{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:49:02Z","timestamp":1792655342906,"version":"4.5.0"},"reference-count":137,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T00:00:00Z","timestamp":1635811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010699","name":"Monash University Malaysia","doi-asserted-by":"publisher","award":["SED-000057"],"award-info":[{"award-number":["SED-000057"]}],"id":[{"id":"10.13039\/501100010699","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.biopha.2021.112396","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T12:44:58Z","timestamp":1636634698000},"page":"112396","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Transitioning pre-clinical glioblastoma models to clinical settings with biomarkers identified in 3D cell-based models: A systematic scoping review"],"prefix":"10.1016","volume":"145","author":[{"given":"Brandon Wee Siang","family":"Phon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhamad N.A.","family":"Kamarudin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saatheeyavaane","family":"Bhuvanendran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ammu K.","family":"Radhakrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2021.112396_bib1","article-title":"Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma","volume":"40","author":"Stupp","year":"2004","journal-title":"New Engl. J. Med."},{"issue":"1","key":"10.1016\/j.biopha.2021.112396_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3171\/2011.2.JNS10998","article-title":"An extent of resection threshold for newly diagnosed glioblastomas","volume":"115","author":"Sanai","year":"2011","journal-title":"J. Neurosurg."},{"issue":"9","key":"10.1016\/j.biopha.2021.112396_bib3","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1093\/neuonc\/nos153","article-title":"A population-based study on the effect of temozolomide in the treatment of glioblastoma multiforme","volume":"14","author":"R\u00f8nning","year":"2012","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.biopha.2021.112396_bib4","doi-asserted-by":"crossref","first-page":"v1","DOI":"10.1093\/neuonc\/noz150","article-title":"CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2012\u20132016","volume":"21","author":"Ostrom","year":"2019","journal-title":"Neuro-Oncol."},{"issue":"4","key":"10.1016\/j.biopha.2021.112396_bib5","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/nrclinonc.2011.34","article-title":"High drug attrition rates\u2014where are we going wrong?","volume":"8","author":"Hutchinson","year":"2011","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.biopha.2021.112396_bib6","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.trecan.2015.10.009","article-title":"Glioblastoma: defining tumor niches","volume":"1","author":"Hambardzumyan","year":"2015","journal-title":"Trends Cancer"},{"issue":"30","key":"10.1016\/j.biopha.2021.112396_bib7","doi-asserted-by":"crossref","first-page":"6076","DOI":"10.1016\/j.biomaterials.2009.07.054","article-title":"Hyaluronic acid-based hydrogels as 3D matrices for in vitro evaluation of chemotherapeutic drugs using poorly adherent prostate cancer cells","volume":"30","author":"Gurski","year":"2009","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.biopha.2021.112396_bib8","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.3892\/or.2015.3767","article-title":"Comparison of 2D- and 3D-culture models as drug-testing platforms in breast cancer","volume":"33","author":"Imamura","year":"2015","journal-title":"Oncol. Rep."},{"issue":"32","key":"10.1016\/j.biopha.2021.112396_bib9","doi-asserted-by":"crossref","first-page":"8494","DOI":"10.1016\/j.biomaterials.2010.07.064","article-title":"Bioengineered 3D platform to explore cell\u2013ECM interactions and drug resistance of epithelial ovarian cancer cells","volume":"31","author":"Loessner","year":"2010","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.biopha.2021.112396_bib10","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.bcp.2013.06.020","article-title":"Animal models of disease: pre-clinical animal models of cancer and their applications and utility in drug discovery","volume":"87","author":"Ruggeri","year":"2014","journal-title":"Biochem. Pharmacol."},{"issue":"5","key":"10.1016\/j.biopha.2021.112396_bib11","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/j.1747-4949.2012.00772.x","article-title":"The use of animal as models: ethical considerations","volume":"7","author":"Levy","year":"2012","journal-title":"Int. J. Stroke"},{"issue":"4","key":"10.1016\/j.biopha.2021.112396_bib12","first-page":"910","article-title":"2D and 3D cell cultures - a comparison of different types of cancer cell cultures","volume":"14","author":"Kapa\u0142czy\u0144ska","year":"2018","journal-title":"Arch. Med. Sci."},{"issue":"3","key":"10.1016\/j.biopha.2021.112396_bib13","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nrm1858","article-title":"Capturing complex 3D tissue physiology in vitro","volume":"7","author":"Griffith","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"5","key":"10.1016\/j.biopha.2021.112396_bib14","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.semcancer.2005.06.009","article-title":"Gene expression perturbation in vitro\u2014a growing case for three-dimensional (3D) culture systems","volume":"15","author":"Birgersdotter","year":"2005","journal-title":"Semin. Cancer Biol."