{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:08:24Z","timestamp":1790618904550,"version":"4.1.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:00:00Z","timestamp":1645574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006393","name":"University of Granada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006393","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.biopha.2022.112759","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:05:51Z","timestamp":1646265951000},"page":"112759","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Evaluating the effects of a standardized polyphenol mixture extracted from poplar-type propolis on healthy and diseased human gut microbiota"],"prefix":"10.1016","volume":"148","author":[{"given":"Emanuele Ugo","family":"Garzarella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Navajas-Porras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"P\u00e9rez-Burillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hammad","family":"Ullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Santarcangelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Hinojosa-Nogueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Pastoriza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Zaccaria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbo","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 \u00c1ngel","family":"Rufi\u00e1n-Henares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Daglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2022.112759_bib1","doi-asserted-by":"crossref","first-page":"8787","DOI":"10.3748\/wjg.v21.i29.8787","article-title":"Role of the normal gut microbiota","volume":"21","author":"Jandhyala","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.biopha.2022.112759_bib2","article-title":"Modulating gut microbiota: an emerging approach in the prevention and treatment of multiple sclerosis","volume":"19","author":"Ullah","year":"2021","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.biopha.2022.112759_bib3","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1042\/BCJ20160510","article-title":"Introduction to the human gut microbiota","volume":"474","author":"Thursby","year":"2017","journal-title":"Biochem. J."},{"key":"10.1016\/j.biopha.2022.112759_bib4","first-page":"180","article-title":"The causes of intestinal dysbiosis: a review","volume":"9","author":"Hawrelak","year":"2004","journal-title":"Altern. Med. Rev."},{"key":"10.1016\/j.biopha.2022.112759_bib5","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1152\/physrev.00045.2009","article-title":"Gut microbiota in health and disease","volume":"90","author":"Sekirov","year":"2010","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.biopha.2022.112759_bib6","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1097\/MIB.0000000000000750","article-title":"Current understanding of dysbiosis in disease in human and animal models","volume":"22","author":"DeGruttola","year":"2016","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.biopha.2022.112759_bib7","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1111\/cmi.12308","article-title":"Defining dysbiosis and its influence on host immunity and disease","volume":"16","author":"Petersen","year":"2014","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.biopha.2022.112759_bib8","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.4465","article-title":"An overview on the interplay between nutraceuticals and gut microbiota","volume":"6","author":"Catinean","year":"2018","journal-title":"PeerJ"},{"key":"10.1016\/j.biopha.2022.112759_bib9","doi-asserted-by":"crossref","first-page":"308","DOI":"10.5455\/jice.20160331064836","article-title":"The consumption of propolis and royal jelly in preventing upper respiratory tract infections and as dietary supplementation in children","volume":"5","author":"Yuksel","year":"2016","journal-title":"J. Intercult. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2022.112759_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153368","article-title":"A standardized polyphenol mixture extracted from poplar-type propolis for remission of symptoms of uncomplicated upper respiratory tract infection (URTI): a monocentric, randomized, double-blind, placebo-controlled clinical trial","volume":"80","author":"Esposito","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.biopha.2022.112759_bib11","article-title":"Propolis: a wonder bees product and its pharmacological potentials","volume":"2013","author":"Wagh","year":"2013","journal-title":"Adv. Pharmacol. Sci."