{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:55:53Z","timestamp":1790268953975,"version":"4.1.0"},"reference-count":128,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:00:00Z","timestamp":1642464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.biopha.2022.112656","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T00:11:31Z","timestamp":1643069491000},"page":"112656","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["Uncoupling proteins as a therapeutic target for the development of new era drugs against neurodegenerative disorder"],"prefix":"10.1016","volume":"147","author":[{"given":"Rahul","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amruthanjali","family":"T","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siva","family":"Singothu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashi Bala","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasundhra","family":"Bhandari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.biopha.2022.112656_bib1","doi-asserted-by":"crossref","first-page":"795","DOI":"10.3390\/cells8080795","article-title":"Mitochondrial uncoupling: a key controller of biological processes in physiology and diseases","volume":"8","author":"Demine","year":"2019","journal-title":"Cells"},{"issue":"Suppl 1","key":"10.1016\/j.biopha.2022.112656_bib2","doi-asserted-by":"crossref","first-page":"S199","DOI":"10.33549\/physiolres.930000.53.S199","article-title":"Mitochondrial uncoupling proteins--facts and fantasies","volume":"53","author":"Jezek","year":"2004","journal-title":"Physiol. Res."},{"issue":"6","key":"10.1016\/j.biopha.2022.112656_bib3","first-page":"36","article-title":"Mitochondrial uncoupling proteins and energy metabolism","volume":"10","author":"Busiello","year":"2015","journal-title":"Front. Physiol."},{"issue":"4","key":"10.1016\/j.biopha.2022.112656_bib4","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/brb3.55","article-title":"Human neuronal uncoupling proteins 4 and 5 (UCP4 and UCP5): structural properties, regulation, and physiological role in protection against oxidative stress and mitochondrial dysfunction","volume":"2","author":"Ramsden","year":"2012","journal-title":"Brain Behav."},{"issue":"8","key":"10.1016\/j.biopha.2022.112656_bib5","doi-asserted-by":"crossref","first-page":"795","DOI":"10.3390\/cells8080795","article-title":"Mitochondrial uncoupling: a key controller of biological processes in physiology and diseases","volume":"8","author":"Demine","year":"2019","journal-title":"Cells"},{"issue":"8","key":"10.1016\/j.biopha.2022.112656_bib6","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/j.bpj.2009.12.4301","article-title":"Role of the transmembrane potential in the membrane proton leak","volume":"98","author":"Rupprecht","year":"2010","journal-title":"Biophys. J."},{"key":"10.1016\/j.biopha.2022.112656_bib7","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1385\/NMM:8:3:389","article-title":"Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress","volume":"8","author":"Liu","year":"2006","journal-title":"Neuromol. Med."},{"issue":"Pt 2","key":"10.1016\/j.biopha.2022.112656_bib8","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1042\/bj3450161","article-title":"The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP","volume":"345 Pt 2","author":"Ricquier","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.biopha.2022.112656_bib9","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.mito.2020.10.003","article-title":"The contribution of uncoupling protein 2 to mitochondrial Ca2+ homeostasis in health and disease - a short revisit","volume":"55","author":"Koshenov","year":"2020","journal-title":"Mitochondrion"},{"issue":"3","key":"10.1016\/j.biopha.2022.112656_bib10","first-page":"549","article-title":"UCP2 in early diagnosis and prognosis of sepsis","volume":"21","author":"Jiang","year":"2017","journal-title":"Eur. Rev. Med. Pharm. Sci."},{"issue":"6","key":"10.1016\/j.biopha.2022.112656_bib11","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/jcbfm.2009.4","article-title":"Neuroprotective role of mitochondrial uncoupling protein 2 in cerebral stroke","volume":"29","author":"Mehta","year":"2009","journal-title":"J. Cereb. Blood Flow. Metab."},{"issue":"9\u201310","key":"10.1016\/j.biopha.2022.112656_bib12","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1089\/ars.2005.7.1173","article-title":"Mitochondrial uncoupling proteins in the central nervous system","volume":"7","author":"Kim-Han","year":"2005","journal-title":"Antioxid. Redox Signal"},{"issue":"Pt 2","key":"10.1016\/j.biopha.2022.112656_bib13","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1042\/bj3450161","article-title":"The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP","volume":"345 Pt 2","author":"Ricquier","year":"2000","journal-title":"Biochem. J."},{"issue":"3","key":"10.1016\/j.biopha.2022.112656_bib14","doi-asserted-by":"crossref","first-page":"726","DOI":"10.2337\/diabetes.53.3.726","article-title":"Uncoupling proteins prevent glucose-induced neuronal oxidative stress and programmed cell death","volume":"53","author":"Vincent","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.biopha.2022.112656_bib15","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1097\/01.WCB.0000122743.72175.52","article-title":"Quantitative rt-PCR analysis of uncoupling protein isoforms in mouse brain cortex: methodological optimization and comparison of expression with brown adipose tissue and skeletal muscle","volume":"24","author":"Lengacher","year":"2004","journal-title":"J. Cereb. Blood Flow. Metab."