{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T23:52:40Z","timestamp":1779148360938,"version":"3.51.4"},"reference-count":223,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T00:00:00Z","timestamp":1629158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.biopha.2021.112079","type":"journal-article","created":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T22:59:41Z","timestamp":1630018781000},"page":"112079","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Drosophila as a model to explore secondary injury cascades after traumatic brain injury"],"prefix":"10.1016","volume":"142","author":[{"given":"Lori M.","family":"Buhlman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gokul","family":"Krishna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. Bucky","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa Currier","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2021.112079_bib1","first-page":"1","article-title":"Estimating the global incidence of traumatic brain injury","author":"Dewan","year":"2018","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.biopha.2021.112079_bib2","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.neubiorev.2017.05.022","article-title":"Elucidating opportunities and pitfalls in the treatment of experimental traumatic brain injury to optimize and facilitate clinical translation","volume":"85","author":"de la Tremblaye","year":"2018","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"8","key":"10.1016\/j.biopha.2021.112079_bib3","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/S1474-4422(08)70164-9","article-title":"Moderate and severe traumatic brain injury in adults","volume":"7","author":"Maas","year":"2008","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.biopha.2021.112079_bib4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/B978-0-444-52892-6.00001-5","article-title":"Epidemiology of traumatic brain injury","volume":"127","author":"Faul","year":"2015","journal-title":"Handb. Clin. Neurol."},{"issue":"Pt B","key":"10.1016\/j.biopha.2021.112079_bib5","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.mcn.2015.03.001","article-title":"Epidemiology of mild traumatic brain injury and neurodegenerative disease","volume":"66","author":"Gardner","year":"2015","journal-title":"Mol. Cell. Neurosci."},{"issue":"5","key":"10.1016\/j.biopha.2021.112079_bib6","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/S1474-4422(15)00002-2","article-title":"Diagnosis, prognosis, and clinical management of mild traumatic brain injury","volume":"14","author":"Levin","year":"2015","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.biopha.2021.112079_bib7","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1515\/revneuro-2015-0017","article-title":"Traumatic brain injury: a risk factor for neurodegenerative diseases","volume":"27","author":"Gupta","year":"2016","journal-title":"Rev. Neurosci."},{"issue":"2","key":"10.1016\/j.biopha.2021.112079_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21020588","article-title":"Approaches to monitor circuit disruption after traumatic brain injury: frontiers in preclinical research","volume":"21","author":"Krishna","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.biopha.2021.112079_bib9","doi-asserted-by":"crossref","first-page":"633","DOI":"10.3171\/jns.1997.86.4.0633","article-title":"Cerebral blood flow as a predictor of outcome following traumatic brain injury","volume":"86","author":"Kelly","year":"1997","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.biopha.2021.112079_bib10","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.wneu.2019.10.048","article-title":"Cortical spreading depression in the setting of traumatic brain injury","volume":"134","author":"Soldozy","year":"2020","journal-title":"World Neurosurg."},{"key":"10.1016\/j.biopha.2021.112079_bib11","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3389\/fphar.2012.00060","article-title":"Altered calcium signaling following traumatic brain injury","volume":"3","author":"Weber","year":"2012","journal-title":"Front. Pharmacol."},{"issue":"Suppl. S18\u201325","key":"10.1016\/j.biopha.2021.112079_bib12","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1038\/nrn1434","article-title":"Oxidative stress in neurodegeneration: cause or consequence?","volume":"10","author":"Andersen","year":"2004","journal-title":"Nat. Med."},{"issue":"12","key":"10.1016\/j.biopha.2021.112079_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20123048","article-title":"Proteasome and autophagy-mediated Impairment of Late Long-Term Potentiation (l-LTP) after traumatic brain injury in the somatosensory cortex of mice","volume":"20","author":"Feldmann","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.biopha.2021.112079_bib14","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.4161\/15548627.2014.981787","article-title":"Impaired autophagy flux is associated with neuronal cell death after traumatic brain injury","volume":"10","author":"Sarkar","year":"2014","journal-title":"Autophagy"},{"issue":"6","key":"10.1016\/j.biopha.2021.112079_bib15","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1089\/ars.2015.6306","article-title":"Function and mechanisms of autophagy in brain and spinal cord trauma","volume":"23","author":"Lipinski","year":"2015","journal-title":"Antioxid. Redox Signal."},{"issue":"7","key":"10.1016\/j.biopha.2021.112079_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/cells8070693","article-title":"Autophagy in neurotrauma: good, bad, or dysregulated","volume":"8","author":"Wu","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.biopha.2021.112079_bib17","doi-asserted-by":"crossref","first-page":"528","DOI":"10.3389\/fncel.2019.00528","article-title":"Traumatic brain injuries: pathophysiology and potential therapeutic targets","volume":"13","author":"Ng","year":"2019","journal-title":"Front. Cell. Neurosci."},{"issue":"1","key":"10.1016\/j.biopha.2021.112079_bib18","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s10787-017-0396-2","article-title":"Anti-inflammatory effects of Ginkgo biloba extract against trimethyltin-induced hippocampal neuronal injury","volume":"26","author":"Kaur","year":"2018","journal-title":"Inflammopharmacology"},{"issue":"8","key":"10.1016\/j.biopha.2021.112079_bib19","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.bbi.2012.06.008","article-title":"Neuroinflammation after traumatic brain injury: opportunities for therapeutic intervention","volume":"26","author":"Kumar","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.biopha.2021.112079_bib20","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jneuroim.2019.04.005","article-title":"The immunological response to traumatic brain injury","volume":"332","author":"Needham","year":"2019","journal-title":"J. Neuroimmunol."},{"issue":"26","key":"10.1016\/j.biopha.2021.112079_bib21","first-page":"4284","article-title":"Bridge between neuroimmunity and traumatic brain injury","volume":"20","author":"Kelso","year":"2014","journal-title":"Curr. Pharm. Des."},{"issue":"2","key":"10.1016\/j.biopha.2021.112079_bib22","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.expneurol.2005.12.017","article-title":"Traumatic axonal injury in the perisomatic domain triggers ultrarapid secondary axotomy and Wallerian degeneration","volume":"198","author":"Kelley","year":"2006","journal-title":"Exp. Neurol."},{"issue":"5","key":"10.1016\/j.biopha.2021.112079_bib23","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.tins.2016.03.002","article-title":"Traumatic axonal injury: mechanisms and translational opportunities","volume":"39","author":"Hill","year":"2016","journal-title":"Trends Neurosci."},{"issue":"1","key":"10.1016\/j.biopha.2021.112079_bib24","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.neuron.2015.05.019","article-title":"Dealing with danger in the CNS: the response of the immune system to injury","volume":"87","author":"Gadani","year":"2015","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.biopha.2021.112079_bib25","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/imm.12677","article-title":"Understanding the regulation of pattern recognition receptors in inflammatory diseases \u2013 a \u2018Nod\u2019 in the right direction","volume":"150","author":"Feerick","year":"2017","journal-title":"Immunology"},{"issue":"3","key":"10.1016\/j.biopha.2021.112079_bib26","doi-asserted-by":"crossref","first-page":"931","DOI":"10.3233\/JAD-201186","article-title":"Broader insights into understanding tumor necrosis factor and neurodegenerative disease pathogenesis infer new therapeutic approaches","volume":"79","author":"Clark","year":"2021","journal-title":"J. Alzheimers Dis."