{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:38:29Z","timestamp":1792723109753,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007421","name":"Li Ka Shing Foundation","doi-asserted-by":"publisher","award":["2020LKSFG02E"],"award-info":[{"award-number":["2020LKSFG02E"]}],"id":[{"id":"10.13039\/100007421","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2147613"],"award-info":[{"award-number":["2147613"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.biopha.2020.110941","type":"journal-article","created":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T11:24:42Z","timestamp":1605957882000},"page":"110941","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Long-term treatment of polysaccharides-based hydrogel microparticles as oral insulin delivery in streptozotocin-induced type 2 diabetic mice"],"prefix":"10.1016","volume":"133","author":[{"given":"Yu","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengqin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingbei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kit-Leong","family":"Cheong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2020.110941_bib0005","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jddst.2016.10.010","article-title":"Nanoencapsulated chitosan nanoparticles in emulsion-based oral delivery system: in vitro and in vivo evaluation of insulin loaded formulation","volume":"36","author":"Erel","year":"2016","journal-title":"J Drug Deliv Sci Tec"},{"key":"10.1016\/j.biopha.2020.110941_bib0010","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.ijbiomac.2016.09.041","article-title":"Preparation and characterization of chitosan microparticles for immunoaffinity extraction and determination of enrofloxacin","volume":"93","author":"Yang","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.biopha.2020.110941_bib0015","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.carbpol.2017.06.112","article-title":"Preparation and evaluation of chitosan\/alginate porousmicrospheres\/Bletillastriata polysaccharide composite hemostaticsponges","volume":"174","author":"Wang","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.biopha.2020.110941_bib0020","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.ijpharm.2017.11.018","article-title":"Cyclodextrins: structure, physicochemical properties and pharmaceutical applications","volume":"535","author":"Jansook","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.biopha.2020.110941_bib0025","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.ijbiomac.2018.03.106","article-title":"Supramolecular hydrogel formation between chitosan andhydroxypropyl \u03b2-cyclodextrin via Diels-Alder reaction and itsdrug delivery","volume":"114","author":"Zhang","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.biopha.2020.110941_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119861","article-title":"Combination of inulin and beta-cyclodextrin properties for colon delivery of hydrophobic drugs","volume":"589","author":"Catenacci","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.biopha.2020.110941_bib0035","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.bej.2016.03.011","article-title":"Design and evaluation of chitosan-\u03b2-cyclodextrin based thermosensitive hydrogel","volume":"111","author":"Zhou","year":"2016","journal-title":"Biochem. Eng. J."},{"key":"10.1016\/j.biopha.2020.110941_bib0040","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.ijbiomac.2018.12.150","article-title":"Facile synthesis of chitosan-grafted beta-cyclodextrin for stimuli-responsive drug delivery","volume":"125","author":"Wang","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.biopha.2020.110941_bib0045","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ijbiomac.2017.06.120","article-title":"Sensitive complex micelles based on host-guest recognition fromchitosan-graft-\u03b2-cyclodextrinfor drug release","volume":"105","author":"Gao","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.biopha.2020.110941_bib0050","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.ijbiomac.2016.09.068","article-title":"Stimuli-sensitive hollow spheres from chitosan-graft-\u03b2-cyclodextrin for controlled drug release","volume":"93","author":"Yu","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.biopha.2020.110941_bib0055","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.reactfunctpolym.2017.05.008","article-title":"Carboxymethyl-\u03b2-cyclodextrin grafted chitosan nanoparticles as oral delivery carrier of protein drugs","volume":"117","author":"Song","year":"2017","journal-title":"React. Funct. Polym."