{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T01:00:40Z","timestamp":1794445240271,"version":"4.9.1"},"reference-count":146,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:00:00Z","timestamp":1652659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety","doi-asserted-by":"publisher","award":["KMDF_PR_20200901_0082"],"award-info":[{"award-number":["KMDF_PR_20200901_0082"]}],"id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019266","name":"Korea Medical Device Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002632","name":"Hallym University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002632","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2019R1F1A1059300"],"award-info":[{"award-number":["NRF-2019R1F1A1059300"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003052","name":"Ministry of Trade, Industry and Energy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.biopha.2022.113134","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T23:21:20Z","timestamp":1653348080000},"page":"113134","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":133,"special_numbering":"C","title":["Diabetes mellitus and diabetic foot ulcer: Etiology, biochemical and molecular based treatment strategies via gene and nanotherapy"],"prefix":"10.1016","volume":"151","author":[{"given":"Arokia Vijaya Anand","family":"Mariadoss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allur Subramaniyan","family":"Sivakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Hun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Jae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2022.113134_bib1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/9781118924853.ch2","article-title":"Classification and diagnosis of diabetes","author":"Ramachandran","year":"2017","journal-title":"Textb. Diabetes"},{"issue":"5","key":"10.1016\/j.biopha.2022.113134_bib2","doi-asserted-by":"crossref","first-page":"950","DOI":"10.2337\/dc08-2022","article-title":"Metabolic syndrome as a risk factor for cardiovascular disease, mortality, and progression of diabetic nephropathy in type 1 diabetes","volume":"32","author":"Thorn","year":"2009","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.biopha.2022.113134_bib3","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.diabres.2009.10.007","article-title":"Global estimates of the prevalence of diabetes for 2010 and 2030","volume":"87","author":"Shaw","year":"2010","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.biopha.2022.113134_bib4","doi-asserted-by":"crossref","first-page":"S173","DOI":"10.1016\/S0020-7292(15)30007-2","article-title":"The International Federation of Gynecology and Obstetrics (FIGO) Initiative on gestational diabetes mellitus: a pragmatic guide for diagnosis, management, and care","volume":"131","author":"Hod","year":"2015","journal-title":"Int. J. Gynecol. Obstet."},{"issue":"9","key":"10.1016\/j.biopha.2022.113134_bib5","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1016\/j.bbadis.2019.05.004","article-title":"Molecular and cellular bases of diabetes: focus on type 2 diabetes mouse model-TallyHo","volume":"1865","author":"Tamarai","year":"2019","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Basis Dis."},{"issue":"11","key":"10.1016\/j.biopha.2022.113134_bib6","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/s41574-019-0254-y","article-title":"The heterogeneous pathogenesis of type 1 diabetes mellitus","volume":"15","author":"Ilonen","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"issue":"5","key":"10.1016\/j.biopha.2022.113134_bib7","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1017\/S0007114508966137","article-title":"Eating behaviours and obesity in the adult population of Spain","volume":"100","author":"Marin-Guerrero","year":"2008","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.biopha.2022.113134_bib8","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.smrv.2016.07.002","article-title":"Prevalence of obstructive sleep apnea in the general population: a systematic review","volume":"34","author":"Senaratna","year":"2017","journal-title":"Sleep Med. Rev."},{"issue":"Suppl.","key":"10.1016\/j.biopha.2022.113134_bib9","doi-asserted-by":"crossref","first-page":"S1395","DOI":"10.1515\/jpem-2000-s613","article-title":"Emergence of type 2 diabetes mellitus in children: epidemiological evidence: division of diabetes translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA","volume":"13","author":"Fagot-Campagna","year":"2000","journal-title":"J. Pediatr. Endocrinol. Metab."},{"issue":"11","key":"10.1016\/j.biopha.2022.113134_bib10","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.2337\/dc09-0227","article-title":"Alcohol as a risk factor for type 2 diabetes: a systematic review and meta-analysis","volume":"32","author":"Baliunas","year":"2009","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.biopha.2022.113134_bib11","first-page":"463","article-title":"Glucose counterregulatory responses to hypoglycemia","volume":"9","author":"Sprague","year":"2011","journal-title":"Pediatr. Endocrinol. Rev."},{"issue":"2","key":"10.1016\/j.biopha.2022.113134_bib12","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/s41580-020-00317-7","article-title":"Mechanisms controlling pancreatic islet cell function in insulin secretion","volume":"22","author":"Campbell","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"14","key":"10.1016\/j.biopha.2022.113134_bib13","doi-asserted-by":"crossref","first-page":"9677","DOI":"10.1021\/acs.jmedchem.1c00410","article-title":"Targeting small GTPases and their prenylation in diabetes mellitus","volume":"64","author":"Gendaszewska-Darmach","year":"2021","journal-title":"J. Med. Chem."},{"issue":"11","key":"10.1016\/j.biopha.2022.113134_bib14","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.7150\/ijbs.27173","article-title":"The PI3K\/AKT pathway in obesity and type 2 diabetes","volume":"14","author":"Huang","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.biopha.2022.113134_bib15","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/9601801","article-title":"Pancreatic beta cell death: novel potential mechanisms in diabetes therapy","volume":"2018","author":"Rojas","year":"2018","journal-title":"J. Diabetes Res."