{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:23:16Z","timestamp":1790198596199,"version":"4.1.0"},"reference-count":88,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:00:00Z","timestamp":1645574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016247","name":"Uniwersytet Przyrodniczy we Wroc\u0142awiu","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016247","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.biopha.2022.112752","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T19:47:38Z","timestamp":1645732058000},"page":"112752","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":70,"special_numbering":"C","title":["Exosomes \u2013 Spectacular role in reproduction"],"prefix":"10.1016","volume":"148","author":[{"given":"Alicja","family":"Kowalczyk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcjanna","family":"Wrzeci\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Czerniawska-Pi\u0105tkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Kupczy\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.biopha.2022.112752_bib1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3390\/cells8040307","article-title":"Review of the isolation, characterization, biological function, and multifarious therapeutic approaches of exosomes","volume":"8","author":"Gurunathan","year":"2019","journal-title":"Cells"},{"issue":"7","key":"10.1016\/j.biopha.2022.112752_bib2","doi-asserted-by":"crossref","first-page":"727","DOI":"10.3390\/cells8070727","article-title":"Overview of extracellular vesicles, their origin, composition, purpose, and methods for exosome isolation and analysis","volume":"8","author":"Doyle","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.biopha.2022.112752_bib3","doi-asserted-by":"crossref","first-page":"518","DOI":"10.3389\/fimmu.2014.00518","article-title":"Immunotherapeutic potential of extracellular vesicles","volume":"5","author":"Zhang","year":"2014","journal-title":"Front Immunol."},{"key":"10.1016\/j.biopha.2022.112752_bib4","doi-asserted-by":"crossref","first-page":"12567","DOI":"10.2147\/OTT.S281909","article-title":"The role of exosomes in the female reproductive system and breast cancers","volume":"13","author":"Bai","year":"2020","journal-title":"OTT"},{"issue":"1","key":"10.1016\/j.biopha.2022.112752_bib5","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41392-020-00261-0","article-title":"Exosomes: key players in cancer and potential therapeutic strategy","volume":"5","author":"Dai","year":"2020","journal-title":"Signal Transduct. Target Ther."},{"issue":"1","key":"10.1016\/j.biopha.2022.112752_bib6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13578-019-0282-2","article-title":"Exosomes: biogenesis, biologic function and clinical potential","volume":"9","author":"Zhang","year":"2019","journal-title":"Cell Biosci."},{"issue":"1","key":"10.1016\/j.biopha.2022.112752_bib7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13048-020-0609-y","article-title":"Proteomic and lipidomic analysis of exosomes derived from ovarian cancer cells and ovarian surface epithelial cells","volume":"13","author":"Cheng","year":"2020","journal-title":"J. Ovarian Res."},{"issue":"4","key":"10.1016\/j.biopha.2022.112752_bib8","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.3390\/ijms22042165","article-title":"Exosomes as biomarkers for female reproductive diseases diagnosis and therapy","volume":"22","author":"Esfandyari","year":"2021","journal-title":"IJMS"},{"issue":"1","key":"10.1016\/j.biopha.2022.112752_bib9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41413-020-0100-9","article-title":"Exosomes: roles and therapeutic potential in osteoarthritis","volume":"8","author":"Ni","year":"2020","journal-title":"Bone Res."},{"key":"10.1016\/j.biopha.2022.112752_bib10","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/bs.acc.2019.08.004","article-title":"Exosomes of male reproduction","volume":"95","author":"Baskaran","year":"2020","journal-title":"Adv. Clin. Chem."},{"key":"10.1016\/j.biopha.2022.112752_bib11","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.cca.2018.11.009","article-title":"Exosomes in inflammation and role as biomarkers","volume":"488","author":"Console","year":"2019","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.biopha.2022.112752_bib12","doi-asserted-by":"crossref","first-page":"604","DOI":"10.3389\/fimmu.2020.00604","article-title":"The biogenesis, biology, and clinical significance of exosomal PD-L1 in cancer","volume":"11","author":"Tang","year":"2020","journal-title":"Front. Immunol."},{"issue":"1\u20132","key":"10.1016\/j.biopha.2022.112752_bib13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11010-020-03703-z","article-title":"Inside(sight) of tiny communicator: exosome biogenesis, secretion, and uptake","volume":"467","author":"Jadli","year":"2020","journal-title":"Mol. Cell. Biochem."