},{"issue":"2","key":"10.1016\/j.biopha.2021.112079_bib27","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s10571-010-9617-6","article-title":"Increased expression of TNF receptor-associated factor 6 after rat traumatic brain injury","volume":"31","author":"Chen","year":"2011","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.biopha.2021.112079_bib28","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.2147\/JIR.S284471","article-title":"Approved drugs as JNK3 inhibitor for prevention of neuroinflammation induced by MCAO in rats","volume":"13","author":"Zulfiqar","year":"2020","journal-title":"J. Inflamm. Res."},{"issue":"2","key":"10.1016\/j.biopha.2021.112079_bib29","first-page":"166","article-title":"Effect of expression of c-jun N-terminal kinase on neuron autophagy following diffuse brain injury in rats","volume":"50","author":"Hong","year":"2012","journal-title":"Zhonghua Wai Ke Za Zhi"},{"key":"10.1016\/j.biopha.2021.112079_bib30","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ejphar.2017.04.002","article-title":"Anfibatide protects against rat cerebral ischemia\/reperfusion injury via TLR4\/JNK\/caspase-3 pathway","volume":"807","author":"Luo","year":"2017","journal-title":"Eur. J. Pharmacol."},{"issue":"23","key":"10.1016\/j.biopha.2021.112079_bib31","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1089\/neu.2014.3352","article-title":"Long-term consequences of traumatic brain injury: current status of potential mechanisms of injury and neurological outcomes","volume":"32","author":"Bramlett","year":"2015","journal-title":"J. Neurotrauma"},{"issue":"3","key":"10.1016\/j.biopha.2021.112079_bib32","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nrneurol.2017.13","article-title":"The far-reaching scope of neuroinflammation after traumatic brain injury","volume":"13","author":"Simon","year":"2017","journal-title":"Nat. Rev. Neurol."},{"issue":"2","key":"10.1016\/j.biopha.2021.112079_bib33","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/aja.2010.162","article-title":"Three important components in the regeneration of the cavernous nerve: brain-derived neurotrophic factor, vascular endothelial growth factor and the JAK\/STAT signaling pathway","volume":"13","author":"Zhang","year":"2011","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.biopha.2021.112079_bib34","first-page":"29510","article-title":"Effects of JAK2-STAT3 signaling after cerebral insults","volume":"3","author":"Raible","year":"2014","journal-title":"JAKSTAT"},{"issue":"1","key":"10.1016\/j.biopha.2021.112079_bib35","first-page":"321","article-title":"Effect of the JAK2\/STAT3 signaling pathway on nerve cell apoptosis in rats with white matter injury","volume":"23","author":"Chen","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.biopha.2021.112079_bib36","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.expneurol.2015.07.001","article-title":"JAK\/STAT pathway regulation of GABAA receptor expression after differing severities of experimental TBI","volume":"271","author":"Raible","year":"2015","journal-title":"Exp. Neurol."},{"issue":"2","key":"10.1016\/j.biopha.2021.112079_bib37","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1523\/JNEUROSCI.22-02-00446.2002","article-title":"Repetitive mild brain trauma accelerates Abeta deposition, lipid peroxidation, and cognitive impairment in a transgenic mouse model of Alzheimer amyloidosis","volume":"22","author":"Uryu","year":"2002","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"issue":"2","key":"10.1016\/j.biopha.2021.112079_bib38","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3233\/JAD-130182","article-title":"Blast exposure causes early and persistent aberrant phospho- and cleaved-tau expression in a murine model of mild blast-induced traumatic brain injury","volume":"37","author":"Huber","year":"2013","journal-title":"J. Alzheimer\u2019s Dis.: JAD"},{"key":"10.1016\/j.biopha.2021.112079_bib39","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.neuropharm.2016.05.001","article-title":"Sodium selenate, a protein phosphatase 2A activator, mitigates hyperphosphorylated tau and improves repeated mild traumatic brain injury outcomes","volume":"108","author":"Tan","year":"2016","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.biopha.2021.112079_bib40","first-page":"461","article-title":"The role of oxidative stress in Parkinson\u2019s disease","volume":"3","author":"Dias","year":"2013","journal-title":"J. Park. Dis."},{"issue":"11","key":"10.1016\/j.biopha.2021.112079_bib41","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1523\/JNEUROSCI.2516-19.2020","article-title":"Interferon-\u03b2 plays a detrimental role in experimental traumatic brain injury by enhancing neuroinflammation that drives chronic neurodegeneration","volume":"40","author":"Barrett","year":"2020","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"issue":"1","key":"10.1016\/j.biopha.2021.112079_bib42","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/NEN.0000000000000021","article-title":"Progressive neurodegeneration after experimental brain trauma: association with chronic microglial activation","volume":"73","author":"Loane","year":"2014","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"1","key":"10.1016\/j.biopha.2021.112079_bib43","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1089\/neu.2015.4339","article-title":"Early and persistent dendritic hypertrophy in the basolateral amygdala following experimental diffuse traumatic brain injury","volume":"34","author":"Hoffman","year":"2017","journal-title":"J. Neurotrauma"},{"issue":"1434","key":"10.1016\/j.biopha.2021.112079_bib44","first-page":"1434","article-title":"Experimental traumatic brain injury induces chronic glutamatergic dysfunction in amygdala circuitry known to regulate anxiety-like behavior","volume":"13","author":"Beitchman","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.biopha.2021.112079_bib45","unstructured":"Krishna G., Bromberg C.E., Thomas T.C. (in press). Circuit reorganization after diffuse axonal injury: Utility of the whisker barrel circuit. In: Diagnosis and Treatment of Traumatic Brain Injury (pp. XX-XX). Rajendram R., Preedy V., Martin C. (Eds). San Diego: Academic Press."},{"issue":"10","key":"10.1016\/j.biopha.2021.112079_bib46","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1093\/jnen\/61.10.831","article-title":"Plasticity-associated molecular and structural events in the injured brain","volume":"61","author":"Keyvani","year":"2002","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"13","key":"10.1016\/j.biopha.2021.112079_bib47","doi-asserted-by":"crossref","first-page":"5089","DOI":"10.1523\/JNEUROSCI.5103-10.2011","article-title":"Diffuse traumatic axonal injury in the mouse induces atrophy, c-Jun activation, and axonal outgrowth in the axotomized neuronal population","volume":"31","author":"Greer","year":"2011","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.biopha.2021.112079_bib48","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1530\/EC-16-0031","article-title":"Diffuse traumatic brain injury affects chronic corticosterone function in the rat","volume":"5","author":"Rowe","year":"2016","journal-title":"Endocr. Connect."},{"key":"10.1016\/j.biopha.2021.112079_bib49","doi-asserted-by":"crossref","first-page":"946","DOI":"10.3389\/fneur.2020.00946","article-title":"Sex-dependent pathology in the HPA axis at a sub-acute period after experimental traumatic brain injury","volume":"11","author":"Bromberg","year":"2020","journal-title":"Front. Neurol."},{"key":"10.1016\/j.biopha.2021.112079_bib50","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.bbr.2016.12.038","article-title":"Does time heal all wounds? Experimental diffuse traumatic brain injury results in persisting histopathology in the thalamus","volume":"340","author":"Thomas","year":"2018","journal-title":"Behav. Brain Res."},{"issue":"Suppl. 1","key":"10.1016\/j.biopha.2021.112079_bib51","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1542\/pir.2018-0069","article-title":"Failure to thrive in a 15-month-old with a history of head trauma","volume":"42","author":"Sukhina","year":"2021","journal-title":"Pediatr. Rev."},{"issue":"1","key":"10.1016\/j.biopha.2021.112079_bib52","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1089\/neur.2020.0019","article-title":"Mild and moderate traumatic brain injury and repeated stress affect corticosterone in the rat","volume":"1","author":"Rowe","year":"2020","journal-title":"Neurotrauma Rep."},{"key":"10.1016\/j.biopha.2021.112079_bib53","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.tins.2020.12.004","article-title":"Bidirectional brain-systemic interactions and outcomes after TBI","volume":"44","author":"Faden","year":"2021","journal-title":"Trends Neurosci."