{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:42:39Z","timestamp":1787726559207,"version":"build-2784847793"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T00:00:00Z","timestamp":1609113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016003","name":"Mie University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016003","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007132","name":"Otsuka Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007132","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.biopha.2020.111181","type":"journal-article","created":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T05:00:56Z","timestamp":1609477256000},"page":"111181","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Branched-chain amino acids and l-carnitine attenuate lipotoxic hepatocellular damage in rat cirrhotic liver"],"prefix":"10.1016","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8012-8578","authenticated-orcid":false,"given":"Yasuyuki","family":"Tamai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5339-2499","authenticated-orcid":false,"given":"Zhen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Okabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2447-684X","authenticated-orcid":false,"given":"Yoshinao","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Chiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Ping","family":"Hui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0555-2707","authenticated-orcid":false,"given":"Akiko","family":"Eguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoh","family":"Iwasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Takei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.biopha.2020.111181_bib0005","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1111\/j.1440-1746.2006.04231.x","article-title":"Oxidative stress in the development of liver cirrhosis: a comparison of two different experimental models","volume":"21","author":"Natarajan","year":"2006","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"23","key":"10.1016\/j.biopha.2020.111181_bib0010","doi-asserted-by":"crossref","first-page":"17078","DOI":"10.1074\/jbc.M701742200","article-title":"Inhibiting proteasomal degradation of microsomal triglyceride transfer protein prevents CCl4-induced steatosis","volume":"282","author":"Pan","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"4 Pt 1","key":"10.1016\/j.biopha.2020.111181_bib0015","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/0016-5085(92)90775-T","article-title":"Direct evidence for the intact hepatocyte theory in patients with liver cirrhosis","volume":"102","author":"Kawasaki","year":"1992","journal-title":"Gastroenterology"},{"issue":"9 Pt B","key":"10.1016\/j.biopha.2020.111181_bib0020","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.bbamem.2017.04.006","article-title":"The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease","volume":"1859","author":"van der Veen","year":"2017","journal-title":"Biochim. Biophys. Acta Biomembr."},{"issue":"12","key":"10.1016\/j.biopha.2020.111181_bib0025","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.2337\/diabetes.52.12.2905","article-title":"Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement","volume":"52","author":"Ono","year":"2003","journal-title":"Diabetes"},{"issue":"45","key":"10.1016\/j.biopha.2020.111181_bib0030","doi-asserted-by":"crossref","first-page":"47402","DOI":"10.1074\/jbc.M404027200","article-title":"Targeted deletion of hepatic CTP:phosphocholine cytidylyltransferase alpha in mice decreases plasma high density and very low density lipoproteins","volume":"279","author":"Jacobs","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.biopha.2020.111181_bib0035","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1194\/jlr.M600045-JLR200","article-title":"Lysophosphatidylethanolamine in Grifola frondosa as a neurotrophic activator via activation of MAPK","volume":"47","author":"Nishina","year":"2006","journal-title":"J. Lipid Res."},{"issue":"4","key":"10.1016\/j.biopha.2020.111181_bib0040","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.jhep.2010.07.028","article-title":"The synthetic bile acid-phospholipid conjugate ursodeoxycholyl lysophosphatidylethanolamide suppresses TNFalpha-induced liver injury","volume":"54","author":"Pathil","year":"2011","journal-title":"J. Hepatol."},{"issue":"9","key":"10.1016\/j.biopha.2020.111181_bib0045","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1194\/jlr.M083741","article-title":"Oxidized linoleic acid metabolites induce liver mitochondrial dysfunction, apoptosis, and NLRP3 activation in mice","volume":"59","author":"Schuster","year":"2018","journal-title":"J. Lipid Res."