},{"issue":"1","key":"10.1016\/j.biopha.2021.112396_bib15","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"issue":"24","key":"10.1016\/j.biopha.2021.112396_bib16","first-page":"8634","article-title":"Karyotypic complexity of the NCI-60 drug-screening panel","volume":"63","author":"Roschke","year":"2003","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.biopha.2021.112396_bib17","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/73432","article-title":"Systematic variation in gene expression patterns in human cancer cell lines","volume":"24","author":"Ross","year":"2000","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.biopha.2021.112396_bib18","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cell.2004.06.028","article-title":"Single cell profiling of potentiated phospho-protein networks in cancer cells","volume":"118","author":"Irish","year":"2004","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.biopha.2021.112396_bib19","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/35043102","article-title":"Human cancer cell lines: fact and fantasy","volume":"1","author":"Masters","year":"2000","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"7","key":"10.1016\/j.biopha.2021.112396_bib20","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/S0092-8674(02)01229-1","article-title":"Taking the study of cancer cell survival to a new dimension","volume":"111","author":"Jacks","year":"2002","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.biopha.2021.112396_bib21","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/1364557032000119616","article-title":"Scoping studies: towards a methodological framework","volume":"8","author":"Arksey","year":"2005","journal-title":"Int. J. Soc. Res. Methodol."},{"key":"10.1016\/j.biopha.2021.112396_bib22","doi-asserted-by":"crossref","first-page":"b2535","DOI":"10.1136\/bmj.b2535","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"339","author":"Moher","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.biopha.2021.112396_bib23","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.biopha.2021.112396_bib24","unstructured":"VH Innovation, Covidence Systematic Review Software. Melbourne, Australia."},{"issue":"D1","key":"10.1016\/j.biopha.2021.112396_bib25","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.biopha.2021.112396_bib26","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.bbrc.2018.03.114","article-title":"Enrichment of glioma stem cell-like cells on 3D porous scaffolds composed of different extracellular matrix","volume":"498","author":"Wang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.biopha.2021.112396_bib27","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s13402-018-0374-8","article-title":"A HIF-independent, CD133-mediated mechanism of cisplatin resistance in glioblastoma cells","volume":"41","author":"Ahmed","year":"2018","journal-title":"Cell Oncol."},{"key":"10.1016\/j.biopha.2021.112396_bib28","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.colsurfb.2018.09.034","article-title":"The comparison genomics analysis with glioblastoma multiforme (GBM) cells under 3D and 2D cell culture conditions","volume":"172","author":"Ma","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"12","key":"10.1016\/j.biopha.2021.112396_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0052335","article-title":"Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition","volume":"7","author":"Smith","year":"2012","journal-title":"PLoS One"},{"issue":"33","key":"10.1016\/j.biopha.2021.112396_bib30","doi-asserted-by":"crossref","first-page":"9137","DOI":"10.1016\/j.biomaterials.2014.07.037","article-title":"Proliferation and enrichment of CD133+ glioblastoma cancer stem cells on 3D chitosan-alginate scaffolds","volume":"35","author":"Kievit","year":"2014","journal-title":"Biomaterials"},{"issue":"30","key":"10.1016\/j.biopha.2021.112396_bib31","doi-asserted-by":"crossref","first-page":"7408","DOI":"10.1016\/j.biomaterials.2013.06.024","article-title":"Regulation of glioma cell phenotype in 3D matrices by hyaluronic acid","volume":"34","author":"Pedron","year":"2013","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.biopha.2021.112396_bib32","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1002\/jcp.27209","article-title":"The mechanical and pharmacological regulation of glioblastoma cell migration in 3D matrices","volume":"234","author":"Kaphle","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"6","key":"10.1016\/j.biopha.2021.112396_bib33","first-page":"1787","article-title":"Effects of three-dimensional collagen scaffolds on the expression profiles and biological functions of glioma cells","volume":"52","author":"Jia","year":"2018","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.biopha.2021.112396_bib34","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.omto.2020.11.005","article-title":"Anti-oncogenic activities exhibited by paracrine factors of mesenchymal stem cells can be mediated by modulation Of KITLG and DKK1 genes in glioma stem cells, in vitro","volume":"20","author":"Aslam","year":"2020","journal-title":"Mol. Ther. Oncol."},{"issue":"2","key":"10.1016\/j.biopha.2021.112396_bib35","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s11060-019-03107-0","article-title":"A novel 3D in vitro model of glioblastoma reveals resistance to temozolomide which was potentiated by hypoxia","volume":"142","author":"Musah-Eroje","year":"2019","journal-title":"J. Neuro Oncol."