{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T13:17:10Z","timestamp":1778505430878,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["142286\/2017"],"award-info":[{"award-number":["142286\/2017"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["301676\/2013\\u20135"],"award-info":[{"award-number":["301676\/2013\\u20135"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["301676\/2013?"],"award-info":[{"award-number":["301676\/2013?"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.biopha.2021.112211","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T23:51:35Z","timestamp":1633477895000},"page":"112211","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Artesunate strongly modulates myeloid and regulatory T cells to prevent LPS-induced systemic inflammation"],"prefix":"10.1016","volume":"143","author":[{"given":"Rubia Isler","family":"Mancuso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana Hofst\u00e4tter","family":"Azambuja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara Teresinha","family":"Olalla Saad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2021.112211_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00280-020-04170-5","article-title":"Artemisinin-type drugs for the treatment of hematological malignancies","volume":"87","author":"Mancuso","year":"2021","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.biopha.2021.112211_bib2","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.pt.2015.10.010","article-title":"A brief history of Qinghaosu","volume":"31","author":"White","year":"2015","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.biopha.2021.112211_bib3","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.pharmthera.2013.12.001","article-title":"Artemisinins: pharmacological actions beyond anti-malarial","volume":"142","author":"Ho","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.biopha.2021.112211_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/435713","article-title":"Anti-inflammatory and immunoregulatory functions of artemisinin and its derivatives","volume":"2015","author":"Shi","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.biopha.2021.112211_bib5","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1093\/rheumatology\/kem014","article-title":"Anti-malarial agent artesunate inhibits TNF-alpha-induced production of proinflammatory cytokines via inhibition of NF-kappaB and PI3 kinase\/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes","volume":"46","author":"X. H","year":"2007","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.biopha.2021.112211_bib6","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1080\/08923973.2016.1267744","article-title":"Artemisinin inhibits inflammatory response via regulating NF-\u03baB and MAPK signaling pathways","volume":"39","author":"Wang","year":"2017","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.biopha.2021.112211_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109181","article-title":"Artemisinin, a potential option to inhibit inflammation and angiogenesis in rosacea","volume":"117","author":"Yuan","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2021.112211_bib8","doi-asserted-by":"crossref","DOI":"10.1186\/1475-2875-12-388","article-title":"Further evidence for an anti-inflammatory role of artesunate in experimental cerebral malaria","volume":"12","author":"Miranda","year":"2013","journal-title":"Malar. J."},{"key":"10.1016\/j.biopha.2021.112211_bib9","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1128\/AAC.01277-10","article-title":"Artemether and artesunate show the highest efficacies in rescuing mice with late-stage cerebral malaria and rapidly decrease leukocyte accumulation in the brain","volume":"55","author":"Clemmer","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.biopha.2021.112211_bib10","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/ilar\/ilx007","article-title":"Murine models of sepsis and trauma: can we bridge the gap?","volume":"58","author":"Stortz","year":"2017","journal-title":"ILAR J."},{"key":"10.1016\/j.biopha.2021.112211_bib11","doi-asserted-by":"crossref","first-page":"13337","DOI":"10.1038\/s41598-020-70390-7","article-title":"Lipopolysaccharide administration for a mouse model of cerebellar ataxia with neuroinflammation","volume":"10","author":"Hong","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2021.112211_bib12","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12929-017-0370-8","article-title":"Comprehensive comparison of three different animal models for systemic inflammation","volume":"24","author":"Seemann","year":"2017","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.biopha.2021.112211_bib13","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1146\/annurev-med-043015-123453","article-title":"Antimalarial drugs as immune modulators: new mechanisms for old drugs","volume":"68","author":"A. J","year":"2017","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.biopha.2021.112211_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104901","article-title":"Anti-malarial drug, artemisinin and its derivatives for the treatment of respiratory diseases","volume":"158","author":"Cheong","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.biopha.2021.112211_bib15","first-page":"1","article-title":"The effect of artemisinin on inflammation-associated lymphangiogenesis in experimental acute colitis","volume":"21","author":"Lee","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2021.112211_bib16","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/imr.12671","article-title":"Dynamic balance of pro- and anti-inflammatory signals controls disease and limits pathology","volume":"285","author":"Cicchese","year":"2018","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.biopha.2021.112211_bib17","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1182\/blood-2005-03-0916","article-title":"Platelets express functional Toll-like receptor-4","volume":"106","author":"Andonegui","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.biopha.2021.112211_bib18","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3109\/09537101003637240","article-title":"Mechanisms underlying the inhibitory effects of lipopolysaccharide on human platelet adhesion","volume":"21","author":"Morganti","year":"2010","journal-title":"Platelets"},{"key":"10.1016\/j.biopha.2021.112211_bib19","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1189\/jlb.1012518","article-title":"LPS-induced systemic inflammation is more severe in P2Y12 null mice","volume":"95","author":"Liverani","year":"2014","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.biopha.2021.112211_bib20","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1159\/000475665","article-title":"Monocyte subsets are differentially lost from the circulation during acute inflammation induced by human experimental endotoxemia","volume":"9","author":"Tak","year":"2017","journal-title":"J. Innate Immun."