},{"issue":"4","key":"10.1016\/j.biopha.2022.112656_bib16","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/jn\/130.4.711","article-title":"Uncoupling protein homologs: emerging views of physiological function","volume":"130","author":"Adams","year":"2000","journal-title":"J. Nutr."},{"issue":"10","key":"10.1016\/j.biopha.2022.112656_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025921","article-title":"Hydrogen sulfide protects against chemical hypoxia-induced injury by inhibiting ROS-activated ERK1\/2 and p38MAPK signalling pathways in PC12 cells","volume":"6","author":"Lan","year":"2011","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.biopha.2022.112656_bib18","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1042\/BCJ20190463","article-title":"UCP1-independent thermogenesis","volume":"477","author":"Roesler","year":"2020","journal-title":"Biochem. J."},{"issue":"1","key":"10.1016\/j.biopha.2022.112656_bib19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmet.2018.11.002","article-title":"New advances in adaptive thermogenesis: UCP1 and beyond","volume":"29","author":"Chouchani","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.biopha.2022.112656_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2020.154396","article-title":"UCP1-dependent and UCP1-independent metabolic changes induced by acute cold exposure in brown adipose tissue of mice","volume":"113","author":"Okamatsu-Ogura","year":"2020","journal-title":"Metabolism"},{"key":"10.1016\/j.biopha.2022.112656_bib21","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/S1357-2725(99)00049-7","article-title":"the mitochondrial uncoupling protein-2: current status","volume":"31","author":"Fleury","year":"1999","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"2","key":"10.1016\/j.biopha.2022.112656_bib22","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/obr.12796","article-title":"Mechanisms underlying UCP1 dependent and independent adipocyte thermogenesis","volume":"20","author":"Park","year":"2019","journal-title":"Obes. Rev."},{"key":"10.1016\/j.biopha.2022.112656_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2020.154396","article-title":"UCP1-dependent and UCP1-independent metabolic changes induced by acute cold exposure in brown adipose tissue of mice","volume":"113","author":"Okamatsu-Ogura","year":"2020","journal-title":"Metabolism"},{"key":"10.1016\/j.biopha.2022.112656_bib24","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.freeradbiomed.2019.07.001","article-title":"Ghrelin attenuates oxidative stress and neuronal apoptosis via GHSR-1\u03b1\/AMPK\/Sirt1\/PGC-1\u03b1\/UCP2 pathway in a rat model of neonatal HIE","volume":"141","author":"Huang","year":"2019","journal-title":"Free Radic. Biol. Med."},{"issue":"12","key":"10.1016\/j.biopha.2022.112656_bib25","doi-asserted-by":"crossref","first-page":"4289","DOI":"10.3390\/ijms21124289","article-title":"Brain overexpression of uncoupling protein-2 (UCP2) delays renal damage and stroke occurrence in stroke-prone spontaneously hypertensive rats","volume":"21","author":"Busceti","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.biopha.2022.112656_bib26","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.cmet.2019.08.010","article-title":"Microglial UCP2 mediates inflammation and obesity induced by high-fat feeding","volume":"30","author":"Kim","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.biopha.2022.112656_bib27","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.redox.2018.09.022","article-title":"AVE 0991 attenuates oxidative stress and neuronal apoptosis via Mas\/PKA\/CREB\/UCP-2 pathway after subarachnoid hemorrhage in rats","volume":"20","author":"Mo","year":"2019","journal-title":"Redox Biol."},{"issue":"3","key":"10.1016\/j.biopha.2022.112656_bib28","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0006-2952(02)01166-8","article-title":"Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury","volume":"64","author":"Bechmann","year":"2002","journal-title":"Biochem. Pharm."},{"issue":"Suppl 6","key":"10.1016\/j.biopha.2022.112656_bib29","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1038\/sj.ijo.0800947","article-title":"Brain distribution of UCP2 mRNA: in situ hybridization histochemistry studies","volume":"23","author":"Richard","year":"1999","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"issue":"Suppl 2","key":"10.1016\/j.biopha.2022.112656_bib30","first-page":"69","article-title":"Congenital hyperinsulinism: diagnosis and treatment update","volume":"9","author":"Demirbilek","year":"2017","journal-title":"J. Clin. Res. Pediatr. Endocrinol."},{"issue":"1","key":"10.1016\/j.biopha.2022.112656_bib31","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s11064-018-2588-6","article-title":"A ketogenic diet improves mitochondrial biogenesis and bioenergetics via the PGC1\u03b1-SIRT3-UCP2 axis","volume":"44","author":"Hasan-Olive","year":"2019","journal-title":"Neurochem. Res."