},{"issue":"5","key":"10.1016\/j.biopha.2022.113134_bib16","first-page":"224","article-title":"Dose-dependent effect of galangin on fructose-mediated insulin resistance and oxidative events in rat kidney","volume":"15","author":"Sivakumar","year":"2010","journal-title":"Front. Endocrinol."},{"issue":"11","key":"10.1016\/j.biopha.2022.113134_bib17","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.2337\/dc08-1171","article-title":"Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis","volume":"31","author":"Bodmer","year":"2008","journal-title":"Diabetes Care"},{"issue":"3","key":"10.1016\/j.biopha.2022.113134_bib18","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/dom.12591","article-title":"Incretin therapies: highlighting common features and differences in the modes of action of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors","volume":"18","author":"Nauck","year":"2016","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.biopha.2022.113134_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2013.00177","article-title":"The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety","volume":"4","author":"Ekor","year":"2014","journal-title":"Front. Pharm."},{"key":"10.1016\/j.biopha.2022.113134_bib20","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.clnesp.2017.04.082","article-title":"Effect of high and low glycemic index breakfast on postprandial metabolic parameters and satiety in subjects with type 2 diabetes mellitus under intensive insulin therapy: controlled clinical trial","volume":"20","author":"Lobos","year":"2017","journal-title":"Clin. Nutr. ESPEN"},{"key":"10.1016\/j.biopha.2022.113134_bib21","first-page":"26","article-title":"Diabetic foot infections: current diagnosis and treatment","author":"Mendes","year":"2012","journal-title":"J. Diabet. Foot Complicat."},{"issue":"3","key":"10.1016\/j.biopha.2022.113134_bib22","doi-asserted-by":"crossref","first-page":"616","DOI":"10.2337\/dc19-0476","article-title":"A multinational, multicenter, randomized, double-blinded, placebo-controlled trial to evaluate the efficacy of cyclical topical wound oxygen (TWO2) therapy in the treatment of chronic diabetic foot ulcers: the TWO2 study","volume":"43","author":"Frykberg","year":"2020","journal-title":"Diabetes Care"},{"issue":"6","key":"10.1016\/j.biopha.2022.113134_bib23","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/S2213-8587(19)30093-2","article-title":"Morbidity and mortality after lifestyle intervention for people with impaired glucose tolerance: 30-year results of the Da Qing Diabetes Prevention Outcome Study","volume":"7","author":"Gong","year":"2019","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"4","key":"10.1016\/j.biopha.2022.113134_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/dmrr.3258","article-title":"The role of foot pressure measurement in the prediction and prevention of diabetic foot ulceration\u2013a comprehensive review","volume":"36","author":"Chatwin","year":"2020","journal-title":"Diabetes\/Metab. Res. Rev."},{"issue":"8","key":"10.1016\/j.biopha.2022.113134_bib25","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/S2213-8587(19)30082-8","article-title":"The burden of diabetes and use of diabetes care in humanitarian crises in low-income and middle-income countries","volume":"7","author":"Kehlenbrink","year":"2019","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"3","key":"10.1016\/j.biopha.2022.113134_bib26","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1016\/S2666-7568(20)30014-3","article-title":"Frailty measurement, prevalence, incidence, and clinical implications in people with diabetes: a systematic review and study-level meta-analysis","volume":"1","author":"Hanlon","year":"2020","journal-title":"Lancet Healthy Longev."},{"issue":"7","key":"10.1016\/j.biopha.2022.113134_bib27","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1007\/s00125-021-05441-3","article-title":"Diabetes-related lower extremity complications in a multi-ethnic Asian population: a 10 year observational study in Singapore","volume":"64","author":"Riandini","year":"2021","journal-title":"Diabetologia"},{"issue":"11","key":"10.1016\/j.biopha.2022.113134_bib28","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1007\/s00125-021-05554-9","article-title":"Racial differences in all-cause mortality and future complications among people with diabetes: a systematic review and meta-analysis of data from more than 2.4 million individuals","volume":"64","author":"Ezzatvar","year":"2021","journal-title":"Diabetologia"},{"issue":"Suppl. 5","key":"10.1016\/j.biopha.2022.113134_bib29","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.12968\/jowc.2018.27.Sup5.S1","article-title":"Identifying and treating foot ulcers in patients with diabetes: saving feet, legs and lives","volume":"27","author":"Ousey","year":"2018","journal-title":"J. Wound Care"},{"issue":"1","key":"10.1016\/j.biopha.2022.113134_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaad.2013.07.048","article-title":"Diabetic foot ulcers: Part I. Pathophysiology and prevention","volume":"70","author":"Alavi","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"issue":"2","key":"10.1016\/j.biopha.2022.113134_bib31","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1177\/107110078100200202","article-title":"The dysvascular foot: a system for diagnosis and treatment","volume":"2","author":"Wagner","year":"1981","journal-title":"Foot Ankle"},{"issue":"Sup 7","key":"10.1016\/j.biopha.2022.113134_bib32","doi-asserted-by":"crossref","first-page":"212S","DOI":"10.1097\/01.prs.0000222737.09322.77","article-title":"Diagnosis and treatment of diabetic foot infections","volume":"117","author":"Lipsky","year":"2006","journal-title":"Plast. Reconstr. Surg."},{"issue":"3","key":"10.1016\/j.biopha.2022.113134_bib33","doi-asserted-by":"crossref","first-page":"715","DOI":"10.5455\/medscience.2013.02.8069","article-title":"Diabetic foot classifications: review of literature","volume":"2","author":"Jain","year":"2013","journal-title":"Med. Sci."