{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:18:50Z","timestamp":1791559130321,"version":"4.3.4"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T00:00:00Z","timestamp":1625529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.biopha.2021.111908","type":"journal-article","created":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T12:40:11Z","timestamp":1625920811000},"page":"111908","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Supplementation of cumin seed powder prevents oxidative stress, hyperlipidemia and non-alcoholic fatty liver in high fat diet fed rats"],"prefix":"10.1016","volume":"141","author":[{"given":"Pintu","family":"Miah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surovi Binte Sharmin","family":"Mohona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Mizanur","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nusrat","family":"Subhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdous","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemayet","family":"Hossain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shazid Md.","family":"Sharker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Ashraful","family":"Alam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.biopha.2021.111908_bib1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1177\/1043659618786363","article-title":"Early care and education teacher\u2019s role in obesity prevention and healthy development of young American Indian children","volume":"30","author":"Kracht","year":"2018","journal-title":"J. Transcult. Nurs."},{"key":"10.1016\/j.biopha.2021.111908_bib2","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/964236","article-title":"Overweight and obesity epidemic in developing countries: a problem with diet, physical activity, or socioeconomic status?","volume":"2014","author":"Bhurosy","year":"2014","journal-title":"Sci. World J."},{"key":"10.1016\/j.biopha.2021.111908_bib3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev-publhealth-031816-044604","article-title":"Obesity in low- and middle-income countries: burden, drivers, and emerging challenges","volume":"38","author":"Ford","year":"2017","journal-title":"Annu. Rev. Public Health"},{"issue":"6","key":"10.1016\/j.biopha.2021.111908_bib4","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.2105\/AJPH.2009.159491","article-title":"Obesity stigma: important considerations for public health","volume":"100","author":"Puhl","year":"2010","journal-title":"Am. J. Public Health"},{"issue":"1","key":"10.1016\/j.biopha.2021.111908_bib5","first-page":"1","article-title":"Investigation of aflatoxin levels in chips by HPLC using post-column UV derivatization system","volume":"22","author":"Catak","year":"2020","journal-title":"Prog. Nutr."},{"key":"10.1016\/j.biopha.2021.111908_bib6","unstructured":"World Health Organization, Obesity and overweight, (2018)."},{"issue":"1","key":"10.1016\/j.biopha.2021.111908_bib7","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1161\/CIRCULATIONAHA.111.087213","article-title":"Energy balance and obesity","volume":"126","author":"Hill","year":"2012","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.biopha.2021.111908_bib8","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.bpg.2014.07.008","article-title":"Non-alcoholic fatty liver disease, obesity and the metabolic syndrome","volume":"28","author":"Dietrich","year":"2014","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"10.1016\/j.biopha.2021.111908_bib9","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.metabol.2018.11.005","article-title":"Obesity and dyslipidemia","volume":"92","author":"Vekic","year":"2019","journal-title":"Metab. Clin. Exp."},{"issue":"1","key":"10.1016\/j.biopha.2021.111908_bib10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3390\/nu11010051","article-title":"Higher fecal short-chain fatty acid levels are associated with gut microbiome dysbiosis, obesity, hypertension and cardiometabolic disease risk factors","volume":"11","author":"De la Cuesta-Zuluaga","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.biopha.2021.111908_bib11","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1194\/jlr.R087510","article-title":"Muscle and adipose tissue insulin resistance: malady without mechanism?","volume":"60","author":"Fazakerley","year":"2019","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.biopha.2021.111908_bib12","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/hep.23280","article-title":"Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications","volume":"51","author":"Fabbrini","year":"2010","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.biopha.2021.111908_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cld.2013.09.019","article-title":"Obesity