},{"issue":"12","key":"10.1016\/j.biopha.2022.112656_bib32","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1007\/s00424-015-1727-z","article-title":"UCP2 modulates single-channel properties of a MCU-dependent Ca(2+) inward current in mitochondria","volume":"467","author":"Bondarenko","year":"2015","journal-title":"Pflug. Arch."},{"issue":"7","key":"10.1016\/j.biopha.2022.112656_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0069718","article-title":"Selective inhibition by ethanol of mitochondrial calcium influx mediated by uncoupling protein-2 in relation to N-methyl-D-aspartate cytotoxicity in cultured neurons","volume":"8","author":"Fukumori","year":"2013","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.biopha.2022.112656_bib34","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1002\/stem.2605","article-title":"UCP2 regulates embryonic neurogenesis via ROS-mediated yap alternation in the developing neocortex","volume":"35","author":"Ji","year":"2017","journal-title":"Stem Cells"},{"issue":"4","key":"10.1016\/j.biopha.2022.112656_bib35","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s12640-009-9109-y","article-title":"Mitochondrial uncoupling protein-2 (UCP2) mediates leptin protection against MPP+ toxicity in neuronal cells","volume":"17","author":"Ho","year":"2010","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.biopha.2022.112656_bib36","first-page":"001","article-title":"Brown fat tissue: Therapeutic potential for insulin resistance, new hopes for tomorrow","volume":"5","author":"Moradi","year":"2021","journal-title":"New Insights Obes. Gene Beyond"},{"issue":"23","key":"10.1016\/j.biopha.2022.112656_bib37","doi-asserted-by":"crossref","first-page":"10417","DOI":"10.1523\/JNEUROSCI.19-23-10417.1999","article-title":"Brain uncoupling protein 2: uncoupled neuronal mitochondria predict thermal synapses in homeostatic centers","volume":"19","author":"Horvath","year":"1999","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.biopha.2022.112656_bib38","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.molmet.2016.04.002","article-title":"Role of mitochondrial uncoupling protein-2 (UCP2) in higher brain functions, neuronal plasticity and network oscillation","volume":"5","author":"Hermes","year":"2016","journal-title":"Mol. Metab."},{"issue":"42","key":"10.1016\/j.biopha.2022.112656_bib39","doi-asserted-by":"crossref","first-page":"10766","DOI":"10.1523\/JNEUROSCI.2744-08.2008","article-title":"Exercise-induced synaptogenesis in the hippocampus is dependent on UCP2-regulated mitochondrial adaptation","volume":"28","author":"Dietrich","year":"2008","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.biopha.2022.112656_bib40","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/ejcn.2016.185","article-title":"UCP2 expression is associated with weight loss after hypocaloric diet intervention","volume":"71","author":"Cortes-Oliveira","year":"2017","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.biopha.2022.112656_bib41","doi-asserted-by":"crossref","unstructured":"Deierborg T., Wieloch T., Diano S., Warden CH, Horvath TL, Mattiasson G. Overexpression of UCP2 protects thalamic neurons following global ischemia in the mouse. J Cereb Blood Flow Metab. 2008 Jun;28(6):1186\u201395. doi: 10.1038\/jcbfm.2008.8. Epub 2008 Feb 27. Erratum in: J Cereb Blood Flow Metab. 2008 Jun;28(6):1273. Deierborg Olsson, Tomas [corrected to Deierborg, Tomas]. PMID: 18301432; PMCID: PMC2642535.","DOI":"10.1038\/jcbfm.2008.8"},{"issue":"1-2","key":"10.1016\/j.biopha.2022.112656_bib42","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jneuroim.2007.03.013","article-title":"Induction of Ucp2 expression in brain phagocytes and neurons following murine toxoplasmosis: an essential role of IFN-gamma and an association with negative energy balance","volume":"186","author":"Arsenijevic","year":"2007","journal-title":"J Neuroimmunol"},{"issue":"2","key":"10.1016\/j.biopha.2022.112656_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0031739","article-title":"Overexpression of mitochondrial uncoupling protein 2 inhibits inflammatory cytokines and activates cell survival factors after cerebral ischemia","volume":"7","author":"Haines","year":"2012","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.biopha.2022.112656_bib44","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1038\/nm903","article-title":"Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma","volume":"9","author":"Mattiasson","year":"2003","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.biopha.2022.112656_bib45","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00282-16","article-title":"FABP4\/aP2 regulates macrophage redox signaling and inflammasome activation via control of UCP2","volume":"37","author":"Steen","year":"2017","journal-title":"Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.biopha.2022.112656_bib46","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1172\/JCI78253","article-title":"UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis","volume":"125","author":"Moon","year":"2015","journal-title":"J. Clin. Investig."