},{"key":"10.1016\/j.biopha.2022.112759_bib12","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.3390\/ma12223746","article-title":"Multi dynamic extraction: an innovative method to obtain a standardized chemically and biologically reproducible polyphenol extract from poplar-type propolis to be used for its anti-infective properties","volume":"12","author":"Zaccaria","year":"2019","journal-title":"Materials"},{"key":"10.1016\/j.biopha.2022.112759_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109393","article-title":"Propolis modulates the gut microbiota and improves the intestinal mucosal barrier function in diabetic rats","volume":"118","author":"Xue","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2022.112759_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2019.108939","article-title":"Ethanol extract of propolis prevents high-fat diet-induced insulin resistance and obesity in association with modulation of gut microbiota in mice","volume":"130","author":"Cai","year":"2020","journal-title":"Food Res. Int."},{"key":"10.1016\/j.biopha.2022.112759_bib15","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.foodres.2015.07.026","article-title":"Green propolis modulates gut microbiota, reduces endotoxemia and expression of TLR4 pathway in mice fed a high-fat diet","volume":"76","author":"Roquetto","year":"2015","journal-title":"Food Res. Int."},{"key":"10.1016\/j.biopha.2022.112759_bib16","doi-asserted-by":"crossref","first-page":"875","DOI":"10.3390\/nu9080875","article-title":"Dietary propolis ameliorates dextran sulfate sodium-induced colitis and modulates the gut microbiota in rats fed a western diet","volume":"9","author":"Wang","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.biopha.2022.112759_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.14715\/cmb\/2019.65.1.1","article-title":"Ameliorative effect of probiotics (Lactobacillus paracaseii and Protexin\u00ae) and prebiotics (propolis and bee pollen) on clindamycin and propionic acid-induced oxidative stress and altered gut microbiota in a rodent model of autism","volume":"65","author":"Aabed","year":"2019","journal-title":"Cell. Mol. Biol."},{"key":"10.1016\/j.biopha.2022.112759_bib18","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.3390\/ijms20051250","article-title":"Bioavailability and in vivo antioxidant activity of a standardized polyphenol mixture extracted from brown propolis","volume":"20","author":"Curti","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2022.112759_bib19","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.3390\/nu9101090","article-title":"Effect of green and brown propolis extracts on the expression levels of microRNAs, mRNAs and proteins, related to oxidative stress and inflammation","volume":"9","author":"Zaccaria","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.biopha.2022.112759_bib20","article-title":"Procedimento Per L\u2019ottenimento di Estratti Integrali di Propoli Ricchi in Polifenoli e Dot, ati di Attivit\u00e0 Antibatterica e Sua Applicazione Nella Prevenzione e Trattamento di Processi Infettivi di Origine Batterica","author":"Volpi","year":"2017","journal-title":"Uff. e Marchi"},{"key":"10.1016\/j.biopha.2022.112759_bib21","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1038\/s41596-021-00537-x","article-title":"An in vitro batch fermentation protocol for studying the contribution of food to gut microbiota composition and functionality","volume":"16","author":"P\u00e9rez-Burillo","year":"2021","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.biopha.2022.112759_bib22","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.foodchem.2017.07.024","article-title":"Towards an improved global antioxidant response method (GAR+): physiological-resembling in vitro digestion-fermentation method","volume":"239","author":"P\u00e9rez-Burillo","year":"2018","journal-title":"Food Chem."},{"key":"10.1016\/j.biopha.2022.112759_bib23","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/abio.1996.0292","article-title":"The ferric reducing ability of plasma (FRAP) as a measure of \u201cantioxidant power\u201d: the FRAP assay","volume":"239","author":"Benzie","year":"1996","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.biopha.2022.112759_bib24","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1021\/jf00049a007","article-title":"Antioxidant activity of various tea extracts in relation to their antimutagenicity","volume":"43","author":"Yen","year":"1995","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.biopha.2022.112759_bib25","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jfca.2014.10.001","article-title":"Phenolic compounds and antioxidant activity of Spanish commercial grape juices","volume":"38","author":"Moreno-Montoro","year":"2015","journal-title":"J. Food Comp. Anal."