},{"issue":"2","key":"10.1016\/j.biopha.2022.112752_bib14","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/19336918.2016.1251000","article-title":"Role of exosomes in the protection of cellular homeostasis","volume":"11","author":"Desd\u00edn-Mic\u00f3","year":"2017","journal-title":"Cell Adhes. Migr."},{"issue":"4","key":"10.1016\/j.biopha.2022.112752_bib15","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.repbio.2020.07.002","article-title":"A review on the stem cell therapy and an introduction to exosomes as a new tool in reproductive medicine","volume":"20","author":"Kharazi","year":"2020","journal-title":"Reprod. Biol."},{"key":"10.1016\/j.biopha.2022.112752_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2022.118549","article-title":"The application of exosomes and Exosome-nanoparticle in treating brain disorders","volume":"350","author":"Salarpour","year":"2022","journal-title":"J. Mol. Liq."},{"issue":"2","key":"10.1016\/j.biopha.2022.112752_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201802896","article-title":"Exosome biochemistry and advanced nanotechnology for next-generation theranostic platforms","volume":"31","author":"Yang","year":"2019","journal-title":"Adv. Mater."},{"issue":"6","key":"10.1016\/j.biopha.2022.112752_bib18","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat. Cell Biol."},{"issue":"6","key":"10.1016\/j.biopha.2022.112752_bib19","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/cr.2014.44","article-title":"Double-stranded DNA in exosomes: a novel biomarker in cancer detection","volume":"24","author":"Thakur","year":"2014","journal-title":"Cell Res."},{"issue":"48","key":"10.1016\/j.biopha.2022.112752_bib20","doi-asserted-by":"crossref","first-page":"16413","DOI":"10.1021\/jacs.8b10047","article-title":"Reprogramming exosomes as nanoscale controllers of cellular immunity","volume":"140","author":"Cheng","year":"2018","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"10.1016\/j.biopha.2022.112752_bib21","doi-asserted-by":"crossref","first-page":"237","DOI":"10.7150\/thno.21945","article-title":"Exosome theranostics: biology and translational medicine","volume":"8","author":"He","year":"2018","journal-title":"Theranostics"},{"issue":"3","key":"10.1016\/j.biopha.2022.112752_bib22","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1152\/physiol.00045.2018","article-title":"Extracellular vesicles: exosomes and microvesicles, integrators of homeostasis","volume":"34","author":"Stahl","year":"2019","journal-title":"Physiology"},{"issue":"4","key":"10.1016\/j.biopha.2022.112752_bib23","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/sj.onc.1207070","article-title":"The microvesicle as a vehicle for EMMPRIN in tumor\u2013stromal interactions","volume":"23","author":"Sidhu","year":"2004","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.biopha.2022.112752_bib24","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1600-0897.2010.00880.x","article-title":"Trophoblast-derived exosomes mediate monocyte recruitment and differentiation: MONOCYTE education by trophoblast exosomeS","volume":"65","author":"Atay","year":"2011","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.biopha.2022.112752_bib25","first-page":"1064","article-title":"Cardiomyocyte progenitor cell-derived exosomes stimulate migration of endothelial cells","volume":"14","author":"Vrijsen","year":"2010","journal-title":"J. Cell. Mol. Med."},{"issue":"15","key":"10.1016\/j.biopha.2022.112752_bib26","doi-asserted-by":"crossref","first-page":"5346","DOI":"10.1158\/0008-5472.CAN-11-0241","article-title":"Microvesicles released from human renal cancer stem cells stimulate angiogenesis and formation of lung premetastatic niche","volume":"71","author":"Grange","year":"2011","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.biopha.2022.112752_bib27","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.canlet.2011.10.002","article-title":"Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo","volume":"315","author":"Zhu","year":"2012","journal-title":"Cancer Lett."},{"issue":"2","key":"10.1016\/j.biopha.2022.112752_bib28","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.bcmd.2005.07.001","article-title":"Tumor exosomes expressing Fas ligand mediate CD8+ T-cell apoptosis","volume":"35","author":"Abusamra","year":"2005","journal-title":"Blood Cells Mol. Dis."