and liver disease: the epidemic of the twenty-first century","volume":"18","author":"Corey","year":"2014","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.biopha.2021.111908_bib14","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/9547613","article-title":"Role of oxidative stress in pathophysiology of nonalcoholic fatty liver disease","volume":"2018","author":"Masarone","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.biopha.2021.111908_bib15","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1089\/met.2015.0095","article-title":"Oxidative stress, adipose tissue dysfunction, and the associated health risks: causes and therapeutic strategies","volume":"13","author":"Manna","year":"2015","journal-title":"Metab. Syndr. Relat. Disord."},{"key":"10.1016\/j.biopha.2021.111908_bib16","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1179\/1351000213Y.0000000050","article-title":"The relationship between oxidative stress and nonalcoholic fatty liver disease: its effects on the development of nonalcoholic steatohepatitis","volume":"18","author":"Ucar","year":"2013","journal-title":"Redox Rep."},{"key":"10.1016\/j.biopha.2021.111908_bib17","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s12944-017-0539-x","article-title":"Cardamom powder supplementation prevents obesity, improves glucose intolerance, inflammation and oxidative stress in liver of high carbohydrate high fat diet induced obese rats","volume":"16","author":"Rahman","year":"2017","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.biopha.2021.111908_bib18","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1089\/ars.2014.6108","article-title":"Myeloperoxidase-hepatocyte-stellate cell cross talk promotes hepatocyte injury and fibrosis in experimental nonalcoholic steatohepatitis","volume":"23","author":"Pulli","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.biopha.2021.111908_bib19","doi-asserted-by":"crossref","first-page":"5934","DOI":"10.1136\/bmj.f5934","article-title":"Bariatric surgery versus non-surgical treatment for obesity: a systematic review and meta-analysis of randomised controlled trials","volume":"347","author":"Gloy","year":"2013","journal-title":"BMJ"},{"issue":"11","key":"10.1016\/j.biopha.2021.111908_bib20","doi-asserted-by":"crossref","first-page":"773","DOI":"10.2459\/JCM.0000000000000146","article-title":"coupling in hypertension: methodological considerations and clinical implications","volume":"15","author":"Saba","year":"2014","journal-title":"J. Cardiovasc. Med."},{"issue":"1","key":"10.1016\/j.biopha.2021.111908_bib21","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.foodchem.2012.04.074","article-title":"Phenolic compounds and plant extracts as potential natural anti-obesity substances","volume":"135","author":"Sergent","year":"2012","journal-title":"J. Food Chem."},{"key":"10.1016\/j.biopha.2021.111908_bib22","doi-asserted-by":"crossref","first-page":"96969","DOI":"10.1371\/journal.pone.0096969","article-title":"Gallic acid ameliorated impaired glucose and lipid homeostasis in high fat diet-induced NAFLD mice","volume":"9","author":"Chao","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.biopha.2021.111908_bib23","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1039\/c2fo30249g","article-title":"Dietary spices as beneficial modulators of lipid profile in conditions of metabolic disorders and diseases","volume":"4","author":"Srinivasan","year":"2013","journal-title":"Food Funct."},{"key":"10.1016\/j.biopha.2021.111908_bib24","series-title":"Cumin (Cuminum cyminum L.) Oils","first-page":"377","article-title":"Essential oils in food preservation, flavor and safety","author":"Mandal","year":"2016"},{"issue":"11","key":"10.1016\/j.biopha.2021.111908_bib25","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1002\/jsfa.4513","article-title":"Essential oils and fatty acids composition of Tunisian and Indian cumin (Cuminum cyminum L.) seeds: a comparative study","volume":"91","author":"Bettaieb","year":"2011","journal-title":"J. Sci. Food Agric."},{"issue":"2","key":"10.1016\/j.biopha.2021.111908_bib26","first-page":"101","article-title":"Cumin (Cuminum cyminum) as a potential source of antioxidants","volume":"22","author":"Nadeem","year":"2012","journal-title":"Pak. J. Food Sci."},{"issue":"1","key":"10.1016\/j.biopha.2021.111908_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/fqsafe\/fyx031","article-title":"Cumin (Cuminum cyminum) and black cumin (Nigella sativa) seeds: traditional uses, chemical constituents, and nutraceutical effects","volume":"2","author":"Srinivasan","year":"2018","journal-title":"Food Qual. Saf."