},{"issue":"8","key":"10.1016\/j.biopha.2022.112656_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042911","article-title":"UCP2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior","volume":"7","author":"Simon-Areces","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2022.112656_bib48","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.mcn.2013.10.002","article-title":"UCP2 overexpression worsens mitochondrial dysfunction and accelerates disease progression in a mouse model of amyotrophic lateral sclerosis","volume":"57","author":"Peixoto","year":"2013","journal-title":"Mol. Cell Neurosci."},{"key":"10.1016\/j.biopha.2022.112656_bib49","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ghir.2018.01.002","article-title":"Directly stimulates UCP3 expression","volume":"40","author":"Hayashi","year":"2018","journal-title":"Growth Horm. IGF Res."},{"issue":"10","key":"10.1016\/j.biopha.2022.112656_bib50","doi-asserted-by":"crossref","first-page":"470","DOI":"10.3389\/fphys.2019.00470","article-title":"Important trends in UCP3 investigation","volume":"30","author":"Pohl","year":"2019","journal-title":"Front. Physiol."},{"issue":"4","key":"10.1016\/j.biopha.2022.112656_bib51","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1159\/000489244","article-title":"UCP3 ablation exacerbates high-salt induced cardiac hypertrophy and cardiac dysfunction","volume":"46","author":"Lang","year":"2018","journal-title":"Cell Physiol. Biochem."},{"issue":"41","key":"10.1016\/j.biopha.2022.112656_bib52","doi-asserted-by":"crossref","first-page":"25433","DOI":"10.1074\/jbc.272.41.25433","article-title":"The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts","volume":"272","author":"Solanes","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.biopha.2022.112656_bib53","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.exger.2006.02.005","article-title":"Involvement of UCP3 in mild uncoupling and lipotoxicity","volume":"41","author":"Hoeks","year":"2006","journal-title":"Exp. Gerontol."},{"issue":"4","key":"10.1016\/j.biopha.2022.112656_bib54","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1172\/JCI17835","article-title":"The role of uncoupling protein 3 in human physiology","volume":"111","author":"Garvey","year":"2003","journal-title":"J. Clin. Investig."},{"issue":"11","key":"10.1016\/j.biopha.2022.112656_bib55","article-title":"Aucubin attenuates liver ischemia-reperfusion injury by inhibiting the HMGB1\/TLR-4\/NF-\u03baB signaling pathway, oxidative stress, and apoptosis","volume":"8","author":"Zhang","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.biopha.2022.112656_bib56","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1136\/acupmed-2017-011405","article-title":"Auricular acupuncture induces FNDC5\/irisin and attenuates obese inflammation in mice","volume":"38","author":"Lu","year":"2020","journal-title":"Acupunct. Med."},{"issue":"51","key":"10.1016\/j.biopha.2022.112656_bib57","doi-asserted-by":"crossref","first-page":"34611","DOI":"10.1074\/jbc.273.51.34611","volume":"273","author":"Sanchis","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2022.112656_bib58","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.mito.2017.03.005","article-title":"Uncoupling protein 2 and metabolic diseases","volume":"34","author":"Sreedhar","year":"2017","journal-title":"Mitochondrion"},{"key":"10.1016\/j.biopha.2022.112656_bib59","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/ng0397-269","article-title":"Uncouplingprotein-: a novel gene linked to obesity and hyperinsulinemia","volume":"15","author":"Fleury","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.biopha.2022.112656_bib60","doi-asserted-by":"crossref","unstructured":"Forman HJ, Zhang H. Targeting oxidative stress in disease: promise and limitations of antioxidant therapy. Nat Rev Drug Discov. 2021 Sep; 20(9):689\u2013709. doi: 10.1038\/s41573\u2013021-00233\u20131. Epub 2021 Jun 30. Erratum in: Nat Rev Drug Discov. 2021 Aug; 20(8):652. PMID: 34194012; PMCID: PMC8243062.","DOI":"10.1038\/s41573-021-00233-1"},{"issue":"1","key":"10.1016\/j.biopha.2022.112656_bib61","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/s41419-020-03355-3","article-title":"The redox language in neurodegenerative diseases: oxidative post-translational modifications by hydrogen peroxide","volume":"12","author":"Lee","year":"2021","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.biopha.2022.112656_bib62","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/01616412.2016.1251711","article-title":"Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders","volume":"39","author":"Islam","year":"2017","journal-title":"Neurol. Res."},{"issue":"3","key":"10.1016\/j.biopha.2022.112656_bib63","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/1440-1681.12717","article-title":"Hypoxia-inducible factors as neuroprotective agent in Alzheimer's disease","volume":"44","author":"Ashok","year":"2017","journal-title":"Clin. Exp. Pharm. Physiol."