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Proteome Res."},{"key":"10.1016\/j.biopha.2020.111192_bib0575","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.atherosclerosis.2020.02.024","article-title":"l-Arginine prevents inflammatory and pro-calcific differentiation of interstitial aortic valve cells","volume":"298","author":"Rattazzi","year":"2020","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.biopha.2020.111192_bib0580","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3389\/fcvm.2019.00049","article-title":"Standardization of human calcific aortic valve disease in vitro modeling reveals passage-dependent calcification","volume":"6","author":"Goto","year":"2019","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.biopha.2020.111192_bib0585","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.atherosclerosis.2018.03.025","article-title":"Pathological significance of lipoprotein(a) in aortic valve stenosis","volume":"272","author":"Yu","year":"2018","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.biopha.2020.111192_bib0590","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1161\/ATVBAHA.114.304706","article-title":"Proteome analysis of human arterial tissue discloses associations between the vascular content of small leucine-rich repeat proteoglycans and pulse wave velocity","volume":"35","author":"Lyck Hansen","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. 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Cell. Physiol."},{"key":"10.1016\/j.biopha.2020.111192_bib0625","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1161\/CIRCRESAHA.116.305012","article-title":"Vascular smooth muscle cell calcification is mediated by regulated exosome secretion","volume":"116","author":"Kapustin","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.biopha.2020.111192_bib0630","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1097\/HJH.0b013e3283441129","article-title":"Markers of vascular disease in plasma from patients with chronic kidney disease identified by proteomic analysis","volume":"29","author":"Schiffer","year":"2011","journal-title":"J. Hypertens."},{"key":"10.1016\/j.biopha.2020.111192_bib0635","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/03008207.2018.1444759","article-title":"Proteomic profiling of extracellular vesicles released from vascular smooth muscle cells during initiation of phosphate-induced mineralization","volume":"59","author":"Chaudhary","year":"2018","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.biopha.2020.111192_bib0640","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1161\/CIRCRESAHA.110.238808","article-title":"Calcium regulates key components of vascular smooth muscle cell-derived matrix vesicles to enhance mineralization","volume":"109","author":"Kapustin","year":"2011","journal-title":"Circ. 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