},{"issue":"1","key":"10.1016\/j.biopha.2021.112396_bib36","doi-asserted-by":"crossref","first-page":"199","DOI":"10.21873\/invivo.11762","article-title":"Transcriptomic profiling of 3D glioblastoma tumoroids for the identification of mechanisms involved in anticancer drug resistance","volume":"34","author":"Chaicharoenaudomrung","year":"2020","journal-title":"Vivo"},{"key":"10.1016\/j.biopha.2021.112396_bib37","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.biomaterials.2015.11.031","article-title":"Collaboration of 3D context and extracellular matrix in the development of glioma stemness in a 3D model","volume":"78","author":"Ma","year":"2016","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.biopha.2021.112396_bib38","doi-asserted-by":"crossref","first-page":"20085","DOI":"10.1002\/jcp.28608","article-title":"Fabrication of 3D calcium-alginate scaffolds for human glioblastoma modeling and anticancer drug response evaluation","volume":"234","author":"Chaicharoenaudomrung","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.biopha.2021.112396_bib39","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.fob.2014.11.005","article-title":"Secretory prostate apoptosis response (Par)-4 sensitises multicellular spheroids (MCS) of glioblastoma multiforme cells to tamoxifen-induced cell death","volume":"5","author":"Jagtap","year":"2015","journal-title":"FEBS Open Bio"},{"issue":"6","key":"10.1016\/j.biopha.2021.112396_bib40","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1080\/07357900802072913","article-title":"Heterogeneity of human glioblastoma: glutathione-S-transferase and methylguanine-methyltransferase","volume":"26","author":"Juillerat-Jeanneret","year":"2008","journal-title":"Cancer Invest."},{"issue":"10","key":"10.1016\/j.biopha.2021.112396_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2020.100819","article-title":"The neural stem-cell marker CD24 is specifically upregulated in IDH-mutant glioma","volume":"13","author":"Tiburcio","year":"2020","journal-title":"Transl. Oncol."},{"issue":"3","key":"10.1016\/j.biopha.2021.112396_bib42","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s11060-019-03359-w","article-title":"Extracellular glutamate and IDH1R132H inhibitor promote glioma growth by boosting redox potential","volume":"146","author":"Tiburcio","year":"2020","journal-title":"J. Neuro Oncol."},{"issue":"38","key":"10.1016\/j.biopha.2021.112396_bib43","doi-asserted-by":"crossref","first-page":"10143","DOI":"10.1016\/j.biomaterials.2013.09.034","article-title":"Porous chitosan-hyaluronic acid scaffolds as a mimic of glioblastoma microenvironment ECM","volume":"34","author":"Florczyk","year":"2013","journal-title":"Biomaterials"},{"issue":"24","key":"10.1016\/j.biopha.2021.112396_bib44","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1002\/adhm.201600684","article-title":"Culture on 3D chitosan-hyaluronic acid scaffolds enhances stem cell marker expression and drug resistance in human glioblastoma cancer stem cells","volume":"5","author":"Wang","year":"2016","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.biopha.2021.112396_bib45","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.actbio.2020.09.007","article-title":"A comparative study of brain tumor cells from different age and anatomical locations using 3D biomimetic hydrogels","volume":"116","author":"Wang","year":"2020","journal-title":"Acta Biomater."},{"issue":"2","key":"10.1016\/j.biopha.2021.112396_bib46","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/bit.27219","article-title":"Three-dimensional biomimetic hyaluronic acid hydrogels to investigate glioblastoma stem cell behaviors","volume":"117","author":"Nakod","year":"2020","journal-title":"Biotechnol. Bioeng."},{"issue":"2","key":"10.1016\/j.biopha.2021.112396_bib47","first-page":"229","article-title":"A novel 3D human glioblastoma cell culture system for modelling drug and radiation responses","volume":"19","author":"Gomez-Roman","year":"2017","journal-title":"Neuro Oncol."},{"issue":"7","key":"10.1016\/j.biopha.2021.112396_bib48","first-page":"3739","article-title":"Clinical value of CD133 and nestin in patients with glioma: a population-based study","volume":"7","author":"Dahlrot","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"issue":"1","key":"10.1016\/j.biopha.2021.112396_bib49","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1756-9966-27-85","article-title":"Nestin and CD133: valuable stem cell-specific markers for determining clinical outcome of glioma patients","volume":"27","author":"Zhang","year":"2008","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.biopha.2021.112396_bib50","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/9628289","article-title":"Association of glioblastoma multiforme stem cell characteristics, differentiation, and microglia marker genes with patient survival","volume":"2018","author":"Bien-M\u00f6ller","year":"2018","journal-title":"Stem Cells Int."},{"issue":"2","key":"10.1016\/j.biopha.2021.112396_bib51","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.surneu.2006.10.050","article-title":"Neural stem cell markers, nestin and musashi proteins, in the progression of human glioma: correlation of nestin with prognosis of patient survival","volume":"68","author":"Strojnik","year":"2007","journal-title":"Surg. Neurol."