},{"issue":"14","key":"10.1016\/j.biopha.2022.112752_bib29","doi-asserted-by":"crossref","first-page":"5439","DOI":"10.18632\/oncotarget.2118","article-title":"Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma","volume":"5","author":"Ye","year":"2014","journal-title":"Oncotarget"},{"issue":"31","key":"10.1016\/j.biopha.2022.112752_bib30","doi-asserted-by":"crossref","first-page":"E2110","DOI":"10.1073\/pnas.1209414109","article-title":"MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response","volume":"109","author":"Fabbri","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.biopha.2022.112752_bib31","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3389\/fnagi.2019.00232","article-title":"Exosome determinants of physiological aging and age-related neurodegenerative diseases","volume":"11","author":"D\u2019Anca","year":"2019","journal-title":"Front. Aging Neurosci."},{"issue":"11","key":"10.1016\/j.biopha.2022.112752_bib32","doi-asserted-by":"crossref","first-page":"19212","DOI":"10.1002\/jcp.28668","article-title":"Exosome\u2010based intercellular communication in female reproductive microenvironments","volume":"234","author":"Ranjbaran","year":"2019","journal-title":"J. Cell Physiol."},{"issue":"3","key":"10.1016\/j.biopha.2022.112752_bib33","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/biof.1497","article-title":"Physiological impact of extracellular vesicles on female reproductive system; highlights to possible restorative effects on female age\u2010related fertility","volume":"45","author":"Mobarak","year":"2019","journal-title":"BioFactors"},{"key":"10.1016\/j.biopha.2022.112752_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2020.103181","article-title":"Exosomes: emerging biomarkers and targets in folliculogenesis and endometriosis","volume":"142","author":"Shomali","year":"2020","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.biopha.2022.112752_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2019.102624","article-title":"Exosomes from dairy cows of divergent fertility; action on endometrial cells","volume":"137","author":"Koh","year":"2020","journal-title":"J. Reprod. Immunol."},{"issue":"1","key":"10.1016\/j.biopha.2022.112752_bib36","doi-asserted-by":"crossref","first-page":"13879","DOI":"10.1038\/s41598-019-50244-7","article-title":"Circulating exosomes may identify biomarkers for cows at risk for metabolic dysfunction","volume":"9","author":"Almughlliq","year":"2019","journal-title":"Sci. Rep."},{"issue":"23","key":"10.1016\/j.biopha.2022.112752_bib37","doi-asserted-by":"crossref","first-page":"9106","DOI":"10.3390\/ijms21239106","article-title":"The role of exosomal epigenetic modifiers in cell communication and fertility of dairy cows","volume":"21","author":"Abeysinghe","year":"2020","journal-title":"IJMS"},{"key":"10.1016\/j.biopha.2022.112752_bib38","first-page":"432","article-title":"Feto-maternal trafficking of exosomes in murine pregnancy models","volume":"7","author":"Sheller-Miller","year":"2016","journal-title":"Front Pharm. [Internet]"},{"issue":"5","key":"10.1016\/j.biopha.2022.112752_bib39","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1095\/biolreprod.115.132977","article-title":"Extracellular vesicles from bovine follicular fluid support cumulus expansion","volume":"93","author":"Hung","year":"2015","journal-title":"Biol. Reprod."},{"issue":"11","key":"10.1016\/j.biopha.2022.112752_bib40","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.3390\/ani10111971","article-title":"Exosomes as a potential tool for supporting canine oocyte development","volume":"10","author":"Lee","year":"2020","journal-title":"Animals"},{"issue":"1","key":"10.1016\/j.biopha.2022.112752_bib41","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1262\/jrd.2016-124","article-title":"Effects of exosome-like vesicles on cumulus expansion in pigs in vitro","volume":"63","author":"Matsuno","year":"2017","journal-title":"J. Reprod. Dev."},{"issue":"1","key":"10.1016\/j.biopha.2022.112752_bib42","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.theriogenology.2016.04.019","article-title":"Bidirectional communication between cumulus cells and the oocyte: old hands and new players?","volume":"86","author":"Russell","year":"2016","journal-title":"Theriogenology"},{"issue":"5","key":"10.1016\/j.biopha.2022.112752_bib43","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1071\/RD18450","article-title":"Follicular fluid exosomes act on the bovine oocyte to improve oocyte competence to support development and survival to heat shock","volume":"31","author":"Rodrigues","year":"2019","journal-title":"Reprod. Fertil. Dev."