{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T23:36:05Z","timestamp":1782862565353,"version":"3.54.5"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:00:00Z","timestamp":1641340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.biopha.2022.112623","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T20:52:06Z","timestamp":1642020726000},"page":"112623","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Metabolomic changes after DAAs therapy are related to the improvement of cirrhosis and inflammation in HIV\/HCV-coinfected patients"],"prefix":"10.1016","volume":"147","author":[{"given":"Ana","family":"Virseda-Berdices","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Rojo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isidoro","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Berenguer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Gonz\u00e1lez-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Brochado-Kith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Fern\u00e1ndez-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"D\u00edez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor","family":"Honta\u00f1on","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leire","family":"P\u00e9rez-Latorre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Mic\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coral","family":"Barbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Resino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Angeles","family":"Jim\u00e9nez-Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1 Suppl","key":"10.1016\/j.biopha.2022.112623_bib1","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1016\/j.jhep.2014.07.012","article-title":"Natural history of hepatitis C","volume":"61","author":"Westbrook","year":"2014","journal-title":"J. Hepatol."},{"issue":"4","key":"10.1016\/j.biopha.2022.112623_bib2","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1002\/hep.23136","article-title":"Fast fibrosis progression between repeated liver biopsies in patients coinfected with human immunodeficiency virus\/hepatitis C virus","volume":"50","author":"Macias","year":"2009","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.biopha.2022.112623_bib3","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1136\/gut.52.7.1035","article-title":"Impact of human immunodeficiency virus (HIV) infection on the progression of liver fibrosis in hepatitis C virus infected patients","volume":"52","author":"Mohsen","year":"2003","journal-title":"Gut"},{"issue":"10","key":"10.1016\/j.biopha.2022.112623_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/v10100545","article-title":"Epidemiology and elimination of HCV-related liver disease","volume":"10","author":"Pradat","year":"2018","journal-title":"Viruses"},{"issue":"5","key":"10.1016\/j.biopha.2022.112623_bib5","first-page":"642","article-title":"Hepatitis C virus therapy in advanced liver disease: outcomes and challenges, United European","volume":"7","author":"Ekpanyapong","year":"2019","journal-title":"Gastroenterol. J."},{"issue":"5","key":"10.1016\/j.biopha.2022.112623_bib6","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1097\/QCO.0b013e32835635df","article-title":"Coinfection by human immunodeficiency virus and hepatitis C virus: noninvasive assessment and staging of fibrosis","volume":"25","author":"Resino","year":"2012","journal-title":"Curr. Opin. Infect. Dis."},{"issue":"8","key":"10.1016\/j.biopha.2022.112623_bib7","article-title":"Child-pugh versus MELD score for the assessment of prognosis in liver cirrhosis: a systematic review and meta-analysis of observational studies","volume":"95","author":"Peng","year":"2016","journal-title":"Med. (Baltim. )"},{"issue":"3","key":"10.1016\/j.biopha.2022.112623_bib8","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3748\/wjg.v25.i3.308","article-title":"Elastography-based screening for esophageal varices in patients with advanced chronic liver disease","volume":"25","author":"Paternostro","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.biopha.2022.112623_bib9","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1111\/jgh.14707","article-title":"Effectiveness of direct-acting agents for hepatitis C and liver stiffness changing after sustained virological response","volume":"34","author":"Fernandes","year":"2019","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.biopha.2022.112623_bib10","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/jvh.12990","article-title":", Similar recovery of liver function after response to all-oral HCV therapy in patients with cirrhosis with and without HIV coinfection","volume":"26","author":"Macias","year":"2019","journal-title":"J. Viral Hepat."},{"issue":"4","key":"10.1016\/j.biopha.2022.112623_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0214323","article-title":"The change in liver stiffness, controlled attenuation parameter and fibrosis-4 index for chronic hepatitis C patients with direct-acting antivirals","volume":"14","author":"Lee","year":"2019","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.biopha.2022.112623_bib12","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/jvh.12706","article-title":"Effect of viral suppression on hepatic venous pressure gradient in hepatitis C with cirrhosis and portal hypertension","volume":"24","author":"Afdhal","year":"2017","journal-title":"J. Viral Hepat."