},{"key":"10.1016\/j.biopha.2021.112211_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.02035","article-title":"Human monocyte subsets and phenotypes in major chronic inflammatory diseases","volume":"10","author":"Kapellos","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.biopha.2021.112211_bib22","doi-asserted-by":"crossref","first-page":"608","DOI":"10.3390\/ijms22020608","article-title":"Artesunate switches monocytes to an inflammatory phenotype with the ability to kill leukemic cells","volume":"22","author":"Mancuso","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2021.112211_bib23","doi-asserted-by":"crossref","first-page":"00651","DOI":"10.1002\/mbo3.651","article-title":"Hemozoin-induced activation of human monocytes toward M2-like phenotype is partially reversed by antimalarial drugs\u2014chloroquine and artemisinin","volume":"8","author":"Bobade","year":"2019","journal-title":"Microbiologyopen"},{"key":"10.1016\/j.biopha.2021.112211_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107284","article-title":"Artemisinin ameliorates intestinal inflammation by skewing macrophages to the M2 phenotype and inhibiting epithelial\u2013mesenchymal transition","volume":"91","author":"Huai","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.biopha.2021.112211_bib25","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.intimp.2019.02.050","article-title":"M1 and M2 macrophage polarization and potentially therapeutic naturally occurring compounds","volume":"70","author":"Wang","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.biopha.2021.112211_bib26","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/imm.12910","article-title":"Implications of macrophage polarization in autoimmunity","volume":"154","author":"Funes","year":"2018","journal-title":"Immunology"},{"key":"10.1016\/j.biopha.2021.112211_bib27","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.bbadis.2015.10.015","article-title":"Myeloid derived suppressor cells in inflammatory conditions of the central nervous system","volume":"1862","author":"Melero-Jerez","year":"2016","journal-title":"Biochim. Biophys. Acta - Mol. Basis Dis."},{"key":"10.1016\/j.biopha.2021.112211_bib28","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.1080\/21691401.2019.1687504","article-title":"The role of myeloid-derived suppressor cells in the pathogenesis of rheumatoid arthritis; anti- or pro-inflammatory cells?","volume":"47","author":"Rajabinejad","year":"2019","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.biopha.2021.112211_bib29","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1182\/blood-2018-11-844548","article-title":"Neutrophil plasticity in the tumor microenvironment","volume":"133","author":"Giese","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.biopha.2021.112211_bib30","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3389\/fphys.2018.00113","article-title":"Neutrophil: a cell with many roles in inflammation or several cell types?","volume":"9","author":"Rosales","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.biopha.2021.112211_bib31","doi-asserted-by":"crossref","first-page":"532","DOI":"10.3389\/fimmu.2020.00532","article-title":"An attempt to polarize human neutrophils toward N1 and N2 phenotypes in vitro","volume":"11","author":"Ohms","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.biopha.2021.112211_bib32","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1038\/aps.2017.185","article-title":"Artemisinin analogue SM934 ameliorates DSS-induced mouse ulcerative colitis via suppressing neutrophils and macrophages","volume":"39","author":"xi Yan","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.biopha.2021.112211_bib33","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.intimp.2015.11.016","article-title":"The anti-malaria drug artesunate inhibits cigarette smoke and ovalbumin concurrent exposure-induced airway inflammation and might reverse glucocorticoid insensitivity","volume":"29","author":"Luo","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.biopha.2021.112211_bib34","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/JLB.1MR0120-196R","article-title":"Mechanisms of T REG cell adaptation to inflammation","volume":"108","author":"Alvarez","year":"2020","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.biopha.2021.112211_bib35","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-020-01759-8","article-title":"Sustained exposure to systemic endotoxin triggers chemokine induction in the brain followed by a rapid influx of leukocytes","volume":"17","author":"Thomson","year":"2020","journal-title":"J. Neuroinflamm."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332221009951?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332221009951?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:59:04Z","timestamp":1778504344000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332221009951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":35,"alternative-id":["S0753332221009951"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2021.112211","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Artesunate strongly modulates myeloid and regulatory T cells to prevent LPS-induced systemic inflammation","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2021.112211","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"112211"}}