},{"key":"10.1016\/j.biopha.2021.112396_bib52","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.wneu.2017.05.099","article-title":"Stemness Marker Detection in the Periphery of Glioblastoma and Ability of Glioblastoma to Generate Glioma Stem Cells: Clinical Correlations","volume":"105","author":"Raysi Dehcordi","year":"2017","journal-title":"World Neurosurg."},{"issue":"5","key":"10.1016\/j.biopha.2021.112396_bib53","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1002\/jcb.25043","article-title":"Immunophenotypic characterization of human glioblastoma stem cells: correlation with clinical outcome","volume":"116","author":"Miconi","year":"2015","journal-title":"J. Cell. Biochem."},{"issue":"8","key":"10.1016\/j.biopha.2021.112396_bib54","first-page":"2215","article-title":"CD24 and nanog expression in stem cells in glioblastoma: correlation with response to chemoradiation and overall survival","volume":"18","author":"Soni","year":"2017","journal-title":"Asian Pac. J. Cancer Prev."},{"issue":"183","key":"10.1016\/j.biopha.2021.112396_bib55","article-title":"Genomics and prognosis analysis of epithelial-mesenchymal transition in glioma","volume":"10","author":"Tao","year":"2020","journal-title":"Front. Oncol."},{"issue":"10","key":"10.1016\/j.biopha.2021.112396_bib56","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1007\/s12031-020-01583-y","article-title":"The prognostic value of EMT in glioma and its role in the glioma immune microenvironment","volume":"70","author":"Ning","year":"2020","journal-title":"J. Mol. Neurosci."},{"issue":"11","key":"10.1016\/j.biopha.2021.112396_bib57","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.3390\/cells8111312","article-title":"Promising prognosis marker candidates on the status of epithelial\u2013mesenchymal transition and glioma stem cells in glioblastoma","volume":"8","author":"Takashima","year":"2019","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.biopha.2021.112396_bib58","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0118201","article-title":"A combined gene signature of hypoxia and notch pathway in human glioblastoma and its prognostic relevance","volume":"10","author":"Irshad","year":"2015","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.biopha.2021.112396_bib59","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1200\/JCO.2004.07.193","article-title":"The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas","volume":"22","author":"Chakravarti","year":"2004","journal-title":"J. Clin. Oncol."},{"issue":"3","key":"10.1016\/j.biopha.2021.112396_bib60","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s11060-018-2819-3","article-title":"ATP binding cassette (ABC) transporters: expression and clinical value in glioblastoma","volume":"138","author":"Dr\u00e9an","year":"2018","journal-title":"J. Neuro Oncol."},{"issue":"1","key":"10.1016\/j.biopha.2021.112396_bib61","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1186\/s12885-020-07481-1","article-title":"Clinical characteristics and prognostic implications of BRCA-associated tumors in males: a pan-tumor survey","volume":"20","author":"Sun","year":"2020","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.biopha.2021.112396_bib62","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s13014-020-01619-y","article-title":"ATM mutations improve radio-sensitivity in wild-type isocitrate dehydrogenase-associated high-grade glioma: retrospective analysis using next-generation sequencing data","volume":"15","author":"Kim","year":"2020","journal-title":"Radiat. Oncol."},{"issue":"6","key":"10.1016\/j.biopha.2021.112396_bib63","doi-asserted-by":"crossref","first-page":"4867","DOI":"10.1002\/jcb.26699","article-title":"ATM and p53 combined analysis predicts survival in glioblastoma multiforme patients: a clinicopathologic study","volume":"119","author":"Romano","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.biopha.2021.112396_bib64","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1100\/2011\/736480","article-title":"The three-layer concentric model of glioblastoma: cancer stem cells, microenvironmental regulation, and therapeutic implications","volume":"11","author":"Persano","year":"2011","journal-title":"ScientificWorldJournal"},{"issue":"15","key":"10.1016\/j.biopha.2021.112396_bib65","doi-asserted-by":"crossref","first-page":"4936","DOI":"10.1158\/1078-0432.CCR-10-1499","article-title":"Stem cell quiescence","volume":"17","author":"Li","year":"2011","journal-title":"Clin. Cancer Res."},{"issue":"7120","key":"10.1016\/j.biopha.2021.112396_bib66","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/nature05236","article-title":"Glioma stem cells promote radioresistance by preferential activation of the DNA damage response","volume":"444","author":"Bao","year":"2006","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.biopha.2021.112396_bib67","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/cr.2012.13","article-title":"Understanding cancer stem cell heterogeneity and plasticity","volume":"22","author":"Tang","year":"2012","journal-title":"Cell Res"},{"issue":"9","key":"10.1016\/j.biopha.2021.112396_bib68","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2011.80","article-title":"Distribution of CD133 reveals glioma stem cells self-renew through symmetric and asymmetric cell divisions","volume":"2","author":"Lathia","year":"2011","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.biopha.2021.112396_bib69","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.stem.2019.11.015","article-title":"Outer radial glia-like cancer stem cells contribute to heterogeneity of glioblastoma","volume":"26","author":"Bhaduri","year":"2020","journal-title":"Cell Stem Cell"},{"issue":"9","key":"10.1016\/j.biopha.2021.112396_bib70","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/mc.22340","article-title":"Regulation of NANOG in cancer cells","volume":"54","author":"Gong","year":"2015","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.biopha.2021.112396_bib71","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.abb.2015.07.005","article-title":"The role of Myc and let-7a in glioblastoma, glucose metabolism and response to therapy","volume":"580","author":"Wang","year":"2015","journal-title":"Arch. Biochem. Biophys."