhibition in heart failure, beneficial, harmful, or both","volume":"302","author":"Cheng","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"3","key":"10.1016\/j.biopha.2020.110896_bib0150","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1093\/cvr\/cvu055","article-title":"Disease and region-related cardiac fibroblast potassium current variations and potential functional significance","volume":"102","author":"Wu","year":"2014","journal-title":"Cardiovasc. Res."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S075333222031088X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S075333222031088X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:14:56Z","timestamp":1760098496000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S075333222031088X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":30,"alternative-id":["S075333222031088X"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110896","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Over-expression of Kv4.3 gene reverses cardiac remodeling and transient-outward K+ current (Ito) reduction via CaMKII inhibition in myocardial infarction","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110896","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"110896"}}