},{"issue":"1","key":"10.1016\/j.biopha.2021.112079_bib54","doi-asserted-by":"crossref","DOI":"10.3390\/nu12010079","article-title":"The gut microbiota affects host pathophysiology as an endocrine organ: a focus on cardiovascular disease","volume":"12","author":"Busnelli","year":"2019","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.biopha.2021.112079_bib55","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nrg1554","article-title":"Research resources for Drosophila: the expanding universe","volume":"6","author":"Matthews","year":"2005","journal-title":"Nat. Rev. Genet."},{"issue":"44","key":"10.1016\/j.biopha.2021.112079_bib56","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1316895110","article-title":"A Drosophila model of closed head traumatic brain injury","volume":"110","author":"Katzenberger","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"100","key":"10.1016\/j.biopha.2021.112079_bib57","first-page":"52905","article-title":"A method to inflict closed head traumatic brain injury in Drosophila","author":"Katzenberger","year":"2015","journal-title":"J. Vis. Exp.: JoVE"},{"issue":"1\u20134","key":"10.1016\/j.biopha.2021.112079_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19336934.2019.1664363","article-title":"Expansion of a fly TBI model to four levels of injury severity reveals synergistic effects of repetitive injury for moderate injury conditions","volume":"13","author":"Putnam","year":"2019","journal-title":"Fly"},{"key":"10.1016\/j.biopha.2021.112079_bib59","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.04790","article-title":"Death following traumatic brain injury in Drosophila is associated with intestinal barrier dysfunction","volume":"4","author":"Katzenberger","year":"2015","journal-title":"Elife"},{"issue":"12","key":"10.1016\/j.biopha.2021.112079_bib60","doi-asserted-by":"crossref","first-page":"4151","DOI":"10.1534\/g3.116.036194","article-title":"Age and diet affect genetically separable secondary injuries that cause acute mortality following traumatic brain injury in Drosophila","volume":"6","author":"Katzenberger","year":"2016","journal-title":"Genes Genomes Genet."},{"issue":"4","key":"10.1016\/j.biopha.2021.112079_bib61","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1534\/genetics.120.303776","article-title":"Survival following traumatic brain injury in Drosophila is increased by heterozygosity for a mutation of the NF-\u03baB innate immune response transcription factor relish","volume":"216","author":"Swanson","year":"2020","journal-title":"Genetics"},{"issue":"9","key":"10.1016\/j.biopha.2021.112079_bib62","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1534\/g3.120.401377","article-title":"Loss of the antimicrobial peptide metchnikowin protects against traumatic brain injury outcomes in Drosophila melanogaster","volume":"10","author":"Swanson","year":"2020","journal-title":"G3"},{"issue":"1","key":"10.1016\/j.biopha.2021.112079_bib63","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12993-019-0163-1","article-title":"Traumatic injury in female Drosophila melanogaster affects the development and induces behavioral abnormalities in the offspring","volume":"15","author":"Chauhan","year":"2019","journal-title":"Behav. Brain Funct."},{"key":"10.1016\/j.biopha.2021.112079_bib64","doi-asserted-by":"crossref","first-page":"25252","DOI":"10.1038\/srep25252","article-title":"Using Drosophila as an integrated model to study mild repetitive traumatic brain injury","volume":"6","author":"Barekat","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2021.112079_bib65","first-page":"55602","article-title":"A novel method to model chronic traumatic encephalopathy in Drosophila","volume":"125","author":"Sun","year":"2017","journal-title":"J. Vis. Exp.: JoVE"},{"key":"10.1016\/j.biopha.2021.112079_bib66","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/oxfordjournals.jbchem.a132339","article-title":"Biochemical studies on the muscle microsomes of Ascaris lumbricoides var. suum. I. Biochemical characterization and electron transport of Ascaris microsomes","volume":"85","author":"van Alphen","year":"1979","journal-title":"J. Biochem."},{"issue":"1","key":"10.1016\/j.biopha.2021.112079_bib67","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s41596-020-00415-y","article-title":"Inducing different severities of traumatic brain injury in Drosophila using a piezoelectric actuator","volume":"16","author":"Saikumar","year":"2021","journal-title":"Nat. Protoc."},{"issue":"29","key":"10.1016\/j.biopha.2021.112079_bib68","doi-asserted-by":"crossref","first-page":"17269","DOI":"10.1073\/pnas.2003909117","article-title":"Dynamic neural and glial responses of a head-specific model for traumatic brain injury in Drosophila","volume":"117","author":"Saikumar","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"6","key":"10.1016\/j.biopha.2021.112079_bib69","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1111\/j.1471-4159.2006.03907.x","article-title":"Oxidative stress and neurodegeneration: where are we now?","volume":"97","author":"Halliwell","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.biopha.2021.112079_bib70","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3389\/fgene.2017.00175","article-title":"Smooth, an hnRNP-L homolog, might decrease mitochondrial metabolism by post-transcriptional regulation of isocitrate dehydrogenase (Idh) and other metabolic genes in the sub-acute phase of traumatic brain injury","volume":"8","author":"Sen","year":"2017","journal-title":"Front. Genet."},{"key":"10.1016\/j.biopha.2021.112079_bib71","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3389\/fnins.2019.00409","article-title":"Mammalian models of traumatic brain injury and a place for Drosophila in TBI research","volume":"13","author":"Shah","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.biopha.2021.112079_bib72","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3389\/fncel.2018.00039","article-title":"Vulnerable Parkin loss-of-function Drosophila dopaminergic neurons have advanced mitochondrial aging, mitochondrial network loss and transiently reduced autophagosome recruitment","volume":"12","author":"Cackovic","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.biopha.2021.112079_bib73","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/9302761","article-title":"Slower dynamics and aged mitochondria in sporadic Alzheimer\u2019s disease","volume":"2017","author":"Mart\u00edn-Maestro","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.biopha.2021.112079_bib74","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.freeradbiomed.2013.06.029","article-title":"Clinical perspective on oxidative stress in sporadic amyotrophic lateral sclerosis","volume":"65","author":"D\u2019Amico","year":"2013","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.biopha.2021.112079_bib75","doi-asserted-by":"crossref","first-page":"981","DOI":"10.3233\/JAD-190863","article-title":"Molecular mechanisms and genetics of oxidative stress in Alzheimer\u2019s disease","volume":"72","author":"Cioffi","year":"2019","journal-title":"J. Alzheimer\u2019s Dis.: JAD"},{"issue":"22","key":"10.1016\/j.biopha.2021.112079_bib76","doi-asserted-by":"crossref","first-page":"8024","DOI":"10.1073\/pnas.0501078102","article-title":"Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson\u2019s disease","volume":"102","author":"Whitworth","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"Suppl. S10\u20137","key":"10.1016\/j.biopha.2021.112079_bib77","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1038\/nm1066","article-title":"Protein aggregation and neurodegenerative disease","volume":"10","author":"Ross","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.biopha.2021.112079_bib78","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.neuint.2017.04.016","article-title":"Nrf2-ARE signaling provides neuroprotection in traumatic brain injury via modulation of the ubiquitin proteasome system","volume":"111","author":"Ding","year":"2017","journal-title":"Neurochem. Int."},{"issue":"8","key":"10.1016\/j.biopha.2021.112079_bib79","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1093\/hmg\/ddy047","article-title":"Traumatic injury induces stress granule formation and enhances motor dysfunctions in ALS\/FTD models","volume":"27","author":"Anderson","year":"2018","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.biopha.2021.112079_bib80","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40035-017-0088-2","article-title":"Pathological correlations between traumatic brain injury and chronic neurodegenerative diseases","volume":"6","author":"Cruz-Haces","year":"2017","journal-title":"Transl. Neurodegener."