},{"issue":"11","key":"10.1016\/j.biopha.2021.112396_bib72","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003769","article-title":"c-Myc is required for maintenance of glioma cancer stem cells","volume":"3","author":"Wang","year":"2008","journal-title":"PloS One"},{"issue":"7216","key":"10.1016\/j.biopha.2021.112396_bib73","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1038\/nature07443","article-title":"p53 and Pten control neural and glioma stem\/progenitor cell renewal and differentiation","volume":"455","author":"Zheng","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2021.112396_bib74","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1097\/MD.0000000000004764","article-title":"Cancer stem cells: understanding tumor hierarchy and heterogeneity","volume":"95","author":"Rich","year":"2016","journal-title":"Medicine"},{"issue":"6","key":"10.1016\/j.biopha.2021.112396_bib75","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1172\/JCI39104","article-title":"The basics of epithelial-mesenchymal transition","volume":"119","author":"Kalluri","year":"2009","journal-title":"J. Clin. Investig."},{"issue":"11","key":"10.1016\/j.biopha.2021.112396_bib76","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.3390\/ijms20112746","article-title":"Proneural-mesenchymal transition: phenotypic plasticity to acquire multitherapy resistance in glioblastoma","volume":"20","author":"Fedele","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.biopha.2021.112396_bib77","doi-asserted-by":"crossref","first-page":"17727","DOI":"10.1038\/s41598-021-97059-z","article-title":"Gelatin methacrylate hydrogels culture model for glioblastoma cells enriches for mesenchymal-like state and models interactions with immune cells","volume":"11","author":"Shah","year":"2021","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.biopha.2021.112396_bib78","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.3892\/ol.2016.4113","article-title":"Epithelial\u2011mesenchymal transition in glioblastoma progression (Review)","volume":"11","author":"Iwadate","year":"2016","journal-title":"Oncol. Lett."},{"issue":"12","key":"10.1016\/j.biopha.2021.112396_bib79","first-page":"22073","article-title":"Clinical and prognostic significance of HIF-1\u03b1 in glioma patients: a meta-analysis","volume":"8","author":"Liu","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"issue":"5","key":"10.1016\/j.biopha.2021.112396_bib80","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.mam.2008.05.002","article-title":"Progress in matrix metalloproteinase research","volume":"29","author":"Murphy","year":"2008","journal-title":"Mol. Asp. Med."},{"issue":"8","key":"10.1016\/j.biopha.2021.112396_bib81","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/nrn2175","article-title":"Angiogenesis in brain tumours","volume":"8","author":"Jain","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.biopha.2021.112396_bib82","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.phrs.2016.08.004","article-title":"Integrins in glioblastoma: still an attractive target?","volume":"113","author":"Paolillo","year":"2016","journal-title":"Pharmacol. Res."},{"issue":"Pt 2","key":"10.1016\/j.biopha.2021.112396_bib83","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1042\/bj20020809","article-title":"The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3","volume":"369","author":"Ludbrook","year":"2003","journal-title":"Biochem J."},{"issue":"1","key":"10.1016\/j.biopha.2021.112396_bib84","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ydbio.2006.09.048","article-title":"Periostin promotes atrioventricular mesenchyme matrix invasion and remodeling mediated by integrin signaling through Rho\/PI 3-kinase","volume":"302","author":"Butcher","year":"2007","journal-title":"Dev. Biol."},{"issue":"4","key":"10.1016\/j.biopha.2021.112396_bib85","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0123553","article-title":"Endogenous brain pericytes are widely activated and contribute to mouse glioma microvasculature","volume":"10","author":"Svensson","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2021.112396_bib86","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.558961","article-title":"Identification of prognostic model and biomarkers for cancer stem cell characteristics in glioblastoma by network analysis of multi-omics data and stemness indices","volume":"8","author":"Du","year":"2020","journal-title":"Front Cell Dev. Biol."},{"key":"10.1016\/j.biopha.2021.112396_bib87","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ebiom.2018.10.024","article-title":"Identification of a panel of genes as a prognostic biomarker for glioblastoma","volume":"37","author":"Wang","year":"2018","journal-title":"EBioMedicine"},{"issue":"24","key":"10.1016\/j.biopha.2021.112396_bib88","doi-asserted-by":"crossref","first-page":"11419","DOI":"10.1158\/0008-5472.CAN-05-1271","article-title":"ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier","volume":"65","author":"Bronger","year":"2005","journal-title":"Cancer Res."