},{"key":"10.1016\/j.biopha.2022.112759_bib26","doi-asserted-by":"crossref","first-page":"6452","DOI":"10.1021\/acs.jafc.7b02302","article-title":"High antioxidant action and prebiotic activity of hydrolyzed spent coffee grounds (HSCG) in a simulated digestion\u2013fermentation model: toward the development of a novel food supplement","volume":"65","author":"Panzella","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.biopha.2022.112759_bib27","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gks808","article-title":"Evaluation of general 16S ribosomal RNA gene PCR primers for classical and next-generation sequencing-based diversity studies","volume":"41","author":"Klindworth","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.biopha.2022.112759_bib28","first-page":"6","article-title":"Effect of some domestic cooking methods on antioxidant activity, total phenols and total flavonoid content of common beans","volume":"7","author":"AKILLIO\u011eLU","year":"2009","journal-title":"Akad. G\u0131da"},{"key":"10.1016\/j.biopha.2022.112759_bib29","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.foodres.2019.05.028","article-title":"Investigation of antioxidant capacity, bioaccessibility and LC-MS\/MS phenolic profile of Turkish propolis","volume":"122","author":"Ozdal","year":"2019","journal-title":"Food Res. Int."},{"key":"10.1016\/j.biopha.2022.112759_bib30","doi-asserted-by":"crossref","first-page":"12403","DOI":"10.1021\/jf3042775","article-title":"Yu, Identification and quantification of phytochemical composition and anti-inflammatory and radical scavenging properties of methanolic extracts of Chinese propolis","volume":"60","author":"Shi","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.biopha.2022.112759_bib31","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.foodchem.2006.03.045","article-title":"Antioxidant activity and constituents of propolis collected in various areas of China","volume":"101","author":"Ahn","year":"2017","journal-title":"Food Chem."},{"key":"10.1016\/j.biopha.2022.112759_bib32","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1007\/s10068-018-0413-2","article-title":"Biotransformation of propolis phenols by L. plantarum as a strategy for reduction of allergens","volume":"27","author":"Y\u0131ld\u0131r\u0131m","year":"2018","journal-title":"Food Sci. Biotechnol."},{"key":"10.1016\/j.biopha.2022.112759_bib33","doi-asserted-by":"crossref","first-page":"4654","DOI":"10.1128\/AEM.00811-12","article-title":"Biotransformation strategy to reduce allergens in propolis","volume":"78","author":"Gardana","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.biopha.2022.112759_bib34","doi-asserted-by":"crossref","DOI":"10.1111\/jfpp.13642","article-title":"Antioxidant and anti\u2010inflammatory effects of biotechnologically transformed propolis","volume":"42","author":"Aldemir","year":"2018","journal-title":"J. Food Process. Preserv."},{"key":"10.1016\/j.biopha.2022.112759_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2020.109833","article-title":"Do short chain fatty acids and phenolic metabolites of the gut have synergistic anti-inflammatory effects?\u2013New insights from a TNF-\u03b1-induced Caco-2 cell model","volume":"139","author":"Zheng","year":"2021","journal-title":"Food Res. Int."},{"key":"10.1016\/j.biopha.2022.112759_bib36","article-title":"Antioxidant properties and cardioprotective mechanism of Malaysian propolis in rats","volume":"2017","author":"Ahmed","year":"2017","journal-title":"Evid. Based Complement. Alter."},{"key":"10.1016\/j.biopha.2022.112759_bib37","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/cbf.2986","article-title":"Propolis reduces oxidative stress in l\u2010NAME\u2010induced hypertension rats","volume":"32","author":"Talas","year":"2014","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.biopha.2022.112759_bib38","doi-asserted-by":"crossref","first-page":"227","DOI":"10.17219\/acem\/40461","article-title":"Antioxidant effect of ethanolic extract of propolis in liver of L-NAME treated rats","volume":"24","author":"Selamoglu","year":"2015","journal-title":"Adv. Clin. Exp. Med."},{"key":"10.1016\/j.biopha.2022.112759_bib39","doi-asserted-by":"crossref","first-page":"301","DOI":"10.33594\/000000140","article-title":"The therapeutic mechanisms of propolis against CCl4-mediated liver injury by mediating apoptosis of activated hepatic stellate cells and improving the hepatic architecture through PI3K\/AKT\/mTOR, TGF-\u03b2\/Smad2, Bcl2\/BAX\/P53 and iNOS signaling pathways","volume":"53","author":"Badr","year":"2019","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.biopha.2022.112759_bib40","first-page":"915","article-title":"Effects of propolis on blood biochemical and hematological parameters in nitric oxide synthase inhibited rats by N\u03c9-nitro-L-arginine methyl ester","volume":"26","author":"Talas","year":"2013","journal-title":"Pak. J. Pharm. Sci."