},{"issue":"6","key":"10.1016\/j.biopha.2021.112079_bib81","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.neuron.2017.07.010","article-title":"Neuroimmunology of traumatic brain injury: time for a paradigm shift","volume":"95","author":"Jassam","year":"2017","journal-title":"Neuron"},{"issue":"10","key":"10.1016\/j.biopha.2021.112079_bib82","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.tins.2015.08.002","article-title":"Priming the inflammatory pump of the CNS after traumatic brain injury","volume":"38","author":"Witcher","year":"2015","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.biopha.2021.112079_bib83","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1146\/annurev.immunol.16.1.225","article-title":"NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses","volume":"16","author":"Ghosh","year":"1998","journal-title":"Annu. Rev. Immunol."},{"issue":"12","key":"10.1016\/j.biopha.2021.112079_bib84","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19123922","article-title":"Drosophila as a model to study brain innate immunity in health and disease","volume":"19","author":"Lye","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.biopha.2021.112079_bib85","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nri2240","article-title":"Phagocytosis and comparative innate immunity: learning on the fly","volume":"8","author":"Stuart","year":"2008","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.biopha.2021.112079_bib86","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S1534-5807(01)00059-4","article-title":"Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis","volume":"1","author":"Georgel","year":"2001","journal-title":"Dev. Cell"},{"issue":"11","key":"10.1016\/j.biopha.2021.112079_bib87","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nri2194","article-title":"The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections","volume":"7","author":"Ferrandon","year":"2007","journal-title":"Nat. Rev. Immunol."},{"issue":"18","key":"10.1016\/j.biopha.2021.112079_bib88","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1101\/gad.909001","article-title":"NF-kappaB signaling pathways in mammalian and insect innate immunity","volume":"15","author":"Silverman","year":"2001","journal-title":"Genes Dev."},{"issue":"5","key":"10.1016\/j.biopha.2021.112079_bib89","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nri.2016.29","article-title":"The immunology of host defence peptides: beyond antimicrobial activity","volume":"16","author":"Hancock","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.biopha.2021.112079_bib90","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000086648","article-title":"Antimicrobial peptides in Drosophila: structures, activities and gene regulation","volume":"86","author":"Imler","year":"2005","journal-title":"Chem. Immunol. Allergy"},{"issue":"6490","key":"10.1016\/j.biopha.2021.112079_bib91","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau5480","article-title":"Antimicrobial peptides: application informed by evolution","volume":"368","author":"Lazzaro","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.biopha.2021.112079_bib92","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1146\/annurev.immunol.25.022106.141615","article-title":"The host defense of Drosophila melanogaster","volume":"25","author":"Lemaitre","year":"2007","journal-title":"Annu. Rev. Immunol."},{"issue":"12","key":"10.1016\/j.biopha.2021.112079_bib93","doi-asserted-by":"crossref","first-page":"4578","DOI":"10.1128\/MCB.01814-06","article-title":"and IMD pathways synergistically activate an innate immune response in Drosophila melanogaster","volume":"27","author":"Tanji","year":"2007","journal-title":"Mol. Cell. Biol."},{"issue":"19","key":"10.1016\/j.biopha.2021.112079_bib94","doi-asserted-by":"crossref","first-page":"E1752","DOI":"10.1073\/pnas.1306220110","article-title":"Dnr1 mutations cause neurodegeneration in Drosophila by activating the innate immune response in the brain","volume":"110","author":"Cao","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"10","key":"10.1016\/j.biopha.2021.112079_bib95","doi-asserted-by":"crossref","first-page":"E605","DOI":"10.1073\/pnas.1110666109","article-title":"Alternative pathway of cell death in Drosophila mediated by NF-kappaB transcription factor Relish","volume":"109","author":"Chinchore","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"4","key":"10.1016\/j.biopha.2021.112079_bib96","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.celrep.2017.04.007","article-title":"NF-kappaB immunity in the brain determines fly lifespan in healthy aging and age-related neurodegeneration","volume":"19","author":"Kounatidis","year":"2017","journal-title":"Cell Rep."},{"issue":"11","key":"10.1016\/j.biopha.2021.112079_bib97","doi-asserted-by":"crossref","first-page":"E656","DOI":"10.1073\/pnas.1110470109","article-title":"ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila","volume":"109","author":"Petersen","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.biopha.2021.112079_bib98","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.coi.2013.12.004","article-title":"Molecular determinants of sterile inflammation","volume":"26","author":"Kono","year":"2014","journal-title":"Curr. Opin. Immunol."},{"issue":"6","key":"10.1016\/j.biopha.2021.112079_bib99","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008312","article-title":"Nitric oxide mediates neuro-glial interaction that shapes Drosophila circadian behavior","volume":"16","author":"Kozlov","year":"2020","journal-title":"PLoS Genet."},{"issue":"9","key":"10.1016\/j.biopha.2021.112079_bib100","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/nrneurol.2017.116","article-title":"The far-reaching scope of neuroinflammation after traumatic brain injury","volume":"13","author":"Simon","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.biopha.2021.112079_bib101","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3389\/fneur.2020.00511","article-title":"Drosophila exhibit divergent sex-based responses in transcription and motor function after traumatic brain injury","volume":"11","author":"Shah","year":"2020","journal-title":"Front. Neurol."},{"key":"10.1016\/j.biopha.2021.112079_bib102","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.bbi.2019.04.023","article-title":"Normal aging hyperactivates innate immunity and reduces the medical efficacy of minocycline in brain injury","volume":"80","author":"Sanuki","year":"2019","journal-title":"Brain Behav. Immun."},{"issue":"15","key":"10.1016\/j.biopha.2021.112079_bib103","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1101\/gad.203301","article-title":"Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel\/NF-kappaB-dependent innate immune responses","volume":"15","author":"Vidal","year":"2001","journal-title":"Genes Dev."},{"issue":"4","key":"10.1016\/j.biopha.2021.112079_bib104","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1534\/genetics.120.303776","article-title":"Survival following traumatic brain injury in Drosophila is increased by heterozygosity for a mutation of the NF-kappaB innate immune response transcription factor Relish","volume":"216","author":"Swanson","year":"2020","journal-title":"Genetics"},{"issue":"3","key":"10.1016\/j.biopha.2021.112079_bib105","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1074\/jbc.M111.269431","article-title":"Sh3rf2\/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein","volume":"287","author":"Wilhelm","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.biopha.2021.112079_bib106","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1089\/ars.2012.5149","article-title":"Reactive oxygen species in inflammation and tissue injury","volume":"20","author":"Mittal","year":"2014","journal-title":"Antioxid. Redox Signal."},{"issue":"5","key":"10.1016\/j.biopha.2021.112079_bib107","doi-asserted-by":"crossref","first-page":"R192","DOI":"10.1016\/j.cub.2016.01.033","article-title":"Tissue repair: how to inflame your neighbours","volume":"26","author":"Meier","year":"2016","journal-title":"Curr. Biol.: CB"},{"issue":"5","key":"10.1016\/j.biopha.2021.112079_bib108","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1101\/gad.1168104","article-title":"Targeting of TAK1 by the NF-kappa B protein Relish regulates the JNK-mediated immune response in Drosophila","volume":"18","author":"Park","year":"2004","journal-title":"Genes Dev."},{"issue":"2","key":"10.1016\/j.biopha.2021.112079_bib109","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.neulet.2011.05.001","article-title":"Activation of JAK2\/STAT pathway in cerebral cortex after experimental traumatic brain injury of rats","volume":"498","author":"Zhao","year":"2011","journal-title":"Neurosci. Lett."},{"issue":"9","key":"10.1016\/j.biopha.2021.112079_bib110","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1371\/journal.pbio.0050238","article-title":"Down-regulation of NF-kappaB target genes by the AP-1 and STAT complex during the innate immune response in Drosophila","volume":"5","author":"Kim","year":"2007","journal-title":"PLoS Biol."