},{"key":"10.1016\/j.biopha.2022.113134_bib34","article-title":"Ulcer and wound care: getting to the depth of the tissue","author":"Corum","year":"2019","journal-title":"Natl. Cent. Contin. Educ."},{"issue":"12","key":"10.1016\/j.biopha.2022.113134_bib35","doi-asserted-by":"crossref","first-page":"3928","DOI":"10.18203\/2349-2902.isj20175159","article-title":"Clinicopathological study and management of diabetic foot","volume":"4","author":"Chethan","year":"2017","journal-title":"Int. Surg. J."},{"issue":"2","key":"10.1016\/j.biopha.2022.113134_bib36","doi-asserted-by":"crossref","first-page":"3S","DOI":"10.1016\/j.jvs.2015.10.003","article-title":"The management of diabetic foot: a clinical practice guideline by the Society for Vascular Surgery in collaboration with the American Podiatric Medical Association and the Society for Vascular Medicine","volume":"63","author":"Hingorani","year":"2016","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.biopha.2022.113134_bib37","series-title":"Foot Self-Care Practices among Patients with Type 2 Diabetes and Diabetic Foot Ulcers: The Lived Experience","author":"Oni","year":"2018"},{"issue":"11","key":"10.1016\/j.biopha.2022.113134_bib38","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1016\/j.clinthera.2013.09.013","article-title":"Clinical and economic assessment of diabetic foot ulcer debridement with collagenase: results of a randomized controlled study","volume":"35","author":"Tallis","year":"2013","journal-title":"Clin. Ther."},{"issue":"4","key":"10.1016\/j.biopha.2022.113134_bib39","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0738-081X(91)90088-3","article-title":"Debridement of cutaneous ulcers: medical and surgical aspects","volume":"9","author":"Witkowski","year":"1991","journal-title":"Clin. Dermatol."},{"issue":"5","key":"10.1016\/j.biopha.2022.113134_bib40","first-page":"517","article-title":"Increased burden of disease and role of health economics: Asia-pacific region","volume":"19","author":"Shah","year":"2019","journal-title":"Expert Rev. Pharm. Outcomes Res."},{"issue":"11","key":"10.1016\/j.biopha.2022.113134_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113020","article-title":"Differential stimulation of insulin secretion by GLP-1 and Kisspeptin-10","volume":"9","author":"Schwetz","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.biopha.2022.113134_bib42","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s12013-007-0028-3","article-title":"The role of islet neogenesis-associated protein (INGAP) in islet neogenesis","volume":"48","author":"Lipsett","year":"2007","journal-title":"Cell Biochem. Biophys."},{"issue":"4","key":"10.1016\/j.biopha.2022.113134_bib43","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/sj.bjp.0707452","article-title":"Thiazolidinediones: effects on insulin resistance and the cardiovascular system","volume":"153","author":"Quinn","year":"2008","journal-title":"Br. J. Pharm."},{"issue":"4","key":"10.1016\/j.biopha.2022.113134_bib44","doi-asserted-by":"crossref","first-page":"840","DOI":"10.5114\/aoms.2015.53304","article-title":"Sulfonylureas and their use in clinical practice","volume":"11","author":"Sola","year":"2015","journal-title":"Arch. Med. Sci."},{"issue":"1","key":"10.1016\/j.biopha.2022.113134_bib45","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s12325-018-0824-8","article-title":"Body weight considerations in the management of Type 2 diabetes","volume":"36","author":"Apovian","year":"2019","journal-title":"Adv. Ther."},{"issue":"10","key":"10.1016\/j.biopha.2022.113134_bib46","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1016\/j.biochi.2013.06.013","article-title":"Antihyperglycemic effect of fraxetin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats","volume":"95","author":"Murali","year":"2013","journal-title":"Biochimie"},{"issue":"1","key":"10.1016\/j.biopha.2022.113134_bib47","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12986-015-0057-7","article-title":"Anti-diabetic properties of dietary flavonoids: a cellular mechanism review","volume":"12","author":"Vinayagam","year":"2015","journal-title":"Nutr. Metab."},{"issue":"1","key":"10.1016\/j.biopha.2022.113134_bib48","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cbi.2011.10.003","article-title":"Ameliorative effect of diosmin, a citrus flavonoid against streptozotocin-nicotinamide generated oxidative stress induced diabetic rats","volume":"195","author":"Srinivasan","year":"2012","journal-title":"Chem.-Biol. Interact."},{"key":"10.1016\/j.biopha.2022.113134_bib49","series-title":"Bioactive Food as Dietary Interventions for Diabetes","first-page":"335","article-title":"Chapter 22 \u2013 anti-diabetic efficacy of citrus fruits with special allusion to flavone glycosides","author":"Srinivasan","year":"2019"},{"issue":"6","key":"10.1016\/j.biopha.2022.113134_bib50","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.3390\/ijms21062217","article-title":"Plant-based antidiabetic nanoformulations: the emerging paradigm for effective therapy","volume":"21","author":"Dewanjee","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.biopha.2022.113134_bib51","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.molmed.2010.08.002","article-title":"Nanosensors and nanomaterials for monitoring glucose in diabetes","volume":"16","author":"Cash","year":"2010","journal-title":"Trends Mol. Med."},{"issue":"2","key":"10.1016\/j.biopha.2022.113134_bib52","first-page":"65","article-title":"Microencapsulation: a promising technique for controlled drug delivery","volume":"5","author":"Singh","year":"2010","journal-title":"Res. Pharm. Sci."},{"key":"10.1016\/j.biopha.2022.113134_bib53","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/474605","article-title":"Nanoparticulate adjuvants and delivery systems for allergen immunotherapy","volume":"2012","author":"De Souza Rebou\u00e7as","year":"2012","journal-title":"J. Biomed. Biotechnol."},{"issue":"2","key":"10.1016\/j.biopha.2022.113134_bib54","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2147\/IJN.S596","article-title":"Drug delivery and nanoparticles: applications and hazards","volume":"3","author":"De Jong","year":"2008","journal-title":"Int. J. Nanomed."