},{"issue":"8\u20139","key":"10.1016\/j.biopha.2021.111908_bib28","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1016\/j.fct.2010.04.048","article-title":"Antihyperglycemic activity and inhibition of advanced glycation end product formation by Cuminum cyminum in streptozotocin induced diabetic rats","volume":"48","author":"Jagtap","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2021.111908_bib29","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/474509","article-title":"Anti-inflammatory effects of cumin essential oil by blocking JNK, ERK, and NF-\u03baB signaling pathways in LPS-stimulated RAW 264.7 cells","volume":"2015","author":"Wei","year":"2015","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"10.1016\/j.biopha.2021.111908_bib30","first-page":"39","article-title":"Effects of cumin extract on oxLDL, paraoxanase 1 activity, FBS, total cholesterol, triglycerides, HDL-C, LDL-C, Apo A1, and Apo B in in the patients with hypercholesterolemia","volume":"8","author":"Samani","year":"2014","journal-title":"Int. J. Health Sci."},{"issue":"17","key":"10.1016\/j.biopha.2021.111908_bib31","first-page":"2116","article-title":"Antioxidant properties and HPLC assay of bioactive polyphenols of the ethanol extract of Excoecaria agallocha stem bark growing in Bangladesh","volume":"4","author":"Jahan","year":"2014","journal-title":"J. Pharm. Res. Int."},{"key":"10.1016\/j.biopha.2021.111908_bib32","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1186\/s12906-017-1799-8","article-title":"Supplementation of Syzygium cumini seed powder prevented obesity, glucose intolerance, hyperlipidemia and oxidative stress in high carbohydrate high fat diet induced obese rats","volume":"17","author":"Ulla","year":"2017","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.biopha.2021.111908_bib33","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1432-1033.1968.tb00428.x","article-title":"Formation of malonaldehyde from phospholipid arachidonate during microsomal lipid peroxidation","volume":"6","author":"Niehaus","year":"1968","journal-title":"Eur. J. Biochem."},{"issue":"3","key":"10.1016\/j.biopha.2021.111908_bib34","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/S0022-3565(25)24521-9","article-title":"Lipopolysaccharide-induced changes in plasma nitrite and nitrate concentrations in rats and mice: pharmacological evaluation of nitric oxide synthase inhibitors","volume":"272","author":"Tracey","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.biopha.2021.111908_bib35","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/608590","article-title":"Efficacy of composite extract from leaves and fruits of medicinal plants used in traditional diabetic therapy against oxidative stress in alloxan-induced diabetic rats","volume":"2014","author":"Tiwari","year":"2014","journal-title":"ISRN Pharmacol."},{"key":"10.1016\/j.biopha.2021.111908_bib36","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s12944-017-0539-x","article-title":"Cardamom powder supplementation prevents obesity, improves glucose intolerance, inflammation and oxidative stress in liver of high carbohydrate high fat diet induced obese rats","volume":"16","author":"Rahman","year":"2017","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.biopha.2021.111908_bib37","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","article-title":"The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase","volume":"247","author":"Misra","year":"1972","journal-title":"J. Bio. Chem."},{"key":"10.1016\/j.biopha.2021.111908_bib38","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000136485","article-title":"Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3, 4-bromobenzene oxide as the hepatotoxic metabolite","volume":"11","author":"Jollow","year":"1974","journal-title":"Pharmacology"},{"issue":"5","key":"10.1016\/j.biopha.2021.111908_bib39","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.soard.2006.07.006","article-title":"The Swedish obese subjects study\u2014what has been accomplished to date?","volume":"2","author":"Ryden","year":"2006","journal-title":"Surg. Obes. Relat. Dis."},{"issue":"2","key":"10.1016\/j.biopha.2021.111908_bib40","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1210\/er.2017-00253","article-title":"The science of obesity management: an endocrine society scientific statement","volume":"39","author":"Bray","year":"2018","journal-title":"Endocr. Rev."