},{"issue":"23","key":"10.1016\/j.biopha.2021.112079_bib111","doi-asserted-by":"crossref","first-page":"6010","DOI":"10.1523\/JNEUROSCI.0101-08.2008","article-title":"Axonal injury and regeneration in the adult brain of Drosophila","volume":"28","author":"Ayaz","year":"2008","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"issue":"6","key":"10.1016\/j.biopha.2021.112079_bib112","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.neuron.2006.04.028","article-title":"The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons","volume":"50","author":"MacDonald","year":"2006","journal-title":"Neuron"},{"issue":"15","key":"10.1016\/j.biopha.2021.112079_bib113","doi-asserted-by":"crossref","first-page":"4768","DOI":"10.1523\/JNEUROSCI.5951-08.2009","article-title":"Ensheathing glia function as phagocytes in the adult Drosophila brain","volume":"29","author":"Doherty","year":"2009","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"issue":"11","key":"10.1016\/j.biopha.2021.112079_bib114","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001985","article-title":"PI3K signaling and Stat92E converge to modulate glial responsiveness to axonal injury","volume":"12","author":"Doherty","year":"2014","journal-title":"PLoS Biol."},{"issue":"11","key":"10.1016\/j.biopha.2021.112079_bib115","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a020552","article-title":"Drosophila central nervous system glia","volume":"7","author":"Freeman","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"9","key":"10.1016\/j.biopha.2021.112079_bib116","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1038\/cdd.2013.30","article-title":"The c-Jun kinase signaling cascade promotes glial engulfment activity through activation of draper and phagocytic function","volume":"20","author":"Macdonald","year":"2013","journal-title":"Cell Death Differ."},{"issue":"8","key":"10.1016\/j.biopha.2021.112079_bib117","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001133","article-title":"The glial regenerative response to central nervous system injury is enabled by pros-notch and pros-NF\u03baB feedback","volume":"9","author":"Kato","year":"2011","journal-title":"PLoS Biol."},{"issue":"6","key":"10.1016\/j.biopha.2021.112079_bib118","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/nm1056","article-title":"cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury","volume":"10","author":"Pearse","year":"2004","journal-title":"Nat. Med."},{"issue":"12 Pt B","key":"10.1016\/j.biopha.2021.112079_bib119","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/j.bbadis.2014.07.012","article-title":"The role of soluble adenylyl cyclase in neurite outgrowth","volume":"1842","author":"Stiles","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.biopha.2021.112079_bib120","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.celrep.2013.12.022","article-title":"Dendrite injury triggers DLK-independent regeneration","volume":"6","author":"Stone","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.biopha.2021.112079_bib121","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.3389\/fnins.2019.01140","article-title":"Dietary supplementation with the ketogenic diet metabolite beta-hydroxybutyrate ameliorates post-TBI aggression in young-adult male Drosophila","volume":"13","author":"Lee","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.biopha.2021.112079_bib122","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3389\/fneur.2020.00401","article-title":"Loss of highwire protects against the deleterious effects of traumatic brain injury in Drosophila melanogaster","volume":"11","author":"Hill","year":"2020","journal-title":"Front. Neurol."},{"issue":"6","key":"10.1016\/j.biopha.2021.112079_bib123","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1089\/neu.2007.0398","article-title":"Cerebral apoptosis in severe traumatic brain injury patients: an in vitro, in vivo, and postmortem study","volume":"25","author":"Mi\u00f1ambres","year":"2008","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.biopha.2021.112079_bib124","doi-asserted-by":"crossref","first-page":"24547","DOI":"10.1038\/srep24547","article-title":"Therapeutic hypothermia attenuates tissue damage and cytokine expression after traumatic brain injury by inhibiting necroptosis in the rat","volume":"6","author":"Liu","year":"2016","journal-title":"Sci. Rep."},{"issue":"5159","key":"10.1016\/j.biopha.2021.112079_bib125","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1126\/science.8171319","article-title":"Genetic control of programmed cell death in Drosophila","volume":"264","author":"White","year":"1994","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.biopha.2021.112079_bib126","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.semcdb.2005.01.002","article-title":"Genetic control of programmed cell death in Drosophila melanogaster","volume":"16","author":"Cashio","year":"2005","journal-title":"Semin. Cell Dev. Biol."},{"issue":"5","key":"10.1016\/j.biopha.2021.112079_bib127","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S1097-2765(00)80386-X","article-title":"Control of the cell death pathway by Dapaf-1, a Drosophila Apaf-1\/CED-4-related caspase activator","volume":"4","author":"Kanuka","year":"1999","journal-title":"Mol. Cell"},{"issue":"5","key":"10.1016\/j.biopha.2021.112079_bib128","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/12984","article-title":"Dark is a Drosophila homologue of Apaf-1\/CED-4 and functions in an evolutionarily conserved death pathway","volume":"1","author":"Rodriguez","year":"1999","journal-title":"Nat. Cell Biol."},{"issue":"5","key":"10.1016\/j.biopha.2021.112079_bib129","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S1097-2765(00)80385-8","article-title":"HAC-1, a Drosophila homolog of APAF-1 and CED-4 functions in developmental and radiation-induced apoptosis","volume":"4","author":"Zhou","year":"1999","journal-title":"Mol. Cell"},{"issue":"17","key":"10.1016\/j.biopha.2021.112079_bib130","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1242\/dev.02495","article-title":"The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process","volume":"133","author":"Muro","year":"2006","journal-title":"Development"},{"issue":"14","key":"10.1016\/j.biopha.2021.112079_bib131","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.1093\/emboj\/cdg355","article-title":"Buffy, a Drosophila Bcl-2 protein, has anti-apoptotic and cell cycle inhibitory functions","volume":"22","author":"Quinn","year":"2003","journal-title":"EMBO J."},{"issue":"4","key":"10.1016\/j.biopha.2021.112079_bib132","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1083\/jcb.144.4.701","article-title":"Altered cytochrome c display precedes apoptotic cell death in Drosophila","volume":"144","author":"Varkey","year":"1999","journal-title":"J. Cell Biol."},{"issue":"6","key":"10.1016\/j.biopha.2021.112079_bib133","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1083\/jcb.200111107","article-title":"The role of cytochrome c in caspase activation in Drosophila melanogaster cells","volume":"156","author":"Dorstyn","year":"2002","journal-title":"J. Cell Biol."},{"issue":"6","key":"10.1016\/j.biopha.2021.112079_bib134","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1083\/jcb.20112068","article-title":"The role of ARK in stress-induced apoptosis in Drosophila cells","volume":"156","author":"Zimmermann","year":"2002","journal-title":"J. Cell Biol."},{"issue":"13","key":"10.1016\/j.biopha.2021.112079_bib135","doi-asserted-by":"crossref","first-page":"3144","DOI":"10.1038\/sj.emboj.7601745","article-title":"Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease","volume":"26","author":"Challa","year":"2007","journal-title":"EMBO J."