{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T14:03:32Z","timestamp":1787580212183,"version":"build-2736575974"},"reference-count":120,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T00:00:00Z","timestamp":1613692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007046","name":"Wuhan University","doi-asserted-by":"publisher","award":["ZNJC201923"],"award-info":[{"award-number":["ZNJC201923"]}],"id":[{"id":"10.13039\/501100007046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.biopha.2021.111422","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T23:08:21Z","timestamp":1622848101000},"page":"111422","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Advances in the applications of polymer biomaterials for in vitro follicle culture"],"prefix":"10.1016","volume":"140","author":[{"given":"Du","family":"Xiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Encheng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.biopha.2021.111422_bib1","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nrendo.2017.12","article-title":"The effects of oestrogens and their receptors on cardiometabolic health","volume":"13","author":"Morselli","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"issue":"3","key":"10.1016\/j.biopha.2021.111422_bib2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/GCO.0000000000000536","article-title":"Diminished ovarian reserve versus ovarian aging","volume":"31","author":"Ata","year":"2019","journal-title":"Curr. Opin. Obstet. Gynecol."},{"issue":"6","key":"10.1016\/j.biopha.2021.111422_bib3","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/humupd\/dmz027","article-title":"Ovarian damage from chemotherapy and current approaches to its protection","volume":"25","author":"Spears","year":"2019","journal-title":"Hum. Reprod. Update"},{"issue":"4","key":"10.1016\/j.biopha.2021.111422_bib4","doi-asserted-by":"crossref","first-page":"597","DOI":"10.3945\/an.116.014647","article-title":"Current evidence on associations of nutritional factors with ovarian reserve and timing of menopause: a systematic review","volume":"8","author":"Moslehi","year":"2017","journal-title":"Adv. Nutr."},{"issue":"4","key":"10.1016\/j.biopha.2021.111422_bib5","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nrendo.2017.180","article-title":"Symptoms of menopause \u2013 global prevalence, physiology and implications","volume":"14","author":"Monteleone","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.biopha.2021.111422_bib6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.maturitas.2016.01.007","article-title":"Managing the menopause: an update","volume":"86","author":"Roberts","year":"2016","journal-title":"Maturitas"},{"issue":"3","key":"10.1016\/j.biopha.2021.111422_bib7","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1097\/gme.0b013e3182843aad","article-title":"Timing hypothesis for postmenopausal hormone therapy: its origin, current status, and future","volume":"20","author":"Clarkson","year":"2013","journal-title":"Menopause"},{"key":"10.1016\/j.biopha.2021.111422_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/srep03111","article-title":"Effects of high and low 17\u03b2-estradiol doses on focal cerebral ischemia: negative results","volume":"3","author":"Strom","year":"2013","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.biopha.2021.111422_bib9","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.maturitas.2005.02.019","article-title":"Climacteric medicine: European menopause and andropause society (EMAS) 2004\/2005 position statements on peri- and postmenopausal hormone replacement therapy","volume":"51","author":"Skouby","year":"2005","journal-title":"Maturitas"},{"issue":"4","key":"10.1016\/j.biopha.2021.111422_bib10","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nrendo.2016.164","article-title":"Hormone-replacement therapy: current thinking","volume":"13","author":"Lobo","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.biopha.2021.111422_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-01851-3","article-title":"In vivo transplantation of 3D encapsulated ovarian constructs in rats corrects abnormalities of ovarian failure","volume":"8","author":"Sittadjody","year":"2017","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.biopha.2021.111422_bib12","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1002\/term.2870","article-title":"A new possibility in fertility preservation: the artificial ovary","volume":"13","author":"Cho","year":"2019","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"10.1016\/j.biopha.2021.111422_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2018.00347","article-title":"Cryopreservation of ovarian tissue: opportunities beyond fertility preservation and a positive view into the future","volume":"9","author":"Kristensen","year":"2018","journal-title":"Front. Endocrinol."},{"issue":"11","key":"10.1016\/j.biopha.2021.111422_bib14","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1093\/annonc\/mdz284","article-title":"Preserving fertility in female patients with hematological malignancies: a multidisciplinary oncofertility approach","volume":"30","author":"Salama","year":"2019","journal-title":"Ann. Oncol."