},{"issue":"2","key":"10.1016\/j.biopha.2021.111908_bib41","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1017\/S0954422410000168","article-title":"High-fat diet-induced obesity in animal models","volume":"23","author":"Hariri","year":"2010","journal-title":"Nutr. Res. Rev."},{"issue":"1","key":"10.1016\/j.biopha.2021.111908_bib42","doi-asserted-by":"crossref","DOI":"10.1002\/0471141755.ph0561s58","article-title":"Overview of animal models of obesity","volume":"58","author":"Lutz","year":"2012","journal-title":"Curr. Protoc. Pharmacol."},{"key":"10.1016\/j.biopha.2021.111908_bib43","doi-asserted-by":"crossref","DOI":"10.5812\/ircmj.34212","article-title":"The effect of Cumin cyminum L. plus lime administration on weight loss and metabolic status in overweight subjects: a randomized double-blind placebo-controlled clinical trial","volume":"18","author":"Taghizadeh","year":"2016","journal-title":"Iran. Red. Crescent Med. J."},{"key":"10.1016\/j.biopha.2021.111908_bib44","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.ctcp.2014.10.001","article-title":"Effect of cumin powder on body composition and lipid profile in overweight and obese women","volume":"20","author":"Zare","year":"2014","journal-title":"Complement. Ther. Clin. Pract."},{"key":"10.1016\/j.biopha.2021.111908_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112355","article-title":"Measurement of visceral fat: should we include retroperitoneal fat?","volume":"9","author":"Hung","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.biopha.2021.111908_bib46","doi-asserted-by":"crossref","first-page":"56","DOI":"10.2337\/db10-0697","article-title":"The portal theory supported by venous drainage-selective fat transplantation","volume":"60","author":"Rytka","year":"2011","journal-title":"Diabetes"},{"issue":"5","key":"10.1016\/j.biopha.2021.111908_bib47","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1358\/mf.2004.26.5.831322","article-title":"Reversal of glucose intolerance by by pioglitazone in high fat diet-fed rats","volume":"26","author":"Srinivasan","year":"2004","journal-title":"Methods Find Exp. Clin. Pharmacol."},{"issue":"8","key":"10.1016\/j.biopha.2021.111908_bib48","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.metabol.2008.03.010","article-title":"Increased oxidative stress precedes the onset of high-fat diet\u2013induced insulin resistance and obesity","volume":"57","author":"Matsuzawa-Nagata","year":"2008","journal-title":"Metab. Clin. Exp."},{"key":"10.1016\/j.biopha.2021.111908_bib49","doi-asserted-by":"crossref","first-page":"4617","DOI":"10.1074\/jbc.M411863200","article-title":"The hyperglycemia-induced inflammatory response in adipocytes the role of reactive oxygen species","volume":"280","author":"Lin","year":"2005","journal-title":"J. Bio. Chem."},{"issue":"2","key":"10.1016\/j.biopha.2021.111908_bib50","first-page":"127","article-title":"Obesity and oxidative stress: role of antioxidant supplementation","volume":"61","author":"Valdecantos","year":"2009","journal-title":"Rev. Invest. Clin."},{"issue":"8\u20139","key":"10.1016\/j.biopha.2021.111908_bib51","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1016\/j.fct.2010.04.048","article-title":"Antihyperglycemic activity and inhibition of advanced glycation end product formation by Cuminum cyminum in streptozotocin induced diabetic rats","volume":"48","author":"Jagtap","year":"2010","journal-title":"Food Chem. Toxicol."},{"issue":"8","key":"10.1016\/j.biopha.2021.111908_bib52","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1017\/S0007114513000627","article-title":"Insulinotropic and \u03b2-cell protective action of cuminaldehyde, cuminol and an inhibitor isolated from Cuminum cyminum in streptozotocin-induced diabetic rats","volume":"110","author":"Patil","year":"2013","journal-title":"Br. J. Nutr."},{"issue":"11\u201312","key":"10.1016\/j.biopha.2021.111908_bib53","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.nut.2006.08.018","article-title":"Effect of antioxidant capacity on blood lipid metabolism and lipoprotein lipase activity of rats fed a high-fat diet","volume":"22","author":"Yang","year":"2006","journal-title":"Nutrition"},{"key":"10.1016\/j.biopha.2021.111908_bib54","first-page":"10","article-title":"A high-fat, high-fructose diet induces antioxidant imbalance and increases the risk and progression of nonalcoholic fatty liver disease in mice","volume":"2016","author":"Jarukamjorn","year":"2016","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.biopha.2021.111908_bib55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chemphyslip.2008.09.004","article-title":"Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and\/or pathological conditions","volume":"157","author":"Catala","year":"2009","journal-title":"Chem. Phys. Lipids"},{"issue":"3","key":"10.1016\/j.biopha.2021.111908_bib56","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1271\/bbb.64.555","article-title":"Increased hepatic activity of inducible nitric oxide synthase in rats fed on a high-fat diet","volume":"64","author":"Wan","year":"2000","journal-title":"Biosci. Biotechnol. Biochem."