{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:57:32Z","timestamp":1787162252613,"version":"build-2736575974"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["109-2221-E-005-012"],"award-info":[{"award-number":["109-2221-E-005-012"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["110-2221-E-005-010"],"award-info":[{"award-number":["110-2221-E-005-010"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.biopha.2021.112586","type":"journal-article","created":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T04:27:38Z","timestamp":1641443258000},"page":"112586","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Cell-derived artificial nanovesicle as a drug delivery system for malignant melanoma treatment"],"prefix":"10.1016","volume":"147","author":[{"given":"Ying-Yi","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Yi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dik-Lung","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Hang","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu-Yu","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Min David","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2021.112586_bib1","first-page":"1","article-title":"Curcumin\u2013silica nanocomplex preparation, hemoglobin and DNA interaction and photocytotoxicity against melanoma cancer cells","author":"Ghazaeian","year":"2020","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.biopha.2021.112586_bib2","series-title":"In.Seminars in oncology nursing","first-page":"160","article-title":"Skin cancer: an overview of epidemiology and risk factors","author":"Gordon","year":"2013"},{"issue":"13","key":"10.1016\/j.biopha.2021.112586_bib3","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.3390\/molecules24132483","article-title":"Evaluating the anti-cancer efficacy of a synthetic curcumin analog on human melanoma cells and its interaction with standard chemotherapeutics","volume":"24","author":"Parashar","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2021.112586_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110883","article-title":"Effects of curcumin based PDT on the viability and the organization of actin in melanotic (A375) and amelanotic melanoma (C32) - in vitro studies","volume":"132","author":"Szlasa","year":"2020","journal-title":"Biomed. Pharm."},{"issue":"37","key":"10.1016\/j.biopha.2021.112586_bib5","doi-asserted-by":"crossref","first-page":"9171","DOI":"10.1021\/jf501665v","article-title":"6-Dehydrogingerdione restrains lipopolysaccharide-induced inflammatory responses in RAW 264.7 macrophages","volume":"62","author":"Huang","year":"2014","journal-title":"J. Agric. Food Chem."},{"issue":"6","key":"10.1016\/j.biopha.2021.112586_bib6","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1021\/jf304340q","article-title":"Enhancements of skin cell proliferations and migrations via 6-dehydrogingerdione","volume":"61","author":"Chen","year":"2013","journal-title":"J. Agric. Food Chem."},{"issue":"12","key":"10.1016\/j.biopha.2021.112586_bib7","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1002\/ptr.3201","article-title":"Zingiber officinale (ginger) compounds have tetracycline\u2010resistance modifying effects against clinical extensively drug\u2010resistant Acinetobacter baumannii","volume":"24","author":"Wang","year":"2010","journal-title":"Phytother. Res."},{"issue":"5","key":"10.1016\/j.biopha.2021.112586_bib8","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1021\/np800555y","article-title":"Antiallergic potential on RBL-2H3 cells of some phenolic constituents of Zingiber officinale (ginger)","volume":"72","author":"Chen","year":"2009","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.biopha.2021.112586_bib9","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.biopha.2017.09.026","article-title":"Curcumin inhibited growth of human melanoma A375 cells via inciting oxidative stress","volume":"95","author":"Liao","year":"2017","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.biopha.2021.112586_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110181","article-title":"Anti prostate cancer therapy: Aptamer-functionalized, curcumin and cabazitaxel co-delivered, tumor targeted lipid-polymer hybrid nanoparticles","volume":"127","author":"Chen","year":"2020","journal-title":"Biomed. Pharm."},{"issue":"9","key":"10.1016\/j.biopha.2021.112586_bib11","doi-asserted-by":"crossref","first-page":"7698","DOI":"10.1021\/nn402232g","article-title":"Bioinspired exosome-mimetic nanovesicles for targeted delivery of chemotherapeutics to malignant tumors","volume":"7","author":"Jang","year":"2013","journal-title":"ACS nano"},{"key":"10.1016\/j.biopha.2021.112586_bib12","article-title":"Biomimetic nanotheranostics camouflaged with cancer cell membranes integrating persistent oxygen supply and homotypic targeting for hypoxic tumor elimination","author":"Chen","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"29","key":"10.1016\/j.biopha.2021.112586_bib13","doi-asserted-by":"crossref","first-page":"20826","DOI":"10.18632\/oncotarget.24846","article-title":"Exosomes in melanoma: a role in tumor progression, metastasis and impaired immune system activity","volume":"9","author":"Tucci","year":"2018","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.biopha.2021.112586_bib14","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3390\/ijms17020175","article-title":"Focus on extracellular vesicles: new frontiers of cell-to-cell communication in cancer","volume":"17","author":"Ciardiello","year":"2016","journal-title":"Int J. Mol. Sci."