},{"issue":"5","key":"10.1016\/j.biopha.2022.112623_bib13","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1053\/j.gastro.2017.07.016","article-title":"Effects of all-oral anti-viral therapy on HVPG and systemic hemodynamics in patients with hepatitis C virus-associated cirrhosis","volume":"153","author":"Lens","year":"2017","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.biopha.2022.112623_bib14","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.jhep.2016.05.027","article-title":"Sustained virologic response to interferon-free therapies ameliorates HCV-induced portal hypertension","volume":"65","author":"Mandorfer","year":"2016","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.biopha.2022.112623_bib15","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s12072-018-9914-6","article-title":"Treatment with direct-acting antivirals improves the clinical outcome in patients with HCV-related decompensated cirrhosis: results from an Italian real-life cohort (Liver Network Activity-LINA cohort)","volume":"13","author":"Gentile","year":"2019","journal-title":"Hepatol. Int."},{"issue":"8","key":"10.1016\/j.biopha.2022.112623_bib16","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1053\/j.gastro.2018.03.022","article-title":"Baseline factors associated with improvements in decompensated cirrhosis after direct-acting antiviral therapy for hepatitis C virus infection","volume":"154","author":"El-Sherif","year":"2018","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.biopha.2022.112623_bib17","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/apt.14404","article-title":"Liver association clinical research, sofosbuvir and daclatasvir therapy in patients with hepatitis C-related advanced decompensated liver disease (MELD >\/= 15)","volume":"47","author":"McCaughan","year":"2018","journal-title":"Aliment Pharmacol. Ther."},{"key":"10.1016\/j.biopha.2022.112623_bib18","article-title":"Successful HCV therapy reduces liver disease severity and inflammation biomarkers in HIV\/HCV-coinfected patients with advanced cirrhosis: a cohort study","volume":"8","author":"Medrano","year":"2021","journal-title":"Front. Med. (Lausanne)"},{"issue":"Suppl 1","key":"10.1016\/j.biopha.2022.112623_bib19","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1093\/cid\/ciw219","article-title":"Management of hepatitis C\/HIV coinfection in the era of highly effective hepatitis C virus direct-acting antiviral therapy","volume":"63","author":"Wyles","year":"2016","journal-title":"Clin. Infect. Dis."},{"issue":"10","key":"10.1016\/j.biopha.2022.112623_bib20","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1093\/cid\/ciaa502","article-title":"Persistence of clinically significant portal hypertension after eradication of hepatitis C virus in patients with advanced cirrhosis","volume":"71","author":"Diez","year":"2020","journal-title":"Clin. Infect. Dis."},{"issue":"9","key":"10.1016\/j.biopha.2022.112623_bib21","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1111\/liv.14580","article-title":"Plasma metabolomic fingerprint of advanced cirrhosis stages among HIV\/HCV-coinfected and HCV-monoinfected patients","volume":"40","author":"Salguero","year":"2020","journal-title":"Liver Int."},{"issue":"12","key":"10.1016\/j.biopha.2022.112623_bib22","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1093\/infdis\/jiaa316","article-title":"Metabolomic signature as a predictor of liver disease events in patients with HIV\/HCV coinfection","volume":"222","author":"Naggie","year":"2020","journal-title":"J. Infect. Dis."},{"issue":"9","key":"10.1016\/j.biopha.2022.112623_bib23","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1097\/QAD.0000000000001787","article-title":"G.b.S. group, elevated liver stiffness is linked to increased biomarkers of inflammation and immune activation in HIV\/hepatitis C virus-coinfected patients","volume":"32","author":"Medrano","year":"2018","journal-title":"AIDS"},{"issue":"1","key":"10.1016\/j.biopha.2022.112623_bib24","first-page":"169","article-title":"Flow cytometry has a significant impact on the cellular metabolome","volume":"18","author":"Binek","year":"2019","journal-title":"J. Proteome Res"},{"issue":"24","key":"10.1016\/j.biopha.2022.112623_bib25","doi-asserted-by":"crossref","first-page":"10038","DOI":"10.1021\/ac9019522","article-title":"FiehnLib: mass spectral and retention index libraries for metabolomics based on quadrupole and time-of-flight gas chromatography\/mass spectrometry","volume":"81","author":"Kind","year":"2009","journal-title":"Anal. Chem."},{"issue":"2","key":"10.1016\/j.biopha.2022.112623_bib26","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1021\/acs.jproteome.8b00720","article-title":"CEU mass mediator 3.0: a metabolite annotation tool","volume":"18","author":"Gil-de-la-Fuente","year":"2019","journal-title":"J. Proteome Res"},{"issue":"8","key":"10.1016\/j.biopha.2022.112623_bib27","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/nbt0807-846b","article-title":"The metabolomics standards initiative","volume":"25","author":"Sansone","year":"2007","journal-title":"Nat. Biotechnol."},{"issue":"1","key":"10.1016\/j.biopha.2022.112623_bib28","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/2047-217X-2-13","article-title":"The role of reporting standards for metabolite annotation and identification in metabolomic studies","volume":"2","author":"Salek","year":"2013","journal-title":"Gigascience"},{"issue":"1","key":"10.1016\/j.biopha.2022.112623_bib29","doi-asserted-by":"crossref","first-page":"4128","DOI":"10.1038\/s41598-019-40028-4","article-title":"The metabolic fingerprints of HCV and HBV infections studied by nuclear magnetic resonance spectroscopy","volume":"9","author":"Meoni","year":"2019","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.biopha.2022.112623_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0111348","article-title":"Alterations of plasma lysophosphatidylcholine species in obesity and weight loss","volume":"9","author":"Heimerl","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.biopha.2022.112623_bib31","doi-asserted-by":"crossref","first-page":"9653","DOI":"10.1038\/s41598-019-45906-5","article-title":"Intra- and inter-individual metabolic profiling highlights carnitine and lysophosphatidylcholine pathways as key molecular defects in type 2 