{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:55:52Z","timestamp":1791453352881,"version":"4.3.3"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T00:00:00Z","timestamp":1609113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007162","name":"Guangdong Science and Technology Department","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003009","name":"Science and Technology Development Fund","doi-asserted-by":"publisher","award":["0003\/2019\/AKP"],"award-info":[{"award-number":["0003\/2019\/AKP"]}],"id":[{"id":"10.13039\/501100003009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003009","name":"Science and Technology Development Fund","doi-asserted-by":"publisher","award":["0017\/2018\/A1"],"award-info":[{"award-number":["0017\/2018\/A1"]}],"id":[{"id":"10.13039\/501100003009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.biopha.2020.111195","type":"journal-article","created":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T16:55:45Z","timestamp":1609520145000},"page":"111195","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["Sinomenine protects bone from destruction to ameliorate arthritis via activating p62Thr269\/Ser272-Keap1-Nrf2 feedback loop"],"prefix":"10.1016","volume":"135","author":[{"given":"Kangsheng","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kawai","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongqiu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qibiao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hudan","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingchun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiye","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"23","key":"10.1016\/j.biopha.2020.111195_bib0005","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1056\/NEJMra1004965","article-title":"The pathogenesis of rheumatoid arthritis","volume":"365","author":"McInnes","year":"2011","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.biopha.2020.111195_bib0010","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.0105-2896.2009.00859.x","article-title":"Fibroblast\u2010like synoviocytes: key effector cells in rheumatoid arthritis","volume":"233","author":"Bartok","year":"2010","journal-title":"Immunol. Rev."},{"issue":"10","key":"10.1016\/j.biopha.2020.111195_bib0015","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.molmed.2010.07.004","article-title":"Rheumatoid arthritis progression mediated by activated synovial fibroblasts","volume":"16","author":"Neumann","year":"2010","journal-title":"Trends Mol. Med."},{"issue":"1","key":"10.1016\/j.biopha.2020.111195_bib0020","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1600-065X.2008.00648.x","article-title":"The role and therapeutic implications of fibroblast\u2010like synoviocytes in inflammation and cartilage erosion in rheumatoid arthritis","volume":"223","author":"Noss","year":"2008","journal-title":"Immunol. Rev."},{"issue":"3","key":"10.1016\/j.biopha.2020.111195_bib0025","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jbspin.2018.07.004","article-title":"Methotrexate mechanism in treatment of rheumatoid arthritis","volume":"86","author":"Friedman","year":"2019","journal-title":"Joint Bone Spine"},{"issue":"5","key":"10.1016\/j.biopha.2020.111195_bib0030","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1136\/ard.2010.132720","article-title":"Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout mice","volume":"70","author":"Wruck","year":"2011","journal-title":"Ann. Rheum. Dis."},{"issue":"2","key":"10.1016\/j.biopha.2020.111195_bib0035","doi-asserted-by":"crossref","first-page":"139","DOI":"10.5483\/BMBRep.2004.37.2.139","article-title":"An important role of Nrf2-ARE pathway in the cellular defense mechanism","volume":"37","author":"Lee","year":"2004","journal-title":"BMB Rep."},{"issue":"1","key":"10.1016\/j.biopha.2020.111195_bib0040","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.redox.2012.10.001","article-title":"The Keap1-Nrf2 pathway: mechanisms of activation and dysregulation in cancer","volume":"1","author":"Kansanen","year":"2013","journal-title":"Redox Biol."},{"issue":"4","key":"10.1016\/j.biopha.2020.111195_bib0045","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1080\/03602530600971974","article-title":"Mechanistic studies of the Nrf2-Keap1 signaling pathway","volume":"38","author":"Zhang","year":"2006","journal-title":"Drug Metab. Rev."