},{"issue":"5","key":"10.1016\/j.biopha.2021.111422_bib15","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/aogs.13552","article-title":"From bench to bedside: current developments and future possibilities of artificial human ovary to restore fertility","volume":"98","author":"Salama","year":"2019","journal-title":"Acta Obstet. Gynecol. Scand."},{"issue":"17","key":"10.1016\/j.biopha.2021.111422_bib16","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1056\/NEJMra1614676","article-title":"Fertility preservation in women","volume":"377","author":"Donnez","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.biopha.2021.111422_bib17","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s13770-016-9107-0","article-title":"Efficient biomaterials for tissue engineering of female reproductive organs","volume":"13","author":"Tamadon","year":"2016","journal-title":"Tissue Eng. Regen. Med."},{"issue":"20","key":"10.1016\/j.biopha.2021.111422_bib18","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.2217\/fon-2016-0202","article-title":"The artificial ovary: current status and future perspectives","volume":"12","author":"Amorim","year":"2016","journal-title":"Future Oncol."},{"issue":"1","key":"10.1016\/j.biopha.2021.111422_bib19","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.theriogenology.2016.04.036","article-title":"In vitro culture methods of preantral follicles","volume":"86","author":"Green","year":"2016","journal-title":"Theriogenology"},{"issue":"2","key":"10.1016\/j.biopha.2021.111422_bib20","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1210\/edrv-17-2-121","article-title":"Regulation of ovarian follicular development in primates: facts and hypotheses","volume":"17","author":"Gougeon","year":"1996","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.biopha.2021.111422_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/npjregenmed.2016.10","article-title":"Synthetic hydrogel supports the function and regeneration of artificial ovarian tissue in mice","volume":"1","author":"Kim","year":"2016","journal-title":"npj Regen. Med."},{"issue":"2","key":"10.1016\/j.biopha.2021.111422_bib22","article-title":"Influence of follicle stage on artificial ovary outcome using fibrin as a matrix","volume":"31","author":"Chiti","year":"2015","journal-title":"Hum. Reprod."},{"issue":"7","key":"10.1016\/j.biopha.2021.111422_bib23","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1093\/humrep\/dew049","article-title":"Survival and growth of isolated pre-antral follicles from human ovarian medulla tissue during long-term 3D culture","volume":"31","author":"Yin","year":"2016","journal-title":"Hum. Reprod."},{"issue":"6","key":"10.1016\/j.biopha.2021.111422_bib24","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1093\/molehr\/gax016","article-title":"Further insights into the impact of mouse follicle stage on graft outcome in an artificial ovary environment","volume":"23","author":"Chiti","year":"2017","journal-title":"Mol. Hum. Reprod."},{"issue":"8","key":"10.1016\/j.biopha.2021.111422_bib25","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1093\/humrep\/dez077","article-title":"Initial steps in reconstruction of the human ovary: survival of pre-antral stage follicles in a decellularized human ovarian scaffold","volume":"34","author":"Pors","year":"2019","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.biopha.2021.111422_bib26","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.biomaterials.2015.01.051","article-title":"Initiation of puberty in mice following decellularized ovary transplant","volume":"50","author":"Laronda","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.biopha.2021.111422_bib27","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/s41586-020-3027-9","article-title":"Reconstitution of the oocyte transcriptional network with transcription factors","volume":"589","author":"Hamazaki","year":"2020","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.biopha.2021.111422_bib28","doi-asserted-by":"crossref","first-page":"5053","DOI":"10.3892\/mmr.2016.5191","article-title":"Transplantation of ovarian granulosalike cells derived from human induced pluripotent stem cells for the treatment of murine premature ovarian failure","volume":"13","author":"Liu","year":"2016","journal-title":"Mol. Med. Rep."},{"issue":"2","key":"10.1016\/j.biopha.2021.111422_bib29","first-page":"139","article-title":"Oocyte, embryo and blastocyst cryopreservation in ART: systematic review and meta-analysis comparing slow-freezing versus vitrification to produce evidence for the development of global guidance","volume":"23","author":"Rienzi","year":"2017","journal-title":"Hum. Reprod. Update"},{"issue":"4","key":"10.1016\/j.biopha.2021.111422_bib30","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1093\/humrep\/dew005","article-title":"Human single follicle growthin vitro from cryopreserved ovarian tissue after slow freezing or vitrification","volume":"31","author":"Wang","year":"2016","journal-title":"Hum. Reprod."