diabetes","volume":"9","author":"Diamanti","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.biopha.2022.112623_bib32","doi-asserted-by":"crossref","first-page":"31","DOI":"10.5853\/jos.2018.03454","article-title":"Biomarker for ischemic stroke using metabolome: a clinician perspective","volume":"21","author":"Sidorov","year":"2019","journal-title":"J. Stroke"},{"issue":"21","key":"10.1016\/j.biopha.2022.112623_bib33","doi-asserted-by":"crossref","first-page":"6590","DOI":"10.1158\/0008-5472.CAN-11-0885","article-title":"Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling","volume":"71","author":"Patterson","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.biopha.2022.112623_bib34","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1476-511X-6-17","article-title":"Plasma lyso-phosphatidylcholine concentration is decreased in cancer patients with weight loss and activated inflammatory status","volume":"6","author":"Taylor","year":"2007","journal-title":"Lipids Health Dis."},{"issue":"8","key":"10.1016\/j.biopha.2022.112623_bib35","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1089\/ars.2009.2597","article-title":"Generation and biological activities of oxidized phospholipids","volume":"12","author":"Bochkov","year":"2010","journal-title":"Antioxid. Redox Signal"},{"issue":"8","key":"10.1016\/j.biopha.2022.112623_bib36","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1002\/eji.201545676","article-title":"The regulation of inflammation by oxidized phospholipids","volume":"46","author":"Freigang","year":"2016","journal-title":"Eur. J. Immunol."},{"issue":"7","key":"10.1016\/j.biopha.2022.112623_bib37","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S1542-3565(05)00017-0","article-title":"Effects of oral branched-chain amino acid granules on event-free survival in patients with liver cirrhosis","volume":"3","author":"Muto","year":"2005","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"3","key":"10.1016\/j.biopha.2022.112623_bib38","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1159\/000327571","article-title":"Oral branched-chain amino acid granules reduce the incidence of hepatocellular carcinoma and improve event-free survival in patients with liver cirrhosis","volume":"29","author":"Hayaishi","year":"2011","journal-title":"Dig. Dis."},{"issue":"3","key":"10.1016\/j.biopha.2022.112623_bib39","doi-asserted-by":"crossref","first-page":"C518","DOI":"10.1152\/ajpcell.00062.2016","article-title":"Ketoisocaproic acid, a metabolite of leucine, suppresses insulin-stimulated glucose transport in skeletal muscle cells in a BCAT2-dependent manner","volume":"311","author":"Moghei","year":"2016","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.biopha.2022.112623_bib40","first-page":"57","article-title":"Branched-chain amino acid levels are related with surrogates of disturbed lipid metabolism among older men","volume":"3","author":"Kujala","year":"2016","journal-title":"Front Med (Lausanne)"},{"issue":"7","key":"10.1016\/j.biopha.2022.112623_bib41","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1007\/s11606-020-05782-6","article-title":"Excess weight gain after cure of hepatitis c infection with direct-acting antivirals","volume":"35","author":"Do","year":"2020","journal-title":"J. Gen. Intern Med"},{"issue":"9","key":"10.1016\/j.biopha.2022.112623_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0223061","article-title":"Serum and urinary metabolomics and outcomes in cirrhosis","volume":"14","author":"Bajaj","year":"2019","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.biopha.2022.112623_bib43","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1038\/ismej.2016.76","article-title":"The fermentation product 2,3-butanediol alters P. aeruginosa clearance, cytokine response and the lung microbiome","volume":"10","author":"Nguyen","year":"2016","journal-title":"ISME J."},{"issue":"1","key":"10.1016\/j.biopha.2022.112623_bib44","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12876-018-0842-7","article-title":"Taurocholic acid is an active promoting factor, not just a biomarker of progression of liver cirrhosis: evidence from a human metabolomic study and in vitro experiments","volume":"18","author":"Liu","year":"2018","journal-title":"BMC Gastroenterol."},{"issue":"2","key":"10.1016\/j.biopha.2022.112623_bib45","doi-asserted-by":"crossref","first-page":"72","DOI":"10.15430\/JCP.2019.24.2.72","article-title":"Therapeutic effects of amino acids in liver diseases: current studies and future perspectives","volume":"24","author":"Lee","year":"2019","journal-title":"J. Cancer Prev."},{"issue":"3","key":"10.1016\/j.biopha.2022.112623_bib46","doi-asserted-by":"crossref","first-page":"E347","DOI":"10.1111\/hepr.12971","article-title":"Elevated serum uric acid level was a notable adverse event during combination therapy with sofosbuvir and ribavirin","volume":"48","author":"Sato","year":"2018","journal-title":"Hepatol. Res"},{"issue":"6965","key":"10.1016\/j.biopha.2022.112623_bib47","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S0140-6736(57)90460-9","article-title":"Blood pyruvic-acid and alpha-ketoglutaric-acid levels in liver disease and hepatic coma","volume":"272","author":"Dawson","year":"1957","journal-title":"Lancet"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332222000117?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332222000117?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:41:18Z","timestamp":1760100078000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332222000117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":47,"alternative-id":["S0753332222000117"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2022.112623","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolomic changes after DAAs therapy are related to the improvement of cirrhosis and inflammation in HIV\/HCV-coinfected patients","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2022.112623","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"112623"}}