},{"key":"10.1016\/j.biopha.2022.112656_bib64","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.617588","article-title":"Mitochondrial dysfunction and oxidative stress in Alzheimer's disease","volume":"13","author":"Misrani","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.biopha.2022.112656_bib65","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13024-019-0333-5","article-title":"The neuropathological diagnosis of Alzheimer\u2019s disease","volume":"14","author":"DeTure","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.biopha.2022.112656_bib66","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/j.bbadis.2014.04.012","article-title":"Is Alzheimer\u2019s disease a systemic disease?","volume":"1842","author":"Morris","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biopha.2022.112656_bib67","doi-asserted-by":"crossref","unstructured":"Ho PW, Ho JW, Tse HM, So DH, Yiu DC, Liu HF, Chan KH, Kung MH, Ramsden DB, Ho SL. Uncoupling protein-4 (UCP4) increases ATP supply by interacting with mitochondrial Complex II in neuroblastoma cells. PLoS One. 2012;7(2):e32810. doi: 10.1371\/journal.pone.0032810. Epub 2012 Feb 29. PMID: 22427795; PMCID: PMC3303587.","DOI":"10.1371\/journal.pone.0032810"},{"issue":"6","key":"10.1016\/j.biopha.2022.112656_bib68","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.freeradbiomed.2010.06.017","article-title":"Mitochondrial UCP5 is neuroprotective by preserving mitochondrial membrane potential, ATP levels, and reducing oxidative stress in MPP+ and dopamine toxicity","volume":"49","author":"Kwok","year":"2010","journal-title":"Free Radic. Biol. Med."},{"issue":"Suppl 1","key":"10.1016\/j.biopha.2022.112656_bib69","doi-asserted-by":"crossref","first-page":"S110","DOI":"10.2337\/diabetes.53.2007.S110","article-title":"Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes","volume":"53","author":"Green","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.biopha.2022.112656_bib70","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.617588","article-title":"Mitochondrial dysfunction and oxidative stress in Alzheimer's disease","volume":"13","author":"Misrani","year":"2021","journal-title":"Front. Aging Neurosci."},{"issue":"1","key":"10.1016\/j.biopha.2022.112656_bib71","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13024-020-00376-6","article-title":"Mitochondria dysfunction in the pathogenesis of Alzheimer's disease: recent advances","volume":"15","author":"Wang","year":"2020","journal-title":"Mol. Neurodegener."},{"issue":"Suppl 1","key":"10.1016\/j.biopha.2022.112656_bib72","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/jnc.13731","article-title":"Mitochondrial dysfunction in Parkinson's disease","volume":"139","author":"Bose","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.biopha.2022.112656_bib73","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/7086512","article-title":"Oxidative stress, neuroinflammation, and NADPH oxidase: implications in the pathogenesis and treatment of Alzheimer's disease","volume":"2021","author":"Ganguly","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"issue":"9","key":"10.1016\/j.biopha.2022.112656_bib74","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1084\/jem.20051529","article-title":"Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase","volume":"202","author":"Nathan","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.biopha.2022.112656_bib75","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3389\/fnagi.2017.00150","article-title":"Glia maturation factor and mitochondrial uncoupling proteins 2 and 4 expression in the temporal cortex of Alzheimer's disease brain","volume":"9","author":"Thangavel","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.biopha.2022.112656_bib76","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/j.1471-4159.2006.04385.x","article-title":"A novel role of glia maturation factor: induction of granulocyte macrophage colony-stimulating factor and pro-inflammatory cytokines","volume":"101","author":"Zaheer","year":"2007","journal-title":"J. Neurochem."},{"issue":"49","key":"10.1016\/j.biopha.2022.112656_bib77","doi-asserted-by":"crossref","first-page":"37391","DOI":"10.1074\/jbc.M605552200","article-title":"Mitochondrial uncoupling protein-4 regulates calcium homeostasis and sensitivity to store depletion-induced apoptosis in neural cells","volume":"281","author":"Chan","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.biopha.2022.112656_bib78","doi-asserted-by":"crossref","first-page":"5014","DOI":"10.1210\/en.2003-0667","article-title":"Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning","volume":"144","author":"Diano","year":"2003","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.biopha.2022.112656_bib79","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/jnc.13244","article-title":"The mitochondrial uncoupling protein-2 is a master regulator of both M1 and M2 microglial responses","volume":"135","author":"De Simone","year":"2015","journal-title":"J. Neurochem."},{"key":"10.1016\/j.biopha.2022.112656_bib80","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1073\/pnas.94.6.2642","article-title":"Transcription factor NF-\u03baB is activated in primary neurons by amyloid \u03b2 peptides and in neurons surrounding early plaques from patients with Alzheimer disease","volume":"94","author":"Kaltschmidt","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.biopha.2022.112656_bib81","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.freeradbiomed.2012.05.002","article-title":"UCP4 is a target effector of the NF-\u03baB c-Relprosurvival pathway against oxidative stress","volume":"53","author":"Ho","year":"2012","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.biopha.2022.112656_bib82","first-page":"79","article-title":"Glia maturation factor in the pathogenesis of Alzheimer's disease","volume":"12","author":"Ramaswamy","year":"2019","journal-title":"Open Access J. Neurol. Neurosurg."