},{"key":"10.1016\/j.biopha.2022.112752_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0187569","article-title":"Cellular and exosome mediated molecular defense mechanism in bovine granulosa cells exposed to oxidative stress","volume":"12","author":"Saeed-Zidane","year":"2017","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.biopha.2022.112752_bib45","doi-asserted-by":"crossref","first-page":"645","DOI":"10.3390\/cells9030645","article-title":"MicroRNAs in small extracellular vesicles indicate successful embryo implantation during early pregnancy","volume":"9","author":"Tan","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.biopha.2022.112752_bib46","first-page":"1","volume":"2021","author":"Kowalczyk","year":"2021"},{"issue":"1","key":"10.1016\/j.biopha.2022.112752_bib47","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.bbrc.2017.11.176","article-title":"Intrauterine exosomes are required for bovine conceptus implantation","volume":"495","author":"Kusama","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2022.112752_bib48","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.theriogenology.2018.03.027","article-title":"Bovine uterus-derived exosomes improve developmental competence of somatic cell nuclear transfer embryos","volume":"114","author":"Qiao","year":"2018","journal-title":"Theriogenology"},{"issue":"4","key":"10.1016\/j.biopha.2022.112752_bib49","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.3390\/ijms22042024","article-title":"Exosomal cargo may hold the key to improving reproductive outcomes in dairy cows","volume":"22","author":"Turner","year":"2021","journal-title":"IJMS"},{"issue":"1","key":"10.1016\/j.biopha.2022.112752_bib50","doi-asserted-by":"crossref","first-page":"35","DOI":"10.12750\/JARB.36.1.35","article-title":"Identification of plasma miRNA biomarkers for pregnancy detection in dairy cattle","volume":"36","author":"Lim","year":"2021","journal-title":"J. Anim. Reprod. Biotechnol."},{"issue":"6","key":"10.1016\/j.biopha.2022.112752_bib51","doi-asserted-by":"crossref","first-page":"3607","DOI":"10.1016\/j.sjbs.2021.03.038","article-title":"Seminal exosomes \u2013 An important biological marker for various disorders and syndrome in human reproduction","volume":"28","author":"Vickram","year":"2021","journal-title":"Saudi J. Biol. Sci."},{"issue":"9","key":"10.1016\/j.biopha.2022.112752_bib52","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/sj.ki.5002486","article-title":"CD24 is a marker of exosomes secreted into urine and amniotic fluid","volume":"72","author":"Keller","year":"2007","journal-title":"Kidney Int."},{"issue":"1","key":"10.1016\/j.biopha.2022.112752_bib53","doi-asserted-by":"crossref","first-page":"11116","DOI":"10.1038\/s41598-021-90630-8","article-title":"The impact of regular sperm donation on bulls\u2019 seminal plasma hormonal profile and phantom response","volume":"11","author":"Kowalczyk","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2022.112752_bib54","first-page":"27","article-title":"Exosome composition and seminal plasma proteome: a promising source of biomarkers of male infertility","author":"Candenas","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2022.112752_bib55","doi-asserted-by":"crossref","DOI":"10.1111\/aji.13338","article-title":"Roles of male reproductive tract extracellular vesicles in reproduction","volume":"85","author":"Tamessar","year":"2021","journal-title":"Am J Reprod Immunol."},{"key":"10.1016\/j.biopha.2022.112752_bib56","doi-asserted-by":"crossref","DOI":"10.1111\/and.14155","article-title":"Epididymosomes: a potential male fertility influencer","volume":"53","author":"Paul","year":"2021","journal-title":"Andrologia"},{"issue":"1","key":"10.1016\/j.biopha.2022.112752_bib57","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1093\/pcmedi\/pbaa007","article-title":"Clinical applications of exosome membrane proteins","volume":"3","author":"Hu","year":"2020","journal-title":"Precis. Clin. Med."},{"issue":"1","key":"10.1016\/j.biopha.2022.112752_bib58","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.bbrc.2020.04.076","article-title":"Exploring the potential of engineered exosomes as delivery systems for tumor-suppressor microRNA replacement therapy in ovarian cancer","volume":"527","author":"Kobayashi","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.biopha.2022.112752_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2020.112113","article-title":"Extracellular vesicle encapsulated microRNA-320a inhibits endometrial cancer by suppression of the HIF1\u03b1\/VEGFA axis","volume":"394","author":"Zhang","year":"2020","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.biopha.2022.112752_bib60","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.8640","article-title":"The expression of small RNAs in exosomes of follicular fluid altered in human polycystic ovarian syndrome","volume":"8","author":"Hu","year":"2020","journal-title":"PeerJ"},{"key":"10.1016\/j.biopha.2022.112752_bib61","article-title":"High throughput microRNAs sequencing profile of serum exosomes in women with and without polycystic ovarian