{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:39:13Z","timestamp":1792723153430,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018540","name":"Natural Science Foundation of Guangdong Province for Distinguished Young Scholars","doi-asserted-by":"publisher","award":["2018B030306027"],"award-info":[{"award-number":["2018B030306027"]}],"id":[{"id":"10.13039\/501100018540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770736"],"award-info":[{"award-number":["81770736"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC1700400"],"award-info":[{"award-number":["2017YFC1700400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003397","name":"Huazhong University of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003397","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.biopha.2020.110949","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T19:50:59Z","timestamp":1605901859000},"page":"110949","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Contribution of TFEB-mediated autophagy to tubulointerstitial fibrosis in mice with adenine-induced chronic kidney disease"],"prefix":"10.1016","volume":"133","author":[{"given":"Huiqi","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqing","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linfeng","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingzong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0476-3198","authenticated-orcid":false,"given":"Jing","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.biopha.2020.110949_bib0005","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/sj.ki.5002343","article-title":"Chronic kidney disease as a global public health problem: approaches and initiatives - a position statement from Kidney Disease Improving Global Outcomes","volume":"72","author":"Levey","year":"2007","journal-title":"Kidney Int."},{"issue":"6","key":"10.1016\/j.biopha.2020.110949_bib0010","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1080\/15548627.2016.1166317","article-title":"Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction","volume":"12","author":"Livingston","year":"2016","journal-title":"Autophagy."},{"issue":"9","key":"10.1016\/j.biopha.2020.110949_bib0015","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nm.3938","article-title":"A new Twist in kidney fibrosis","volume":"21","author":"Ovadya","year":"2015","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.biopha.2020.110949_bib0020","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: renovation of cells and tissues","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.biopha.2020.110949_bib0025","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1080\/15548627.2016.1190071","article-title":"Atg5-mediated autophagy deficiency in proximal tubules promotes cell cycle G2\/M arrest and renal fibrosis","volume":"12","author":"Li","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.biopha.2020.110949_bib0030","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41420-018-0065-2","article-title":"Autophagy activation contributes to lipid accumulation in tubular epithelial cells during kidney fibrosis","volume":"4","author":"Yan","year":"2018","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.biopha.2020.110949_bib0035","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3389\/fncel.2017.00350","article-title":"The role of Netrin-1 in improving functional recovery through autophagy stimulation following spinal cord injury in rats","volume":"11","author":"Bai","year":"2017","journal-title":"Front. Cell. Neurosci."},{"issue":"9","key":"10.1016\/j.biopha.2020.110949_bib0040","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1097\/PAS.0b013e31825aafb5","volume":"36","author":"Rao","year":"2012","journal-title":"Am. J. Surg. Pathol."},{"issue":"34","key":"10.1016\/j.biopha.2020.110949_bib0045","doi-asserted-by":"crossref","first-page":"30225","DOI":"10.1074\/jbc.M502380200","article-title":"Renal carcinoma-associated transcription factors TFE3 and TFEB are leukemia inhibitory factor-responsive transcription activators of E-cadherin","volume":"280","author":"Huan","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.biopha.2020.110949_bib0050","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/01.pas.0000146007.54092.37","article-title":"Renal carcinomas with the t(6;11)(p21;q12) - Clinicopathologic features and demonstration of the specific Alpha-TFEB gene fusion by immunohistochemistry, RT-PCR, and DNA PCR","volume":"29","author":"Argani","year":"2005","journal-title":"Am. J. Surg. Pathol."},{"issue":"2","key":"10.1016\/j.biopha.2020.110949_bib0055","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/labinvest.2013.134","article-title":"Induction of chemokines and cytokines before neutrophils and macrophage recruitment in different regions of rat liver after TAA administration","volume":"94","author":"Amanzada","year":"2014","journal-title":"Lab. Invest."