},{"issue":"19","key":"10.1016\/j.biopha.2021.111908_bib57","doi-asserted-by":"crossref","first-page":"10410","DOI":"10.1021\/jf102248j","article-title":"Essential oils, phenolics, and antioxidant activities of different parts of cumin (Cuminum cyminum L.)","volume":"58","author":"Bettaieb","year":"2010","journal-title":"J. Agric. Food Chem."},{"issue":"4","key":"10.1016\/j.biopha.2021.111908_bib58","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/s11130-014-0442-9","article-title":"Ripening stage and extraction method effects on physical properties, polyphenol composition and antioxidant activities of cumin (Cuminum cyminum L.) seeds","volume":"69","author":"Rebey","year":"2014","journal-title":"Plant Foods Hum. Nutr."},{"key":"10.1016\/j.biopha.2021.111908_bib59","first-page":"2026","article-title":"Comparative study of hepatoprotective effect produced by Cuminum cyminum, fruits of Phyllanthus emblicus and silymarin against cisplatin-induced hepatotoxicity","volume":"8","author":"Abbas","year":"2017","journal-title":"Int. J. Pharm. Sci. Res."},{"issue":"4","key":"10.1016\/j.biopha.2021.111908_bib60","first-page":"506","article-title":"Hepatoprotective investigations of Cuminum cyminum dried seeds in nimesulide intoxicated albino rats by phytochemical and biochemical methods","volume":"6","author":"Mushtaq","year":"2014","journal-title":"Int. J. Pharm. Pharm. Sci."},{"key":"10.1016\/j.biopha.2021.111908_bib61","first-page":"416","article-title":"Therapeutic role of Cuminum cyminum on ethanol and thermally oxidized sunflower oil induced toxicity","volume":"19","author":"Aruna","year":"2005","journal-title":"Phytother. Res. Int. J. Devoted Pharmacol. Toxicol. Eval. Nat. Prod. Deriv."},{"key":"10.1016\/j.biopha.2021.111908_bib62","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13098-018-0307-8","article-title":"Dietary fat stimulates development of NAFLD more potently than dietary fructose in Sprague-Dawley rats","volume":"10","author":"Jensen","year":"2018","journal-title":"Diabetol. Metab. Syndr."},{"issue":"1","key":"10.1016\/j.biopha.2021.111908_bib63","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/FJC.0b013e3181feb90a","article-title":"High-carbohydrate high-fat diet\u2013induced metabolic syndrome and cardiovascular remodeling in rats","volume":"57","author":"Panchal","year":"2011","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"3","key":"10.1016\/j.biopha.2021.111908_bib64","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S1043-6618(02)00131-7","article-title":"Hypolipidemic effect of Cuminum cyminum L. on alloxan-induced diabetic rats","volume":"46","author":"Dhandapani","year":"2002","journal-title":"Pharmacol. Res."},{"issue":"2","key":"10.1016\/j.biopha.2021.111908_bib65","doi-asserted-by":"crossref","first-page":"92","DOI":"10.4103\/0253-7613.51353","article-title":"Effects of methanolic extract of Cuminum cyminum on total serum cholesterol in ovariectomized rats","volume":"41","author":"Shirke","year":"2009","journal-title":"Indian J. Pharmacol."},{"issue":"6","key":"10.1016\/j.biopha.2021.111908_bib66","doi-asserted-by":"crossref","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory responses and inflammation-associated diseases in organs","volume":"9","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.biopha.2021.111908_bib67","first-page":"1","article-title":"Oxidative stress and hepatic stellate cells: a paradoxical relationship","volume":"7","author":"Gandhi","year":"2012","journal-title":"Trends Cell Mol. Biol."},{"issue":"4","key":"10.1016\/j.biopha.2021.111908_bib68","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.jhep.2011.05.008","article-title":"Iron in fatty liver and in the metabolic syndrome: a promising therapeutic target","volume":"55","author":"Dongiovanni","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.biopha.2021.111908_bib69","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev.pa.02.040162.000435","article-title":"The relationship between chemical structure and pharmacological activity","volume":"2","author":"Bloom","year":"1962","journal-title":"Ann. Rev. Pharmacol."