},{"issue":"13","key":"10.1016\/j.biopha.2022.113134_bib55","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.2174\/1389557519666190311154425","article-title":"Pharmacological aspects and potential use of phloretin: a systemic review","volume":"19","author":"Mariadoss","year":"2019","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.biopha.2022.113134_bib56","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.ijbiomac.2019.03.031","article-title":"Phloretin loaded chitosan nanoparticles augments the pH-dependent mitochondrial-mediated intrinsic apoptosis in human oral cancer cells","volume":"130","author":"Mariadoss","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"issue":"4","key":"10.1016\/j.biopha.2022.113134_bib57","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S2221-6189(13)60149-3","article-title":"Syringic acid, a novel natural phenolic acid, normalizes hyperglycemia with special reference to glycoprotein components in experimental diabetic rats","volume":"2","author":"Muthukumaran","year":"2013","journal-title":"J. Acute Dis."},{"key":"10.1016\/j.biopha.2022.113134_bib58","article-title":"Green synthesis of gold nanoparticle using Eclipta alba and its anti-diabetic activities through regulation of Bcl-2 expression in pancreatic cell line","volume":"58","author":"Vijayakumar","year":"2020","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"1","key":"10.1016\/j.biopha.2022.113134_bib59","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3390\/antiox9010008","article-title":"Anti-diabetic activity of gold nanoparticles synthesized using wedelolactone in RIN-5F cell line","volume":"9","author":"Ramachandran","year":"2020","journal-title":"Antioxidants"},{"issue":"1","key":"10.1016\/j.biopha.2022.113134_bib60","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3390\/antiox10010099","article-title":"Ethyl acetate fraction of Helianthus tuberosus L. induces anti-diabetic, and wound-healing activities in insulin-resistant human liver cancer and mouse fibroblast cells","volume":"10","author":"Mariadoss","year":"2021","journal-title":"Antioxidants"},{"issue":"2","key":"10.1016\/j.biopha.2022.113134_bib61","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.cbi.2011.06.003","article-title":"Effect of galangin supplementation on oxidative damage and inflammatory changes in fructose-fed rat liver","volume":"193","author":"Sivakumar","year":"2011","journal-title":"Chem.-Biol. Interact."},{"issue":"6","key":"10.1016\/j.biopha.2022.113134_bib62","doi-asserted-by":"crossref","first-page":"8618","DOI":"10.1016\/j.ceramint.2020.11.230","article-title":"Antioxidant and anti-diabetic properties of biocompatible ceria oxide (CeO2) nanoparticles in mouse fibroblast NIH3T3 and insulin resistant HepG2 cells","volume":"47","author":"Saravanakumar","year":"2021","journal-title":"Ceram. Int."},{"issue":"3","key":"10.1016\/j.biopha.2022.113134_bib63","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s11101-017-9496-2","article-title":"An insight into anti-diabetic properties of dietary phytochemicals","volume":"16","author":"Vinayagam","year":"2017","journal-title":"Phytochem. Rev."},{"issue":"4","key":"10.1016\/j.biopha.2022.113134_bib64","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S2221-6189(13)60150-X","article-title":"Antihyperglycemic effect of carvone: effect on the levels of glycoprotein components in streptozotocin-induced diabetic rats","volume":"2","author":"Muruganathan","year":"2013","journal-title":"J. Acute Dis."},{"issue":"6909","key":"10.1016\/j.biopha.2022.113134_bib65","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1136\/bmj.307.6909.881","article-title":"Diabetic control and complications","volume":"307","author":"Amiel","year":"1993","journal-title":"BMJ"},{"key":"10.1016\/j.biopha.2022.113134_bib66","doi-asserted-by":"crossref","first-page":"10215","DOI":"10.2147\/IJN.S285134","article-title":"Oral nano drug delivery systems for the treatment of type 2 diabetes mellitus: an available administration strategy for antidiabetic phytocompounds","volume":"15","author":"Nie","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.biopha.2022.113134_bib67","doi-asserted-by":"crossref","DOI":"10.1186\/s40824-016-0083-1","article-title":"Liposomal delivery systems for intestinal lymphatic drug transport","volume":"20","author":"Ahn","year":"2016","journal-title":"Biomater. Res."},{"key":"10.1016\/j.biopha.2022.113134_bib68","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cbi.2019.05.008","article-title":"Phloretin loaded chitosan nanoparticles enhance the antioxidants and apoptotic mechanisms in DMBA induced experimental carcinogenesis","volume":"308","author":"Mariadoss","year":"2019","journal-title":"Chem.-Biol. Interact."},{"issue":"1","key":"10.1016\/j.biopha.2022.113134_bib69","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12951-018-0392-8","article-title":"Nano based drug delivery systems: recent developments and future prospects","volume":"16","author":"Patra","year":"2018","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.biopha.2022.113134_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2019.07.004","article-title":"Enhanced cancer therapy with pH-dependent and aptamer functionalized doxorubicin loaded polymeric (poly d,l-lactic-co-glycolic acid) nanoparticles","volume":"671","author":"Saravanakumar","year":"2019","journal-title":"Arch. Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.biopha.2022.113134_bib71","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1080\/10717544.2017.1321062","article-title":"PEG\u2013lipid\u2013PLGA hybrid nanoparticles loaded with berberine\u2013phospholipid complex to facilitate the oral delivery efficiency","volume":"24","author":"Yu","year":"2017","journal-title":"Drug Deliv."},{"key":"10.1016\/j.biopha.2022.113134_bib72","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24234209","article-title":"Nanoparticle delivery systems in the treatment of diabetes complications","author":"Souto","year":"2019","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.biopha.2022.113134_bib73","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1515\/biol-2018-0035","article-title":"Nanoparticles as carriers of proteins, peptides and other therapeutic molecules","volume":"13","author":"Pudlarz","year":"2018","journal-title":"Open Life Sci."