},{"key":"10.1016\/j.biopha.2022.112759_bib41","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/10641963.2020.1806294","article-title":"The investigation of antioxidant and anti-inflammatory potentials of apitherapeutic agents on heart tissues in nitric oxide synthase inhibited rats via N\u03c9-nitro-L-arginine methyl ester","volume":"43","author":"Ozdemir","year":"2021","journal-title":"Clin. Exp. Hypertens."},{"key":"10.1016\/j.biopha.2022.112759_bib42","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","article-title":"From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites","volume":"165","author":"Koh","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2022.112759_bib43","article-title":"Dietary fibers and their fermented short-chain fatty acids in prevention of human diseases","volume":"17","author":"Prasad","year":"2019","journal-title":"Bioact. Carbohydr. Diet. Fibre"},{"key":"10.1016\/j.biopha.2022.112759_bib44","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.tibs.2014.02.005","article-title":"How do gut microbes break down dietary fiber?","volume":"39","author":"Terrapon","year":"2014","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.biopha.2022.112759_bib45","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1053\/j.gastro.2016.02.028","article-title":"The intestinal microenvironment and functional gastrointestinal disorders","volume":"150","author":"Barbara","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biopha.2022.112759_bib46","doi-asserted-by":"crossref","first-page":"5543","DOI":"10.3748\/wjg.v25.i36.5543","article-title":"Evaluation and comparison of short chain fatty acids composition in gut diseases","volume":"25","author":"Niccolai","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.biopha.2022.112759_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0247378","article-title":"Stool metabolome-microbiota evaluation among children and adolescents with obesity, overweight, and normal-weight using 1H NMR and 16S rRNA gene profiling","volume":"16","author":"Jaimes","year":"2021","journal-title":"PloS One"},{"key":"10.1016\/j.biopha.2022.112759_bib48","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s10096-017-3143-0","article-title":"Gut microbiome production of short-chain fatty acids and obesity in children","volume":"37","author":"Murugesan","year":"2018","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.biopha.2022.112759_bib49","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/oby.2009.167","article-title":"Microbiota and SCFA in lean and overweight healthy subjects","volume":"18","author":"Schwiertz","year":"2010","journal-title":"Obesity"},{"key":"10.1016\/j.biopha.2022.112759_bib50","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1016\/j.clnu.2020.11.014","article-title":"The associations of the gut microbiome composition and short-chain fatty acid concentrations with body fat distribution in children","volume":"40","author":"Wei","year":"2021","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.biopha.2022.112759_bib51","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1126\/science.1155725","article-title":"Evolution of mammals and their gut microbes","volume":"320","author":"Ley","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.biopha.2022.112759_bib52","first-page":"1","article-title":"Eubiosis and dysbiosis: the two sides of the microbiota","volume":"39","author":"Iebba","year":"2016","journal-title":"N. Microbiol"},{"key":"10.1016\/j.biopha.2022.112759_bib53","first-page":"1679","article-title":"Rebuilding the gut microbiota ecosystem","volume":"15","author":"Gagliardi","year":"2018","journal-title":"Int. J. Environ. Res."},{"key":"10.1016\/j.biopha.2022.112759_bib54","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/ijo.2017.281","article-title":"Body size phenotypes comprehensively assess cardiometabolic risk and refine the association between obesity and gut microbiota","volume":"42","author":"de la Cuesta-Zuluaga","year":"2018","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.biopha.2022.112759_bib55","article-title":"Alteration of the gut microbiota associated with childhood obesity by 16S rRNA gene sequencing","volume":"8","author":"Chen","year":"2020","journal-title":"PeerJ"},{"key":"10.1016\/j.biopha.2022.112759_bib56","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1038\/s12276-020-0459-0","article-title":"Exercise training modulates the gut microbiota profile and impairs inflammatory signaling pathways in obese