},{"key":"10.1016\/j.biopha.2020.110941_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.109914","article-title":"Composite probiotics alleviate type 2 diabetes by regulating intestinalmicrobiota and inducing GLP-1 secretion in db\/db mice","volume":"125","author":"Wang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2020.110941_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104723","article-title":"Anti-diabetic potential of plant alkaloids: revisiting current findings andfuture perspectives","volume":"155","author":"Rasouli","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.biopha.2020.110941_bib0070","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.ijbiomac.2015.12.049","article-title":"Anti-diabetic activity of recombinant irisin in STZ-inducedinsulin-deficient diabetic mice","volume":"84","author":"Duan","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.biopha.2020.110941_bib0075","doi-asserted-by":"crossref","first-page":"376","DOI":"10.4239\/wjd.v10.i7.376","article-title":"Recent advances and perspectives in next generation sequencing application to the genetic research of type 2 diabetes","volume":"10","author":"Nasykhova","year":"2019","journal-title":"World J. Diabetes"},{"key":"10.1016\/j.biopha.2020.110941_bib0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119861","article-title":"Combination of inulin and beta-cyclodextrin properties for colon delivery of hydrophobic drugs","volume":"589","author":"Catenacci","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.biopha.2020.110941_bib0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2019.108939","article-title":"Ethanol extract of propolis prevents high-fat diet-induced insulin resistanceand obesity in association with modulation of gut microbiota in mice","volume":"130","author":"Cai","year":"2020","journal-title":"Food Res. Int."},{"key":"10.1016\/j.biopha.2020.110941_bib0090","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/j.biopha.2016.10.101","article-title":"A novel formula Sang-Tong-Jian improves glycometabolism andameliorates insulin resistance by activating PI3K\/AKT pathway in type2 diabetic KKAy mice","volume":"84","author":"Kuai","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2020.110941_bib0095","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.biopha.2018.09.098","article-title":"Comparison of antidiabetic effects of saponins and polysaccharides fromMomordica charantia L. In STZ-induced type 2 diabetic mice","volume":"109","author":"Wang","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2020.110941_bib0100","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.ijbiomac.2018.08.152","article-title":"Recent advances of polysaccharide-based nanoparticles for oralinsulin delivery","volume":"120","author":"Hu","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.biopha.2020.110941_bib0105","article-title":"Chitosan complexed carboxymethylated iota-carrageenan oral insulinparticles: stability, permeability and in vivo evaluation","volume":"20","author":"Sahoo","year":"2019","journal-title":"Mater Today Commun"},{"key":"10.1016\/j.biopha.2020.110941_bib0110","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ijpharm.2019.03.020","article-title":"Cp1-11 peptide\/insulin complex loaded pH-responsive nanoparticles with enhanced oral bioactivity","volume":"562","author":"Chen","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.biopha.2020.110941_bib0115","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.msec.2016.06.059","article-title":"A composite hydrogel system containing glucose-responsive nanocarriers for oral delivery of insulin","volume":"69","author":"Li","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.biopha.2020.110941_bib0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2019.10.006","article-title":"Chitosan coating of zein-carboxymethylated short-chain amylose nanocomposites improves oral bioavailability of insulin in vitro and in vivo","volume":"313","author":"Ji","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.biopha.2020.110941_bib0125","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.eurpolymj.2017.05.015","article-title":"Preparation of polyurethane\u2013alginate\/chitosan core shell nanoparticles for the purpose of oral insulin delivery","volume":"92","author":"Bhattacharyya","year":"2017","journal-title":"Eur. Polym. J."},{"key":"10.1016\/j.biopha.2020.110941_bib0130","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.ijpharm.2017.11.020","article-title":"In-vitro and in-vivo cytotoxicity and efficacy evaluation of novel glycylglycine and alanyl-alanine conjugates of chitosan and trimethyl chitosannano-particles as carriers for oral insulin delivery","volume":"535","author":"Jafary Omid","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.biopha.2020.110941_bib0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119736","article-title":"Optimization of phytic acid-crosslinked chitosan microspheres for oral insulin delivery using response surface methodology","volume":"588","author":"Kim","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.biopha.2020.110941_bib0140","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ijpharm.2018.10.068","article-title":"Enhanced oral insulin delivery via surface hydrophilic modification of chitosan copolymer based self-assembly polyelectrolyte nanocomplex","volume":"554","author":"Liu","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.biopha.2020.110941_bib0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.116617","article-title":"Carboxymethyl \u03b2-cyclodextrin grafted carboxymethyl chitosan hydrogel-based microparticles for oral insulin delivery","volume":"246","author":"Yang","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.biopha.2020.110941_bib0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108989","article-title":"Antidiabetic effects of water-soluble Korean pine nut protein on type 2 diabetic mice","volume":"117","author":"Liu","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2020.110941_bib0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110800","article-title":"Oligostilbenes extracts from Iris