},{"issue":"116)","key":"10.1016\/j.biopha.2021.112586_bib15","article-title":"Isolation and activation of murine lymphocytes","author":"Lim","year":"2016","journal-title":"J. Vis. Exp."},{"issue":"1","key":"10.1016\/j.biopha.2021.112586_bib16","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.mrrev.2012.08.001","article-title":"In vitro cell migration and invasion assays","volume":"752","author":"Kramer","year":"2013","journal-title":"Mutat. Res Rev. Mutat."},{"issue":"8","key":"10.1016\/j.biopha.2021.112586_bib17","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3390\/antiox8080270","article-title":"Inhibition of LPS-Induced oxidative damages and potential anti-inflammatory effects of Phyllanthus emblica extract via down-regulating NF-\u03baB, COX-2, and iNOS in RAW 264.7 Cells","volume":"8","author":"Wang","year":"2019","journal-title":"Antioxidants"},{"key":"10.1016\/j.biopha.2021.112586_bib18","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.fbio.2019.01.006","article-title":"Inhibitions of melanogenesis via Phyllanthus emblica fruit extract powder in B16F10 cells","volume":"28","author":"Wang","year":"2019","journal-title":"Food Biosci."},{"key":"10.1016\/j.biopha.2021.112586_bib19","first-page":"2020","article-title":"Purified astaxanthin from haematococcus pluvialis promotes tissue regeneration by reducing oxidative stress and the secretion of collagen in vitro and in vivo","author":"Chou","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.biopha.2021.112586_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-020-18626-y","article-title":"Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis","volume":"11","author":"Rao","year":"2020","journal-title":"Nat. Commun."},{"issue":"sup3","key":"10.1016\/j.biopha.2021.112586_bib21","doi-asserted-by":"crossref","first-page":"S166","DOI":"10.1080\/21691401.2018.1489824","article-title":"Novel alternatives to extracellular vesicle-based immunotherapy\u2013exosome mimetics derived from natural killer cells","volume":"46","author":"Zhu","year":"2018","journal-title":"Artif. Cell Nanomed. Biotechnol."},{"key":"10.1016\/j.biopha.2021.112586_bib22","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.2147\/IJN.S131786","article-title":"Doxorubicin-loaded cell-derived nanovesicles: an alternative targeted approach for anti-tumor therapy","volume":"12","author":"Goh","year":"2017","journal-title":"Int J. Nanomed."},{"issue":"1","key":"10.1016\/j.biopha.2021.112586_bib23","doi-asserted-by":"crossref","first-page":"1804105","DOI":"10.1002\/smll.201804105","article-title":"Recent advances in cell membrane\u2013camouflaged nanoparticles for cancer phototherapy","volume":"15","author":"Zhen","year":"2019","journal-title":"Small"},{"key":"10.1016\/j.biopha.2021.112586_bib24","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.taap.2016.02.022","article-title":"Photosensitized 2-amino-3-hydroxypyridine-induced mitochondrial apoptosis via Smac\/DIABLO in human skin cells","volume":"297","author":"Goyal","year":"2016","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.biopha.2021.112586_bib25","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.toxrep.2017.07.008","article-title":"UVB damage onset and progression 24h post exposure in human-derived skin cells","volume":"4","author":"Khalil","year":"2017","journal-title":"Toxicol. Rep."},{"issue":"5","key":"10.1016\/j.biopha.2021.112586_bib26","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1007\/s10495-005-0901-8","article-title":"Differential apoptotic pathways in human keratinocyte HaCaT cells exposed to UVB and UVC","volume":"10","author":"Takasawa","year":"2005","journal-title":"Apoptosis"},{"issue":"3","key":"10.1016\/j.biopha.2021.112586_bib27","doi-asserted-by":"crossref","first-page":"630","DOI":"10.3390\/membranes4030630","article-title":"Calreticulin: roles in cell-surface protein expression","volume":"4","author":"Jiang","year":"2014","journal-title":"Membranes"},{"issue":"4","key":"10.1016\/j.biopha.2021.112586_bib28","first-page":"2189","article-title":"Developmental expression of Sp1 in the mouse","volume":"11","author":"Saffer","year":"1991","journal-title":"Mol. Cell. Biol."