},{"issue":"2","key":"10.1016\/j.biopha.2020.111195_bib0050","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1365-2443.2010.01473.x","article-title":"Molecular mechanisms of the Keap1\u2013Nrf2 pathway in stress response and cancer evolution","volume":"16","author":"Taguchi","year":"2011","journal-title":"Genes Cells"},{"issue":"4","key":"10.1016\/j.biopha.2020.111195_bib0055","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1074\/jbc.M209195200","article-title":"Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium","volume":"278","author":"Stewart","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.biopha.2020.111195_bib0060","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1016\/j.bcp.2010.07.014","article-title":"Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential","volume":"80","author":"Paine","year":"2010","journal-title":"Biochem. Pharmacol."},{"issue":"6","key":"10.1016\/j.biopha.2020.111195_bib0065","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.cell.2009.05.023","article-title":"p62 at the crossroads of autophagy, apoptosis, and cancer","volume":"137","author":"Moscat","year":"2009","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.biopha.2020.111195_bib0070","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/ncb2021","article-title":"The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1","volume":"12","author":"Komatsu","year":"2010","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.biopha.2020.111195_bib0075","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.molimm.2015.01.014","article-title":"Sinomenine suppresses collagen-induced arthritis by reciprocal modulation of regulatory T cells and Th17 cells in gut-associated lymphoid tissues","volume":"65","author":"Tong","year":"2015","journal-title":"Mol. Immunol."},{"issue":"5","key":"10.1016\/j.biopha.2020.111195_bib0080","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.eng.2019.01.018","article-title":"Traditional Chinese medicine as a treatment for rheumatoid arthritis: from empirical practice to evidence-based therapy","volume":"5","author":"Pan","year":"2019","journal-title":"Engineering"},{"key":"10.1016\/j.biopha.2020.111195_bib0085","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.bcp.2017.07.010","article-title":"Suppressing mPGES-1 expression by sinomenine ameliorates inflammation and arthritis","volume":"142","author":"Zhou","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biopha.2020.111195_bib0090","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ejphar.2016.03.014","article-title":"Sinomenine down-regulates TLR4\/TRAF6 expression and attenuates lipopolysaccharide-induced osteoclastogenesis and osteolysis","volume":"779","author":"He","year":"2016","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2020.111195_bib0095","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s11596-020-2156-6","article-title":"Anti-inflammation effects of sinomenine on macrophages through suppressing activated TLR4\/NF-\u03baB signaling pathway","volume":"40","author":"Zeng","year":"2020","journal-title":"Curr. Med. Sci."},{"issue":"1","key":"10.1016\/j.biopha.2020.111195_bib0100","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1080\/08923973.2019.1568451","article-title":"Sinomenine regulates CD14\/TLR4, JAK2\/STAT3 pathway and calcium signal via \u03b17nAChR to inhibit inflammation in LPS-stimulated macrophages","volume":"41","author":"Zhu","year":"2019","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.biopha.2020.111195_bib0105","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.freeradbiomed.2017.12.004","article-title":"Licochalcone A activates Keap1-Nrf2 signaling to suppress arthritis via phosphorylation of p62 at serine 349","volume":"115","author":"Su","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biopha.2020.111195_bib0110","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.phrs.2016.09.031","article-title":"Calycosin suppresses expression of pro-inflammatory cytokines via the activation of p62\/Nrf2-linked heme oxygenase 1 in rheumatoid arthritis synovial fibroblasts","volume":"113","author":"Su","year":"2016","journal-title":"Pharmacol. Res."},{"issue":"9","key":"10.1016\/j.biopha.2020.111195_bib0115","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1002\/art.27584","article-title":"Rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League against Rheumatism collaborative initiative","volume":"62","author":"Aletaha","year":"2010","journal-title":"Arthritis Rheum."