},{"issue":"11","key":"10.1016\/j.biopha.2021.112396_bib89","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1080\/14737175.2016.1202761","article-title":"Blood-brain barrier, cytotoxic chemotherapies and glioblastoma","volume":"16","author":"Dr\u00e9an","year":"2016","journal-title":"Expert Rev. Neurother."},{"issue":"8","key":"10.1016\/j.biopha.2021.112396_bib90","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1093\/brain\/awz202","article-title":"Acquired temozolomide resistance in MGMT-deficient glioblastoma cells is associated with regulation of DNA repair by DHC2","volume":"142","author":"Yi","year":"2019","journal-title":"Brain"},{"issue":"11","key":"10.1016\/j.biopha.2021.112396_bib91","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1158\/1535-7163.MCT-13-0136","article-title":"Contribution of ATM and ATR to the resistance of glioblastoma and malignant melanoma cells to the methylating anticancer drug temozolomide","volume":"12","author":"Eich","year":"2013","journal-title":"Mol. Cancer Ther."},{"issue":"5","key":"10.1016\/j.biopha.2021.112396_bib92","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019659","article-title":"FANCD1\/BRCA2 plays predominant role in the repair of DNA damage induced by ACNU or TMZ","volume":"6","author":"Kondo","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.biopha.2021.112396_bib93","doi-asserted-by":"crossref","first-page":"5045","DOI":"10.1038\/s41598-021-84465-6","article-title":"B2M overexpression correlates with malignancy and immune signatures in human gliomas","volume":"11","author":"Zhang","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2021.112396_bib94","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3389\/fonc.2012.00186","article-title":"Complex DNA repair pathways as possible therapeutic targets to overcome temozolomide resistance in glioblastoma","volume":"2","author":"Yoshimoto","year":"2012","journal-title":"Front. Oncol."},{"issue":"11","key":"10.1016\/j.biopha.2021.112396_bib95","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143285","article-title":"Expression Profile of Genes Related to Drug Metabolism in Human Brain Tumors","volume":"10","author":"Stavrinou","year":"2015","journal-title":"PloS One"},{"issue":"2","key":"10.1016\/j.biopha.2021.112396_bib96","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0360-3016(01)01489-4","article-title":"ATM protein expression correlates with radioresistance in primary glioblastoma cells in culture","volume":"50","author":"Tribius","year":"2001","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.biopha.2021.112396_bib97","first-page":"3","article-title":"Chapter one - cytochrome P450 in pharmacogenetics: an update","volume":"vol 83","author":"Tornio","year":"2018"},{"issue":"2","key":"10.1016\/j.biopha.2021.112396_bib98","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.abb.2010.05.012","article-title":"Glutathione transferases and development of new principles to overcome drug resistance","volume":"500","author":"Sau","year":"2010","journal-title":"Arch. Biochem. Biophys."},{"issue":"7","key":"10.1016\/j.biopha.2021.112396_bib99","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.3390\/cancers13071566","article-title":"UGT1A1 guided cancer therapy: review of the evidence and considerations for clinical implementation","volume":"13","author":"Nelson","year":"2021","journal-title":"Cancers"},{"issue":"3","key":"10.1016\/j.biopha.2021.112396_bib100","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2174\/1389200043335621","article-title":"Cytochrome P450 gene polymorphism and cancer","volume":"5","author":"Agundez","year":"2004","journal-title":"Curr. Drug Metab."},{"issue":"4","key":"10.1016\/j.biopha.2021.112396_bib101","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.coph.2007.06.009","article-title":"Genetic polymorphism and function of glutathione S-transferases in tumor drug resistance","volume":"7","author":"Lo","year":"2007","journal-title":"Curr. Opin. Pharm."},{"issue":"1","key":"10.1016\/j.biopha.2021.112396_bib102","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01054717","article-title":"Glutathione S-transferases and cytochrome P450 detoxifying enzyme distribution in human cerebral glioma","volume":"25","author":"Grant","year":"1995","journal-title":"J. Neuro Oncol."},{"issue":"1","key":"10.1016\/j.biopha.2021.112396_bib103","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1159\/000494496","article-title":"Glutathione S-transferases and cytochrome P450 enzyme expression in patients with intracranial tumors: preliminary report of 55 patients","volume":"28","author":"Kural","year":"2019","journal-title":"Med Princ. Pr."},{"key":"10.1016\/j.biopha.2021.112396_bib104","article-title":"Machine learning revealed stemness features and a novel stemness-based classification with appealing implications in discriminating the prognosis, immunotherapy and temozolomide responses of 906 glioblastoma patients","author":"Wang","year":"2021","journal-title":"Brief. Bioinforma."},{"issue":"1","key":"10.1016\/j.biopha.2021.112396_bib105","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1186\/s12974-018-1330-2","article-title":"The IFN-\u03b3\/PD-L1 axis between T cells and tumor microenvironment: hints for glioma anti-PD-1\/PD-L1 therapy","volume":"15","author":"Qian","year":"2018","journal-title":"J. Neuroinflamm."