},{"issue":"3","key":"10.1016\/j.biopha.2021.111422_bib31","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.cryobiol.2015.11.001","article-title":"Three dimensional in vitro culture of preantral follicles following slow-freezing and vitrification of mouse ovarian tissue","volume":"71","author":"Asgari","year":"2015","journal-title":"Cryobiology"},{"issue":"8","key":"10.1016\/j.biopha.2021.111422_bib32","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1177\/1933719117737851","article-title":"Comparison of follicle isolation methods for mouse ovarian follicle culture in vitro","volume":"25","author":"Kim","year":"2018","journal-title":"Reprod. Sci."},{"issue":"8","key":"10.1016\/j.biopha.2021.111422_bib33","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1093\/humrep\/dez077","article-title":"Initial steps in reconstruction of the human ovary: survival of pre-antral stage follicles in a decellularized human ovarian scaffold","volume":"34","author":"Pors","year":"2019","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.biopha.2021.111422_bib34","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.semcdb.2016.07.006","article-title":"In vitro culture of ovarian follicles from Peromyscus","volume":"61","author":"He","year":"2017","journal-title":"Semin. Cell Dev. Biol."},{"issue":"4","key":"10.1016\/j.biopha.2021.111422_bib35","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1152\/physiol.00036.2016","article-title":"Modeling physiological events in 2D vs. 3D cell culture","volume":"32","author":"Duval","year":"2017","journal-title":"Physiology"},{"key":"10.1016\/j.biopha.2021.111422_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2020.00033","article-title":"Is it time to start transitioning from 2D to 3D cell culture?","volume":"7","author":"Jensen","year":"2020","journal-title":"Front. Mol. Biosci."},{"issue":"19","key":"10.1016\/j.biopha.2021.111422_bib37","doi-asserted-by":"crossref","first-page":"5122","DOI":"10.1016\/j.biomaterials.2014.03.028","article-title":"The crucial role of mechanical heterogeneity in regulating follicle development and ovulation with engineered ovarian microtissue","volume":"35","author":"Choi","year":"2014","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.biopha.2021.111422_bib38","doi-asserted-by":"crossref","first-page":"F59","DOI":"10.1530\/REP-18-0173","article-title":"In vitro follicle culture in the context of IVF","volume":"156","author":"Herta","year":"2018","journal-title":"Reproduction"},{"issue":"1","key":"10.1016\/j.biopha.2021.111422_bib39","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s10815-017-1043-y","article-title":"Development of macaque secondary follicles exposed to neutral red prior to 3-dimensional culture","volume":"35","author":"Bulgarelli","year":"2018","journal-title":"J. Assist. Reprod. Genet."},{"issue":"1","key":"10.1016\/j.biopha.2021.111422_bib40","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/humrep\/den343","article-title":"Survival of human pre-antral follicles after cryopreservation of ovarian tissue, follicular isolation and in vitro culture in a calcium alginate matrix","volume":"24","author":"Amorim","year":"2008","journal-title":"Hum. Reprod."},{"issue":"12","key":"10.1016\/j.biopha.2021.111422_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17121976","article-title":"Applications of alginate-based bioinks in 3D bioprinting","volume":"17","author":"Axpe","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.biopha.2021.111422_bib42","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1021\/acs.biomac.7b01331","article-title":"Oxidized alginate-based hydrogels for tissue engineering applications: a review","volume":"19","author":"Reakasame","year":"2017","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.biopha.2021.111422_bib43","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.carbpol.2018.02.086","article-title":"Synthesis and evaluation of functional alginate hydrogels based on click chemistry for drug delivery applications","volume":"190","author":"Garcia-Astrain","year":"2018","journal-title":"Carbohydr. Polym."},{"issue":"7","key":"10.1016\/j.biopha.2021.111422_bib44","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1007\/s10439-017-1816-6","article-title":"Alginate: a versatile biomaterial to encapsulate isolated ovarian follicles","volume":"45","author":"Vanacker","year":"2017","journal-title":"Ann. Biomed. Eng."},{"issue":"6","key":"10.1016\/j.biopha.2021.111422_bib45","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1095\/biolreprod.106.054833","article-title":"Identification of a stage-specific permissive in vitro culture environment for follicle growth and oocyte development1","volume":"75","author":"Xu","year":"2006","journal-title":"Biol. Reprod."