},{"issue":"47","key":"10.1016\/j.biopha.2022.113134_bib74","doi-asserted-by":"crossref","first-page":"20853","DOI":"10.1039\/D0NJ04202A","article-title":"Synthesis of vildagliptin conjugated metal nanoparticles for type II diabetes control: targeting the DPP-IV enzyme","volume":"44","author":"Fayyaz","year":"2020","journal-title":"New J. Chem."},{"issue":"1","key":"10.1016\/j.biopha.2022.113134_bib75","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3390\/antiox9010008","article-title":"Anti-diabetic activity of gold nanoparticles synthesized using wedelolactone in RIN-5F cell line","volume":"9","author":"Ramachandran","year":"2020","journal-title":"Antioxidants"},{"issue":"46","key":"10.1016\/j.biopha.2022.113134_bib76","doi-asserted-by":"crossref","first-page":"40162","DOI":"10.1039\/C5RA24391B","article-title":"Anti-diabetic activity of silver nanoparticles from green synthesis using Lonicera japonica leaf extract","volume":"6","author":"Balan","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.biopha.2022.113134_bib77","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jphotobiol.2017.02.017","article-title":"Biosynthesis of polyphenol-stabilised nanoparticles and assessment of anti-diabetic activity","volume":"169","author":"Li","year":"2017","journal-title":"J. Photochem. Photobiol. B: Biol."},{"issue":"1","key":"10.1016\/j.biopha.2022.113134_bib78","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1080\/14686996.2020.1788907","article-title":"Biosynthesis of selenium nanoparticles and their protective, antioxidative effects in streptozotocin induced diabetic rats","volume":"21","author":"Fan","year":"2020","journal-title":"Sci. Technol. Adv. Mater."},{"issue":"43","key":"10.1016\/j.biopha.2022.113134_bib79","doi-asserted-by":"crossref","first-page":"36870","DOI":"10.1039\/C6RA03890E","article-title":"Synthesis and preliminary therapeutic evaluation of copper nanoparticles against diabetes mellitus and -induced micro- (renal) and macro-vascular (vascular endothelial and cardiovascular) abnormalities in rats","volume":"6","author":"Sharma","year":"2016","journal-title":"RSC Adv."},{"issue":"5","key":"10.1016\/j.biopha.2022.113134_bib80","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.ejps.2012.08.018","article-title":"Topical treatment with anti-oxidants and Au nanoparticles promote healing of diabetic wound through receptor for advance glycation end-products","volume":"47","author":"Chen","year":"2012","journal-title":"Eur. J. Pharm. Sci."},{"issue":"8","key":"10.1016\/j.biopha.2022.113134_bib81","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1049\/iet-nbt.2020.0079","article-title":"Zinc oxide nanoparticles augment CD4, CD8, and GLUT-4 expression and restrict inflammation response in streptozotocin-induced diabetic rats","volume":"14","author":"Elassy","year":"2020","journal-title":"IET Nanobiotechnol."},{"issue":"5","key":"10.1016\/j.biopha.2022.113134_bib82","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1049\/nbt2.12026","article-title":"Alleviation of diabetic nephropathy by zinc oxide nanoparticles in streptozotocin-induced type 1 diabetes in rats","volume":"15","author":"Alomari","year":"2021","journal-title":"IET Nanobiotechnol."},{"issue":"8","key":"10.1016\/j.biopha.2022.113134_bib83","doi-asserted-by":"crossref","first-page":"8597","DOI":"10.1021\/acsnano.9b02050","article-title":"Gadofullerene nanoparticles reverse dysfunctions of pancreas and improve hepatic insulin resistance for type 2 diabetes mellitus treatment","volume":"13","author":"Li","year":"2019","journal-title":"ACS Nano"},{"issue":"9\u201310","key":"10.1016\/j.biopha.2022.113134_bib84","first-page":"391","article-title":"Antihyperglycemic activities of extracts of the mistletoes Plicosepalus acaciae and P. curviflorus in comparison to their solid lipid nanoparticle suspension formulations, Zeitschrift fur Naturforschung. C","volume":"69","author":"Aldawsari","year":"2014","journal-title":"J. Biosci."},{"key":"10.1016\/j.biopha.2022.113134_bib85","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jddst.2017.08.006","article-title":"Optimization of processing parameters for the development of Ficus religiosa L. extract loaded solid lipid nanoparticles using central composite design and evaluation of anti-diabetic efficacy","volume":"43","author":"Priyanka","year":"2018","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.biopha.2022.113134_bib86","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.msec.2018.06.055","article-title":"In-vivo sustained release of nanoencapsulated ferulic acid and its impact in induced diabetes","volume":"92","author":"Panwar","year":"2018","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"issue":"2","key":"10.1016\/j.biopha.2022.113134_bib87","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s13346-012-0063-5","article-title":"Development of quercetin nanoformulation and in vivo evaluation using streptozotocin induced diabetic rat model","volume":"2","author":"Chitkara","year":"2012","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.biopha.2022.113134_bib88","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1016\/j.ijbiomac.2018.09.010","article-title":"In-vivo anti-diabetic and wound healing potential of chitosan\/alginate\/maltodextrin\/pluronic-based mixed polymeric micelles: curcumin therapeutic potential","volume":"120","author":"Akbar","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.biopha.2022.113134_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcab.2019.101433","article-title":"Nano-suspension of ursolic acid for improving oral bioavailability and attenuation of type II diabetes: a histopathological investigation","volume":"22","author":"Singh","year":"2019","journal-title":"Biocatal. Agric. Biotechnol."