{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:29:32Z","timestamp":1792783772888,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T00:00:00Z","timestamp":1604880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Scientific Research Projects in Key Fields of Tianjin, China","award":["2018009"],"award-info":[{"award-number":["2018009"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.biopha.2020.110998","type":"journal-article","created":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T00:14:37Z","timestamp":1606868077000},"page":"110998","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Proteomic and mechanistic study of Qingxuan Tongluo formula and curcumin in the treatment of Mycoplasma pneumoniae pneumonia"],"prefix":"10.1016","volume":"133","author":[{"given":"Lina","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilong","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanmin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaowei","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.biopha.2020.110998_bib0005","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1590\/S0066-782X2003000900001","article-title":"Coinfection with Mycoplasma Pneumoniae and Chlamydia Pneumoniae in ruptured plaques associated with acute myocardial infarction","volume":"81","author":"Higuchi","year":"2003","journal-title":"Arquivos Brasileiros De Cardiologia"},{"key":"10.1016\/j.biopha.2020.110998_bib0010","series-title":"Mycoplasma Pneumoniae Pneumonia in an Urban Area","author":"Foy","year":"1970"},{"issue":"10","key":"10.1016\/j.biopha.2020.110998_bib0015","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s13312-016-0951-8","article-title":"Bacterial co-infection in hospitalized children with Mycoplasma pneumoniae pneumonia","volume":"53","author":"Song","year":"2016","journal-title":"Indian Pediatr."},{"issue":"11","key":"10.1016\/j.biopha.2020.110998_bib0020","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1002\/jmv.24258","article-title":"Molecular viral epidemiology and clinical characterization of acute febrile respiratory infections in hospitalized children in Taiwan","volume":"87","author":"Lee","year":"2015","journal-title":"J. Med. Virol."},{"issue":"1","key":"10.1016\/j.biopha.2020.110998_bib0025","first-page":"20","article-title":"Epidemiology of community-acquired Mycoplasma Pneumoniae respiratory tract infections among hospitalized Chinese children, including relationships with meteorological factors","volume":"17","author":"Chen","year":"2013","journal-title":"Hippokratia"},{"key":"10.1016\/j.biopha.2020.110998_bib0030","series-title":"Mycoplasma Pneumoniae and Its Role as a Human Pathogen","author":"Waites","year":"2004"},{"key":"10.1016\/j.biopha.2020.110998_bib0035","first-page":"508","article-title":"Mycoplasma pneumoniae and toll-like receptors: a mutual avenue","volume":"46","author":"Naghib","year":"2018","journal-title":"Allergologia Et Immunopathologia Int. J. Clin. Investigate Allergol. Clin. Immunol."},{"issue":"4","key":"10.1016\/j.biopha.2020.110998_bib0040","first-page":"507","article-title":"Mycoplasma pneumoniae","volume":"24","author":"Jones","year":"1969","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.biopha.2020.110998_bib0045","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1164\/ajrccm.149.5.8173777","article-title":"Association of Mycoplasma pneumoniae antigen with initial onset of bronchial asthma","volume":"149","author":"Yano","year":"1994","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.biopha.2020.110998_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.transproceed.2017.12.059","article-title":"Immunosuppressive treatment and its impact on the occurrence of Pneumocystis jiroveci, Mycoplasma pneumoniae, Chlamydophila pnemoniae and Legionella pneumophila infections\/ colonisations among lung transplant recipients","author":"Wojarski","year":"2018","journal-title":"Transplant. Proc."},{"issue":"Supplement_1","key":"10.1016\/j.biopha.2020.110998_bib0055","doi-asserted-by":"crossref","DOI":"10.1093\/clinids\/17.Supplement_1.S37","article-title":"Infections caused by Mycoplasma pneumoniae and possible carrier state in different populations of patients","author":"Foy","year":"1993","journal-title":"Clin. Infect. Dis."},{"issue":"4","key":"10.1016\/j.biopha.2020.110998_bib0060","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1046\/j.1469-0691.2003.00590.x","article-title":"Laboratory diagnosis of Mycoplasma pneumoniae infection","volume":"9","author":"Daxboeck","year":"2003","journal-title":"Clin. Microbiol. Infect."},{"issue":"7","key":"10.1016\/j.biopha.2020.110998_bib0065","doi-asserted-by":"crossref","first-page":"535","DOI":"10.14740\/jocmr3421w","article-title":"Mycoplasma pneumoniae: a Potentially Severe Infection","volume":"10","author":"Bajantri","year":"2018","journal-title":"J. Clin. Med. Res."},{"issue":"2","key":"10.1016\/j.biopha.2020.110998_bib0070","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1183\/09031936.01.17202410","article-title":"Mycoplasma pneumoniae and Chlamydia pneumoniae infections in children with pneumonia. Mowgli Study Group","volume":"17","author":"Esposito","year":"2001","journal-title":"Eur. Respir. J."