},{"issue":"4","key":"10.1016\/j.biopha.2021.112079_bib136","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.bbrc.2007.03.079","article-title":"Evolution of mitochondrial cell death pathway: proapoptotic role of HtrA2\/Omi in Drosophila","volume":"356","author":"Igaki","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.biopha.2021.112079_bib137","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1242\/dev.019042","article-title":"The Bax\/Bak ortholog in Drosophila, Debcl, exerts limited control over programmed cell death","volume":"136","author":"Galindo","year":"2009","journal-title":"Development"},{"issue":"9","key":"10.1016\/j.biopha.2021.112079_bib138","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0960-9822(00)00474-7","article-title":"The Drosophila bcl-2 family member dBorg-1 functions in the apoptotic response to UV-irradiation","volume":"10","author":"Brachmann","year":"2000","journal-title":"Curr. Biol.: CB"},{"issue":"4","key":"10.1016\/j.biopha.2021.112079_bib139","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1083\/jcb.148.4.703","article-title":"Debcl, a proapoptotic Bcl-2 homologue, is a component of the Drosophila melanogaster cell death machinery","volume":"148","author":"Colussi","year":"2000","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.biopha.2021.112079_bib140","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1073\/pnas.97.2.662","article-title":"Drob-1, a Drosophila member of the Bcl-2\/CED-9 family that promotes cell death","volume":"97","author":"Igaki","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"35","key":"10.1016\/j.biopha.2021.112079_bib141","doi-asserted-by":"crossref","first-page":"27303","DOI":"10.1016\/S0021-9258(19)61510-3","article-title":"Drosophila pro-apoptotic Bcl-2\/Bax homologue reveals evolutionary conservation of cell death mechanisms","volume":"275","author":"Zhang","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.biopha.2021.112079_bib142","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.devcel.2008.09.012","article-title":"Inhibitor of apoptosis proteins in eukaryotic evolution and development: a model of thematic conservation","volume":"15","author":"O\u2019Riordan","year":"2008","journal-title":"Dev. Cell"},{"issue":"6","key":"10.1016\/j.biopha.2021.112079_bib143","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/cdd.2008.19","article-title":"The interaction of DIAP1 with dOmi\/HtrA2 regulates cell death in Drosophila","volume":"15","author":"Khan","year":"2008","journal-title":"Cell Death Differ."},{"issue":"3","key":"10.1016\/j.biopha.2021.112079_bib144","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1074\/jbc.M608051200","volume":"282","author":"Huh","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"19","key":"10.1016\/j.biopha.2021.112079_bib145","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1038\/sj.emboj.7600807","article-title":"Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway","volume":"24","author":"Kleino","year":"2005","journal-title":"EMBO J."},{"issue":"10","key":"10.1016\/j.biopha.2021.112079_bib146","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.dci.2007.01.004","article-title":"Iap2 is required for a sustained response in the Drosophila Imd pathway","volume":"31","author":"Valanne","year":"2007","journal-title":"Dev. Comp. Immunol."},{"issue":"5","key":"10.1016\/j.biopha.2021.112079_bib147","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.cub.2015.12.064","article-title":"Extracellular reactive oxygen species drive apoptosis-induced proliferation via Drosophila macrophages","volume":"26","author":"Fogarty","year":"2016","journal-title":"Curr. Biol.: CB"},{"issue":"5","key":"10.1016\/j.biopha.2021.112079_bib148","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.exger.2010.11.003","article-title":"Regulation of Drosophila lifespan by JNK signaling","volume":"46","author":"Biteau","year":"2011","journal-title":"Exp. Gerontol."},{"issue":"7","key":"10.1016\/j.biopha.2021.112079_bib149","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1038\/cdd.2008.65","article-title":"Living with death: the evolution of the mitochondrial pathway of apoptosis in animals","volume":"15","author":"Oberst","year":"2008","journal-title":"Cell Death Differ."},{"issue":"Pt 9","key":"10.1016\/j.biopha.2021.112079_bib150","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1242\/jcs.02377","article-title":"Apoptosis in Drosophila: neither fish nor fowl (nor man, nor worm)","volume":"118","author":"Kornbluth","year":"2005","journal-title":"J. Cell Sci."},{"issue":"10","key":"10.1016\/j.biopha.2021.112079_bib151","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.tcb.2016.06.004","article-title":"An evolutionary perspective on the necroptotic pathway","volume":"26","author":"Dondelinger","year":"2016","journal-title":"Trends Cell Biol."},{"issue":"47","key":"10.1016\/j.biopha.2021.112079_bib152","doi-asserted-by":"crossref","first-page":"18977","DOI":"10.1073\/pnas.1103242108","article-title":"Conserved metabolic energy production pathways govern Eiger\/TNF-induced nonapoptotic cell death","volume":"108","author":"Kanda","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"8","key":"10.1016\/j.biopha.2021.112079_bib153","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/s41419-019-1862-0","article-title":"Characterization of TNF-induced cell death in Drosophila reveals caspase- and JNK-dependent necrosis and its role in tumor suppression","volume":"10","author":"Li","year":"2019","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.biopha.2021.112079_bib154","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.celrep.2014.03.046","article-title":"Necrosis-driven systemic immune response alters SAM metabolism through the FOXO-GNMT axis","volume":"7","author":"Obata","year":"2014","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.biopha.2021.112079_bib155","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cmet.2009.11.010","article-title":"Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster","volume":"11","author":"Bjedov","year":"2010","journal-title":"Cell Metab."},{"issue":"5","key":"10.1016\/j.biopha.2021.112079_bib156","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.cmet.2008.02.010","article-title":"The insulin-regulated CREB coactivaTor torC promotes stress resistance in Drosophila","volume":"7","author":"Wang","year":"2008","journal-title":"Cell Metab."},{"issue":"8","key":"10.1016\/j.biopha.2021.112079_bib157","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/ncb1753","article-title":"Regulation of TORC1 by Rag GTPases in nutrient response","volume":"10","author":"Kim","year":"2008","journal-title":"Nat. Cell Biol."},{"issue":"6","key":"10.1016\/j.biopha.2021.112079_bib158","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s11357-019-00131-w","article-title":"The potential role of necroptosis in inflammaging and aging","volume":"41","author":"Royce","year":"2019","journal-title":"Geroscience"},{"issue":"11","key":"10.1016\/j.biopha.2021.112079_bib159","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1038\/cdd.2015.28","article-title":"Distinct requirements of autophagy-related genes in programmed cell death","volume":"22","author":"Xu","year":"2015","journal-title":"Cell Death Differ."},{"issue":"4","key":"10.1016\/j.biopha.2021.112079_bib160","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1080\/09540260310001606692","article-title":"Post concussion syndrome","volume":"15","author":"Ryan","year":"2003","journal-title":"Int. Rev. Psychiatry"},{"issue":"12","key":"10.1016\/j.biopha.2021.112079_bib161","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.tips.2010.09.005","article-title":"Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies","volume":"31","author":"Loane","year":"2010","journal-title":"Trends Pharmacol. Sci."},{"issue":"4","key":"10.1016\/j.biopha.2021.112079_bib162","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1136\/jnnp-2012-302547","article-title":"Risk of epilepsy after traumatic brain injury: a retrospective population-based cohort study","volume":"84","author":"Yeh","year":"2013","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"9","key":"10.1016\/j.biopha.2021.112079_bib163","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1249\/MSS.0b013e31819fcd1b","article-title":"Brain injury forces of moderate magnitude elicit the fencing response","volume":"41","author":"Hosseini","year":"2009","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.biopha.2021.112079_bib164","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/191562","article-title":"The grasp reflex and moro reflex in infants: hierarchy of primitive reflex responses","volume":"2012","author":"Futagi","year":"2012","journal-title":"Int. J. Pediatr."},{"issue":"2","key":"10.1016\/j.biopha.2021.112079_bib165","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0896-6273(01)00305-1","article-title":"Proprioceptor pathway development is dependent on Math1","volume":"30","author":"Bermingham","year":"2001","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.biopha.2021.112079_bib166","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0896-6273(00)81059-4","article-title":"atonal regulates neurite arborization but does not act as a proneural gene in the Drosophila brain","volume":"25","author":"Hassan","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.biopha.2021.112079_bib167","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2806(08)60013-2","article-title":"Chordotonal organs of insects","volume":"27","author":"Field","year":"1998","journal-title":"Adv. Insect Physiol."