},{"key":"10.1016\/j.biopha.2022.113134_bib90","article-title":"Berberine nanosuspension enhances hypoglycemic efficacy on streptozotocin induced diabetic C57BL\/6 mice","volume":"2015","author":"Wang","year":"2015","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.biopha.2022.113134_bib91","doi-asserted-by":"crossref","first-page":"9265","DOI":"10.2147\/IJN.S268941","article-title":"Sesamol-loaded PLGA nanosuspension for accelerating wound healing in diabetic foot ulcer in rats","volume":"15","author":"Gourishetti","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.biopha.2022.113134_bib92","article-title":"Nanosuspension of flavonoid-rich fraction from Psidium guajava Linn for improved type 2-diabetes potential","volume":"62","author":"Gaur","year":"2021","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"2","key":"10.1016\/j.biopha.2022.113134_bib93","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s12668-021-00843-4","article-title":"Engineering of crystalline nano-suspension of lycopene for potential management of oxidative stress\u2013linked diabetes in experimental animals","volume":"11","author":"Mishra","year":"2021","journal-title":"BioNanoScience"},{"issue":"4","key":"10.1016\/j.biopha.2022.113134_bib94","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1208\/s12249-012-9833-0","article-title":"Eudragit-based nanosuspension of poorly water-soluble drug: formulation and in vitro-in vivo evaluation","volume":"13","author":"Yadav","year":"2012","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.biopha.2022.113134_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2019.118838","article-title":"Nanostructured lipid carriers for oral delivery of silymarin: improving its absorption and in vivo efficacy in type 2 diabetes and metabolic syndrome model","volume":"572","author":"Piazzini","year":"2019","journal-title":"Int. J. Pharm."},{"issue":"10","key":"10.1016\/j.biopha.2022.113134_bib96","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1089\/wound.2018.0831","article-title":"Nanostructured lipid carriers of pioglitazone loaded collagen\/chitosan composite Scaffold for diabetic wound healing","volume":"8","author":"Natarajan","year":"2019","journal-title":"Adv. Wound Care"},{"issue":"20","key":"10.1016\/j.biopha.2022.113134_bib97","doi-asserted-by":"crossref","first-page":"4610","DOI":"10.3390\/molecules25204610","article-title":"An EGF- and curcumin-co-encapsulated nanostructured lipid carrier accelerates chronic-wound healing in diabetic rats","volume":"25","author":"Lee","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2022.113134_bib98","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.foot.2019.03.007","article-title":"The impact of topical phenytoin loaded nanostructured lipid carriers in diabetic foot ulceration","volume":"40","author":"Motawea","year":"2019","journal-title":"Foot"},{"issue":"47","key":"10.1016\/j.biopha.2022.113134_bib99","doi-asserted-by":"crossref","first-page":"198","DOI":"10.4103\/0973-1296.186347","article-title":"Nanostructured lipid carriers loaded with baicalin: an efficient carrier for enhanced anti-diabetic effects","volume":"12","author":"Shi","year":"2016","journal-title":"Pharmacogn. Mag."},{"key":"10.1016\/j.biopha.2022.113134_bib100","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9725738","article-title":"Migration and proliferation effects of thymoquinone-loaded nanostructured lipid carrier (TQ-NLC) and thymoquinone (TQ) on in vitro wound healing models","volume":"2019","author":"Alexander","year":"2019","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"10.1016\/j.biopha.2022.113134_bib101","first-page":"103","article-title":"Anti-diabetic activity of lycopene niosomes: experimental observation","volume":"4","author":"Sharma","year":"2017","journal-title":"J. Pharm. Drug Dev."},{"key":"10.1016\/j.biopha.2022.113134_bib102","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.colsurfb.2019.06.006","article-title":"Nanoemulsion improves hypoglycemic efficacy of berberine by overcoming its gastrointestinal challenge","volume":"181","author":"Xu","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.biopha.2022.113134_bib103","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1016\/j.biopha.2017.11.073","article-title":"Embelin-loaded oral niosomes ameliorate streptozotocin-induced diabetes in Wistar rats","volume":"97","author":"Alam","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.biopha.2022.113134_bib104","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1166\/jpsp.2015.1042","article-title":"Pioglitazone loaded vesicular carriers for anti-diabetic activity: development and optimization as per central composite design","volume":"2","author":"Haider","year":"2015","journal-title":"J. Pharm. Sci. Pharmacol."},{"issue":"8","key":"10.1016\/j.biopha.2022.113134_bib105","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.2217\/nnm.12.162","article-title":"Development and biological evaluation of Gymnema sylvestre extract-loaded nonionic surfactant-based niosomes","volume":"8","author":"Kamble","year":"2013","journal-title":"Nanomedicine"},{"issue":"1","key":"10.1016\/j.biopha.2022.113134_bib106","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13020-020-00321-1","article-title":"Niosomes of active Fumaria officinalis phytochemicals: anti-diabetic, antineuropathic, anti-inflammatory, and possible mechanisms of action","volume":"15","author":"Raafat","year":"2020","journal-title":"Chin. Med."},{"issue":"13","key":"10.1016\/j.biopha.2022.113134_bib107","doi-asserted-by":"crossref","first-page":"12904","DOI":"10.1021\/acsami.9b03275","article-title":"Facile fabrication of an amentoflavone-loaded micelle system for oral delivery to improve bioavailability and hypoglycemic effects in KKAy mice","volume":"11","author":"Zhang","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"19","key":"10.1016\/j.biopha.2022.113134_bib108","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.2217\/nnm-2016-0204","article-title":"A newly developed silymarin nanoformulation as a potential anti-diabetic agent in experimental diabetes","volume":"11","author":"El-Far","year":"2016","journal-title":"Nanomedicine"},{"key":"10.1016\/j.biopha.2022.113134_bib109","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jff.2019.05.015","article-title":"Enhancement of therapeutic efficacy of betanin for diabetes treatment by liposomal nanocarriers","volume":"59","author":"Amjadi","year":"2019","journal-title":"J. Funct. Foods"},{"issue":"2","key":"10.1016\/j.biopha.2022.113134_bib110","article-title":"Diabetes management using modern information and communication technologies and new care models","volume":"1","author":"Spanakis","year":"2012","journal-title":"Interact. J. Med. Res."