},{"issue":"9","key":"10.1016\/j.biopha.2020.110998_bib0075","first-page":"869","article-title":"Therapeutic effect analysis of 266 cases of mycoplasma pneumoniae pneumonia in children with wind an head blocking the lung syndrome by \u201cXuanfei Qingre, Huayu Tongluo\u201d method","volume":"36","year":"2019","journal-title":"Tianjin J. Tradit. Chin. Med."},{"key":"10.1016\/j.biopha.2020.110998_bib0080","doi-asserted-by":"crossref","first-page":"28254","DOI":"10.1038\/srep28254","article-title":"Curcumin protects mice from Staphylococcus aureus pneumonia by interfering with the self-assembly process of \u03b1-hemolysin","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.biopha.2020.110998_bib0085","doi-asserted-by":"crossref","first-page":"874","DOI":"10.3923\/ijp.2011.874.879","article-title":"Antibacterial Activities of Curcumin Bioconjugates","volume":"7","author":"Pandey","year":"2011","journal-title":"Int. J. Pharmacol."},{"key":"10.1016\/j.biopha.2020.110998_bib0090","article-title":"Curcumin ameliorates severe influenza pneumonia via attenuating lung injury and regulating macrophage cytokines production","author":"Han","year":"2017","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"9","key":"10.1016\/j.biopha.2020.110998_bib0095","first-page":"15666","article-title":"Effects of bacterial and viral co-infections of mycoplasma pneumoniae pneumonia in children: analysis report from Beijing Children\u2019s Hospital between 2010 and 2014","volume":"8","author":"Song","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"issue":"5","key":"10.1016\/j.biopha.2020.110998_bib0100","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/S1473-3099(01)00147-5","article-title":"Emerging role of Mycoplasma pneumoniae and Chlamydia pneumoniae in paediatric respiratory-tract infections","volume":"1","author":"Principi","year":"2002","journal-title":"Lancet Infect. Dis."},{"issue":"6","key":"10.1016\/j.biopha.2020.110998_bib0105","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1378\/chest.121.6.1782","article-title":"Mycoplasma pneumoniae and Chlamydia pneumoniae in Asthma","volume":"121","author":"Kraft","year":"2002","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.biopha.2020.110998_bib0110","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41426-018-0097-y","article-title":"The concordance between upper and lower respiratory microbiota in children with Mycoplasma pneumoniae pneumonia","volume":"7","author":"Dai","year":"2018","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.biopha.2020.110998_bib0115","series-title":"Detection of Mycoplasma pneumoniae Among Children with Pneumonia Using Bacterial Culture, Polymerase Chain Reaction, and the Enzyme-Linked Immunosorbent Assay Techniques in Ahvaz, Iran","author":"Amin","year":"2018"},{"issue":"2","key":"10.1016\/j.biopha.2020.110998_bib0120","doi-asserted-by":"crossref","DOI":"10.1177\/0748233713498458","article-title":"Antibacterial effects of curcumin","volume":"32","author":"Gunes","year":"2013","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.biopha.2020.110998_bib0125","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.intimp.2017.11.009","article-title":"Inhibition of curcumin on influenza A virus infection and influenzal pneumonia via oxidative stress, TLR2\/4, p38\/JNK MAPK and NF-\u03baB pathways","volume":"54","author":"Dai","year":"2018","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.biopha.2020.110998_bib0130","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1099\/jmm.0.016873-0","article-title":"Curcumin alone and in combination with augmentin protects against pulmonary inflammation and acute lung injury generated during Klebsiella pneumoniae B5055-induced lung infection in BALB\/c mice","volume":"59","author":"Bansal","year":"2010","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.biopha.2020.110998_bib0135","article-title":"Inhibition of cell surface mediated plasminogen activation by a monoclonal antibody against \u03b1-Enolase","author":"Roser","year":"2003","journal-title":"Am. J. Hematol."},{"issue":"1","key":"10.1016\/j.biopha.2020.110998_bib0140","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1146\/annurev.bi.63.070194.004411","article-title":"Repair of oxidative damage to DNA: enzymology and biology","volume":"63","author":"Demple","year":"1994","journal-title":"Annu. Rev. Biochem."},{"issue":"2","key":"10.1016\/j.biopha.2020.110998_bib0145","doi-asserted-by":"crossref","first-page":"e0116270","DOI":"10.1371\/journal.pone.0116270","article-title":"Alpha-enolase is upregulated on the cell surface and responds to plasminogen activation in mice expressing a \u0394133p53\u03b1 mimic","volume":"10","author":"Sawhney","year":"2015","journal-title":"PLoS One"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220311902?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220311902?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:15:35Z","timestamp":1792721735000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332220311902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":29,"alternative-id":["S0753332220311902"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110998","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteomic and mechanistic study of Qingxuan Tongluo formula and curcumin in the treatment of Mycoplasma pneumoniae pneumonia","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2020.110998","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"110998"}}