},{"issue":"30","key":"10.1016\/j.biopha.2021.111422_bib46","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.1016\/j.biomaterials.2007.07.001","article-title":"Physical properties of alginate hydrogels and their effects on in vitro follicle development","volume":"28","author":"West","year":"2007","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.biopha.2021.111422_bib47","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3109\/02652048.2015.1134691","article-title":"Formulation and stability evaluation of 3D alginate beads potentially useful for cumulus-oocyte complexes culture","volume":"33","author":"Dorati","year":"2016","journal-title":"J. Microencapsul."},{"issue":"3","key":"10.1016\/j.biopha.2021.111422_bib48","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1095\/biolreprod.108.074732","article-title":"Encapsulated three-dimensional culture supports development of nonhuman primate secondary follicles1","volume":"81","author":"Xu","year":"2009","journal-title":"Biol. Reprod."},{"issue":"6","key":"10.1016\/j.biopha.2021.111422_bib49","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1093\/humrep\/der468","article-title":"Isolated primate primordial follicles require a rigid physical environment to survive and grow in vitro","volume":"27","author":"Hornick","year":"2012","journal-title":"Hum. Reprod."},{"issue":"3","key":"10.1016\/j.biopha.2021.111422_bib50","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1093\/humrep\/deu335","article-title":"Direct actions of androgens on the survival, growth and secretion of steroids and anti-Mullerian hormone by individual macaque follicles during three-dimensional culture","volume":"30","author":"Rodrigues","year":"2015","journal-title":"Hum. Reprod."},{"issue":"5","key":"10.1016\/j.biopha.2021.111422_bib51","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1093\/humrep\/der049","article-title":"Secondary follicle growth and oocyte maturation during encapsulated three-dimensional culture in rhesus monkeys: effects of gonadotrophins, oxygen and fetuin","volume":"26","author":"Xu","year":"2011","journal-title":"Hum. Reprod."},{"issue":"2","key":"10.1016\/j.biopha.2021.111422_bib52","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1095\/biolreprod.111.091124","article-title":"Meiotic and developmental competence in mice are compromised following follicle development in vitro using an alginate-based culture system","volume":"85","author":"Mainigi","year":"2011","journal-title":"Biol. Reprod."},{"issue":"5","key":"10.1016\/j.biopha.2021.111422_bib53","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1177\/1535370219831615","article-title":"Hesperidin improves the follicular development in 3D culture of isolated preantral ovarian follicles of mice","volume":"244","author":"Shoorei","year":"2019","journal-title":"Exp. Biol. Med."},{"issue":"5","key":"10.1016\/j.biopha.2021.111422_bib54","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.biomaterials.2005.06.016","article-title":"The in vitro regulation of ovarian follicle development using alginate-extracellular matrix gels","volume":"27","author":"Kreeger","year":"2006","journal-title":"Biomaterials"},{"issue":"7","key":"10.1016\/j.biopha.2021.111422_bib55","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1016\/j.fertnstert.2016.08.037","article-title":"Direct vitamin D3 actions on rhesus macaque follicles in three-dimensional culture: assessment of follicle survival, growth, steroid, and antim\u00fcllerian hormone production","volume":"106","author":"Xu","year":"2016","journal-title":"Fertil. Steril."},{"issue":"2","key":"10.1016\/j.biopha.2021.111422_bib56","first-page":"210","article-title":"Panax ginseng extract improves follicular development after mouse preantral follicle 3D culture","volume":"21","author":"Majdi Seghinsara","year":"2019","journal-title":"Cell J."},{"issue":"9","key":"10.1016\/j.biopha.2021.111422_bib57","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.theriogenology.2014.08.004","article-title":"In vitro development of bovine secondary follicles in two- and three-dimensional culture systems using vascular endothelial growth factor, insulin-like growth factor-1, and growth hormone","volume":"82","author":"Ara\u00fajo","year":"2014","journal-title":"Theriogenology"},{"issue":"1","key":"10.1016\/j.biopha.2021.111422_bib58","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.repbio.2018.02.001","article-title":"Mouse preantral follicle growth in 3D co-culture system using human menstrual blood mesenchymal stem cell","volume":"18","author":"Rajabi","year":"2018","journal-title":"Reprod. Biol."