syndrome","volume":"9","author":"Zhang","year":"2021","journal-title":"PeerJ"},{"key":"10.1016\/j.biopha.2022.112752_bib62","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.omtn.2019.03.008","article-title":"Human amniotic epithelial cell-derived exosomes restore ovarian function by transferring microRNAs against apoptosis","volume":"16","author":"Zhang","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"12","key":"10.1016\/j.biopha.2022.112752_bib63","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.3390\/cancers11121946","article-title":"Exosomal thrombospondin-1 disrupts the integrity of endothelial intercellular junctions to facilitate breast cancer cell metastasis","volume":"11","author":"Cen","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.biopha.2022.112752_bib64","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.cca.2019.11.032","article-title":"Diagnostic and prognostic value of the cancer-testis antigen lactate dehydrogenase C4 in breast cancer","volume":"503","author":"Cui","year":"2020","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.biopha.2022.112752_bib65","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jbiotec.2019.03.018","article-title":"Expression of CD24 in plasma, exosome and ovarian tissue samples of serous ovarian cancer patients","volume":"298","author":"Solt\u00e9sz","year":"2019","journal-title":"J. Biotechnol."},{"issue":"7","key":"10.1016\/j.biopha.2022.112752_bib66","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1038\/s41388-019-1087-9","article-title":"The exosome-mediated autocrine and paracrine actions of plasma gelsolin in ovarian cancer chemoresistance","volume":"39","author":"Asare-Werehene","year":"2020","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.biopha.2022.112752_bib67","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ygyno.2008.04.033","article-title":"MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer","volume":"110","author":"Taylor","year":"2008","journal-title":"Gynecol. Oncol."},{"issue":"1","key":"10.1016\/j.biopha.2022.112752_bib68","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1186\/s12935-021-02026-3","article-title":"Exosomes from cervical cancer cells facilitate pro-angiogenic endothelial reconditioning through transfer of Hedgehog\u2013GLI signaling components","volume":"21","author":"Bhat","year":"2021","journal-title":"Cancer Cell Int."},{"issue":"1","key":"10.1016\/j.biopha.2022.112752_bib69","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.ygyno.2021.02.004","article-title":"Exosomal microRNAs and exosomal long non-coding RNAs in gynecologic cancers","volume":"161","author":"Hashemipour","year":"2021","journal-title":"Gynecol. Oncol."},{"issue":"3","key":"10.1016\/j.biopha.2022.112752_bib70","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/s41388-020-01555-x","article-title":"Plasma exosomes from endometrial cancer patients contain LGALS3BP to promote endometrial cancer progression","volume":"40","author":"Song","year":"2021","journal-title":"Oncogene"},{"issue":"19","key":"10.1016\/j.biopha.2022.112752_bib71","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.7150\/jca.26071","article-title":"Prognostic impact of high c-Met expression in ovarian cancer: a meta-analysis","volume":"9","author":"Kim","year":"2018","journal-title":"J. Cancer"},{"key":"10.1016\/j.biopha.2022.112752_bib72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2019.12.005","article-title":"Exosome-mediated siRNA delivery to suppress postoperative breast cancer metastasis","volume":"318","author":"Zhao","year":"2020","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.biopha.2022.112752_bib73","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/s13287-021-02295-9","article-title":"Mesenchymal stromal\/stem cells and their exosomes for restoration of spermatogenesis in non-obstructive azoospermia: a systemic review","volume":"12","author":"Zhankina","year":"2021","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.biopha.2022.112752_bib74","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1186\/s13287-021-02596-z","article-title":"Applications, challenges and prospects of mesenchymal stem cell exosomes in regenerative medicine","volume":"12","author":"Rezabakhsh","year":"2021","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.biopha.2022.112752_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.acthis.2019.151465","article-title":"Effects of uterus derived mesenchymal stem cells and their exosomes on asherman\u2019s syndrome","volume":"122","author":"Saribas","year":"2020","journal-title":"Acta Histochem."