},{"key":"10.1016\/j.biopha.2021.111908_bib70","doi-asserted-by":"crossref","first-page":"S112","DOI":"10.1038\/ejcn.2010.221","article-title":"Identification of the 100 richest dietary sources of polyphenols: an application of the Phenol-Explorer database","volume":"64","author":"Perez-Jimenez","year":"2010","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.biopha.2021.111908_bib71","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/10496475.2013.861379","article-title":"Comparative study on antioxidant potential and phytochemical composition of cumin and fennel","volume":"20","author":"Usha Rani","year":"2014","journal-title":"J. Herbs Spices Med. Plants"},{"issue":"1","key":"10.1016\/j.biopha.2021.111908_bib72","first-page":"1","article-title":"A monographic profile on quality specifications for a herbal drug and spice of commerce-Cuminum cyminum L.","volume":"1","author":"Rai","year":"2012","journal-title":"Int. J. Adv. Herbal Sci. Technol."},{"key":"10.1016\/j.biopha.2021.111908_bib73","doi-asserted-by":"crossref","first-page":"3814","DOI":"10.1007\/s13197-016-2372-z","article-title":"Nutraceutical properties of cumin residue generated from Ayurvedic industries using cell line models","volume":"53","author":"Arun","year":"2016","journal-title":"J. Food Sci. Technol."},{"key":"10.1016\/j.biopha.2021.111908_bib74","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.foodchem.2016.09.178","article-title":"A computational investigation on the structure, global parameters and antioxidant capacity of a polyphenol, Gallic acid","volume":"220","author":"Rajan","year":"2017","journal-title":"Food Chem."},{"key":"10.1016\/j.biopha.2021.111908_bib75","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.biopha.2017.10.001","article-title":"Mechanisms of antidiabetic effects of flavonoid rutin","volume":"96","author":"Ghorbani","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2021.111908_bib76","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.tiv.2017.01.016","article-title":"Antioxidant activity of rosmarinic acid and its principal metabolites in chemical and cellular systems: importance of physico-chemical characteristics","volume":"40","author":"Adomako-Bonsu","year":"2017","journal-title":"Toxicol. Vitro"},{"issue":"1","key":"10.1016\/j.biopha.2021.111908_bib77","first-page":"19","article-title":"Preformulation studies of myricetin: a natural antioxidant flavonoid","volume":"69","author":"Yao","year":"2014","journal-title":"Die Pharm. \u2013 Int. J. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.biopha.2021.111908_bib78","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.lwt.2012.11.014","article-title":"Phenolic compounds and antioxidant properties of gooseberry as affected by in vitro digestion","volume":"51","author":"Chiang","year":"2013","journal-title":"LWT-Food Sci. Technol."},{"issue":"2","key":"10.1016\/j.biopha.2021.111908_bib79","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.lwt.2013.09.017","article-title":"In vitro comparison of antioxidant capacity of cumin (Cuminum cyminum L.) oils and their main components","volume":"55","author":"Chen","year":"2014","journal-title":"LWT-Food Sci. Technol."},{"key":"10.1016\/j.biopha.2021.111908_bib80","doi-asserted-by":"crossref","first-page":"702","DOI":"10.3109\/13880209.2010.541923","article-title":"Cuminum cyminum extract attenuates scopolamine-induced memory loss and stress-induced urinary biochemical changes in rats: a noninvasive biochemical approach","volume":"49","author":"Koppula","year":"2011","journal-title":"Pharm. Biol."},{"issue":"10","key":"10.1016\/j.biopha.2021.111908_bib81","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3390\/foods8100437","article-title":"Postprandial glycemic and insulinemic effects of the addition of aqueous extracts of dried corn silk, cumin seed powder or tamarind pulp, in two forms, consumed with high glycemic index rice","volume":"8","author":"Haldar","year":"2019","journal-title":"Foods"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332221006909?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332221006909?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T21:15:17Z","timestamp":1776460517000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332221006909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":81,"alternative-id":["S0753332221006909"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2021.111908","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Supplementation of cumin seed powder prevents oxidative stress, hyperlipidemia and non-alcoholic fatty liver in high fat diet fed rats","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2021.111908","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"111908"}}