},{"issue":"4","key":"10.1016\/j.biopha.2021.111422_bib59","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.rbmo.2017.04.007","article-title":"Platelet-rich plasma promotes the development of isolated human primordial and primary follicles to the preantral stage","volume":"35","author":"Hosseini","year":"2017","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.biopha.2021.111422_bib60","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-019-1199-8","article-title":"Adipose-derived stem cells promote survival, growth, and maturation of early-stage murine follicles","volume":"10","author":"Green","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.biopha.2021.111422_bib61","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.biomaterials.2019.03.013","article-title":"Reconstruction of the ovary microenvironment utilizing macroporous scaffold with affinity-bound growth factors","volume":"205","author":"Felder","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.biopha.2021.111422_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119311","article-title":"3D porous chitosan-alginate scaffold stiffness promotes differential responses in prostate cancer cell lines","volume":"217","author":"Xu","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.biopha.2021.111422_bib63","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.carbpol.2018.07.057","article-title":"3D-printed chitosan-based scaffolds: an in vitro study of human skin cell growth and an in-vivo wound healing evaluation in experimental diabetes in rats","volume":"199","author":"Intini","year":"2018","journal-title":"Carbohydr. Polym."},{"issue":"4","key":"10.1016\/j.biopha.2021.111422_bib64","first-page":"479","article-title":"Chitosan hydrogel supports integrity of ovarian follicles during in vitro culture: a preliminary of a novel biomaterial for three dimensional culture of ovarian follicles","volume":"21","author":"Hassani","year":"2020","journal-title":"Cell J."},{"issue":"4","key":"10.1016\/j.biopha.2021.111422_bib65","doi-asserted-by":"crossref","DOI":"10.1002\/wnan.1503","article-title":"Extracellular matrix remodeling in 3D: implications in tissue homeostasis and disease progression: extracellular matrix remodeling in 3D","volume":"10","author":"Ford","year":"2018","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.biopha.2021.111422_bib66","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.biomaterials.2017.11.004","article-title":"Stress relaxing hyaluronic acid-collagen hydrogels promote cell spreading, fiber remodeling, and focal adhesion formation in 3D cell culture","volume":"154","author":"Lou","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.biopha.2021.111422_bib67","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.theriogenology.2019.12.009","article-title":"The new biocompatible material for mouse ovarian follicle development in three-dimensional in vitro culture systems","volume":"144","author":"Kim","year":"2020","journal-title":"Theriogenology"},{"issue":"2","key":"10.1016\/j.biopha.2021.111422_bib68","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1089\/bio.2017.0087","article-title":"Utilizing fibrin-alginate and matrigel-alginate for mouse follicle development in three-dimensional culture systems","volume":"16","author":"Sadr","year":"2018","journal-title":"Biopreserv. Biobank."},{"issue":"8","key":"10.1016\/j.biopha.2021.111422_bib69","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1093\/humrep\/dez077","article-title":"Initial steps in reconstruction of the human ovary: survival of pre-antral stage follicles in a decellularized human ovarian scaffold","volume":"34","author":"Pors","year":"2019","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.biopha.2021.111422_bib70","doi-asserted-by":"crossref","first-page":"4937","DOI":"10.2147\/IJN.S124671","article-title":"A review of fibrin and fibrin composites for bone tissue engineering","volume":"12","author":"Noori","year":"2017","journal-title":"Int. J. Nanomed."},{"issue":"7","key":"10.1016\/j.biopha.2021.111422_bib71","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1007\/s10439-017-1817-5","article-title":"Fibrin in reproductive tissue engineering: a review on its application as a biomaterial for fertility preservation","volume":"45","author":"Chiti","year":"2017","journal-title":"Ann. Biomed. Eng."},{"issue":"4","key":"10.1016\/j.biopha.2021.111422_bib72","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.fertnstert.2013.12.025","article-title":"A new step toward the artificial ovary: survival and proliferation of isolated murine follicles after autologous transplantation in a fibrin scaffold","volume":"101","author":"Luyckx","year":"2014","journal-title":"Fertil. Steril."},{"issue":"8","key":"10.1016\/j.biopha.2021.111422_bib73","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1093\/humrep\/det093","article-title":"Fibrin promotes development and function of macaque primary follicles during encapsulated three-dimensional culture","volume":"28","author":"Xu","year":"2013","journal-title":"Hum. Reprod."},{"issue":"3","key":"10.1016\/j.biopha.2021.111422_bib74","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.rbmo.2016.05.003","article-title":"Survival and growth of human preantral follicles after cryopreservation of ovarian tissue, follicle isolation and short-term xenografting","volume":"33","author":"Paulini","year":"2016","journal-title":"Reprod. Biomed. Online"},{"issue":"1","key":"10.1016\/j.biopha.2021.111422_bib75","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s10815-017-1091-3","article-title":"A novel fibrin-based artificial ovary prototype resembling human ovarian tissue in terms of architecture and rigidity","volume":"35","author":"Chiti","year":"2018","journal-title":"J. Assist. Reprod. Genet."