},{"issue":"9","key":"10.1016\/j.biopha.2022.112656_bib83","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3389\/fnagi.2017.00150","article-title":"Glia maturation factor and mitochondrial uncoupling proteins 2 and 4 expression in the temporal cortex of Alzheimer's disease brain","volume":"18","author":"Thangavel","year":"2017","journal-title":"Front. Aging Neurosci."},{"issue":"2","key":"10.1016\/j.biopha.2022.112656_bib84","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1136\/gutjnl-2020-322429","article-title":"Inflammatory bowel disease and Parkinson's disease: common pathophysiological links","volume":"70","author":"Lee","year":"2021","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.biopha.2022.112656_bib85","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00701-020-04495-3","article-title":"Neuromodulation of the subthalamic nucleus in Parkinson's disease: the effect of fiber tract stimulation on tremor control","volume":"163","author":"Abdulbaki","year":"2021","journal-title":"Acta Neurochir."},{"issue":"4","key":"10.1016\/j.biopha.2022.112656_bib86","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/S1474-4422(18)30490-3","article-title":"The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications","volume":"18","author":"Arranz","year":"2019","journal-title":"Lancet Neurol."},{"issue":"5","key":"10.1016\/j.biopha.2022.112656_bib87","first-page":"702","article-title":"[\u03b2 Amyloid hypothesis in Alzheimer's disease: pathogenesis, prevention, and management]","volume":"41","author":"Zhang","year":"2019","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao"},{"issue":"9","key":"10.1016\/j.biopha.2022.112656_bib88","first-page":"1265","article-title":"[TRPM8 mediates PC-12 neuronal cell apoptosis induced by oxygen-glucose deprivation through cAMP-PKA\/UCP4 signaling]","volume":"36","author":"Li","year":"2016","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"10.1016\/j.biopha.2022.112656_bib89","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nrn1767","article-title":"Mitochondrial uncoupling proteins in the CNS: In support of function and survival","volume":"6","author":"Andrews","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"issue":"4","key":"10.1016\/j.biopha.2022.112656_bib90","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/jnc.14297","article-title":"Parkinson's disease-related DJ-1 modulates the expression of uncoupling protein 4 against oxidative stress","volume":"145","author":"Xu","year":"2018","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.biopha.2022.112656_bib91","doi-asserted-by":"crossref","first-page":"12816","DOI":"10.1038\/s41598-017-13146-0","article-title":"Parkinson's disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro","volume":"7","author":"Matsuda","year":"2017","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.biopha.2022.112656_bib92","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s10863-019-09798-4","article-title":"Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease","volume":"51","author":"Dolgacheva","year":"2019","journal-title":"J. Bioenerg. Biomembr."},{"issue":"2","key":"10.1016\/j.biopha.2022.112656_bib93","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.freeradbiomed.2012.05.002","article-title":"UCP4 is a target effector of the NF-\u03baB c-Rel prosurvival pathway against oxidative stress","volume":"53","author":"Ho","year":"2012","journal-title":"Free Radic. Biol. Med."},{"issue":"10","key":"10.1016\/j.biopha.2022.112656_bib94","doi-asserted-by":"crossref","first-page":"6145","DOI":"10.1073\/pnas.0937239100","article-title":"NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease","volume":"100","author":"Wu","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.biopha.2022.112656_bib95","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3389\/fcell.2020.00239","article-title":"MitophAging: mitophagy in aging and disease","volume":"8","author":"Bakula","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"9","key":"10.1016\/j.biopha.2022.112656_bib96","doi-asserted-by":"crossref","first-page":"680","DOI":"10.14348\/molcells.2016.0125","article-title":"Uncoupling protein, UCP-4 may be involved in neuronal defects during aging and resistance to pathogens in Caenorhabditis elegans","volume":"39","author":"Cho","year":"2016","journal-title":"Mol. Cells"},{"issue":"4","key":"10.1016\/j.biopha.2022.112656_bib97","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cellsig.2007.11.014","article-title":"Kainate-induced mitochondrial oxidative stress contributes to hippocampal degeneration in senescence-accelerated mice","volume":"20","author":"Hin","year":"2008","journal-title":"Cell Signal."