},{"issue":"3","key":"10.1016\/j.biopha.2020.111181_bib0050","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.jhep.2016.04.010","article-title":"Nocturnal hypoxia-induced oxidative stress promotes progression of pediatric non-alcoholic fatty liver disease","volume":"65","author":"Sundaram","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1016\/j.biopha.2020.111181_bib0055","doi-asserted-by":"crossref","first-page":"46144","DOI":"10.1038\/srep46144","article-title":"NOX4 regulates CCR2 and CCL2 mRNA stability in alcoholic liver disease","volume":"7","author":"Sasaki","year":"2017","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.biopha.2020.111181_bib0060","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1258\/acb.2012.011284","article-title":"Novel monoclonal antibody recognizing triglyceride-rich oxidized LDLs associated with severe liver disease and small oxidized LDLs in normal subjects","volume":"49","author":"Sakurai","year":"2012","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.biopha.2020.111181_bib0065","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s11745-005-1412-2","article-title":"Improved HPLC assay for lipid peroxides in human plasma using the internal standard of hydroperoxide","volume":"40","author":"Hui","year":"2005","journal-title":"Lipids"},{"issue":"1","key":"10.1016\/j.biopha.2020.111181_bib0070","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jhep.2018.06.024","article-title":"EASL Clinical Practice Guidelines on nutrition in chronic liver disease","volume":"70","year":"2019","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.biopha.2020.111181_bib0075","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1002\/hep.29003","article-title":"A practical approach to nutritional screening and assessment in cirrhosis","volume":"65","author":"Tandon","year":"2017","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.biopha.2020.111181_bib0080","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.jhep.2016.07.040","article-title":"Sarcopenia from mechanism to diagnosis and treatment in liver disease","volume":"65","author":"Dasarathy","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1016\/j.biopha.2020.111181_bib0085","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1002\/hep.510230516","article-title":"Does malnutrition affect survival in cirrhosis? PINC (Policentrica Italiana Nutrizione Cirrosi)","volume":"23","author":"Merli","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.biopha.2020.111181_bib0090","doi-asserted-by":"crossref","DOI":"10.1002\/lt.25602","article-title":"Nutritional assessment in inpatients with cirrhosis can be improved after training and is associated with lower readmissions","author":"Reuter","year":"2019","journal-title":"Liver Transpl."},{"issue":"7","key":"10.1016\/j.biopha.2020.111181_bib0095","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1111\/jgh.14665","article-title":"Significant effects of late evening snack on liver functions in patients with liver cirrhosis: a meta-analysis of randomized controlled trials","volume":"34","author":"Chen","year":"2019","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"8","key":"10.1016\/j.biopha.2020.111181_bib0100","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1002\/hep4.1207","article-title":"L-carnitine suppresses loss of skeletal muscle mass in patients with liver cirrhosis","volume":"2","author":"Ohara","year":"2018","journal-title":"Hepatol. Commun."},{"issue":"7","key":"10.1016\/j.biopha.2020.111181_bib0105","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1016\/S0016-5085(03)00323-8","article-title":"Nutritional supplementation with branched-chain amino acids in advanced cirrhosis: a double-blind, randomized trial","volume":"124","author":"Marchesini","year":"2003","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.biopha.2020.111181_bib0110","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1002\/hep.24412","article-title":"Branched-chain amino acids as pharmacological nutrients in chronic liver disease","volume":"54","author":"Kawaguchi","year":"2011","journal-title":"Hepatology"},{"issue":"10","key":"10.1016\/j.biopha.2020.111181_bib0115","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1111\/hepr.12774","article-title":"Japan Society of Hepatology guidelines for sarcopenia in liver disease (1st edition): recommendation from the working group for creation of sarcopenia assessment criteria","volume":"46","author":"Nishikawa","year":"2016","journal-title":"Hepatol. Res."},{"issue":"2","key":"10.1016\/j.biopha.2020.111181_bib0120","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00535-012-0632-x","article-title":"The efficacy of nocturnal administration of branched-chain amino acid granules to improve quality of life in patients with cirrhosis","volume":"48","author":"Hidaka","year":"2013","journal-title":"J. Gastroenterol."