},{"issue":"6","key":"10.1016\/j.biopha.2020.111195_bib0120","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1016\/j.biomaterials.2013.11.066","article-title":"Rose-bengal-conjugated gold nanorods for in vivo photodynamic and photothermal oral cancer therapies","volume":"35","author":"Wang","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.biopha.2020.111195_bib0125","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/ncomms1892","article-title":"Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell","volume":"3","author":"Yae","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biopha.2020.111195_bib0130","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.imlet.2016.09.001","article-title":"The bispecific antibody aimed at the vicious circle of IL-1\u03b2 and IL-17A, is beneficial for the collagen-induced rheumatoid arthritis of mice through NF-\u03baB signaling pathway","volume":"179","author":"Wu","year":"2016","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.biopha.2020.111195_bib0135","first-page":"6","article-title":"CO02. Bone mineral density and trabecular bone score in patients with rheumatoid arthritis, Revista Portuguesa de Endocrinologia","volume":"11","author":"Povoroznyuk","year":"2016","journal-title":"Diabetes e Metabol."},{"issue":"6","key":"10.1016\/j.biopha.2020.111195_bib0140","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.diii.2015.12.007","article-title":"Micro-CT evaluation of rheumatoid arthritis mouse model disease progression: manual tracings versus semi-automated routines","volume":"97","author":"Antill","year":"2016","journal-title":"Diagn. Interv. Imaging"},{"key":"10.1016\/j.biopha.2020.111195_bib0145","first-page":"15","article-title":"Role of reactive oxygen and nitrogen species in etiopathogenesis of rheumatoid arthritis","volume":"18","author":"Bauerova","year":"2000","journal-title":"Gen. Physiol. Biophys."},{"issue":"1","key":"10.1016\/j.biopha.2020.111195_bib0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0191192","article-title":"The polymethoxy flavonoid sudachitin suppresses inflammatory bone destruction by directly inhibiting osteoclastogenesis due to reduced ROS production and MAPK activation in osteoclast precursors","volume":"13","author":"Ohyama","year":"2018","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.biopha.2020.111195_bib0155","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.autrev.2009.01.012","article-title":"Interleukin-6 as a key player in systemic inflammation and joint destruction","volume":"8","author":"Fonseca","year":"2009","journal-title":"Autoimmun. Rev."},{"issue":"1","key":"10.1016\/j.biopha.2020.111195_bib0160","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.cyto.2011.12.010","article-title":"Increased levels of interleukin-33 associated with bone erosion and interstitial lung diseases in patients with rheumatoid arthritis","volume":"58","author":"Xiangyang","year":"2012","journal-title":"Cytokine"},{"issue":"3","key":"10.1016\/j.biopha.2020.111195_bib0165","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1365-2249.2008.03634.x","article-title":"Redox signalling and the inflammatory response in rheumatoid arthritis","volume":"152","author":"Filippin","year":"2008","journal-title":"Clin. Exp. Immunol."},{"issue":"9","key":"10.1016\/j.biopha.2020.111195_bib0170","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.cellsig.2011.05.013","article-title":"An I\u03baB\u03b1 phosphorylation inhibitor induces heme oxygenase-1 (HO-1) expression through the activation of reactive oxygen species (ROS)\u2013Nrf2\u2013ARE signaling and ROS\u2013PI3K\/Akt signaling in an NF-\u03baB-independent mechanism","volume":"23","author":"Min","year":"2011","journal-title":"Cell. Signal."},{"issue":"1","key":"10.1016\/j.biopha.2020.111195_bib0175","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.intimp.2014.02.031","article-title":"Sour cherry (Prunus cerasus) seed extract increases heme oxygenase-1 expression and decreases proinflammatory signaling in peripheral blood human leukocytes from rheumatoid arthritis patients","volume":"20","author":"Mahmoud","year":"2014","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.biopha.2020.111195_bib0180","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1089\/ars.2010.3835","article-title":"Deficiency of Nrf2 accelerates the effector phase of arthritis and aggravates joint disease","volume":"15","author":"Maicas","year":"2011","journal-title":"Antioxid. Redox Signal."},{"issue":"8","key":"10.1016\/j.biopha.2020.111195_bib0185","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/jhbp.364","article-title":"Accumulation of phosphorylated p62 is associated with NF\u2010E2\u2010related factor 2 activation in hepatocellular carcinoma","volume":"23","author":"Shimizu","year":"2016","journal-title":"J. Hepatobiliary Pancreatic Sci."