},{"issue":"1","key":"10.1016\/j.biopha.2021.111422_bib76","first-page":"145","article-title":"Morphological study of isolated ovarian preantral follicles using fibrin gel plus platelet lysate after subcutaneous transplantation","volume":"17","author":"Rajabzadeh","year":"2015","journal-title":"Cell J."},{"issue":"7","key":"10.1016\/j.biopha.2021.111422_bib77","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1007\/s10439-017-1817-5","article-title":"Fibrin in reproductive tissue engineering: a review on its application as a biomaterial for fertility preservation","volume":"45","author":"Chiti","year":"2017","journal-title":"Ann. Biomed. Eng."},{"issue":"3","key":"10.1016\/j.biopha.2021.111422_bib78","doi-asserted-by":"crossref","first-page":"506","DOI":"10.2174\/0929867325666171205170339","article-title":"Medical applications of collagen and collagen-based materials","volume":"26","author":"Shekhter","year":"2019","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.biopha.2021.111422_bib79","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.addr.2015.11.013","article-title":"Collagen interactions: drug design and delivery","volume":"97","author":"An","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"4","key":"10.1016\/j.biopha.2021.111422_bib80","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/aa857c","article-title":"GelMA-collagen blends enable drop-on-demand 3D printablility and promote angiogenesis","volume":"9","author":"Stratesteffen","year":"2017","journal-title":"Biofabrication"},{"issue":"1","key":"10.1016\/j.biopha.2021.111422_bib81","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201801651","article-title":"The collagen suprafamily: from biosynthesis to advanced biomaterial","volume":"31","author":"Sorushanova","year":"2019","journal-title":"Adv. Mater."},{"issue":"6","key":"10.1016\/j.biopha.2021.111422_bib82","doi-asserted-by":"crossref","DOI":"10.1088\/1748-6041\/11\/6\/065009","article-title":"The effect of collagen hydrogel on 3D culture of ovarian follicles","volume":"11","author":"Joo","year":"2016","journal-title":"Biomed. Mater."},{"issue":"1","key":"10.1016\/j.biopha.2021.111422_bib83","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.repbio.2018.02.001","article-title":"Mouse preantral follicle growth in 3D co-culture system using human menstrual blood mesenchymal stem cell","volume":"18","author":"Rajabi","year":"2018","journal-title":"Reprod. Biol."},{"issue":"5","key":"10.1016\/j.biopha.2021.111422_bib84","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1093\/humrep\/dew041","article-title":"Transplantation of adipose-derived stem cells combined with collagen scaffolds restores ovarian function in a rat model of premature ovarian insufficiency","volume":"31","author":"Su","year":"2016","journal-title":"Hum. Reprod."},{"issue":"12","key":"10.1016\/j.biopha.2021.111422_bib85","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1007\/s11427-017-9272-2","article-title":"Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility","volume":"61","author":"Ding","year":"2018","journal-title":"Sci. China Life Sci."},{"issue":"4\u20136","key":"10.1016\/j.biopha.2021.111422_bib86","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1387\/ijdb.150172mz","article-title":"3D culture of ovarian follicles: a system towards their engineering?","volume":"59","author":"Zuccotti","year":"2015","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.biopha.2021.111422_bib87","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.msec.2018.03.009","article-title":"2-Thiophene ethylamine modified hyaluronic acid with its application on hepatocytes culture","volume":"88","author":"Wang","year":"2018","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.biopha.2021.111422_bib88","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.copbio.2016.02.008","article-title":"Recent advances in hyaluronic acid hydrogels for biomedical applications","volume":"40","author":"Highley","year":"2016","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.biopha.2021.111422_bib89","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.ijbiomac.2016.02.032","article-title":"Emerging roles of hyaluronic acid bioscaffolds in tissue engineering and regenerative medicine","volume":"86","author":"Hemshekhar","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.biopha.2021.111422_bib90","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1477-7827-10-29","article-title":"Three dimensional culture of fresh and vitrified mouse pre-antral follicles in a hyaluronan-based hydrogel: a preliminary investigation of a novel biomaterial for in vitro follicle maturation","volume":"10","author":"Desai","year":"2012","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"5","key":"10.1016\/j.biopha.2021.111422_bib91","doi-asserted-by":"crossref","first-page":"F15","DOI":"10.1530\/REP-18-0536","article-title":"Fertility preservation: construction and use of artificial ovaries","volume":"158","author":"Dolmans","year":"2019","journal-title":"Reproduction"},{"issue":"3\u20134","key":"10.1016\/j.biopha.2021.111422_bib92","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1089\/ten.tea.2016.0555","article-title":"Suitability of different natural and synthetic biomaterials for dental pulp tissue engineering","volume":"24","author":"Galler","year":"2018","journal-title":"Tissue Eng. Part A"},{"issue":"6","key":"10.1016\/j.biopha.2021.111422_bib93","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1021\/acs.biomac.8b00276","article-title":"Conducting polymers for tissue engineering","volume":"19","author":"Guo","year":"2018","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.biopha.2021.111422_bib94","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.actbio.2018.08.027","article-title":"Elastic materials for tissue engineering applications: natural, synthetic, and hybrid polymers","volume":"79","author":"Coenen","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biopha.2021.111422_bib95","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/978-1-4939-7741-3_9","article-title":"Synthetic PEG hydrogel for engineering the environment of ovarian follicles","volume":"1758","author":"Mendez","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.biopha.2021.111422_bib96","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.biomaterials.2018.04.047","article-title":"Design of a vascularized synthetic poly(ethylene glycol) macroencapsulation device for islet transplantation","volume":"172","author":"Weaver","year":"2018","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.biopha.2021.111422_bib97","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/ajt.14547","article-title":"Immunoisolation of murine islet allografts in vascularized sites through conformal coating with polyethylene glycol","volume":"18","author":"Manzoli","year":"2018","journal-title":"Am. J. Transplant."},{"issue":"5","key":"10.1016\/j.biopha.2021.111422_bib98","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1002\/jbm.a.36338","article-title":"Immunoisolating poly(ethylene glycol) based capsules support ovarian tissue survival to restore endocrine function","volume":"106","author":"Day","year":"2018","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"10.1016\/j.biopha.2021.111422_bib99","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.biomaterials.2019.02.004","article-title":"Varying PEG density to control stress relaxation in alginate-PEG hydrogels for 3D cell culture studies","volume":"200","author":"Nam","year":"2019","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.biopha.2021.111422_bib100","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/term.1824","article-title":"Culture of preantral follicles in poly(ethylene) glycol-based, three-dimensional hydrogel: a relationship between swelling ratio and follicular developments","volume":"9","author":"Ahn","year":"2015","journal-title":"J. Tissue Eng. Regen. Med."},{"issue":"2","key":"10.1016\/j.biopha.2021.111422_bib101","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1039\/C8BM01253A","article-title":"Adipose-derived stem cell-secreted factors promote early stage follicle development in a biomimetic matrix","volume":"7","author":"Tomaszewski","year":"2019","journal-title":"Biomater. Sci."},{"issue":"6","key":"10.1016\/j.biopha.2021.111422_bib102","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1093\/humrep\/dev052","article-title":"Engineering the ovarian cycle using in vitro follicle culture","volume":"30","author":"Skory","year":"2015","journal-title":"Hum. Reprod."},{"issue":"10","key":"10.1016\/j.biopha.2021.111422_bib103","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0140205","article-title":"Hydrogel based 3-dimensional (3D) system for toxicity and high-throughput (HTP) analysis for cultured murine ovarian follicles","volume":"10","author":"Zhou","year":"2015","journal-title":"PLOS One"},{"issue":"2","key":"10.1016\/j.biopha.2021.111422_bib104","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1093\/toxsci\/kfx047","article-title":"Doxorubicin has dose-dependent toxicity on mouse ovarian follicle development","volume":"157","author":"Xiao","year":"2017","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.biopha.2021.111422_bib105","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.tiv.2019.03.019","article-title":"Establishment of in-vitro three dimensional rat follicle culture system and validation of the applicability as an in vitro female reproductive toxicity testing system","volume":"58","author":"Zhang","year":"2019","journal-title":"Toxicol. Vitr."},{"issue":"9","key":"10.1016\/j.biopha.2021.111422_bib106","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1002\/jat.3335","article-title":"Effects ofin vitro exposure to butylparaben and di-(2 ethylhexyl) phthalate, alone or in combination, on ovarian function","volume":"36","author":"Guerra","year":"2016","journal-title":"J. Appl. Toxicol."