},{"issue":"9","key":"10.1016\/j.biopha.2022.112752_bib76","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1021\/acs.molpharmaceut.8b00277","article-title":"Exosomes as a drug delivery system in cancer therapy: potential and challenges","volume":"15","author":"Kibria","year":"2018","journal-title":"Mol. Pharm."},{"issue":"6","key":"10.1016\/j.biopha.2022.112752_bib77","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1248\/bpb.b18-00133","article-title":"Possibility of exosome-based therapeutics and challenges in production of exosomes eligible for therapeutic application","volume":"41","author":"Yamashita","year":"2018","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.biopha.2022.112752_bib78","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.ejps.2016.10.009","article-title":"Cell type-specific and common characteristics of exosomes derived from mouse cell lines: yield, physicochemical properties, and pharmacokinetics","volume":"96","author":"Charoenviriyakul","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.biopha.2022.112752_bib79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejpb.2015.10.017","article-title":"Effect of exosome isolation methods on physicochemical properties of exosomes and clearance of exosomes from the blood circulation","volume":"98","author":"Yamashita","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"3","key":"10.1016\/j.biopha.2022.112752_bib80","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1039\/C7NR08360B","article-title":"Technical challenges of working with extracellular vesicles","volume":"10","author":"Ramirez","year":"2018","journal-title":"Nanoscale"},{"key":"10.1016\/j.biopha.2022.112752_bib81","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.biomaterials.2016.07.003","article-title":"Efficient production and enhanced tumor delivery of engineered extracellular vesicles","volume":"105","author":"Watson","year":"2016","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.biopha.2022.112752_bib82","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/jop.12486","article-title":"Stressors alter intercellular communication and exosome profile of nasopharyngeal carcinoma cells","volume":"46","author":"Harmati","year":"2017","journal-title":"J. Oral. Pathol. Med."},{"issue":"1","key":"10.1016\/j.biopha.2022.112752_bib83","doi-asserted-by":"crossref","first-page":"20360","DOI":"10.3402\/jev.v2i0.20360","article-title":"Standardization of sample collection, isolation and analysis methods in extracellular vesicle research","volume":"2","author":"Witwer","year":"2013","journal-title":"J. Extracell. Vesicles"},{"issue":"1","key":"10.1016\/j.biopha.2022.112752_bib84","doi-asserted-by":"crossref","first-page":"18397","DOI":"10.3402\/jev.v1i0.18397","article-title":"Diverse subpopulations of vesicles secreted by different intracellular mechanisms are present in exosome preparations obtained by differential ultracentrifugation","volume":"1","author":"Bobrie","year":"2012","journal-title":"J. Extracell. Vesicles"},{"issue":"8","key":"10.1016\/j.biopha.2022.112752_bib85","doi-asserted-by":"crossref","first-page":"E968","DOI":"10.1073\/pnas.1521230113","article-title":"Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes","volume":"113","author":"Kowal","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"7","key":"10.1016\/j.biopha.2022.112752_bib86","doi-asserted-by":"crossref","first-page":"5845","DOI":"10.1021\/nn300223w","article-title":"Effects of the presence or absence of a protein corona on silica nanoparticle uptake and impact on cells","volume":"6","author":"Lesniak","year":"2012","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.biopha.2022.112752_bib87","doi-asserted-by":"crossref","first-page":"22519","DOI":"10.1038\/srep22519","article-title":"Cells release subpopulations of exosomes with distinct molecular and biological properties","volume":"6","author":"Willms","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.biopha.2022.112752_bib88","doi-asserted-by":"crossref","first-page":"36162","DOI":"10.1038\/srep36162","article-title":"Trehalose prevents aggregation of exosomes and cryodamage","volume":"6","author":"Bosch","year":"2016","journal-title":"Sci. Rep."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332222001408?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332222001408?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:22:33Z","timestamp":1781763753000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332222001408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":88,"alternative-id":["S0753332222001408"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2022.112752","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exosomes \u2013 Spectacular role in reproduction","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2022.112752","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"112752"}}