},{"issue":"5","key":"10.1016\/j.biopha.2020.111195_bib0190","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.molcel.2013.08.003","article-title":"Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy","volume":"51","author":"Ichimura","year":"2013","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.biopha.2020.111195_bib0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms12030","article-title":"p62\/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming","volume":"7","author":"Saito","year":"2016","journal-title":"Nat. Commun."},{"issue":"29","key":"10.1016\/j.biopha.2020.111195_bib0200","doi-asserted-by":"crossref","first-page":"22576","DOI":"10.1074\/jbc.M110.118976","article-title":"p62\/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription","volume":"285","author":"Jain","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2020.111195_bib0205","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.biopha.2017.05.055","article-title":"Rheumatoid arthritis: recent advances on its etiology, role of cytokines and pharmacotherapy","volume":"92","author":"Alam","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"Suppl. 2","key":"10.1016\/j.biopha.2020.111195_bib0210","doi-asserted-by":"crossref","first-page":"ii84","DOI":"10.1136\/ard.61.suppl_2.ii84","article-title":"Bone destruction in arthritis","volume":"61","author":"Gravallese","year":"2002","journal-title":"Ann. Rheum. Dis."},{"issue":"12","key":"10.1016\/j.biopha.2020.111195_bib0215","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1055\/s-2008-1081346","article-title":"Sinomenine versus NSAIDs for the treatment of rheumatoid arthritis: a systematic review and meta-analysis","volume":"74","author":"Xu","year":"2008","journal-title":"Planta Med."},{"issue":"11","key":"10.1016\/j.biopha.2020.111195_bib0220","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.eng.2020.04.013","article-title":"3D printing hip prostheses offer accurate reconstruction, stable fixation, and functional recovery for revision total hip arthroplasty with complex acetabular bone defect","volume":"6","author":"Hao","year":"2020","journal-title":"Engineering"},{"issue":"1","key":"10.1016\/j.biopha.2020.111195_bib0225","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jbspin.2011.02.011","article-title":"Distinct serum and synovial fluid interleukin (IL)-33 levels in rheumatoid arthritis, psoriatic arthritis and osteoarthritis","volume":"79","author":"Talabot-Ayer","year":"2012","journal-title":"Joint Bone Spine"},{"issue":"1","key":"10.1016\/j.biopha.2020.111195_bib0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13104-017-2715-5","article-title":"TNF-\u03b1-induced miR-155 regulates IL-6 signaling in rheumatoid synovial fibroblasts","volume":"10","author":"Migita","year":"2017","journal-title":"BMC Res. Notes"},{"issue":"9","key":"10.1016\/j.biopha.2020.111195_bib0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0107890","article-title":"5-Lipoxygenase inhibitors attenuate TNF-\u03b1-induced inflammation in human synovial fibroblasts","volume":"9","author":"Lin","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.biopha.2020.111195_bib0240","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41419-019-1413-8","article-title":"Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors","volume":"10","author":"Yang","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.biopha.2020.111195_bib0245","doi-asserted-by":"crossref","first-page":"10555","DOI":"10.1038\/ncomms10555","article-title":"Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1\u03b2 secretion in response to ATP","volume":"7","author":"Karmakar","year":"2016","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.biopha.2020.111195_bib0250","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.bbagen.2014.11.021","article-title":"Nrf2 regulates ROS production by mitochondria and NADPH oxidase","volume":"1850","author":"Kovac","year":"2015","journal-title":"Biochimica et Biophysica Acta (BBA)-General Subjects"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220313883?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332220313883?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T11:33:45Z","timestamp":1779449625000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332220313883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":50,"alternative-id":["S0753332220313883"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2020.111195","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sinomenine protects bone from destruction to ameliorate arthritis via activating p62Thr269\/Ser272-Keap1-Nrf2 feedback loop","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2020.111195","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"111195"}}