},{"issue":"5","key":"10.1016\/j.biopha.2021.111422_bib107","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.1002\/jcp.29376","article-title":"Premature ovarian failure and tissue engineering","volume":"235","author":"Ghahremani\u2010Nasab","year":"2020","journal-title":"J. Cell. Physiol."},{"issue":"3","key":"10.1016\/j.biopha.2021.111422_bib108","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.cell.2020.01.009","article-title":"Single-cell transcriptomic atlas of primate ovarian aging","volume":"180","author":"Wang","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2021.111422_bib109","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.biopha.2018.03.056","article-title":"Current approaches for the treatment of premature ovarian failure with stem cell therapy","volume":"102","author":"Sheikh Ansari","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.biopha.2021.111422_bib110","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1007\/s10439-019-02334-w","article-title":"Encapsulation of mesenchymal stem cells in 3D ovarian cell constructs promotes stable and long-term hormone secretion with improved physiological outcomes in a syngeneic rat model","volume":"48","author":"Sittadjody","year":"2020","journal-title":"Ann. Biomed. Eng."},{"issue":"4","key":"10.1016\/j.biopha.2021.111422_bib111","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1007\/s11626-019-00337-4","article-title":"Transplantation of umbilical cord-derived mesenchymal stem cells on a collagen scaffold improves ovarian function in a premature ovarian failure model of mice","volume":"55","author":"Yang","year":"2019","journal-title":"Vitr. Cell Dev. Biol. Anim."},{"issue":"12","key":"10.1016\/j.biopha.2021.111422_bib112","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1007\/s11427-017-9272-2","article-title":"Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility","volume":"61","author":"Ding","year":"2018","journal-title":"Sci. China Life Sci."},{"issue":"6","key":"10.1016\/j.biopha.2021.111422_bib113","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/humupd\/dmz027","article-title":"Ovarian damage from chemotherapy and current approaches to its protection","volume":"25","author":"Spears","year":"2019","journal-title":"Hum. Reprod. Update"},{"issue":"2","key":"10.1016\/j.biopha.2021.111422_bib114","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/humupd\/dmz041","article-title":"Do cancer therapies damage the uterus and compromise fertility?","volume":"26","author":"Griffiths","year":"2020","journal-title":"Hum. Reprod. Update"},{"issue":"8","key":"10.1016\/j.biopha.2021.111422_bib115","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1002\/bit.26721","article-title":"Retrievable hydrogels for ovarian follicle transplantation and oocyte collection","volume":"115","author":"Rios","year":"2018","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.biopha.2021.111422_bib116","doi-asserted-by":"crossref","unstructured":"B. Fisch, R. Abir, Female fertility preservation: past, present and future reproduction, 2018, 156 (1), pp. F11\u2013F27.","DOI":"10.1530\/REP-17-0483"},{"key":"10.1016\/j.biopha.2021.111422_bib117","doi-asserted-by":"crossref","DOI":"10.1186\/s13036-018-0134-3","article-title":"Follicle development as an orchestrated signaling network in a 3D organoid","volume":"13","author":"Jones","year":"2019","journal-title":"J. Biol. Eng."},{"key":"10.1016\/j.biopha.2021.111422_bib118","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15261","article-title":"A bioprosthetic ovary created using 3D printed microporous scaffolds restores ovarian function in sterilized mice","volume":"8","author":"Laronda","year":"2017","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.biopha.2021.111422_bib119","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0238812","article-title":"One-step automated bioprinting-based method for cumulus-oocyte complex microencapsulation for 3D in vitro maturation","volume":"15","author":"Mastrorocco","year":"2020","journal-title":"PLOS One"},{"issue":"1","key":"10.1016\/j.biopha.2021.111422_bib120","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-37640-1","article-title":"Electrospun patterned porous scaffolds for the support of ovarian follicles growth: a feasibility study","volume":"9","author":"Liverani","year":"2019","journal-title":"Sci. Rep."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332221002079?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332221002079?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T13:18:01Z","timestamp":1774531081000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332221002079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":120,"alternative-id":["S0753332221002079"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2021.111422","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advances in the applications of polymer biomaterials for in vitro follicle culture","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2021.111422","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"111422"}}