},{"issue":"12","key":"10.1016\/j.biopha.2021.112586_bib29","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.3390\/cancers11121847","article-title":"Targeting angiogenesis by blocking the ATM\u2013SerRS\u2013VEGFA pathway for UV-induced skin photodamage and melanoma growth","volume":"11","author":"Song","year":"2019","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.biopha.2021.112586_bib30","first-page":"1","article-title":"Human mesenchymal stem cells are resistant to UV-B irradiation","volume":"9","author":"Perez","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2021.112586_bib31","doi-asserted-by":"crossref","first-page":"8571","DOI":"10.2147\/IJN.S239172","article-title":"Noninvasive molecular imaging of the enhanced permeability and retention effect by 64Cu-liposomes: in vivo correlations with 68Ga-RGD, fluid pressure, diffusivity and 18F-FDG","volume":"15","author":"B\u00f8rresen","year":"2020","journal-title":"Int J. Nanomed."},{"issue":"12","key":"10.1016\/j.biopha.2021.112586_bib32","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1039\/c1np00051a","article-title":"Multitargeting by curcumin as revealed by molecular interaction studies","volume":"28","author":"Gupta","year":"2011","journal-title":"Nat. Prod. Rep."},{"issue":"105","key":"10.1016\/j.biopha.2021.112586_bib33","doi-asserted-by":"crossref","first-page":"103275","DOI":"10.1039\/C6RA24256A","article-title":"Effect of pH and temperature on conformational equilibria and aggregation behaviour of curcumin in aqueous binary mixtures of ethanol","volume":"6","author":"Bhatia","year":"2016","journal-title":"RSC Adv."},{"issue":"2","key":"10.1016\/j.biopha.2021.112586_bib34","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00280-018-3616-6","article-title":"Pulmonary administration of curcumin inhibits B16F10 melanoma lung metastasis and invasion in mice","volume":"82","author":"Shimada","year":"2018","journal-title":"Cancer Chemother. Pharm."},{"issue":"8","key":"10.1016\/j.biopha.2021.112586_bib35","doi-asserted-by":"crossref","first-page":"694","DOI":"10.3109\/1061186X.2016.1157883","article-title":"Oral bioavailability of curcumin: problems and advancements","volume":"24","author":"Liu","year":"2016","journal-title":"J. Drug Target"},{"issue":"11","key":"10.1016\/j.biopha.2021.112586_bib36","doi-asserted-by":"crossref","first-page":"97","DOI":"10.14715\/cmb\/2017.63.11.17","article-title":"Curcumin induce DNA damage and apoptosis through generation of reactive oxygen species and reducing mitochondrial membrane potential in melanoma cancer cells","volume":"63","author":"Kocyigit","year":"2017","journal-title":"Cell Mol. Biol."},{"key":"10.1016\/j.biopha.2021.112586_bib37","first-page":"2013","article-title":"Functional ginger extracts from supercritical fluid carbon dioxide extraction via in vitro and in vivo assays: antioxidation, antimicroorganism, and mice xenografts models","author":"Lee","year":"2013","journal-title":"Sci. World J."},{"issue":"4","key":"10.1016\/j.biopha.2021.112586_bib38","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nri3191","article-title":"Adoptive immunotherapy for cancer: harnessing the T cell response","volume":"12","author":"Restifo","year":"2012","journal-title":"Nat. Rev. Immunol."},{"issue":"6494","key":"10.1016\/j.biopha.2021.112586_bib39","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1126\/science.abc1464","article-title":"Probing the tumor micro (b) environment","volume":"368","author":"Atreya","year":"2020","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.biopha.2021.112586_bib40","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1002\/eji.202048543","article-title":"Loss of core fucosylation enhances the anticancer activity of cytotoxic T lymphocytes by increasing PD\u20101 degradation","volume":"50","author":"Zhang","year":"2020","journal-title":"Eur. J. Immunol."},{"issue":"4","key":"10.1016\/j.biopha.2021.112586_bib41","doi-asserted-by":"crossref","DOI":"10.1111\/sji.12867","article-title":"Hesperetin as an adjuvant augments protective anti\u2010tumour immunity responses in B16F10 melanoma by stimulating cytotoxic CD8+ T cells","volume":"91","author":"Jiang","year":"2020","journal-title":"Scand. J. Immunol."},{"issue":"4","key":"10.1016\/j.biopha.2021.112586_bib42","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/cmi.2010.11","article-title":"Curcumin reverses T cell-mediated adaptive immune dysfunctions in tumor-bearing hosts","volume":"7","author":"Bhattacharyya","year":"2010","journal-title":"Cell. Mol. Immunol."},{"issue":"8","key":"10.1016\/j.biopha.2021.112586_bib43","doi-asserted-by":"crossref","first-page":"863","DOI":"10.7150\/thno.11852","article-title":"Cell or cell membrane-based drug delivery systems","volume":"5","author":"Tan","year":"2015","journal-title":"Theranostics"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332221013731?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332221013731?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:38:47Z","timestamp":1760099927000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332221013731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":43,"alternative-id":["S0753332221013731"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2021.112586","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cell-derived artificial nanovesicle as a drug delivery system for malignant melanoma treatment","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2021.112586","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"112586"}}