},{"issue":"8","key":"10.1016\/j.biopha.2022.113134_bib111","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.3390\/s17081866","article-title":"Glucose sensing for diabetes monitoring: recent developments","volume":"17","author":"Bruen","year":"2017","journal-title":"Sensors"},{"issue":"2","key":"10.1016\/j.biopha.2022.113134_bib112","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1210\/10.1210\/er.2006-0038","article-title":"Beta-cell failure in diabetes and preservation by clinical treatment","volume":"28","author":"Wajchenberg","year":"2007","journal-title":"Endocr. Rev."},{"issue":"2","key":"10.1016\/j.biopha.2022.113134_bib113","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3390\/genes8020072","article-title":"Type 1 diabetes candidate genes linked to pancreatic islet cell inflammation and beta-cell apoptosis","volume":"8","author":"St\u00f8rling","year":"2017","journal-title":"Genes"},{"issue":"3","key":"10.1016\/j.biopha.2022.113134_bib114","doi-asserted-by":"crossref","first-page":"165","DOI":"10.4161\/self.1.3.12643","article-title":"Gene therapy in diabetes","volume":"1","author":"Wong","year":"2010","journal-title":"Self Nonself"},{"issue":"3","key":"10.1016\/j.biopha.2022.113134_bib115","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/s41574-020-00443-4","article-title":"Type 1 diabetes mellitus as a disease of the \u03b2-cell (do not blame the immune system?)","volume":"17","author":"Roep","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"issue":"5","key":"10.1016\/j.biopha.2022.113134_bib116","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.2337\/db15-1418","article-title":"Antigen-encoding bone marrow terminates islet-directed memory CD8+ T-cell responses to alleviate islet transplant rejection","volume":"65","author":"Coleman","year":"2016","journal-title":"Diabetes"},{"issue":"24","key":"10.1016\/j.biopha.2022.113134_bib117","doi-asserted-by":"crossref","first-page":"13913","DOI":"10.1073\/pnas.251532298","article-title":"Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice","volume":"98","author":"Song","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.biopha.2022.113134_bib118","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2174\/157339913804143225","article-title":"Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes","volume":"9","author":"Fu","year":"2013","journal-title":"Curr. Diabetes Rep."},{"issue":"3","key":"10.1016\/j.biopha.2022.113134_bib119","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/mt.2010.255","article-title":"Remission of diabetes by insulin gene therapy using a hepatocyte-specific and glucose-responsive synthetic promoter","volume":"19","author":"Han","year":"2011","journal-title":"Mol. Ther."},{"issue":"4","key":"10.1016\/j.biopha.2022.113134_bib120","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/MED.0000000000000174","article-title":"Pancreatic islet cell development and regeneration","volume":"22","author":"Romer","year":"2015","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"issue":"8\u20139","key":"10.1016\/j.biopha.2022.113134_bib121","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/jgm.2835","article-title":"Long-term glycemic control with hepatic insulin gene therapy in streptozotocin-diabetic mice","volume":"17","author":"Thul\u00e9","year":"2015","journal-title":"J. Gene Med."},{"key":"10.1016\/j.biopha.2022.113134_bib122","doi-asserted-by":"crossref","first-page":"6113","DOI":"10.2147\/IJN.S231480","article-title":"Innovative therapies and nanomedicine applications for the treatment of Alzheimer\u2019s disease: a state-of-the-art (2017\u20132020)","volume":"15","author":"Binda","year":"2020","journal-title":"Int. J. Nanomed."},{"issue":"6","key":"10.1016\/j.biopha.2022.113134_bib123","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1089\/hum.2006.17.625","article-title":"\u03b1 1-antitrypsin gene therapy modulates cellular immunity and efficiently prevents type 1 diabetes in nonobese diabetic mice","volume":"17","author":"Lu","year":"2006","journal-title":"Hum. Gene Ther."},{"issue":"5","key":"10.1016\/j.biopha.2022.113134_bib124","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/nm867","article-title":"NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice","volume":"9","author":"Kojima","year":"2003","journal-title":"Nat. Med."},{"issue":"6811","key":"10.1016\/j.biopha.2022.113134_bib125","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/35044106","article-title":"Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue","volume":"408","author":"Lee","year":"2000","journal-title":"Nature"},{"issue":"19","key":"10.1016\/j.biopha.2022.113134_bib126","doi-asserted-by":"crossref","first-page":"4433","DOI":"10.1111\/bph.15183","article-title":"Inhibition of heparanase protects against pancreatic beta cell death in streptozotocin-induced diabetic mice via reducing intra-islet inflammatory cell infiltration","volume":"177","author":"Song","year":"2020","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.biopha.2022.113134_bib127","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3390\/biomedicines8030053","article-title":"Reversal of hyperglycemia and suppression of type 1 diabetes in the NOD mouse with apoptotic DNA immunotherapyTM (ADiTM), ADi-100","volume":"8","author":"Alleva","year":"2020","journal-title":"Biomedicines"},{"issue":"2","key":"10.1016\/j.biopha.2022.113134_bib128","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1080\/21645515.2019.1616504","article-title":"Tolerogenic vaccine composited with islet-derived multipeptides and cyclosporin A induces pTreg and prevents Type 1 diabetes in murine model","volume":"16","author":"Zhou","year":"2020","journal-title":"Hum. Vaccin. Immunother."