},{"key":"10.1016\/j.biopha.2020.110949_bib0060","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.peptides.2015.04.002","article-title":"Beta-casomorphin-7 prevents epithelial-mesenchymal transdifferentiation of NRK-52E cells at high glucose level: involvement of AngII-TGF-\u03b21 pathway","volume":"70","author":"Zhang","year":"2015","journal-title":"Peptides"},{"issue":"10","key":"10.1016\/j.biopha.2020.110949_bib0065","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1681\/ASN.2010020143","article-title":"The NLRP3 inflammasome promotes renal inflammation and contributes to CKD","volume":"21","author":"Vilaysane","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"issue":"2","key":"10.1016\/j.biopha.2020.110949_bib0070","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1159\/000478070","article-title":"Activation of COX-2\/ mPGES-1\/PGE2 cascade via NLRP3 inflammasome contributes to albumin-induced proximal tubule cell injury","volume":"42","author":"Zhuang","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"issue":"6","key":"10.1016\/j.biopha.2020.110949_bib0075","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41374-018-0029-4","article-title":"NLRP3 inflammasome inhibition ameliorates tubulointerstitial injury in the remnant kidney model","volume":"98","author":"Foresto-Neto","year":"2018","journal-title":"Lab. Invest."},{"key":"10.1016\/j.biopha.2020.110949_bib0080","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1471-2369-14-116","article-title":"A novel model of adenine-induced tubulointerstitial nephropathy in mice","volume":"14","author":"Jia","year":"2013","journal-title":"BMC Nephrol."},{"issue":"5","key":"10.1016\/j.biopha.2020.110949_bib0085","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1093\/ndt\/gfs569","article-title":"Thalidomide suppresses inflammation in adenine-induced CKD with uraemia in mice","volume":"28","author":"Santana","year":"2013","journal-title":"Nephrol. Dial. Transplant."},{"issue":"1","key":"10.1016\/j.biopha.2020.110949_bib0090","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.bbrc.2008.01.059","article-title":"Participation of autophagy in renal ischemia\/reperfusion injury","volume":"368","author":"Suzuki","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.biopha.2020.110949_bib0095","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/path.4382","article-title":"Podocyte autophagic activity plays a protective role in renal injury and delays the progression of podocytopathies","volume":"234","author":"Zeng","year":"2014","journal-title":"J. Pathol."},{"key":"10.1016\/j.biopha.2020.110949_bib0100","doi-asserted-by":"crossref","first-page":"43790","DOI":"10.1038\/srep43790","article-title":"Rhein Inhibits Autophagy in Rat Renal Tubular Cells by Regulation of AMPK\/mTOR Signaling","volume":"7","author":"Tu","year":"2017","journal-title":"Sci. Rep."},{"issue":"6036","key":"10.1016\/j.biopha.2020.110949_bib0105","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1126\/science.1204592","article-title":"TFEB links autophagy to lysosomal biogenesis","volume":"332","author":"Settembre","year":"2011","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.biopha.2020.110949_bib0110","doi-asserted-by":"crossref","first-page":"431","DOI":"10.4161\/auto.27344","article-title":"Expression of the autophagy substrate SQSTM1\/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy- derived amino acids","volume":"10","author":"Sahani","year":"2014","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.biopha.2020.110949_bib0115","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nrm3716","article-title":"The return of the nucleus: transcriptional and epigenetic control of autophagy","volume":"15","author":"Fullgrabe","year":"2014","journal-title":"Nat. Rev. Mol. Cell Bio."},{"issue":"1","key":"10.1016\/j.biopha.2020.110949_bib0120","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1681\/ASN.2009040383","article-title":"Mitochondrial autophagy promotes cellular injury in Nephropathic Cystinosis","volume":"21","author":"Sansanwal","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.biopha.2020.110949_bib0125","doi-asserted-by":"crossref","first-page":"15750","DOI":"10.1038\/ncomms15750","article-title":"Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis","volume":"8","author":"Sergin","year":"2017","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.biopha.2020.110949_bib0130","first-page":"303","article-title":"Using trehalose to prevent and treat metabolic function: effectiveness and mechanisms","volume":"22","author":"Zhang","year":"2019","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"issue":"3","key":"10.1016\/j.biopha.2020.110949_bib0135","doi-asserted-by":"crossref","first-page":"628","DOI":"10.3892\/ijmm.2013.1232","article-title":"Autophagy and apoptosis in tubular cells following unilateral ureteral obstruction are associated with mitochondrial oxidative stress","volume":"31","author":"Xu","year":"2013","journal-title":"Int. J. Mol. Med."