},{"issue":"60","key":"10.1016\/j.biopha.2021.112396_bib106","doi-asserted-by":"crossref","first-page":"102277","DOI":"10.18632\/oncotarget.20925","article-title":"PPARG c.1347C>T polymorphism is associated with cancer susceptibility: from a case-control study to a meta-analysis","volume":"8","author":"Ding","year":"2017","journal-title":"Oncotarget"},{"issue":"9","key":"10.1016\/j.biopha.2021.112396_bib107","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1158\/1535-7163.MCT-05-0428","article-title":"Genetic alterations associated with acquired temozolomide resistance in SNB-19, a human glioma cell line","volume":"5","author":"Auger","year":"2006","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.biopha.2021.112396_bib108","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.biopha.2018.06.084","article-title":"MAPK8 mediates resistance to temozolomide and apoptosis of glioblastoma cells through MAPK signaling pathway","volume":"106","author":"Xu","year":"2018","journal-title":"Biomed. Pharm."},{"issue":"5","key":"10.1016\/j.biopha.2021.112396_bib109","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20181051","article-title":"Inhibition of microRNA-299-5p sensitises glioblastoma cells to temozolomide via the MAPK\/ERK signaling pathway","volume":"38","author":"Peng","year":"2018","journal-title":"Biosci. Rep."},{"issue":"1","key":"10.1016\/j.biopha.2021.112396_bib110","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/jcmm.13938","article-title":"IL-17A promotes cell migration and invasion of glioblastoma cells via activation of PI3K\/AKT signalling pathway","volume":"23","author":"Zheng","year":"2019","journal-title":"J. Cell Mol. Med."},{"issue":"3","key":"10.1016\/j.biopha.2021.112396_bib111","first-page":"1631","article-title":"Multiflorane suppresses the proliferation, migration and invasion of human glioblastoma by targeting MAPK signalling pathway","volume":"25","author":"Qiu","year":"2020","journal-title":"JBUON"},{"issue":"1","key":"10.1016\/j.biopha.2021.112396_bib112","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s13046-020-01671-2","article-title":"RND2 attenuates apoptosis and autophagy in glioblastoma cells by targeting the p38 MAPK signalling pathway","volume":"39","author":"Xu","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"6","key":"10.1016\/j.biopha.2021.112396_bib113","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/aps.2013.195","article-title":"\u03b3-secretase inhibitor DAPT sensitises t-AUCB-induced apoptosis of human glioblastoma cells in vitro via blocking the p38 MAPK\/MAPKAPK2\/Hsp27 pathway","volume":"35","author":"Li","year":"2014","journal-title":"Acta Pharm. Sin."},{"issue":"3","key":"10.1016\/j.biopha.2021.112396_bib114","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20194255","article-title":"Expression profiles and prognostic significance of WNT family members in glioma via bioinformatic analysis","volume":"40","author":"Xu","year":"2020","journal-title":"Biosci. Rep."},{"issue":"3","key":"10.1016\/j.biopha.2021.112396_bib115","first-page":"641","article-title":"Prognostic relevance of MAPK expression in glioblastoma multiforme","volume":"23","author":"Mawrin","year":"2003","journal-title":"Int. J. Oncol."},{"issue":"5","key":"10.1016\/j.biopha.2021.112396_bib116","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.cell.2008.08.021","article-title":"Cancer cell metabolism: warburg and beyond","volume":"134","author":"Hsu","year":"2008","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.biopha.2021.112396_bib117","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.cmet.2017.11.001","article-title":"JAK\/STAT3-regulated fatty acid and oxidation is critical for breast cancer stem cell self-renewal and chemoresistance","volume":"27","author":"Wang","year":"2018","journal-title":"Cell Metab."},{"issue":"8","key":"10.1016\/j.biopha.2021.112396_bib118","doi-asserted-by":"crossref","first-page":"1700018","DOI":"10.1002\/mabi.201700018","article-title":"The combined influence of hydrogel stiffness and matrix-bound hyaluronic acid content on glioblastoma invasion","volume":"17","author":"Chen","year":"2017","journal-title":"Macromol. Biosci."},{"issue":"3","key":"10.1016\/j.biopha.2021.112396_bib119","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0040083","article-title":"A new description of cellular quiescence","volume":"4","author":"Coller","year":"2006","journal-title":"PLoS Biol."},{"issue":"6","key":"10.1016\/j.biopha.2021.112396_bib120","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nrm3591","article-title":"Molecular regulation of stem cell quiescence","volume":"14","author":"Cheung","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.biopha.2021.112396_bib121","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/cncr.11079","article-title":"Low expression of p27 indicates a poor prognosis in patients with high-grade astrocytomas","volume":"97","author":"Kirla","year":"2003","journal-title":"Cancer"},{"issue":"1","key":"10.1016\/j.biopha.2021.112396_bib122","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1053\/hupa.2003.54","article-title":"Expression of p27KIP1 in human gliomas: relationship between tumor grade, proliferation index, and patient survival","volume":"34","author":"Zagzag","year":"2003","journal-title":"Hum. Pathol."