lactea Pall. var. chinensis (Fisch.) Koidz improve lipid metabolism in HFD\/STZ-induced diabetic mice and inhibit adipogenesis in 3T3-L1 cells","volume":"131","author":"Tie","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2020.110941_bib0160","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.diabres.2018.03.007","article-title":"Beneficial effect of baicalin on insulin sensitivity inadipocytes of diet-induced obese mice","volume":"139","author":"Fang","year":"2018","journal-title":"Diabetes Res ClinPr"},{"key":"10.1016\/j.biopha.2020.110941_bib0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173557","article-title":"Eurocristatine, a plant alkaloid from Eurotium cristatum, alleviates insulin resistance in db\/db diabetic mice via activation of PI3K\/AKT signaling pathway","volume":"887","author":"Zhang","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2020.110941_bib0170","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jff.2019.03.006","article-title":"Protective mechanism of punicalagin against endoplasmic reticulum stressin the liver of mice with type 2 diabetes mellitus","volume":"56","author":"Mo","year":"2019","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.biopha.2020.110941_bib0175","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.jff.2017.05.050","article-title":"Ginseng berry improves hyperglycemia by downregulating hepaticgluconeogenesis and steatosis in mice with diet-induced type 2 diabetes","volume":"35","author":"Kim","year":"2017","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.biopha.2020.110941_bib0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112926","article-title":"Effects of a rhizome aqueous extract of Dioscorea batatas and its bioactive compound, allantoin in high fat diet and streptozotocin-induced diabetic mice and the regulation of liver, pancreas and skeletal muscle dysfunction","volume":"259","author":"Ma","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2020.110941_bib0185","article-title":"Moringa concanensis Nimmo extracts ameliorates hyperglycemia-mediated oxidative stress and upregulates PPARgamma and GLUT4 gene expression in liver and pancreas of streptozotocin-nicotinamide induced diabetic rats","volume":"112","author":"Balakrishnan","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2020.110941_bib0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.116958","article-title":"Structural characteristics of a mannoglucan isolated from Chinese yam and its treatment effects against gut microbiota dysbiosis and DSS-induced colitis in mice","volume":"250","author":"Li","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.biopha.2020.110941_bib0195","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.carbpol.2018.11.087","article-title":"Inhibition of dextran sodium sulfate-induced colitis in mice by baker\u2019s yeast polysaccharides","volume":"207","author":"Sun","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.biopha.2020.110941_bib0200","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.bjp.2019.04.011","article-title":"Trapa natans pericarp extract ameliorates hyperglycemia and hyperlipidemiain type 2 diabetic mice","volume":"29","author":"L\u00fc","year":"2019","journal-title":"Rev. Bras. Farmacogn."},{"key":"10.1016\/j.biopha.2020.110941_bib0205","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1016\/j.biopha.2017.09.104","article-title":"Anti-diabetic effects of Inonotus obliquus polysaccharides in streptozotocin-induced type 2 diabetic mice and potential mechanism via PI3K-Akt signalpathway","volume":"95","author":"Wang","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2020.110941_bib0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodhyd.2019.105456","article-title":"Antidiabetic effects of polysaccharide from azuki bean (Vigna angularis) intype 2 diabetic rats via insulin\/PI3K\/AKT signaling pathway","volume":"101","author":"Wu","year":"2020","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.biopha.2020.110941_bib0215","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.intimp.2019.04.054","article-title":"Methionine enkephalin (MENK) regulates the immune pathogenesis of type 2 diabetes mellitus via the IL-33\/ST2 pathway","volume":"73","author":"Zhang","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.biopha.2020.110941_bib0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2019.115766","article-title":"Studies on characteristics and anti-diabetic and -nephritic effects ofpolysaccharides isolated from Paecilomyces Hepiali fermentationmycelium in db\/db mice","volume":"232","author":"Hu","year":"2020","journal-title":"Carbohydr. Polym."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220311331?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220311331?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:56:30Z","timestamp":1792720590000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332220311331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":44,"alternative-id":["S0753332220311331"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110941","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term treatment of polysaccharides-based hydrogel microparticles as oral insulin delivery in streptozotocin-induced type 2 diabetic mice","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110941","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"110941"}}