},{"issue":"Pt 2","key":"10.1016\/j.biopha.2021.112079_bib168","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1242\/jeb.00075","article-title":"A comparison of visual and haltere-mediated equilibrium reflexes in the fruit fly Drosophila melanogaster","volume":"206","author":"Sherman","year":"2003","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.biopha.2021.112079_bib169","doi-asserted-by":"crossref","DOI":"10.1177\/1179069518824852","article-title":"Can therapeutic hypothermia diminish the impact of traumatic brain injury in Drosophila melanogaster?","volume":"13","author":"Lateef","year":"2019","journal-title":"J. Exp. Neurosci."},{"key":"10.1016\/j.biopha.2021.112079_bib170","doi-asserted-by":"crossref","first-page":"749","DOI":"10.3389\/fneur.2020.00749","article-title":"Traumatic brain injury-induced sex-dependent changes in late-onset sensory hypersensitivity and glutamate neurotransmission","volume":"11","author":"Krishna","year":"2020","journal-title":"Front. Neurol."},{"issue":"12","key":"10.1016\/j.biopha.2021.112079_bib171","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1136\/jnnp.2009.201913","article-title":"Sleep-wake disturbances 3 years after traumatic brain injury","volume":"81","author":"Kempf","year":"2010","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.biopha.2021.112079_bib172","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.bbi.2019.04.034","article-title":"Infections after a traumatic brain injury: the complex interplay between the immune and neurological systems","volume":"79","author":"Sharma","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.biopha.2021.112079_bib173","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bbi.2018.03.033","article-title":"Cellular players that shape evolving pathology and neurodegeneration following traumatic brain injury","volume":"71","author":"Puntambekar","year":"2018","journal-title":"Brain Behav. Immun."},{"issue":"7","key":"10.1016\/j.biopha.2021.112079_bib174","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1111\/j.1572-0241.1998.00338.x","article-title":"Gastric emptying in head-injured patients","volume":"93","author":"Kao","year":"1998","journal-title":"Am. J. Gastroenterol."},{"issue":"6","key":"10.1016\/j.biopha.2021.112079_bib175","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1097\/00005373-199806000-00016","article-title":"Intestinal permeability correlates with severity of injury in trauma patients","volume":"44","author":"Faries","year":"1998","journal-title":"J. Trauma"},{"issue":"2","key":"10.1016\/j.biopha.2021.112079_bib176","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1080\/19336934.2015.1085623","article-title":"The gut reaction to traumatic brain injury","volume":"9","author":"Katzenberger","year":"2015","journal-title":"Fly"},{"key":"10.1016\/j.biopha.2021.112079_bib177","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3389\/fgene.2017.00175","article-title":"Smooth, an hnRNP-L homolog, might decrease mitochondrial metabolism by post-transcriptional regulation of Isocitrate dehydrogenase (Idh) and other metabolic genes in the sub-acute phase of traumatic brain injury","volume":"8","author":"Sen","year":"2017","journal-title":"Front. Genet."},{"key":"10.1016\/j.biopha.2021.112079_bib178","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/sj.embor.7400869","article-title":"A fruitfly\u2019s guide to keeping the brain wired","volume":"8","author":"Leyssen","year":"2007","journal-title":"EMBO Rep."},{"issue":"2","key":"10.1016\/j.biopha.2021.112079_bib179","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1124\/pr.110.003293","article-title":"Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery","volume":"63","author":"Pandey","year":"2011","journal-title":"Pharmacol. Rev."},{"issue":"6","key":"10.1016\/j.biopha.2021.112079_bib180","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nrg2563","article-title":"Maintaining the brain: insight into human neurodegeneration from Drosophila melanogaster mutants","volume":"10","author":"Lessing","year":"2009","journal-title":"Nat. Rev. Genet."},{"issue":"6129","key":"10.1016\/j.biopha.2021.112079_bib181","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1126\/science.1231828","article-title":"Deep homology of arthropod central complex and vertebrate basal Ganglia","volume":"340","author":"Strausfeld","year":"2013","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.biopha.2021.112079_bib182","first-page":"139","article-title":"Evolutionarily conserved mechanisms regulating neural development: lessons from the development of Drosophila peripheral nervous systems","volume":"10","author":"Okano","year":"1997","journal-title":"Hum. Cell"},{"issue":"10","key":"10.1016\/j.biopha.2021.112079_bib183","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1176\/ajp.2006.163.10.1683","article-title":"The nature of genetic influences on behavior: lessons from \u201csimpler\u201d organisms","volume":"163","author":"Kendler","year":"2006","journal-title":"Am. J. Psychiatry"},{"issue":"1\u20132","key":"10.1016\/j.biopha.2021.112079_bib184","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0925-4773(01)00487-7","article-title":"Identification and characterization of the Drosophila tau homolog","volume":"108","author":"Heidary","year":"2001","journal-title":"Mech. Dev."},{"issue":"12","key":"10.1016\/j.biopha.2021.112079_bib185","doi-asserted-by":"crossref","first-page":"3849","DOI":"10.1523\/JNEUROSCI.10-12-03849.1990","article-title":"Identification, secretion, and neural expression of APPL, a Drosophila protein similar to human amyloid protein precursor","volume":"10","author":"Luo","year":"1990","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"issue":"2","key":"10.1016\/j.biopha.2021.112079_bib186","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.nbd.2008.10.014","article-title":"Neurotoxic effects induced by the Drosophila amyloid-beta peptide suggest a conserved toxic function","volume":"33","author":"Carmine-Simmen","year":"2009","journal-title":"Neurobiol. Dis."},{"issue":"7","key":"10.1016\/j.biopha.2021.112079_bib187","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1073\/pnas.0708452105","article-title":"A Drosophila model for LRRK2-linked parkinsonism","volume":"105","author":"Liu","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.biopha.2021.112079_bib188","doi-asserted-by":"crossref","first-page":"F23","DOI":"10.1083\/jcb.150.2.F23","article-title":"A survey of human disease gene counterparts in the Drosophila genome","volume":"150","author":"Fortini","year":"2000","journal-title":"J. Cell Biol."},{"issue":"7097","key":"10.1016\/j.biopha.2021.112079_bib189","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1038\/nature04779","article-title":"Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin","volume":"441","author":"Clark","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2021.112079_bib190","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2148-4-6","article-title":"Evolutionary and functional relationships within the DJ1 superfamily","volume":"4","author":"Bandyopadhyay","year":"2004","journal-title":"BMC Evol. Biol."},{"issue":"7","key":"10.1016\/j.biopha.2021.112079_bib191","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1534\/g3.112.002998","article-title":"Comparison of parallel high-throughput RNA sequencing between knockout of TDP-43 and its overexpression reveals primarily nonreciprocal and nonoverlapping gene expression changes in the central nervous system of Drosophila","volume":"2","author":"Hazelett","year":"2012","journal-title":"G3"},{"issue":"4","key":"10.1016\/j.biopha.2021.112079_bib192","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.cell.2005.06.012","article-title":"The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1\/Senseless proteins","volume":"122","author":"Tsuda","year":"2005","journal-title":"Cell"},{"issue":"1\u20132","key":"10.1016\/j.biopha.2021.112079_bib193","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0378-1119(00)00343-7","article-title":"dfh is a Drosophila homolog of the Friedreich\u2019s ataxia disease gene","volume":"256","author":"Ca\u00f1izares","year":"2000","journal-title":"Gene"},{"issue":"11","key":"10.1016\/j.biopha.2021.112079_bib194","doi-asserted-by":"crossref","first-page":"7052","DOI":"10.1073\/pnas.78.11.7052","article-title":"Superoxide dismutase in Drosophila melanogaster: biochemical and structural characterization of allozyme variants","volume":"78","author":"Lee","year":"1981","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"16","key":"10.1016\/j.biopha.2021.112079_bib195","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1093\/hmg\/ddl173","article-title":"Ataxin-2 and its Drosophila homolog, ATX2, physically assemble with polyribosomes","volume":"15","author":"Satterfield","year":"2006","journal-title":"Hum. Mol. Genet."