},{"key":"10.1016\/j.biopha.2022.113134_bib129","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.diabres.2016.01.006","article-title":"Effect of systemically increasing human full-length Klotho on glucose metabolism in db\/db mice","volume":"113","author":"Forsberg","year":"2016","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"2","key":"10.1016\/j.biopha.2022.113134_bib130","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/gt.2009.143","article-title":"DsAAV8-mediated expression of glucagon-like peptide-1 in pancreatic beta-cells ameliorates streptozotocin-induced diabetes","volume":"17","author":"Riedel","year":"2010","journal-title":"Gene Ther."},{"issue":"1","key":"10.1016\/j.biopha.2022.113134_bib131","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41434-018-0052-5","article-title":"Immunosuppression overcomes insulin- and vector-specific immune responses that limit efficacy of AAV2\/8-mediated insulin gene therapy in NOD mice","volume":"26","author":"Recino","year":"2019","journal-title":"Gene Ther."},{"key":"10.1016\/j.biopha.2022.113134_bib132","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41434-020-0183-3","article-title":"Lentiviral gene therapy vectors encoding VIP suppressed diabetes-related inflammation and augmented pancreatic beta-cell proliferation","volume":"28","author":"Erendor","year":"2020","journal-title":"Gene Ther."},{"issue":"8","key":"10.1016\/j.biopha.2022.113134_bib133","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201708791","article-title":"FGF21 gene therapy as treatment for obesity and insulin resistance","volume":"10","author":"Jimenez","year":"2018","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.biopha.2022.113134_bib134","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.diabres.2017.03.024","article-title":"IDF diabetes atlas: global estimates for the prevalence of diabetes for 2015 and 2040","volume":"128","author":"Ogurtsova","year":"2017","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"1","key":"10.1016\/j.biopha.2022.113134_bib135","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1089\/wound.2014.0586","article-title":"Choosing a wound dressing based on common wound characteristics","volume":"5","author":"Dabiri","year":"2016","journal-title":"Adv. Wound Care"},{"key":"10.1016\/j.biopha.2022.113134_bib136","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1201\/9781003245513-4","article-title":"Technological advances in nano-science for specific food and nutrition delivery","author":"Anilakumar","year":"2021","journal-title":"Adv. Process. Technol."},{"issue":"13","key":"10.1016\/j.biopha.2022.113134_bib137","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.3390\/ma12132176","article-title":"Nanomaterials for wound healing and infection control","volume":"12","author":"Mihai","year":"2019","journal-title":"Materials"},{"issue":"16","key":"10.1016\/j.biopha.2022.113134_bib138","doi-asserted-by":"crossref","first-page":"10049","DOI":"10.1021\/acsami.6b00291","article-title":"Engineered nanomaterials for infection control and healing acute and chronic wounds","volume":"8","author":"Parani","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.biopha.2022.113134_bib139","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jcis.2021.02.107","article-title":"Nanofibers reinforced injectable hydrogel with self-healing, antibacterial, and hemostatic properties for chronic wound healing","volume":"596","author":"Qiu","year":"2021","journal-title":"J. Colloid Interface Sci."},{"issue":"43","key":"10.1016\/j.biopha.2022.113134_bib140","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202002962","article-title":"Combating implant infections: shifting focus from bacteria to host","volume":"32","author":"Amin Yavari","year":"2020","journal-title":"Adv. Mater."},{"issue":"2","key":"10.1016\/j.biopha.2022.113134_bib141","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1002\/app.31249","article-title":"Hydrogel\u2013silver nanoparticle composites: a new generation of anti-microbials","volume":"115","author":"Varaprasad","year":"2010","journal-title":"J. Appl. Polym. Sci."},{"key":"10.1016\/j.biopha.2022.113134_bib142","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.actbio.2019.12.025","article-title":"Topical anti-microbial peptide formulations for wound healing: current developments and future prospects","volume":"103","author":"Thapa","year":"2020","journal-title":"Acta Biomater."},{"issue":"22","key":"10.1016\/j.biopha.2022.113134_bib143","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.2217\/nnm-2018-0487","article-title":"Improved stability of KGF by conjugation with gold nanoparticles for diabetic wound therapy","volume":"14","author":"Li","year":"2019","journal-title":"Nanomedicine"},{"issue":"1","key":"10.1016\/j.biopha.2022.113134_bib144","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2217\/nnm.12.205","article-title":"Zinc oxide nanoparticles show anti-diabetic activity in streptozotocin-induced Type 1 and 2 diabetic rats","volume":"9","author":"Umrani","year":"2014","journal-title":"Nanomedicine"},{"issue":"1","key":"10.1016\/j.biopha.2022.113134_bib145","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3390\/pharmaceutics14010111","article-title":"Tailoring of novel azithromycin-loaded zinc oxide nanoparticles for wound healing","volume":"14","author":"Saddik","year":"2022","journal-title":"Pharmaceutics"},{"issue":"1","key":"10.1016\/j.biopha.2022.113134_bib146","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40824-022-00252-y","article-title":"Shape-controlled synthesis of zinc nanostructures mediating macromolecules for biomedical applications","volume":"26","author":"Mousavi","year":"2022","journal-title":"Biomater. Res."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332222005236?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332222005236?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:59:31Z","timestamp":1787597971000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332222005236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":146,"alternative-id":["S0753332222005236"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2022.113134","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diabetes mellitus and diabetic foot ulcer: Etiology, biochemical and molecular based treatment strategies via gene and nanotherapy","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2022.113134","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"113134"}}