},{"issue":"1","key":"10.1016\/j.biopha.2021.112396_bib123","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1440-1789.2007.00844.x","article-title":"Expression of cell cycle inhibitors p21, p27, p14 and p16 in gliomas. correlation with classic prognostic factors and patients\u2019 outcome","volume":"28","author":"Zolota","year":"2008","journal-title":"Neuropathology"},{"issue":"2","key":"10.1016\/j.biopha.2021.112396_bib124","first-page":"597","article-title":"The combination of low cytoplasmic and high nuclear expression of p27 predicts a better prognosis in high-grade astrocytoma","volume":"29","author":"HIDAKA","year":"2009","journal-title":"Anticancer Res."},{"issue":"8","key":"10.1016\/j.biopha.2021.112396_bib125","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1038\/s41401-020-00551-x","article-title":"Suppression of the USP10\/CCND1 axis induces glioblastoma cell apoptosis","volume":"42","author":"Sun","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"issue":"1620","key":"10.1016\/j.biopha.2021.112396_bib126","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.3389\/fimmu.2020.01620","article-title":"CCND1 amplification contributes to immunosuppression and is associated with a poor prognosis to immune checkpoint inhibitors in solid tumors","volume":"11","author":"Chen","year":"2020","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.biopha.2021.112396_bib127","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1159\/000495920","article-title":"Inhibition of Cyclin D1 expression in human glioblastoma cells is associated with increased temozolomide chemosensitivity","volume":"51","author":"Zhang","year":"2018","journal-title":"Cell Physiol. Biochem."},{"issue":"4","key":"10.1016\/j.biopha.2021.112396_bib128","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/path.5277","article-title":"Cytoplasmic cyclin D1 regulates glioblastoma dissemination","volume":"248","author":"Cemeli","year":"2019","journal-title":"J. Pathol."},{"issue":"84","key":"10.1016\/j.biopha.2021.112396_bib129","article-title":"Knockdown of long non-coding RNA KCNQ1OT1 restrained glioma cells\u2019 malignancy by activating miR-370\/CCNE2 axis","volume":"11","author":"Gong","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.biopha.2021.112396_bib130","doi-asserted-by":"crossref","first-page":"e492","DOI":"10.1016\/j.wneu.2020.02.159","article-title":"Bioinformatical analysis of gene expression omnibus database associates TAF7\/CCNB1, TAF7\/CCNA2, and GTF2E2\/CDC20 pathways with glioblastoma development and prognosis","volume":"138","author":"Yang","year":"2020","journal-title":"World Neurosurg."},{"issue":"9","key":"10.1016\/j.biopha.2021.112396_bib131","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nrm1988","article-title":"The anaphase promoting complex\/cyclosome: a machine designed to destroy","volume":"7","author":"Peters","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"11","key":"10.1016\/j.biopha.2021.112396_bib132","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/j.celrep.2015.05.027","article-title":"A CDC20-APC\/SOX2 signaling axis regulates human glioblastoma stem-like cells","volume":"11","author":"Mao","year":"2015","journal-title":"Cell Rep."},{"issue":"15","key":"10.1016\/j.biopha.2021.112396_bib133","doi-asserted-by":"crossref","first-page":"13241","DOI":"10.18632\/oncotarget.3676","article-title":"CDC20 maintains tumor initiating cells","volume":"6","author":"Xie","year":"2015","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.biopha.2021.112396_bib134","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.molcel.2008.02.027","article-title":"Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A","volume":"30","author":"Wolthuis","year":"2008","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.biopha.2021.112396_bib135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000832","article-title":"U87MG decoded: the genomic sequence of a cytogenetically aberrant human cancer cell line","volume":"6","author":"Clark","year":"2010","journal-title":"PLoS Genet."},{"issue":"3","key":"10.1016\/j.biopha.2021.112396_bib136","first-page":"316","article-title":"Anaplastic human gliomas grown in athymic mice.\u00a0Morphology and glial fibrillary acidic protein expression","volume":"105","author":"Jones","year":"1981","journal-title":"Am. J. Pathol."},{"issue":"4","key":"10.1016\/j.biopha.2021.112396_bib137","doi-asserted-by":"crossref","first-page":"443","DOI":"10.18632\/oncotarget.27457","article-title":"Patient-derived glioblastoma cultures as a tool for small-molecule drug discovery","volume":"11","author":"Ye","year":"2020","journal-title":"Oncotarget"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332221011823?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332221011823?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:33:28Z","timestamp":1781764408000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332221011823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":137,"alternative-id":["S0753332221011823"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2021.112396","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transitioning pre-clinical glioblastoma models to clinical settings with biomarkers identified in 3D cell-based models: A systematic scoping review","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2021.112396","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"112396"}}