},{"issue":"9","key":"10.1016\/j.biopha.2021.112079_bib196","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21093055","article-title":"Modeling neurodegenerative disorders in Drosophila melanogaster","volume":"21","author":"Bolus","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"7722","key":"10.1016\/j.biopha.2021.112079_bib197","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s41586-018-0448-9","article-title":"Parkin and PINK1 mitigate STING-induced inflammation","volume":"561","author":"Sliter","year":"2018","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.biopha.2021.112079_bib198","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nrn3880","article-title":"Immune attack: the role of inflammation in Alzheimer disease","volume":"16","author":"Heppner","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"issue":"4","key":"10.1016\/j.biopha.2021.112079_bib199","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1515\/revneuro-2014-0076","article-title":"Autophagy in Alzheimer\u2019s disease","volume":"26","author":"Zare-Shahabadi","year":"2015","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.biopha.2021.112079_bib200","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.neulet.2019.03.016","article-title":"Endo-lysosomal pathway and ubiquitin-proteasome system dysfunction in Alzheimer\u2019s disease pathogenesis","volume":"703","author":"Cao","year":"2019","journal-title":"Neurosci. Lett."},{"issue":"3","key":"10.1016\/j.biopha.2021.112079_bib201","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/s41583-019-0132-6","article-title":"Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease","volume":"20","author":"Butterfield","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"issue":"8","key":"10.1016\/j.biopha.2021.112079_bib202","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24081583","article-title":"Oxidative stress: a key modulator in neurodegenerative diseases","volume":"24","author":"Singh","year":"2019","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.biopha.2021.112079_bib203","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s00401-018-1933-9","article-title":"Inflammation in ALS\/FTD pathogenesis","volume":"137","author":"McCauley","year":"2019","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.biopha.2021.112079_bib204","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.nbd.2018.07.005","article-title":"Autophagy and mitophagy in ALS","volume":"122","author":"Evans","year":"2019","journal-title":"Neurobiol. Dis."},{"issue":"2","key":"10.1016\/j.biopha.2021.112079_bib205","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00415-018-9076-4","article-title":"Spinocerebellar ataxia: an update","volume":"266","author":"Sullivan","year":"2019","journal-title":"J. Neurol."},{"issue":"17","key":"10.1016\/j.biopha.2021.112079_bib206","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1093\/hmg\/ddy198","article-title":"Peripheral blood gene expression reveals an inflammatory transcriptomic signature in Friedreich\u2019s ataxia patients","volume":"27","author":"Nachun","year":"2018","journal-title":"Hum. Mol. Genet."},{"issue":"6","key":"10.1016\/j.biopha.2021.112079_bib207","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nmeth.1212","article-title":"Real-time imaging of the intracellular glutathione redox potential","volume":"5","author":"Gutscher","year":"2008","journal-title":"Nat. Methods"},{"key":"10.1016\/j.biopha.2021.112079_bib208","article-title":"Proximity-based protein thiol oxidation by H2O2-scavenging peroxidases","volume":"059246","author":"Gutscher","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"17","key":"10.1016\/j.biopha.2021.112079_bib209","doi-asserted-by":"crossref","first-page":"12005","DOI":"10.1074\/jbc.M113.530527","article-title":"A novel MitoTimer reporter gene for mitochondrial content, structure, stress, and damage in vivo","volume":"289","author":"Laker","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"5496","key":"10.1016\/j.biopha.2021.112079_bib210","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1126\/science.290.5496.1585","article-title":"\u201cFluorescent timer\u201d: protein that changes color with time","volume":"290","author":"Terskikh","year":"2000","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.biopha.2021.112079_bib211","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0896-6273(00)80877-6","article-title":"Rest in Drosophila is a sleep-like state","volume":"25","author":"Hendricks","year":"2000","journal-title":"Neuron"},{"issue":"5459","key":"10.1016\/j.biopha.2021.112079_bib212","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1126\/science.287.5459.1834","article-title":"Correlates of sleep and waking in Drosophila melanogaster","volume":"287","author":"Shaw","year":"2000","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.biopha.2021.112079_bib213","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1101\/pdb.prot068130","article-title":"Scoring and analyzing aggression in Drosophila","volume":"2012","author":"Certel","year":"2012","journal-title":"Cold Spring Harb. Protoc."},{"issue":"11","key":"10.1016\/j.biopha.2021.112079_bib214","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1101\/pdb.prot071647","article-title":"The best laid plans: analyzing courtship defects in Drosophila","volume":"2012","author":"Goodwin","year":"2012","journal-title":"Cold Spring Harb. Protoc."},{"issue":"1","key":"10.1016\/j.biopha.2021.112079_bib215","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/cptx.52","article-title":"Generating germ-free Drosophila to study gut-microbe interactions: protocol to rear Drosophila under axenic conditions","volume":"77","author":"Kietz","year":"2018","journal-title":"Curr. Protoc. Toxicol."},{"issue":"11","key":"10.1016\/j.biopha.2021.112079_bib216","doi-asserted-by":"crossref","first-page":"5518","DOI":"10.1101\/pdb.prot5518","article-title":"Locomotor activity level monitoring using the Drosophila Activity Monitoring (DAM) System","volume":"2010","author":"Pfeiffenberger","year":"2010","journal-title":"Cold Spring Harb. Protoc."},{"issue":"3","key":"10.1016\/j.biopha.2021.112079_bib217","doi-asserted-by":"crossref","first-page":"550","DOI":"10.4103\/1673-5374.316602","article-title":"Female sex in experimental traumatic brain injury research: forging a path forward","volume":"17","author":"Currier Thomas","year":"2022","journal-title":"Neural Regen. Res."},{"issue":"2","key":"10.1016\/j.biopha.2021.112079_bib218","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cmet.2011.01.005","article-title":"The Drosophila estrogen-related receptor directs a metabolic switch that supports developmental growth","volume":"13","author":"Tennessen","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.biopha.2021.112079_bib219","doi-asserted-by":"crossref","DOI":"10.1089\/neu.2021.0048","article-title":"Mice born to mothers with gravida traumatic brain injury have distorted brain circuitry and altered immune responses","author":"Saber","year":"2021","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.biopha.2021.112079_bib220","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.67587","article-title":"Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology","volume":"10","author":"Anderson","year":"2021","journal-title":"Elife"},{"issue":"4","key":"10.1016\/j.biopha.2021.112079_bib221","doi-asserted-by":"crossref","DOI":"10.3390\/cells10040900","article-title":"Treatment with bacterial biologics promotes healthy aging and traumatic brain injury responses in adult Drosophila, modeling the gut-brain axis and inflammation responses","volume":"10","author":"Molina","year":"2021","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.biopha.2021.112079_bib222","doi-asserted-by":"crossref","DOI":"10.3390\/genes12060917","article-title":"Sex-differences in traumatic brain injury in the absence of Tau in Drosophila","volume":"12","author":"Shah","year":"2021","journal-title":"Genes"},{"key":"10.1016\/j.biopha.2021.112079_bib223","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.628777","article-title":"Inhibiting mitochondrial cytochrome c oxidase downregulates gene transcription after traumatic brain injury in Drosophila","volume":"12","author":"Shah","year":"2021","journal-title":"Front. Physiol."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332221008623?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332221008623?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:44:37Z","timestamp":1760100277000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332221008623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":223,"alternative-id":["S0753332221008623"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2021.112079","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Drosophila as a model to explore secondary injury cascades after traumatic brain injury","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2021.112079","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"112079"}}