},{"issue":"3","key":"10.1016\/j.biopha.2022.112656_bib98","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nm.3804","article-title":"The ketone metabolite \u03b2-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease","volume":"21","author":"Youm","year":"2015","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.biopha.2022.112656_bib99","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3164\/jcbn.09-104-2","article-title":"Superoxide anion, uncoupling proteins and Alzheimer's disease","volume":"46","author":"Wu","year":"2010","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.biopha.2022.112656_bib100","doi-asserted-by":"crossref","unstructured":"Lu T., Aron L., Zullo J., Pan Y., Kim H., Chen Y., Yang TH, Kim HM, Drake D., Liu XS, Bennett DA, Colai\u00e1covo MP, Yankner BA. REST and stress resistance in ageing and Alzheimer's disease. Nature. 2014 Mar 27;507(7493):448\u201354. doi: 10.1038\/nature13163. Epub 2014 Mar 19. Update in: Nature. 2016 Dec 15;540(7633):470. PMID: 24670762; PMCID: PMC4110979.","DOI":"10.1038\/nature13163"},{"issue":"8","key":"10.1016\/j.biopha.2022.112656_bib101","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.bbadis.2013.10.015","article-title":"Oxidative stress and mitochondrial dysfunction in Alzheimer's disease","volume":"1842","author":"Wang","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.biopha.2022.112656_bib102","first-page":"3","article-title":"Mitochondrial electron transport chain, ROS generation and uncoupling (Review)","volume":"44","author":"Zhao","year":"2019","journal-title":"Int. J. Mol. Med."},{"issue":"388","key":"10.1016\/j.biopha.2022.112656_bib103","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.neuroscience.2018.07.026","article-title":"Hypobaric hypoxia-induced learning and memory impairment: elucidating the role of small conductance Ca2+-activated K+ channels","volume":"15","author":"Kushwah","year":"2018","journal-title":"Neuroscience"},{"issue":"383","key":"10.1016\/j.biopha.2022.112656_bib104","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.neuroscience.2018.04.026","article-title":"Temporal and spatial changes in glial cells during chronic hypobaric hypoxia: role in neurodegeneration","volume":"15","author":"Dheer","year":"2018","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.biopha.2022.112656_bib105","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1159\/000490368","article-title":"Role of DNA methylation in hypobaric hypoxia-induced neurodegeneration and spatial memory impairment","volume":"25","author":"Kumar","year":"2018","journal-title":"Ann. Neurosci."},{"issue":"9","key":"10.1016\/j.biopha.2022.112656_bib106","doi-asserted-by":"crossref","first-page":"6754","DOI":"10.1002\/jcp.30337","article-title":"HDAC inhibition prevents hypobaric hypoxia-induced spatial memory impairment through P\u03993K\/GSK3\u03b2\/CREB pathway","volume":"236","author":"Kumar","year":"2021","journal-title":"J. Cell Physiol."},{"issue":"5","key":"10.1016\/j.biopha.2022.112656_bib107","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.3390\/cells9051177","article-title":"Mitochondria in health and diseases","volume":"9","author":"Javadov","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.biopha.2022.112656_bib108","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.freeradbiomed.2019.11.005","article-title":"Mitochondria as a therapeutic target for ischemic stroke","volume":"146","author":"He","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biopha.2022.112656_bib109","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.redox.2018.03.002","article-title":"Diverse roles of mitochondria in ischemic stroke","volume":"16","author":"Yang","year":"2018","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.biopha.2022.112656_bib110","doi-asserted-by":"crossref","first-page":"4494","DOI":"10.1038\/s41598-020-80425-8","article-title":"Benefit of a single simulated hypobaric hypoxia in healthy mice performance and analysis of mitochondria-related gene changes","volume":"11","author":"Wu","year":"2021","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.biopha.2022.112656_bib111","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3390\/antiox7010013","article-title":"Reactive oxygen species and mitochondrial dynamics: the yin and yang of mitochondrial dysfunction and cancer progression","volume":"7","author":"Jezek","year":"2018","journal-title":"Antioxidants"},{"key":"10.1016\/j.biopha.2022.112656_bib112","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.neulet.2016.02.046","article-title":"Efects of central irisin administration on the uncoupling proteins in rat brain","volume":"618","author":"Erden","year":"2016","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.biopha.2022.112656_bib113","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ceca.2008.01.001","article-title":"Mitochondrial Ca2+, the secret behind the function of uncoupling proteins 2 and 3?","volume":"44","author":"Graier","year":"2008","journal-title":"Cell Calcium"},{"issue":"9","key":"10.1016\/j.biopha.2022.112656_bib114","doi-asserted-by":"crossref","first-page":"15455","DOI":"10.1002\/jcb.28812","article-title":"UCP2 protect the heart from myocardial ischemia\/reperfusion injury via induction of mitochondrial autophagy","volume":"120","author":"Wu","year":"2019","journal-title":"J. Cell Biochem."