},{"issue":"7","key":"10.1016\/j.biopha.2020.111181_bib0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0070309","article-title":"Branched-chain amino acid supplementation reduces oxidative stress and prolongs survival in rats with advanced liver cirrhosis","volume":"8","author":"Iwasa","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.biopha.2020.111181_bib0130","first-page":"246","article-title":"Carnitine metabolism and human carnitine deficiency","volume":"9","author":"Tanphaichitr","year":"1993","journal-title":"Nutrition"},{"issue":"19","key":"10.1016\/j.biopha.2020.111181_bib0135","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/0024-3205(96)00343-8","article-title":"Carnitine metabolism in chronic liver disease","volume":"59","author":"Krahenbuhl","year":"1996","journal-title":"Life Sci."},{"issue":"5","key":"10.1016\/j.biopha.2020.111181_bib0140","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S1665-2681(19)31323-7","article-title":"Oral acetyl-L-carnitine treatment in hepatic encephalopathy: view of evidence-based medicine","volume":"12","author":"Jiang","year":"2013","journal-title":"Ann. Hepatol."},{"issue":"3","key":"10.1016\/j.biopha.2020.111181_bib0145","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/apt.12827","article-title":"Systematic review: the treatment of muscle cramps in patients with cirrhosis","volume":"40","author":"Vidot","year":"2014","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"6","key":"10.1016\/j.biopha.2020.111181_bib0150","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3177\/jnsv.61.433","article-title":"Usefulness of Levocarnitine and\/or Branched-Chain Amino Acids during Invasive Treatment for Hepatocellular Carcinoma","volume":"61","author":"Iwasa","year":"2015","journal-title":"J. Nutr. Sci. Vitaminol. (Tokyo)"},{"key":"10.1016\/j.biopha.2020.111181_bib0155","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/y59-099","article-title":"A rapid method of total lipid extraction and purufication","volume":"37","author":"Bligh","year":"1959","journal-title":"Can. J. Biochem. Physiol."},{"issue":"20","key":"10.1016\/j.biopha.2020.111181_bib0160","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1016\/j.jchromb.2010.04.011","article-title":"Analyses for phosphatidylcholine hydroperoxides by LC\/MS","volume":"878","author":"Hui","year":"2010","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"issue":"24","key":"10.1016\/j.biopha.2020.111181_bib0165","doi-asserted-by":"crossref","first-page":"5735","DOI":"10.1007\/s00216-017-0515-3","article-title":"Profiling of cardiolipins and their hydroperoxides in HepG2 cells by LC\/MS","volume":"409","author":"Chen","year":"2017","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.biopha.2020.111181_bib0170","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/nmeth.2551","article-title":"LipidBlast in silico tandem mass spectrometry database for lipid identification","volume":"10","author":"Kind","year":"2014","journal-title":"Nat. Methods"},{"issue":"11","key":"10.1016\/j.biopha.2020.111181_bib0175","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s11306-020-01732-9","article-title":"Comprehensive lipidomic profiling in serum and multiple tissues from a mouse model of diabetes","volume":"16","author":"Chen","year":"2020","journal-title":"Metabolomics"},{"issue":"W1","key":"10.1016\/j.biopha.2020.111181_bib0180","doi-asserted-by":"crossref","first-page":"W147","DOI":"10.1093\/nar\/gkw419","article-title":"Heatmapper: web-enabled heat mapping for all","volume":"44","author":"Babicki","year":"2016","journal-title":"Nucleic Acids Res."},{"issue":"12","key":"10.1016\/j.biopha.2020.111181_bib0185","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/nrendo.2017.91","article-title":"SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology","volume":"13","author":"Shimano","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.biopha.2020.111181_bib0190","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.isci.2018.11.028","article-title":"MicroRNA-124 regulates fatty acid and triglyceride homeostasis","volume":"10","author":"Shaw","year":"2018","journal-title":"iScience"},{"issue":"2","key":"10.1016\/j.biopha.2020.111181_bib0195","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1083\/jcb.143.2.351","article-title":"A human dynamin-related protein controls the distribution of mitochondria","volume":"143","author":"Smirnova","year":"1998","journal-title":"J. Cell Biol."},{"issue":"3","key":"10.1016\/j.biopha.2020.111181_bib0200","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1159\/000495555","article-title":"Protective effects of Morus root extract (MRE) against lipopolysaccharide-activated RAW264.7 cells and CCl4-induced mouse hepatic damage","volume":"51","author":"Tseng","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"issue":"5","key":"10.1016\/j.biopha.2020.111181_bib0205","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1002\/hep.25539","article-title":"Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease","volume":"55","author":"Lomonaco","year":"2012","journal-title":"Hepatology"},{"issue":"16","key":"10.1016\/j.biopha.2020.111181_bib0210","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1056\/NEJMra011775","article-title":"Nonalcoholic