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Nutr."},{"issue":"5","key":"10.1016\/j.biopha.2021.112352_bib72","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1136\/gut.20.5.400","article-title":"Rectal absorption of short chain fatty acids in the absence of chloride","volume":"20","author":"McNeil","year":"1979","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.biopha.2021.112352_bib73","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/0016-5085(89)91614-4","article-title":"Short-chain fatty acids stimulate active sodium and chloride absorption in vitro in the rat distal colon","volume":"96","author":"Binder","year":"1989","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.biopha.2021.112352_bib74","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1042\/BJ20050927","article-title":"Cloning and functional identification of slc5a12 as a sodium-coupled low-affinity transporter for monocarboxylates (SMCT2)","volume":"392","author":"Srinivas","year":"2005","journal-title":"Biochem. J."},{"issue":"3","key":"10.1016\/j.biopha.2021.112352_bib75","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1113\/jphysiol.2004.063859","article-title":"The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter","volume":"557","author":"Coady","year":"2004","journal-title":"J. Physiol."},{"issue":"21","key":"10.1016\/j.biopha.2021.112352_bib76","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1016\/j.lfs.2005.10.028","article-title":"SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter","volume":"78","author":"Gupta","year":"2006","journal-title":"Life Sci."},{"issue":"10","key":"10.1016\/j.biopha.2021.112352_bib77","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1172\/JCI1042","article-title":"Na-K-2Cl cotransporter gene expression and function during enterocyte differentiation. Modulation of Cl- secretory capacity by butyrate","volume":"101","author":"Matthews","year":"1998","journal-title":"J. Clin. Investig."},{"issue":"4","key":"10.1016\/j.biopha.2021.112352_bib78","doi-asserted-by":"crossref","first-page":"G687","DOI":"10.1152\/ajpgi.2001.280.4.G687","article-title":"SCFA increase intestinal Na absorption by induction of NHE3 in rat colon and human intestinal C2\/bbe cells","volume":"280","author":"Musch","year":"2001","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"1","key":"10.1016\/j.biopha.2021.112352_bib79","doi-asserted-by":"crossref","first-page":"G374","DOI":"10.1152\/ajpgi.00128.2007","article-title":"Involvement of Sp1 and Sp3 in differential regulation of human NHE3 promoter activity by sodium butyrate and IFN-gamma\/TNF-alpha","volume":"293","author":"Amin","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. 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Chem."},{"issue":"277","key":"10.1016\/j.biopha.2021.112352_bib82","article-title":"Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases","volume":"10","author":"Parada Venegas","year":"2019","journal-title":"Front. Immunol."},{"issue":"28","key":"10.1016\/j.biopha.2021.112352_bib83","doi-asserted-by":"crossref","first-page":"25481","DOI":"10.1074\/jbc.M301403200","article-title":"Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation","volume":"278","author":"Le Poul","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"29","key":"10.1016\/j.biopha.2021.112352_bib84","doi-asserted-by":"crossref","first-page":"26649","DOI":"10.1074\/jbc.C500213200","article-title":"(D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G","volume":"280","author":"Taggart","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.biopha.2021.112352_bib85","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.immuni.2014.05.014","article-title":"Diet, metabolites, and \"western-lifestyle\" inflammatory diseases","volume":"40","author":"Thorburn","year":"2014","journal-title":"Immunity"},{"issue":"17","key":"10.1016\/j.biopha.2021.112352_bib86","doi-asserted-by":"crossref","first-page":"6356","DOI":"10.3390\/ijms21176356","article-title":"Short-chain fatty acids and their association with signalling pathways in inflammation, glucose and lipid metabolism","volume":"21","author":"He","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"13","key":"10.1016\/j.biopha.2021.112352_bib87","doi-asserted-by":"crossref","first-page":"11312","DOI":"10.1074\/jbc.M211609200","article-title":"The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids","volume":"278","author":"Brown","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.biopha.2021.112352_bib88","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1476-5381.2009.00421.x","article-title":"Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3","volume":"158","author":"Milligan","year":"2009","journal-title":"Br. J. 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Chem."},{"issue":"3","key":"10.1016\/j.biopha.2021.112352_bib92","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2220\/biomedres.30.149","article-title":"Expression of short-chain fatty acid receptor GPR41 in the human colon","volume":"30","author":"Tazoe","year":"2009","journal-title":"Biomed. Res."},{"issue":"8","key":"10.1016\/j.biopha.2021.112352_bib93","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042373","article-title":"Duodenal enteroendocrine I-cells contain mRNA transcripts encoding key endocannabinoid and fatty acid receptors","volume":"7","author":"Sykaras","year":"2012","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.biopha.2021.112352_bib94","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00441-005-0140-x","article-title":"Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine","volume":"324","author":"Karaki","year":"2006","journal-title":"Cell Tissue Res."},{"issue":"12","key":"10.1016\/j.biopha.2021.112352_bib95","doi-asserted-by":"crossref","first-page":"5092","DOI":"10.1210\/en.2005-0545","article-title":"Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43","volume":"146","author":"Hong","year":"2005","journal-title":"Endocrinology"},{"issue":"7268","key":"10.1016\/j.biopha.2021.112352_bib96","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1038\/nature08530","article-title":"Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43","volume":"461","author":"Maslowski","year":"2009","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.biopha.2021.112352_bib97","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1677\/joe.0.1760013","article-title":"Reductions in adipose tissue and skeletal growth in rat adult offspring after prenatal leptin exposure","volume":"176","author":"Nilsson","year":"2003","journal-title":"J. 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