},{"issue":"421","key":"10.1016\/j.biopha.2022.112656_bib115","article-title":"Cinacalcet as a surrogate therapy for diabetic cardiomyopathy in rats through AMPK-mediated promotion of mitochondrial and autophagic function","volume":"15","author":"Elrashidy","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"11","key":"10.1016\/j.biopha.2022.112656_bib116","doi-asserted-by":"crossref","first-page":"498","DOI":"10.3389\/fendo.2020.00498","article-title":"UCP1 dependent and independent thermogenesis in brown and beige adipocytes","volume":"28","author":"Ikeda","year":"2020","journal-title":"Front. Endocrinol."},{"issue":"6","key":"10.1016\/j.biopha.2022.112656_bib117","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000024464","article-title":"Association of uncoupling protein-2\u2013866G\/A and Ala55Val polymorphisms with susceptibility to type 2 diabetes mellitus: a meta-analysis of case-control studies","volume":"100","author":"Xu","year":"2021","journal-title":"Medicine"},{"issue":"1","key":"10.1016\/j.biopha.2022.112656_bib118","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2020.112110","article-title":"UCP2 silencing in glioblastoma reduces cell proliferation and invasiveness by inhibiting p38 MAPK pathway","volume":"394","author":"Wu","year":"2020","journal-title":"Exp. Cell Res."},{"issue":"13","key":"10.1016\/j.biopha.2022.112656_bib119","doi-asserted-by":"crossref","first-page":"292","DOI":"10.3389\/fnins.2019.00292","article-title":"The role of PGC-1\u03b1\/UCP2 signaling in the beneficial effects of physical exercise on the brain","volume":"29","author":"De Oliveira Bristot","year":"2019","journal-title":"Front. Neurosci."},{"issue":"3","key":"10.1016\/j.biopha.2022.112656_bib120","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s10863-019-09798-4","article-title":"Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease","volume":"51","author":"Dolgacheva","year":"2019","journal-title":"J. Bioenerg. Biomembr."},{"issue":"4","key":"10.1016\/j.biopha.2022.112656_bib121","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.3233\/JAD-180883","article-title":"Alzheimer's disease markers in aged ApoE-PON1 deficient mice","volume":"67","author":"Aluganti Narasimhulu","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.biopha.2022.112656_bib122","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3389\/fnagi.2020.00150","article-title":"APOE alleles and diet in brain aging and Alzheimer's disease","volume":"12","author":"Yassine","year":"2020","journal-title":"Front. Aging Neurosci."},{"issue":"1","key":"10.1016\/j.biopha.2022.112656_bib123","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0005-2728(00)00247-4","article-title":"UCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency","volume":"1504","author":"Nedergaard","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.biopha.2022.112656_bib124","doi-asserted-by":"crossref","first-page":"5570","DOI":"10.1038\/s41598-017-05766-3","article-title":"Experimental evidence reveals the UCP1 genotype changes the oxygen consumption attributed to non-shivering thermogenesis in humans","volume":"7","author":"Nishimura","year":"2017","journal-title":"Sci. Rep."},{"issue":"18","key":"10.1016\/j.biopha.2022.112656_bib125","first-page":"3582","article-title":"Mitochondrial uncoupling protein 2 knock-out promotes mitophagy to decrease retinal ganglion cell death in a mouse model of Glaucoma","volume":"39","author":"Hass","year":"2019","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.biopha.2022.112656_bib126","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1210\/jc.2005-1572","article-title":"Reduced skeletal muscle uncoupling protein-3 content in prediabetic subjects and type 2 diabetic patients: restoration by rosiglitazone treatment","volume":"91","author":"Schrauwen","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.biopha.2022.112656_bib127","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1172\/JCI17835","article-title":"The role of uncoupling protein 3 in human physiology","volume":"111","author":"Garvey","year":"2003","journal-title":"J. Clin. Investig."},{"issue":"11","key":"10.1016\/j.biopha.2022.112656_bib128","doi-asserted-by":"crossref","first-page":"3283","DOI":"10.18632\/aging.101632","article-title":"Uncoupling protein 4 (UCP4) gene variability in neurodegenerative disorders: further evidence of association in Frontotemporal dementia","volume":"10","author":"Montesanto","year":"2018","journal-title":"Aging"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332222000440?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332222000440?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:46:33Z","timestamp":1760100393000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332222000440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":128,"alternative-id":["S0753332222000440"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2022.112656","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Uncoupling proteins as a therapeutic target for the development of new era drugs against neurodegenerative disorder","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2022.112656","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"112656"}}