fatty liver disease","volume":"346","author":"Angulo","year":"2002","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.biopha.2020.111181_bib0215","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/hep.29380","article-title":"An endogenous DNA adduct as a prognostic biomarker for hepatocarcinogenesis and its prevention by Theaphenon E in mice","volume":"67","author":"Fu","year":"2018","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.biopha.2020.111181_bib0220","doi-asserted-by":"crossref","first-page":"6247","DOI":"10.1038\/s41598-017-06372-z","article-title":"The lipid peroxidation product 4-hydroxynonenal contributes to oxidative stress-mediated deterioration of the ageing oocyte","volume":"7","author":"Mihalas","year":"2017","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.biopha.2020.111181_bib0225","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1089\/ars.2009.2597","article-title":"Generation and biological activities of oxidized phospholipids","volume":"12","author":"Bochkov","year":"2010","journal-title":"Antioxid. Redox Signal."},{"issue":"5","key":"10.1016\/j.biopha.2020.111181_bib0230","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1194\/jlr.M400008-JLR200","article-title":"Plasma phosphatidylcholine hydroperoxide as a new marker of oxidative stress in alcoholic patients","volume":"45","author":"Adachi","year":"2004","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.biopha.2020.111181_bib0235","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s11745-004-1311-6","article-title":"Phosphatidylcholine hydroperoxide levels in human plasma are lower than previously reported","volume":"39","author":"Adachi","year":"2004","journal-title":"Lipids"},{"issue":"15","key":"10.1016\/j.biopha.2020.111181_bib0240","doi-asserted-by":"crossref","first-page":"6264","DOI":"10.1073\/pnas.1015757108","article-title":"Cardiolipin microdomains localize to negatively curved regions of Escherichia coli membranes","volume":"108","author":"Renner","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.biopha.2020.111181_bib0245","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1083\/jcb.200801152","article-title":"Cardiolipin defines the interactome of the major ADP\/ATP carrier protein of the mitochondrial inner membrane","volume":"182","author":"Claypool","year":"2008","journal-title":"J. Cell Biol."},{"issue":"3","key":"10.1016\/j.biopha.2020.111181_bib0250","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1042\/BST0390833","article-title":"Membrane microenvironment regulation of carnitine palmitoyltranferases I and II","volume":"39","author":"Kashfi","year":"2011","journal-title":"Biochem. Soc. Trans."},{"issue":"10","key":"10.1016\/j.biopha.2020.111181_bib0255","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1016\/j.bbamem.2009.04.018","article-title":"Mitochondrial kinases and their molecular interaction with cardiolipin","volume":"1788","author":"Schlattner","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"issue":"18","key":"10.1016\/j.biopha.2020.111181_bib0260","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20184359","article-title":"Combined treatment with L-carnitine and nicotinamide riboside improves hepatic metabolism and attenuates obesity and liver steatosis","volume":"20","author":"Salic","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2020.111181_bib0265","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.mehy.2015.11.016","article-title":"Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid substrate cycle","volume":"87","author":"Boros","year":"2016","journal-title":"Med. Hypotheses"},{"issue":"4","key":"10.1016\/j.biopha.2020.111181_bib0270","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/neuonc\/now284","article-title":"What to eat or what not to eat-that is still the question","volume":"19","author":"Boros","year":"2017","journal-title":"Neuro Oncol."},{"issue":"6","key":"10.1016\/j.biopha.2020.111181_bib0275","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.jhep.2019.01.030","article-title":"Extracellular vesicles, the liquid biopsy of the future","volume":"70","author":"Eguchi","year":"2019","journal-title":"J. Hepatol."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220313743?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220313743?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T11:29:27Z","timestamp":1779449367000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332220313743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":55,"alternative-id":["S0753332220313743"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2020.111181","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Branched-chain amino acids and l-carnitine attenuate lipotoxic hepatocellular damage in rat cirrhotic liver","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2020.111181","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"111181"}}