children","volume":"52","author":"Quiroga","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.biopha.2022.112759_bib57","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2020.1849998","article-title":"From correlation to causality: the case of Subdoligranulum","volume":"12","author":"van Hul","year":"2020","journal-title":"Gut Microbes"},{"key":"10.1016\/j.biopha.2022.112759_bib58","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3389\/fcimb.2020.00063","article-title":"Gut microbiome profiles are associated with type 2 diabetes in urban Africans","volume":"10","author":"Doumatey","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.biopha.2022.112759_bib59","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41586-019-1065-y","article-title":"Structural variation in the gut microbiome associates with host health","volume":"568","author":"Zeevi","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2022.112759_bib60","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1053\/j.gastro.2020.08.007","article-title":"Alterations in intestinal microbiota of children with celiac disease at the time of diagnosis and on a gluten-free diet","volume":"159","author":"Zafeiropoulou","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biopha.2022.112759_bib61","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/j.jaci.2017.05.054","article-title":"Intestinal microbiota in infants at high risk for allergy: Effects of prebiotics and role in eczema development","volume":"141","author":"Wopereis","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.biopha.2022.112759_bib62","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s00405-016-4058-6","article-title":"The possible mechanisms of the human microbiome in allergic diseases","volume":"274","author":"Ipci","year":"2017","journal-title":"Eur. Arch. Oto-Rhino-L"},{"key":"10.1016\/j.biopha.2022.112759_bib63","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2020.1801964","article-title":"A compromised developmental trajectory of the infant gut microbiome and metabolome in atopic eczema","volume":"12","author":"Ta","year":"2020","journal-title":"Gut Microbes"},{"key":"10.1016\/j.biopha.2022.112759_bib64","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aab2271","article-title":"Early infancy microbial and metabolic alterations affect risk of childhood Asthma","volume":"7","author":"Arrieta","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.biopha.2022.112759_bib65","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.tifs.2018.11.007","article-title":"Application of propolis in antimicrobial and antioxidative protection of food quality\u2013a review","volume":"83","author":"Pobiega","year":"2019","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.biopha.2022.112759_bib66","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.tifs.2021.06.041","article-title":"The use of propolis as a functional food ingredient: a review","volume":"115","author":"Irigoiti","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.biopha.2022.112759_bib67","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jscs.2010.10.012","article-title":"Evaluation of the safety and antioxidant activities of Crocus sativus and Propolis ethanolic extracts","volume":"16","author":"Ramadan","year":"2012","journal-title":"J. Saudi Chem. Soc."},{"key":"10.1016\/j.biopha.2022.112759_bib68","article-title":"Propolis in the prevention of oral mucositis in breast cancer patients receiving adjuvant chemotherapy: a pilot randomised controlled trial","volume":"26","author":"Piredda","year":"2017","journal-title":"Eur. J. Cancer Care."},{"key":"10.1016\/j.biopha.2022.112759_bib69","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.3390\/nu13082604","article-title":"Clinical and immunological efficacy of Mangosteen and Propolis extracted complex in patients with gingivitis: a multi-centered randomized controlled clinical trial","volume":"13","author":"Park","year":"2021","journal-title":"Nutrients"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332222001470?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332222001470?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:24:13Z","timestamp":1781763853000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332222001470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":69,"alternative-id":["S0753332222001470"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2022.112759","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluating the effects of a standardized polyphenol mixture extracted from poplar-type propolis on healthy and diseased human gut microbiota","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2022.112759","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"112759"}}