},{"issue":"1-4","key":"10.1016\/j.biopha.2020.110949_bib0140","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1159\/000363677","article-title":"Autophagy in acute kidney injury and repair","volume":"127","author":"He","year":"2014","journal-title":"Nephron Clin. Pract."},{"issue":"12","key":"10.1016\/j.biopha.2020.110949_bib0145","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1681\/ASN.2013101068","article-title":"Autophagy regulates TGF-beta expression and suppresses kidney fibrosis induced by unilateral ureteral obstruction","volume":"25","author":"Ding","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"issue":"8","key":"10.1016\/j.biopha.2020.110949_bib0150","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1681\/ASN.2015010006","article-title":"Failed tubule recovery, AKI-CKD transition, and kidney disease progression","volume":"26","author":"Venkatachalam","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.biopha.2020.110949_bib0155","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mam.2018.06.003","article-title":"Organ and tissue fibrosis: molecular signals, cellular mechanisms and translational implications","volume":"65","author":"Weiskirchen","year":"2019","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.biopha.2020.110949_bib0160","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3389\/fimmu.2017.00405","article-title":"Interleukin-6 signaling pathway and its role in kidney disease: an update","volume":"8","author":"Su","year":"2017","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.biopha.2020.110949_bib0165","doi-asserted-by":"crossref","first-page":"971","DOI":"10.4161\/auto.6.7.13099","article-title":"Abnormal mitochondrial autophagy in nephropathic cystinosis","volume":"6","author":"Sansanwal","year":"2010","journal-title":"Autophagy"},{"issue":"5","key":"10.1016\/j.biopha.2020.110949_bib0170","doi-asserted-by":"crossref","first-page":"457","DOI":"10.4161\/auto.7.5.14226","article-title":"Autophagic cell death Loch Ness monster or endangered species?","volume":"7","author":"Shen","year":"2011","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.biopha.2020.110949_bib0175","doi-asserted-by":"crossref","DOI":"10.1111\/bcpt.12817","article-title":"Curcumin ameliorates kidney function and oxidative stress in experimental chronic kidney disease","volume":"122","author":"Ali","year":"2018","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.biopha.2020.110949_bib0180","doi-asserted-by":"crossref","first-page":"896","DOI":"10.3389\/fphys.2017.00896","article-title":"Lung oxidative stress, DNA damage, apoptosis, and fibrosis in adenine-induced chronic kidney disease in mice","volume":"8","author":"Nemmar","year":"2017","journal-title":"Front. Physiol."},{"issue":"8","key":"10.1016\/j.biopha.2020.110949_bib0185","doi-asserted-by":"crossref","first-page":"5390","DOI":"10.1111\/jcmm.14420","article-title":"Bortezomib attenuates renal interstitial fibrosis in kidney transplantation via regulating the EMT induced by TNF-alpha-Smurf1-Akt-mTOR-P70S6K pathway","volume":"23","author":"Zhou","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.biopha.2020.110949_bib0190","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.taap.2019.04.023","article-title":"Nicotine-induced oxidative stress contributes to EMT and stemness during neoplastic transformation through epigenetic modifications in human kidney epithelial cells","volume":"374","author":"Chang","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.biopha.2020.110949_bib0195","article-title":"The matrix Metalloproteinase-13 inhibitor poricoic acid ZI ameliorates renal fibrosis by mitigating epithelial-mesenchymal transition","volume":"29","author":"Chen","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"issue":"3","key":"10.1016\/j.biopha.2020.110949_bib0200","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1159\/000362457","article-title":"Endoplasmic reticulum stress induces epithelial-mesenchymal transition through autophagy via activation of c-Src kinase","volume":"126","author":"Moon","year":"2014","journal-title":"Nephron Exp. Nephrol."},{"key":"10.1016\/j.biopha.2020.110949_bib0205","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.biocel.2016.05.010","article-title":"Autophagy links beta-catenin and Smad signaling to promote epithelial-mesenchymal transition via upregulation of integrin linked kinase","volume":"76","author":"Pang","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220311410?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220311410?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:13:33Z","timestamp":1792721613000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332220311410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":41,"alternative-id":["S0753332220311410"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110949","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Contribution of TFEB-mediated autophagy to tubulointerstitial fibrosis in mice with adenine-induced chronic kidney disease","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110949","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"110949"}}